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Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Jean-Michel Vallat,Joachim Weiss
  • Publisher :Unknown
  • Release Date :2014-08-01
  • Total pages :320
  • ISBN : 9781118618417
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Summary : Peripheral Nerve Disorders: Pathology and Genetics is a definitive, clinically-oriented guide to the pathology of peripheral nerve disorders. These commonly seen neurological challenges have many causes and accurate diagnosis is often necessary via pathological analysis. New techniques exploiting molecular biological knowledge have opened up new vistas to understanding the pathogenesis of these disorders, and hence their effective management. This new title takes a disease-oriented approach to understanding the pathology of these conditions. It combines classical and contemporary techniques to enable practitioners in neurology and neuropathology to better understanding of the disease processes underlying patients’ presentations and to formulate appropriate management plans. Peripheral Nerve Disorders: Pathology and Genetics is a valuable resource for neurologists, neuropathologists, pathologists, neurobiologists and geneticists.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Gérard Said,Christian Krarup
  • Publisher :Unknown
  • Release Date :2013-08-17
  • Total pages :1008
  • ISBN : 9780444633552
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Summary : Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities. Covers both hereditary and cryptogenic neurologic disorders Includes advances in the basic science of PNS from molecular genetics, biochemistry, immunology, morphology and physiology Detailed coverage of neuropathy in connective tissue disorders, infectious disorders, metabolic disorders and malignancy

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Miki Suzuki
  • Publisher :Unknown
  • Release Date :2013-08-17
  • Total pages :1008
  • ISBN : 9780128078778
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Summary : Peripheral neuropathy is an important factor of disability in the elderly, which is significant now that up to 20% of the population is older than 60 years in industrialized countries. Potentially treatable neuropathies including primary inflammatory polyneuropathies and systemic disorders, especially vasculitic neuropathies, are as common in this age group as in younger patients. Neuropathies associated with diabetes, malignancy, and monoclonal gammopathies are even more common in these patients. It is thus essential to identify the causes of these neuropathies in this group of patients and treat them whenever feasible.

