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Pouchitis and Ileal Pouch Disorders

Pouchitis and Ileal Pouch Disorders
  • Author : Bo Shen
  • Publisher :Unknown
  • Release Date :2018-11-05
  • Total pages :570
  • ISBN : 9780128096291
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Summary : Pouchitis and Ileal Pouch Disorders: A Multidisciplinary Approach for Diagnosis and Management provides much needed information on the evolution of pouch surgery, pouch surgery techniques, and surgery-associated complications, including inflammatory, functional, neoplastic, and metabolic complications. The book provides information on the anatomy of the pouch, pathogenesis of pouchitis and other pouch disorders, proper diagnostic modalities, and medical, endoscopic and surgical options for those disorders. The information has been compiled from a panel of national and international leading experts in the field, including basic scientists, gastrointestinal (GI) pathologists, GI radiologists, gastroenterologists, and more. Features never-before-published information and technology from the vast experience of the contributors and editors in diagnosis and medical, endoscopic, and surgical management of pouchitis and other pouch disorders Contains easy to access recommendations from experts Provides access to an accompanying website with videos of endoscopic demonstrations of various configurations of the pouch, endoscopic evaluation of pouch disorders, and endoscopic treatment of pouch strictures, fistula, and anastomotic leaks/sinuses

Atlas of Endoscopy Imaging in Inflammatory Bowel Disease

Atlas of Endoscopy Imaging in Inflammatory Bowel Disease
  • Author : Bo Shen
  • Publisher :Unknown
  • Release Date :2020-05-14
  • Total pages :612
  • ISBN : 9780128148129
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Summary : Atlas of Endoscopy Imaging in Inflammatory Bowel Disease is a complete reference providing all aspects of endoscopy imaging in inflammatory bowel disease (IBD). Building on the etiology and pathogenesis of IBD and taking into account the wide range of clinical presentations and phenotypes that reflect a long list of endoscopic features, this book systematically and exclusively presents all IBD-related endoscopy imaging for optimal understanding, diagnosis and management. Provides systemic classification and characterization of endoscopy imaging in the surgically altered bowel and in healthy and diseased IBD patients Incorporates state-of-the-art research in the area of endoscopy imaging in CD and UC, from current literature and the vast experience of a panel of national and international experts Covers all possible aspects related to endoscopic imaging in Inflammatory bowel disease

The Kock Pouch

The Kock Pouch
  • Author : Pär Myrelid,Mattias Block
  • Publisher :Unknown
  • Release Date :2018-11-24
  • Total pages :206
  • ISBN : 9783319955919
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Summary : This book is about the recently revived technique of Kock pouch in inflammatory bowel disease. It discusses the Kock pouch as an alternative to patients not suitable for a pelvic pouch or where the pelvic pouch has failed. It provides clinicians with all the necessary information on patient guidance and surgical revisions after a long life with a Kock pouch. The reader will learn about the development of the pouch, pre and post-operative strategies, surveillance, complications and the limitations and weaknesses of the method. New pioneering experimental methods used by the authors are also discussed. The use of ileorectal anastomosis and Kock’s continent ileostomy has regained interest as the long term problems of the pelvic pouch have and this book brings the knowledge and valuable experiences of a few experts at international centres to a large audience. This is an indispensable guide for colorectal surgeons, gastroenterologists and stoma therapi sts involved in the care of patients with inflammatory bowel disease where colectomy is still needed, either in an emergency setting or due to dysplasia or cancer.

Endoscopy in Inflammatory Bowel Disease

Endoscopy in Inflammatory Bowel Disease
  • Author : Richard Kozarek,Michael Chiorean,Michael Wallace
  • Publisher :Unknown
  • Release Date :2014-11-03
  • Total pages :339
  • ISBN : 9783319110776
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Summary : This book conjoins the latest advances on the use of endoscopy to diagnose, monitor, and treat patients with inflammatory bowel disease. Chapters include the historical use of rigid sigmoidoscopy, non-interventional imaging procedures, and the correlation of pathology and endoscopic visualization. This is the first book to include individual chapters in gastroenterology, colorectal surgery, and IBD texts, the preeminent role of endoscopic imaging in the management of chronic ulcerative colitis, and Crohn's disease. It also includes chapters on capsule endoscopy and balloon and overtube-assisted enteroscopy to define the presence and activity of Crohn's enteritis and additional chapters defining the use of random biopsies versus chromoendoscopy, and computer enhanced imaging to define possible dysplasia development. The book also includes access to online videos, making it the ultimate verbal and visual tool for all medical professionals interested in the advances in the field over the last several decades. Endoscopy in Inflammatory Bowel Disease is a concise text that is of great value to practicing endoscopists, gastroenterologists, general or colorectal surgeons, physicians in training, and all medical professionals caring for patients with inflammatory bowel disease.

