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Polymer-Protein Conjugates

Polymer-Protein Conjugates
  • Author : Gianfranco Pasut,Samuel Zalipsky
  • Publisher :Unknown
  • Release Date :2019-10-30
  • Total pages :512
  • ISBN : 9780444640826
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Summary : Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. Provides an overview on the state-of-the-art of protein polymer conjugation Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes Outlines advantages and potential risks of present technology based on PEG Offers new alternatives for PEG and new approaches for on site-selective protein modification Identifies future direction of research in this field

Polymer-Protein Conjugates

Polymer-Protein Conjugates
  • Author : Gianfranco Pasut,Samuel Zalipsky
  • Publisher :Unknown
  • Release Date :2019-11
  • Total pages :312
  • ISBN : 0444640819
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Summary : Polymer-Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. Provides an overview on the state-of-the-art of protein polymer conjugation Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes Outlines advantages and potential risks of present technology based on PEG Offers new alternatives for PEG and new approaches for on site-selective protein modification Identifies future direction of research in this field

Polymer Therapeutics I

Polymer Therapeutics I
  • Author : Ronit Satchi-Fainaro,Ruth Duncan
  • Publisher :Unknown
  • Release Date :2006-02-10
  • Total pages :204
  • ISBN : 3540292101
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Summary :

PEGylated Protein Drugs: Basic Science and Clinical Applications

PEGylated Protein Drugs: Basic Science and Clinical Applications
  • Author : Francesco M. Veronese
  • Publisher :Unknown
  • Release Date :2009-12-30
  • Total pages :290
  • ISBN : 9783764386795
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Summary : PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

Self-Assembly

Self-Assembly
  • Author : Ramanathan Nagarajan
  • Publisher :Unknown
  • Release Date :2019-01-07
  • Total pages :368
  • ISBN : 9781119001362
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Summary : An introduction to the state-of-the-art of the diverse self-assembly systems Self-Assembly: From Surfactants to Nanoparticles provides an effective entry for new researchers into this exciting field while also giving the state of the art assessment of the diverse self-assembling systems for those already engaged in this research. Over the last twenty years, self-assembly has emerged as a distinct science/technology field, going well beyond the classical surfactant and block copolymer molecules, and encompassing much larger and complex molecular, biomolecular and nanoparticle systems. Within its ten chapters, each contributed by pioneers of the respective research topics, the book: Discusses the fundamental physical chemical principles that govern the formation and properties of self-assembled systems Describes important experimental techniques to characterize the properties of self-assembled systems, particularly the nature of molecular organization and structure at the nano, meso or micro scales. Provides the first exhaustive accounting of self-assembly derived from various kinds of biomolecules including peptides, DNA and proteins. Outlines methods of synthesis and functionalization of self-assembled nanoparticles and the further self-assembly of the nanoparticles into one, two or three dimensional materials. Explores numerous potential applications of self-assembled structures including nanomedicine applications of drug delivery, imaging, molecular diagnostics and theranostics, and design of materials to specification such as smart responsive materials and self-healing materials. Highlights the unifying as well as contrasting features of self-assembly, as we move from surfactant molecules to nanoparticles. Written for students and academic and industrial scientists and engineers, by pioneers of the research field, Self-Assembly: From Surfactants to Nanoparticles is a comprehensive resource on diverse self-assembly systems, that is simultaneously introductory as well as the state of the art.

The Evaluation of Polymer-peptide and Polymer-protein Conjugates for Targeted Melanoma Chemotherapy

The Evaluation of Polymer-peptide and Polymer-protein Conjugates for Targeted Melanoma Chemotherapy
  • Author : Kavitha R. Sunassee
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :229
  • ISBN : OCLC:60286636
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Summary :

Bio-inspired Polymers

Bio-inspired Polymers
  • Author : Nico Bruns,Andreas F M Kilbinger
  • Publisher :Unknown
  • Release Date :2016-10-14
  • Total pages :612
  • ISBN : 9781782626664
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Summary : Many key aspects of life are based on naturally occurring polymers, such as polysaccharides, proteins and DNA. Unsurprisingly, their molecular functionalities, macromolecular structures and material properties are providing inspiration for designing new polymeric materials with specific functions, for example, responsive, adaptive and self-healing materials. Bio-inspired Polymers covers all aspects of the subject, ranging from the synthesis of novel polymers, to structure-property relationships, materials with advanced properties and applications of bio-inspired polymers in such diverse fields as drug delivery, tissue engineering, optical materials and lightweight structural materials. Written and edited by leading experts on the topic, the book provides a comprehensive review and essential graduate level text on bio-inspired polymers for biochemists, materials scientists and chemists working in both industry and academia.