Diagnosis and Management of Peripheral Nerve Disorders

Diagnosis and Management of Peripheral Nerve Disorders
  • Author : Jerry R. Mendell,David R. Cornblath,John T. Kissel
  • Publisher :Unknown
  • Release Date :2001-03-08
  • Total pages :695
  • ISBN : 9780195133011
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Summary : Peripheral neuropathies represent a challenging subject for most physicians. This is an up-to-date, comprehensive, and readable book on peripheral neuropathies that includes concise information on the clinical, electrophysiological, pathological, pathogenic, and treatment aspects of the most important disorders. New molecular and serologic diagnostic tests are discussed. Sections are devoted to nerve and skin biopsy techniques and findings, quantitative sensory and autonomic reflex tests. Case examples are used liberally throughout the text. The editors: Mendell, Kissel, and Cornblath are experienced clinicians that bring complementary knowledge to each of the subjects. Additional authors have been handpicked for specific topics which add to the value of the edition.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Jean-Michel Vallat,Joachim Weis
  • Publisher :Unknown
  • Release Date :2014-10-20
  • Total pages :320
  • ISBN : 9781118618431
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Summary : Peripheral Nerve Disorders: Pathology and Genetics is adefinitive, clinically-oriented guide to the pathology ofperipheral nerve disorders. These commonly seen neurological challenges have many causes andaccurate diagnosis is often necessary via pathological analysis.New techniques exploiting molecular biological knowledge haveopened up new vistas to understanding the pathogenesis of thesedisorders, and hence their effective management. This new title takes a disease-oriented approach to understandingthe pathology of these conditions. It combines classical andcontemporary techniques to enable practitioners in neurology andneuropathology to better understanding of the disease processesunderlying patients? presentations and to formulateappropriate management plans. Peripheral Nerve Disorders: Pathology and Genetics is avaluable resource for neurologists, neuropathologists,pathologists, neurobiologists and geneticists.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Alberto Alain Gabbai,Adauto Castelo,Acary Souza Bulle Oliveira
  • Publisher :Unknown
  • Release Date :2013-08-17
  • Total pages :1008
  • ISBN : 9780128078600
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Summary : Peripheral neuropathies are the most common neurological manifestations occurring in HIV-infected individuals. Distal symmetrical sensory neuropathy is the most common form encountered today and is one of the few that are specific to HIV infection or its treatment. The wide variety of other neuropathies is akin to the neuropathies seen in the general population and should be managed accordingly. In the pre-ART era, neuropathies were categorized according to the CD4 count and HIV viral load. In the early stages of HIV infection when CD4 count is high, the inflammatory demyelinating neuropathies predominate and in the late stages with the decline of CD4 count opportunistic infection-related neuropathies prevail. That scenario has changed with the present almost universal use of ART (antiretroviral therapy). Hence, HIV-associated peripheral neuropathies are better classified according to their clinical presentations: distal symmetrical polyneuropathy, acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), mononeuropathies, mononeuropathies multiplex and cranial neuropathies, autonomic neuropathy, lumbosacral polyradiculomyelopathy, and amyotrophic lateral sclerosis (ALS)-like motor neuropathy. Treated with ART, HIV-infected individuals are living longer and are at a higher risk of metabolic and age-related complications; moreover they are also prone to the potentially neurotoxic effects of ART. There are no epidemiological data regarding the incidence and prevalence of the peripheral neuropathies. In the pre-ART era, most data were from case reports, series of patients, and pooled autopsy data. At that time the histopathological evidence of neuropathies in autopsy series was almost 100%. In large prospective cohorts presently being evaluated, it has been found that 57% of HIV-infected individuals have distal symmetrical sensory neuropathy and 38% have neuropathic pain. It is now clear that distal symmetrical sensory neuropathy is caused predominantly by the ART’s neurotoxic effect but may also be caused by the HIV itself. With a sizeable morbidity, the neuropathic pain caused by distal symmetrical sensory neuropathy is very difficult to manage; it is often necessary to change the ART regimen before deciding upon the putative role of HIV infection itself. If the change does not improve the pain, there are few options available; the most common drugs used for neuropathic pain are usually not effective. One is left with cannabis, which cannot be recommended as routine therapy, recombinant human nerve growth factor, which is unavailable, and topical capsaicin with its side-effects. Much has been done to and learned from HIV infection in humans; HIV-infected individuals, treated with ART, are now dying mostly from cardiovascular disease and non-AIDS-related cancers. It hence behooves us to find new approaches to mitigate the residual neurological morbidity that still impacts the quality of life of that population.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Guido Stoll,Einar Wilder-Smith,Martin Bendszus
  • Publisher :Unknown
  • Release Date :2013-08-17
  • Total pages :1008
  • ISBN : 9780128078396
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Summary : This chapter summarizes progress in the evaluation of peripheral nerve (PN) lesions and disorders by imaging techniques encompassing magnetic resonance imaging (MRI) and nerve ultrasound (US). Due to the radiation exposure and limited sensitivity in soft tissue contrast, computed-tomography (CT) plays no significant role in the diagnostic work-up of PN disorders. MRI and US are complementary techniques for the evaluation of peripheral nerves, each having particular advantages and disadvantages. Nerve injury induces intrinsic MRI signal alterations on T2-weighted sequences in degenerating or demyelinating nerve segments as well as in corresponding muscle groups exhibiting denervation which can be exploited diagnostically. Nerve US is based on changes in the nerve echotexture due to tumor formation or focal enlargement caused by entrapment or inflammation. Both MRI and US provide morphological information on the precise site and extent of nerve injury. While US has the advantage of easy accessibility, providing images with superior spatial resolution at low cost, MRI shows better soft tissue contrast and better image quality for deep-lying nerve structures since imaging is not hindered by bone. Recent advances have remarkably increased spatial resolution of both MRI and US making imaging indispensible for the elucidation of causes of nerve compression, peripheral nerve tumors, and focal inflammatory conditions. Both MRI and US further guide neurosurgical exploration and can simplify treatment. Importantly, imaging can reveal treatable conditions even in the absence of gross electrophysiological alterations, illustrating its increasing role in clinical practice. In experimental settings, novel molecular and cellular MRI contrast agents allow in-vivo assessment of nerve regeneration as well as monitoring of neuroinflammation. Depending on further clinical development, contrast-enhanced MRI has the potential to follow cellular responses over time in vivo and to overcome the current limitations of histological assessment of nerve afflictions. Further advances in contrast-enhanced US has the potential for developing into a tool for the assessment of nerve blood perfusion, paving the way for better assessments of ischemic neuropathies.