Inflammatory Bowel Disease and Familial Adenomatous Polyposis

Inflammatory Bowel Disease and Familial Adenomatous Polyposis
  • Author : Gian Gaetano Delaini
  • Publisher :Unknown
  • Release Date :2007-03-06
  • Total pages :481
  • ISBN : 9788847004344
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Summary : Inflammatory bowel disease (IBD) and familial adenomatous polyposis (FAP) are complex diseases. Despite increased knowledge on the pathophysiological process, many aspects remain rather unclear, especially concerning IBD. This book gathers current methods of treatment of these diseases and also presents the management of their complications. The authors give a comprehensive overview of the newer therapies to bring readers up to date.

Atlas of Endoscopy Imaging in Inflammatory Bowel Disease

Atlas of Endoscopy Imaging in Inflammatory Bowel Disease
  • Author : Bo Shen
  • Publisher :Unknown
  • Release Date :2020-05-14
  • Total pages :612
  • ISBN : 9780128148129
GET BOOK HERE

Summary : Atlas of Endoscopy Imaging in Inflammatory Bowel Disease is a complete reference providing all aspects of endoscopy imaging in inflammatory bowel disease (IBD). Building on the etiology and pathogenesis of IBD and taking into account the wide range of clinical presentations and phenotypes that reflect a long list of endoscopic features, this book systematically and exclusively presents all IBD-related endoscopy imaging for optimal understanding, diagnosis and management. Provides systemic classification and characterization of endoscopy imaging in the surgically altered bowel and in healthy and diseased IBD patients Incorporates state-of-the-art research in the area of endoscopy imaging in CD and UC, from current literature and the vast experience of a panel of national and international experts Covers all possible aspects related to endoscopic imaging in Inflammatory bowel disease

Inflammatory Bowel Disease

Inflammatory Bowel Disease
  • Author : Stephan R. Targan,Fergus Shanahan,Loren C. Karp
  • Publisher :Unknown
  • Release Date :2011-08-24
  • Total pages :752
  • ISBN : 9781444359114
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Summary : This is the state-of–the-art book on inflammatory bowel disease you have been waiting for Written and edited by international experts in gastroenterology this up-to-date volume provides a complete review of the basic science behind inflammatory bowel disease (IBD), as well as evidence-based clinical guidance on diagnosis, treatment and long-term management of IBD. In 50 chapters the authors cover the latest and most promising treatment modalities and the science behind them. There are chapters which cover the advances in the medical and surgical treatment of conditions such as Crohn's disease and ulcerative colitis, as well as chapters focusing on nutrition, imaging and complementary medicine. This is an invaluable information resource for all those in the medical team treating patients with IBD. Whether you are a gastroenterologist, gastrointestinal surgeon or GI nurse specialist this book deserves a place in your library.

The Ileoanal Pouch

The Ileoanal Pouch
  • Author : Janindra Warusavitarne,Zarah Perry-Woodford
  • Publisher :Unknown
  • Release Date :2018-11-07
  • Total pages :197
  • ISBN : 9783319943855
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Summary : This book gives a comprehensive overview of surgery that results in creating an ileoanal pouch or continent ileostomy. It deals with the entire journey of pouch surgery starting from patient selection and counselling to technical tips and tricks and ending in managing pouch function and failure. Containing a patient experience section this volume helps clinicians better understand what a patient expects from the ileoanal pouch. This is a very specialised topic but one that is covered very poorly and this book has the potential to consolidate all that is known about the topic to provide a comprehensive overview on the surgery and its consequences.