Protein-based Engineered Nanostructures

Protein-based Engineered Nanostructures
  • Author : Aitziber L. Cortajarena,Tijana Z. Grove
  • Publisher :Unknown
  • Release Date :2016-09-27
  • Total pages :286
  • ISBN : 9783319391960
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Summary : This book is devoted to the engineering of protein-based nanostructures and nanomaterials. One key challenge in nanobiotechnology is to be able to exploit the natural repertoire of protein structures and functions to build materials with defined properties at the nanoscale using “bottom-up” strategies. This book addresses in an integrated manner all the critical aspects that need to be understood and considered to design the next generation of nano-bio assemblies. The book covers first the fundamentals of the design and features of the protein building blocks and their self-assembly illustrating some of the most relevant examples of nanostructural design. Finally, the book contains a section dedicated to demonstrated applications of these novel bioinspired nanostructures in different fields from hybrid nanomaterials to regenerative medicine. This book provides a comprehensive updated review of this rapidly evolving field.

Bioconjugate Techniques

Bioconjugate Techniques
  • Author : Greg T. Hermanson
  • Publisher :Unknown
  • Release Date :2013-07-25
  • Total pages :1200
  • ISBN : 9780123822406
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Summary : Bioconjugate Techniques, 3rd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions, with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. Offers a one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Provides step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates Features full color illustrations Includes a more extensive introduction into the vast field of bioconjugation and one of the most thorough overviews of immobilization chemistry ever presented

Bioresponsive Polymer-protein Conjugates as a Unimolecular Drug Delivery System

Bioresponsive Polymer-protein Conjugates as a Unimolecular Drug Delivery System
  • Author : Helena Rosalind Petra Gilbert
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :229
  • ISBN : OCLC:1118125867
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Summary :

Natural Polymers for Drug Delivery

Natural Polymers for Drug Delivery
  • Author : Harsha Kharkwal,Srinivas Janaswamy
  • Publisher :Unknown
  • Release Date :2016-12-07
  • Total pages :216
  • ISBN : 9781780644479
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Summary : Natural polymers have been utilized extensively in food, pharmaceuticals, cosmetics, textiles, oil drilling and paint industries. Their non-toxic and inexpensive attributes readily enhance their commercial acceptability and make them potent agents in lieu of synthetic polymers. This book explores the opportunistic utility of natural polymers in developing effective drug delivery systems and provides a comprehensive and up-to-date analysis of their source, chemical structure and mechanism of action. Covering novel polymers for drug delivery - in particular extracts from plants, microorganisms and proteins, as well as water soluble and water insoluble biodegradable polymers - it presents an encyclopaedic overview of natural polymers'. Natural Polymers for Drug Delivery is an invaluable resource for researchers, students and industrial scientists in the fields of biochemistry, chemistry, pharmacology and food science.