Basic Principles of Peripheral Nerve Disorders

Basic Principles of Peripheral Nerve Disorders
  • Author : Seyed Mansoor Rayegani
  • Publisher :Unknown
  • Release Date :2012-03-28
  • Total pages :290
  • ISBN : 9789535104070
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Summary : Peripheral nerve disorders are comprising one of the major clinical topics in neuromusculoskeletal disorders. Sharp nerve injuries, chronic entrapment syndromes, and peripheral neuropathic processes can be classified in this common medical topic. Different aspects of these disorders including anatomy, physiology, pathophysiology, injury mechanisms, and different diagnostic and management methods need to be addressed when discussing this topic. The goal of preparing this book was to gather such pertinent chapters to cover these aspects.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Keiko Toyooka
  • Publisher :Unknown
  • Release Date :2013-08-17
  • Total pages :1008
  • ISBN : 9780128078686
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Summary : Fabry disease results from deficient activity of the enzyme α-galactosidase A and progressive lysosomal deposition of globotriaosylceramide (GL-3) in cells throughout the body. The main neurological presentations of Fabry disease patients are painful neuropathy, hypohidrosis, and stroke. Fabry neuropathy is characterized as a length-dependent peripheral neuropathy affecting mainly the small myelinated (Aδ) fibers and unmyelinated (C) fibers. Enzyme replacement therapy (ERT) has been shown to have some positive effects on the reduction of neuropathic pain, the improvement of detection threshold for thermal sensation, and sweat function. On the contrary, the effect of ERT on the central nervous system has not been established. Early initiation of ERT before irreversible organ failure is extremely important, and alternative therapeutic approaches are currently being explored. Heterozygotes suffer from peripheral neuropathy at a higher rate than previously shown, significant multisystemic disease, and severely decreased quality of life. As well as being carriers, heterozygotes also display symptoms of Fabry disease, and should be carefully monitored and given adequate therapy.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Kåre Fugleholm
  • Publisher :Unknown
  • Release Date :2013-08-17
  • Total pages :1008
  • ISBN : 9780128078761
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Summary : Surgical pathology of the peripheral nervous system includes traumatic injury, entrapment syndromes, and tumors. The recent significant advances in the understanding of the pathophysiology and cellular biology of peripheral nerve degeneration and regeneration has yet to be translated into improved surgical techniques and better outcome after peripheral nerve injury. Decision making in peripheral nerve surgery continues to be a complex challenge, where the mechanism of injury, repeated clinical evaluation, neuroradiological and neurophysiological examination, and detailed knowledge of the peripheral nervous system response to injury are prerequisite to obtain the best possible outcome. Surgery continues to be the primary treatment modality for peripheral nerve tumors and advances in adjuvant oncological treatment has improved outcome after malignant peripheral nerve tumors. The present chapter provides background knowledge of surgical peripheral nerve disease and some general and practical guidance toward its clinical management.

Peripheral Nerve Disorders and Treatment

Peripheral Nerve Disorders and Treatment
  • Author : Hande Turker,Leonel Garcia Benavides,Guillermo Ramos Gallardo,Miriam Méndez Del Villar
  • Publisher :Unknown
  • Release Date :2020-07-08
  • Total pages :192
  • ISBN : 9781789852578
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Summary : Neuropathies are one of the main neurological problems in everyday life, and they still have many partially understood parts and unknowns both for physicians and patients. Many systemic conditions may exist within them and therefore they may be difficult to treat. In this book we provide current knowledge concerning neuropathies, which we believe you will find interesting. The subject ‘’neuropathies’’ comprises a number of topics, and each and every one could be the subject of a textbook. On the other hand, this book was never designed as one. This book should be read without prejudgment because the content may not be compatible with general but repeated assumptions and guidelines. However, I believe that the book may be an inspiration for many young investigators as well. It contains current approaches and knowledge and we sincerely believe and hope that it will answer your queries regarding new perspectives about neuropathy in general.