Curbside Consultation in IBD

Curbside Consultation in IBD
  • Author : David T. Rubin,Sonia Friedman,Francis A. Farraye
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :209
  • ISBN : 1556428561
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Summary : Are you looking for concise, practical answers to questions that are often left unanswered by traditional IBD references? Are you seeking brief, evidence-based advice for complicated cases or complications? Curbside Consultation in IBD: 49 Clinical Questions provides quick and direct answers to the thorny questions commonly posed during a “curbside consultation” between colleagues. Dr. David Rubin, Dr. Sonia Friedman and Dr. Francis A. Farraye have designed this unique reference, which offers expert advice, preferences, and opinions on tough clinical questions commonly associated with IBD. The unique Q&A format provides quick access to current information related to IBD with the simplicity of a conversation between two colleagues. Numerous images, diagrams, and references are included to enhance the text and to illustrate IBD. Curbside Consultation in IBD: 49 Clinical Questions provides information that high-volume clinicians will appreciate, and yet is basic enough for residents. Gastroenterologists, fellows and residents in training, surgical attendings, and surgical residents will benefit from the user-friendly and casual format and the expert advice contained within. Some of the questions that are answered: • Which patients might be better for a “top down” approach (using anti-TNF therapy before steroids or proven failure of oral thiopurines)? What clinical behavior or serological markers might you use to identify these patients? • When is it appropriate to switch to another biologic therapy? • Should I be using chromoendoscopy in my surveillance colonoscopy in IBD? How and which agent? Would narrow band imaging be an alternative for this? • Can we follow flat low-grade dysplasia? Is any dysplasia really flat or just a spectrum of depth and size? • If women continue infliximab therapy during pregnancy, what are the implications for the baby? What should we be telling our patients about vaccinations?

Inflammatory Bowel Disease

Inflammatory Bowel Disease
  • Author : Daniel J. Stein,Reza Shaker
  • Publisher :Unknown
  • Release Date :2015-04-21
  • Total pages :237
  • ISBN : 9783319140728
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Summary : This title provides a point-of-care reference for busy clinicians who need the best evidence based answers to patient questions at their fingertips. Additionally, it guides clinicians through the complicated therapeutic management of IBD including drug initiation, medications side effects and complications, therapeutic level monitoring and accurate disease monitoring. Lastly, it addresses special situations such as alternative therapies, pregnancy, fertility, and lactation. Inflammatory Bowel Disease: A Point-of-Care Reference Guide will be a valuable reference for Gastroenterologists, Gastroenterology Fellows and Mid-Level Providers.

Unicorn Farts and Glitter: Quick and Dirty Tips for Surviving a J-Pouch

Unicorn Farts and Glitter: Quick and Dirty Tips for Surviving a J-Pouch
  • Author : AW Cross
  • Publisher :Unknown
  • Release Date :2016-08-02
  • Total pages :131
  • ISBN : 9780995099142
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Summary : You’ve just gotten a j-pouch. Now what? Life with your new j-pouch might feel intimidating, but it doesn’t have to be. In Unicorn Farts and Glitter: Quick and Dirty Tips for Surviving a J-Pouch, author and j-pouch veteran AW Cross gives you a first-hand, non-medical perspective about what to expect from your j-pouch and how to manage it successfully. Through her usual blend of practicality and humor, you’ll learn how to: •Cope with the physical consequences and emotional impact of having a j-pouch •Manage pouchitis, cuffitis, obstructions, strictures, and skin care •Pack a survival kit and leave the house with confidence •Dress, eat, and have sex •Deal with healthcare professionals and enjoy your stays in the hospital •Use social media and parley with non-pouchers Whether you’ve just gotten your j-pouch, or you’ve had one for years, if you’re determined to make the most of it, this book is for you. If you’d rather pretend that you’re normal, have no sense of humor about your j-pouch, and hate unicorns and rainbows, DON’T BUY THIS BOOK! "I don't think that there is anything that this book doesn't cover. I mean it answers every question that you could possibly have. I hope this book gets to everyone who needs it!" - Goodreads Reviewer

Bariatric Surgery

Bariatric Surgery
  • Author : Francis A. Farraye,R. Armour Forse
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :241
  • ISBN : 1556427360
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Summary : Obesity is a serious and rapidly increasing medical problem. Bariatric surgery is the only effective long-term treatment for morbid obesity and the performance of this surgery has increased dramatically over the years. Bariatric Surgery: A Primer for Your Medical Practice is a user-friendly, practical reference text that provides all the necessary information that the health care professional will need to assist in patient selection and preoperative assessment, as well as recommendations in dealing with complex postoperative care of the bariatric patient. Dr. Francis A. Farraye and Dr. R. Armour Forse, joined by leading experts, review what is required by today's practicing physician who will manage the care of obese adults. Inside the chapters of Bariatric Surgery, along with numerous tables, images, and charts, you will find many crucial elements of bariatric surgery extensively and practically covered. Bariatric Surgery is the perfect resource for the primary care physician, family practitioner, general internist, endocrinologist, nutritionist, gastroenterologist, radiologist, medical and surgical resident, and medical student. Long awaited, Bariatric Surgery is the answer many are searching for today. Some chapter topics: The medical management of obesity Types of bariatric surgery Assessments of patients prior to bariatric surgery Medical management of the patient after bariatric surgery Nutritional and psychological consequences of bariatric surgery Endoscopic and radiologic imaging