Renewable Resources for Functional Polymers and Biomaterials

Renewable Resources for Functional Polymers and Biomaterials
  • Author : Peter Williams
  • Publisher :Unknown
  • Release Date :2015-11-09
  • Total pages :466
  • ISBN : 9781782625841
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Summary : This book details polysaccharides and other important biomacromolecules covering their source, production, structures, properties, and current and potential application in the fields of biotechnology and medicine. It includes a systematic discussion on the general strategies of isolation, separation and characterization of polysaccharides and proteins. Subsequent chapters are devoted to polysaccharides obtained from various sources, including botanical, algal, animal and microbial. In the area of botanical polysaccharides, separate chapters are devoted to the sources, structure, properties and medical applications of cellulose and its derivatives, starch and its derivatives, pectins, and exudate gums, notably gum arabic. Another chapter discusses the potential of hemicelluloses (xylans and xylan derivatives) as a new source of functional biopolymers for biomedical and industrial applications. The algal polysaccharide, alginate, has significant application in food, pharmaceuticals and the medical field, all of which are reviewed in a separate chapter. Polysaccharides of animal origin are included with separate chapters on the sources, production, biocompatibility, biodegradability and biomedical applications of chitin (chitosan) and hyaluronan. With the increasing knowledge and applications of genetic engineering there is also an introduction in the book to nucleic acid polymers, the genome research and genetic engineering. Proteins and protein conjugates are covered, with one chapter providing a general review of structural glycoproteins, fibronectin and laminin, together with their role in the promotion of cell adhesion in vascular grafts, implants and tissue engineering. Another chapter discusses general aspects of a number of industrial proteins, including casein, caseinates, whey protein, gluten and soy proteins, with emphasis on their medical applications, and with reference to the potential of bacterial proteins. Another natural polymer resource, microbial polyesters, although small compared with polysaccharides and proteins, is also gaining increasing interest in biomedical technology and other industrial sectors. One chapter, therefore, is devoted to microbial polyesters, with comprehensive coverage of their biosynthesis, properties, enzymic degradation and applications. By dealing with biopolymers at the molecular level, the book is aimed at the biomedical and wider materials science communities and provides an advanced overview of biopolymers at the graduate and postgraduate level. In addition it will appeal to both academic and industrial life scientists who are involved in research and development activities in the medical and biotechnology field.

Polymer Modification

Polymer Modification
  • Author : Graham G. Swift,Charles E. Carraher Jr.,Chris Bowman
  • Publisher :Unknown
  • Release Date :2013-06-29
  • Total pages :212
  • ISBN : 9781489914774
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Summary : Proceedings of an ACS-PMSE Division Symposium held in Orlando, Florida, August 21-25, 1996

Bioconjugation Protocols

Bioconjugation Protocols
  • Author : Sonny S. Mark
  • Publisher :Unknown
  • Release Date :2016-08-23
  • Total pages :605
  • ISBN : 1493960962
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Summary : Contemporary approaches to the synthesis of chemically modified biomacromolecules (proteins, nucleic acids, lipids, and carbohydrates) not only require efficient means to control conjugation and the specific site of attachment of the conjugated moiety but also the effective use of recent developments in the fields of pharmaceutical chemistry, biomolecular/polymer engineering, and nanobiotechnology. In this second edition of Bioconjugation Protocols: Strategies and Methods, expert researchers update the classic methods and introduce valuable new approaches that go beyond basic conjugation techniques to include elements from advanced organic synthesis, molecular biology, surface biotechnology, materials science, and nanobioscience/engineering. These readily reproducible methods cover the preparation of biomolecular conjugates using a variety of labeling techniques and semisynthetic approaches. Additional chapters address the biofunctionalization of surface structures, including organic/inorganic thin films, as well as various types of nanostructures (magnetic nanoparticles, quantum dots, carbon nanotubes, and silicon nanowire devices). All the protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Bioconjugation Protocols: Strategies and Methods, Second Edition offers both novice and experienced researchers access to the broad array of techniques needed to carry out the semisynthesis of functional biomolecular reagents and/or the biofunctionalization of surfaces and structures of unique interest for a wide variety of applications, ranging from novel biomedical diagnostics to powerful new therapeutics to advanced biomaterials.

Bioresorbable Polymers

Bioresorbable Polymers
  • Author : Declan Devine
  • Publisher :Unknown
  • Release Date :2019-04-15
  • Total pages :152
  • ISBN : 9783110640571
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Summary : Bioresorbable implants can be processed via conventional polymer processing methods such as extrusion, injection and compressing moulding, solvent spinning or casting. This book addresses issues and highlights recent advances in the use of biodegradable polymers. It is intended for researchers utilizing biodegradable polymers in areas from tissue engineering to controlled release of active pharmaceuticals, as well as industrial processors.