Surgical Disorders of the Peripheral Nerves

Surgical Disorders of the Peripheral Nerves
  • Author : Rolfe Birch
  • Publisher :Unknown
  • Release Date :2011-01-21
  • Total pages :645
  • ISBN : 1848821085
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Summary : Since the highly praised first edition of Surgical Disorders of the Peripheral Nerves was published in 1998, greater understanding of the the molecular and cellular events which underlie the response of nerves to injury, regeneration and neuropathic pain has been achieved. This second edition has been fully updated in line with new clinical knowledge, and also incorporates the extensive study of thousands of surgical case studies spanning repairs of the supraclavicular plexus in the adult, the birth lesion of the brachial plexus,compound nerve injury and iatrogenous injury. Beginning with the fundamentals of the anatomy and function of the peripheral nervous system, and working its way through various types of injury, operative methods, the regeneration and recovery of nerves, surgical reconstruction, pain, and rehabilitation, this eloquently written work provides the reader with the solid understanding required to successfully perform surgery on the peripheral nervous system. Dr Shelagh Smith, joined by Dr Ravi Knight, has rewritten the chapter Electrodiagnosis. Professor Tara Renton has written a new chapter on injuries to the trigeminal nerve in maxilla-facial and dental work. The drawings, by Mr Philip Wilson, are new. Most of the 700 illustrations are also new. This thorough and authoritative look at the surgical treatment of the peripheral nerves is fully illustrated throughout with exquisite line diagrams and clear, instructive photographs.

Peripheral Nerve Disorders 2

Peripheral Nerve Disorders 2
  • Author : Arthur K. Asbury,Peter Kynaston Thomas
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :316
  • ISBN : UOM:39015038156272
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Summary : The flow of new information in the eleven years since the publication of the first volume (published in the BIMR series), has long necessitated a new look at peripheral nerve disorders. Thus this new volume emphasises the advances of the past decade and includes information on newly recognized neuropathies, hereditary neuropathies, peripheral nerve dysfunction and therapeutic advances. It has over 20 contributors from the UK, USA and continental Europe.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Andrea M. Vincent,Bernadette Calabek,Laurel Roberts,Eva L. Feldman
  • Publisher :Unknown
  • Release Date :2013-08-17
  • Total pages :1008
  • ISBN : 9780128078655
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Summary : More than half of all patients with diabetes develop neuropathic disorders affecting the distal sensory and/or motor nerves, or autonomic or cranial nerve functions. Glycemic control can decrease the incidence of neuropathy but is not adequate alone to prevent or treat the disease. This chapter introduces diabetic neuropathy with a morphological description of the disease then describes our current understanding of metabolic and molecular mechanisms that contribute to neurovascular dysfunctions. Key mechanisms include glucose and lipid imbalances and insulin resistance that are interconnected via oxidative stress, inflammation, and altered gene expression. These complex interactions should be considered for the development of new treatment strategies against the onset or progression of neuropathy. Advances in understanding the combined metabolic stressors and the novel study of epigenetics suggest new therapeutic targets to combat this morbid and intractable disease affecting millions of patients with type 1 or type 2 diabetes.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Gérard Said
  • Publisher :Unknown
  • Release Date :2013-08-17
  • Total pages :1008
  • ISBN : 9780128078587
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Summary : Neurological manifestations of sarcoidosis are relatively rare but constitute a treatable cause of central and peripheral neurological manifestations. Regarding the peripheral nervous system, cranial nerves are predominantly affected, and peripheral facial nerve palsy, often bilateral, is the most common neurological manifestation of sarcoidosis. Multifocal peripheral neuropathy is a rare event in sarcoidosis. In some cases, however, peripheral neuropathy is the presenting manifestation and seemingly the only organ affected. Definite diagnosis of sarcoidosis rests ideally on histological demonstration of sarcoid granulomas in tissue biopsy specimens.

Companion to Peripheral Neuropathy

Companion to Peripheral Neuropathy
  • Author : Peter James Dyck
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :355
  • ISBN : 9781437700015
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Summary : "An excellent companion volume to Dyck and Thomas' authoritative and comprehensive Peripheral Neuropathy, this visually rich resource features illustrated case studies that explore the evaluation and management of the most common peripheral nerve disorders. Leading authorities in the field contribute clues to the diagnosis, clinical features, imaging studies, histopathology, and more for each, case. You'll benefit from new perspectives on the causes of peripheral nerve disorders, helping you to diagnose and treat every condition you're likely to encounter." --Book Jacket.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Gérard Said
  • Publisher :Unknown
  • Release Date :2013-08-17
  • Total pages :1008
  • ISBN : 9780128078440
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Summary : Examination of a patient with peripheral neuropathy starts with careful questioning of the patient about the history of symptoms and signs and of a possible familial disorder. Several steps are required during examination of the patient with peripheral neuropathy: first the pattern of neuropathy and site of lesions should be determined: roots, nerve trunks, focal, multifocal, length-dependent generalized polyneuropathy, the type of nerve fibers predominantly affected, the association with trophic changes and autonomic dysfunction, the course of the disease ranging from acute inflammatory polyneuritis or fulminant multifocal neuropathy to an extremely slow progression as in Charcot−Marie−Tooth syndromes. At the end of this first contact with the patient, the neurologist must decide which investigations seem necessary and their timing including electrophysiological tests, imaging, CSF examination, blood tests, nerve and muscle biopsy, DNA testing, etc. In some cases, life-threatening manifestations, including weakness of respiratory muscles or swallowing difficulty, or autonomic dysfunction, require urgent therapeutic decisions.