Interventional Inflammatory Bowel Disease: Endoscopic Management and Treatment of Complications

Interventional Inflammatory Bowel Disease: Endoscopic Management and Treatment of Complications
  • Author : Bo Shen
  • Publisher :Unknown
  • Release Date :2018-01-16
  • Total pages :380
  • ISBN : 9780128113899
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Summary : Interventional Inflammatory Bowel Diseases: Endoscopic Management and Treatment of Complications covers the preparation, principle, techniques, and damage control of complications in endoscopic therapy, providing the ultimate guidance in endoscopic management of IBD. With contributions from a panel of international leading experts in the field, perspectives are included from GI pathologists, GI radiologists, gastroenterologists, advanced endoscopists, IBD specialists and colorectal surgeons. Recommendations from experts are also included within each chapter. By bridging medical and surgical treatment modalities for IBD, this is the perfect reference for GI researchers, medical students, therapeutic GI endoscopists, IBD specialists, surgeons and advanced health care providers. Incorporates state-of-the-art of research in the area of therapeutic endoscopy in Crohn’s Disease and Ulcerative Colitis Makes the connection between the understanding of the complex nature and disease course of IBD with corresponding advanced endoscopic procedures Explores endoscopic treatment as the missing link between medical and surgical treatment for complex Crohn’s Disease and Ulcerative Colitis Contains access to videos demonstrating important procedural concepts

Cancer and reconstructive surgery in Inflammatory bowel disease

Cancer and reconstructive surgery in Inflammatory bowel disease
  • Author : Maie Abdalla
  • Publisher :Unknown
  • Release Date :2019-11-04
  • Total pages :116
  • ISBN : 9789176851098
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Summary : Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon. According to the literature, some thirty percent of UC patients may require a subtotal colectomy and ileostomy due to failure of medical treatment, acute toxic colitis or dysplasia/cancer diagnosis. Some patients choose to get continence restored with either an ileorectal anastomosis (IRA) or an ileal pouch-anal anastomosis (IPAA). Worldwide most surgeons prefer an IPAA to an IRA, despite reports of pouchitis, impaired fertility and fecundity. Fear of recurring proctitis and fear of rectal cancer in the remaining rectum is contributing to the choice of an IPAA. Little is known regarding the outcomes of IRA compared with IPAA in UC patients. We aimed to investigate the anorectal function, quality of life (QoL), risk of failure and rectal cancer in patients with UC restored with IRA and IPAA respectively. Methods: Data about all Inflammatory bowel disease (IBD) patients was obtained from the Swedish National Patient Register (NPR) between 1964-2014 and in one study from the Linköping University Hospital medical records 2006-2012. Patients who developed cancer were identified from the Swedish National Cancer Register. We investigated the risk of cancer and inflammation, functional outcome and failure as well as the quality of life for IRA and IPAA patients. Investigation of risk for cancer in IRA and IPAA compared with the background population was performed using survival analytic techniques: uni-and multivariate regression, Kaplan Meier curves and standardized incidence ratio. Results: Twelve percent (7,889 /63,795) of UC patients required colectomy according to the NPR. The relative risk for rectal cancer among patients with an IRA was increased (SIR 8.7). However, the absolute risk was 1.8% after a mean follow up of 8.6 years and the cumulative risk 10- and 20-years after IRA was 1.6% and 5.6%, respectively. Risk factors for rectal cancer were primary sclerosing cholangitis in patients with an IRA (hazard ratio 6.12), and severe dysplasia or cancer of the colon prior to subtotal colectomy in patients with a diverted rectum in place (hazard ratio 3.67). Regarding IPAA, the relative risk to develop rectal cancer was (SIR 0.4) compared with the background population and the absolute risk was only 0.06% after a mean of 12.2 years of follow up. Among patients operated at the Linköping University Hospital: IRA patients reported better overall continence according to the Öresland score with in median3 (IQR 2–5) for IRA (n=38) and 10 (IQR 5–15) for IPAA (n=39, p<0.001). There were no major differences regarding the QoL. According to the NPR, after a median follow up of 12.4 years failure occurred in 265(32%) out of 1112 patients, of which 76 were secondarily reconstructed with an IPAA. Failure of the IPAA occurred in 103 (6%) patients with primary and in 6 (8%) patients after secondary IPAA (log-rank p=0.38). Conclusion: IRA is a safe restorative procedure for selected UC patients. Patients should be aware of the annual postoperative endoscopic evaluation with biopsies as well as the need to the use of local anti-inflammatory preparations. However, IRA should not be offered for UC patients with an associated primary sclerosing cholangitis diagnosis due to the increased risk to develop rectal cancer in their rectal mucosa. In such case, IPAA is probably the treatment of choice.