Synthesis and Applications of Copolymers

Synthesis and Applications of Copolymers
  • Author : Anbanandam Parthiban
  • Publisher :Unknown
  • Release Date :2014-06-23
  • Total pages :400
  • ISBN : 9781118860489
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Summary : Understanding the reactivity of monomers is crucial in creating copolymers and determining the outcome of copolymerization. Covering the fundamental aspects of polymerization, Synthesis and Applications of Copolymers explores the reactivity of monomers and reaction conditions that ensure that the newly formed polymeric materials exhibit desired properties. Referencing a wide-range of disciplines, the book provides researchers, students, and scientists with the preparation of a diverse variety of copolymers and their recent developments, with a particular focus on copolymerization, crystallization, and techniques like nanoimprinting and micropatterning.

Reactive Polymers

Reactive Polymers
  • Author : Karl-F. Arndt,Dirk Kuckling,Manfred Stamm,Brigitte Voit,Thomas Wolff
  • Publisher :Unknown
  • Release Date :2001-06-15
  • Total pages :486
  • ISBN : STANFORD:36105110481517
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Summary : This volume of Macromolecular Symposia contains papers presented at the 1st International Symposium on "Reactive Polymers in Inhomogeneous Systems, in Melts and at Interfaces" held in Dresden Germany in July 2000. It includes 42 contributions from renowned scientists dealing with topics of current interest in the field of synthesis, characterization and application of reactive and functional polymers. The papers add significantly to the current understanding of the role of reactive polymers in phenomena such as adhesion, colloidal stability, corrosion resistance and biocompatibility - comprehension which is vital for improving the polymer technologies available today and for the development of new applications.

Cyclodextrins

Cyclodextrins
  • Author : Wanda Sliwa,Tomasz Girek
  • Publisher :Unknown
  • Release Date :2017-04-10
  • Total pages :336
  • ISBN : 9783527339808
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Summary : Authored by two experts working in this important field of research, the timely book covers the latest advances in the synthesis of cyclodextrins, their properties and important industrial applications. To this end, the authors describe covalent and non-covalent assemblies, cyclodextrin inclusion complexes, cyclodextrin polymers, and modified cyclodextrins, resulting in an up-to-date overview of cyclodextrin chemistry. An invaluable reference for organic and polymer chemists in academia as well as those researchers in industry working in polymer, supramolecular and pharmaceutical chemistry, as well as food, textile and cosmetic science.

Bio-Synthetic Hybrid Materials and Bionanoparticles

Bio-Synthetic Hybrid Materials and Bionanoparticles
  • Author : Alexander Boker,Patrick van Rijn
  • Publisher :Unknown
  • Release Date :2015-08-18
  • Total pages :314
  • ISBN : 9781782622109
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Summary : There is much interest in using biological structures for the fabrication of new functional materials. Recent developments in the particle character and behaviour of proteins and viral particles have had a major impact on the development of novel nanoparticle systems with new functions and possibilities. Bio-Synthetic Hybrid Materials and Bionanoparticles approaches the subject by covering the basics of disciplines involved as well as recent advances in new materials. The first section of the book focusses on the design and synthesis of different bionanoparticles and hybrid structures including the use of genetic modification as well as by organic synthesis. The second section of the book looks at the self-assembling behaviour of bionanoparticles to form new materials. The final section looks at bionanoparticle-based functional systems and materials including chapters on biomedical applications and electronic systems and devices. Edited by leading scientists in bionanoparticles, the book is a collaboration between scientists with different backgrounds and perspectives which will initiate the next generation of bio-based structures, materials and devices.

Peptide Hybrid Polymers

Peptide Hybrid Polymers
  • Author : Harm-Anton Klok,Helmut Schlaad
  • Publisher :Unknown
  • Release Date :2010-11-25
  • Total pages :160
  • ISBN : 3642068979
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Summary :

Therapeutic Proteins

Therapeutic Proteins
  • Author : Roland Kontermann
  • Publisher :Unknown
  • Release Date :2012-01-31
  • Total pages :372
  • ISBN : 9783527644780
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Summary : For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.