Diagnosis and Management of Peripheral Nerve Disorders

Diagnosis and Management of Peripheral Nerve Disorders
  • Author : Jerry R. Mendell,John T. Kissel,David R. Cornblath
  • Publisher :Unknown
  • Release Date :2001-03-08
  • Total pages :720
  • ISBN : 0198030487
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Summary : Peripheral neuropathies represent a challenging subject for most physicians. This is an up-to-date, comprehensive, and readable book on peripheral neuropathies that includes concise information on the clinical, electrophysiological, pathological, pathogenic, and treatment aspects of the most important disorders. New molecular and serologic diagnostic tests are discussed. Sections are devoted to nerve and skin biopsy techniques and findings, quantitative sensory and autonomic reflex tests. Case examples are used liberally throughout the text. The editors: Mendell, Kissel, and Cornblath are experienced clinicians that bring complementary knowledge to each of the subjects. Additional authors have been handpicked for specific topics which add to the value of the edition.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : Gérard Said
  • Publisher :Unknown
  • Release Date :2013-08-17
  • Total pages :1008
  • ISBN : 9780128078648
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Summary : Diabetes is the most common cause of peripheral neuropathy in the world. Both type 1 (insulin-dependent) and type 2 diabetes are commonly complicated by peripheral nerve disorders. Two main types of neuropathy are observed: the most common is a nerve fiber length-dependent, distal symmetrical sensory polyneuropathy with little motor involvement but frequent, and potentially life threatening, autonomic dysfunction. Alteration of temperature and pain sensations in the feet is an early manifestation of diabetic polyneuropathy. The second pattern is a focal neuropathy, which more commonly complicates or reveals type 2 diabetes. Poor diabetic control increases the risk of neuropathy with subsequent neuropathic pains and trophic changes in the feet, which can be prevented by education of patients.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
  • Author : W. Grisold,Chiara Briani,Andrea Vass
  • Publisher :Unknown
  • Release Date :2013-08-17
  • Total pages :1008
  • ISBN : 9780128078716
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Summary : The peripheral nervous system can be affected by malignancies involving different mechanisms. Neoplastic nerve lesion by compression, invasion, and infiltration is rare and occurs in particular in leukemia (neuroleukemiosis) and lymphoma (neurolymphomatosis). Its occurrence is much rarer in cancer, and even less so in sarcoma. The neoplastic infiltration of peripheral nerves by solid tumors is characterized by specific topographical sites such as the base of the skull, the ear, nose and throat region, and the cervico-brachial plexus as well as the lumbar and sacral plexus. Rarely malignant invasion affects the cranial nerves of the face where it can spread centripetally. Autonomic nerves and ganglia can also be affected. The retrograde spread of cancer in nerves is a bad prognostic sign. The clinical diagnosis is determined by tumor type, the pattern of involvement, and often pain.

Peripheral Neuropathies in Clinical Practice

Peripheral Neuropathies in Clinical Practice
  • Author : Steven Herskovitz,Stephen Scelsa,Herbert Schaumburg
  • Publisher :Unknown
  • Release Date :2010-02-11
  • Total pages :408
  • ISBN : 9780199884773
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Summary : The last 2 decades have seen enormous strides in our understanding of the biological, genetic and clinical basis of the peripheral nerve disorders. This remains a difficult area for most practitioners. This text combines a thorough review of the neurologic literature with clinical experience in presenting a comprehensive yet concise and readable approach to the understanding, evaluation and management of these disorders. All practitioners seeing these patients, as well as all trainees in Neurology and related fields, should find this a useful, approachable initial resource.