Advanced Therapy of Inflammatory Bowel Disease

Advanced Therapy of Inflammatory Bowel Disease
  • Author : Theodore M. Bayless,Stephen B. Hanauer
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :621
  • ISBN : 1607950340
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Summary : Now published in two volumes to accommodate new chapters on the many advances in understanding and treatment options, this volume represents the definitive reference on inflammatory bowel disease, a spectrum of diseases that is receiving increasing attention as our understanding of the etiological factors increases and diagnostic tools are refined. Basic research accelerated at the beginning of this decade and is now yielding new, more targeted treatments than were available just a few years ago. Volume 1 is on IBD and Ulcerative Colitis, and Volume 2 is on IBD and Crohn's Disease. All areas that were covered in the second edition have been expanded and updated. New sections include one addressing etiology and pathophysiology of IBD, including environmental influences and effect of age at onset, and one with a focus on aggravating factors in the IBD patient such as infectious agents, non-steroidal anti-inflammatory drugs, and pregnancy.

Handbook of Inflammatory Bowel Disease

Handbook of Inflammatory Bowel Disease
  • Author : Stephen J. Bickston,Richard S. Bloomfeld
  • Publisher :Unknown
  • Release Date :2009-10-01
  • Total pages :177
  • ISBN : 9780781766302
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Summary : Geared to a wide readership of practicing clinicians and trainees in primary care medicine and gastroenterology, this handbook offers practical information on Crohn's disease and ulcerative colitis. Coverage begins with the patient's first visit and proceeds through the diagnostic workup: endoscopy, radiologic testing, and instruments for rating and classifying inflammatory bowel disease. Discussions of therapy include conventional therapies, immunomodulators, biologic therapies, surgical approaches, and intestinal stomas. Chapters discuss extraintestinal manifestations of inflammatory bowel disease, inflammatory bowel disease and the liver, infections, and pouchitis. Additional chapters focus on nursing considerations, nutrition, women's health issues, and inflammatory bowel disease and the workplace.

Mosaic of Autoimmunity

Mosaic of Autoimmunity
  • Author : Carlo Perricone,Yehuda Shoenfeld
  • Publisher :Unknown
  • Release Date :2019-02-15
  • Total pages :1136
  • ISBN : 9780128143070
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Summary : The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications

Trends in Inflammatory Bowel Disease Therapy 1996

Trends in Inflammatory Bowel Disease Therapy 1996
  • Author : R.S. McLeod,F. Martin,L.R. Sutherland,J.L. Wallace,C. Noel Williams
  • Publisher :Unknown
  • Release Date :1997-03-31
  • Total pages :320
  • ISBN : UOM:39015038606094
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Summary : This book is the proceedings of an international symposium held in Ottawa, Ontario, Canada, June 12-15 1996, and sponsored by Axcan Pharma, the Canadian Association of Gastroenterology and the Canadian Society of Colon and Rectal Surgeons. While the etiology and cure of inflammatory bowel disease (IBD) remain elusive, it is safe to say that there have been exciting advances in the field since the last symposium was held two years ago. A faculty of international experts from a range of disciplines - including molecular genetics, physiology, epidemiology, pediatrics, gastroenterology and surgery - was assembled and provided updates on the most current and controversial areas. The first part of the book is devoted to a review of advances in determining the etiology of IBD with focus on mucosal inflammation and genetics. The clinical part of the book includes sessions on ileal pouches, new therapies for the treatment of Crohn's disease, controversies related to the management of ulcerative colitis, cancer risk in IBD and management of IBD in the pediatric population. This volume will be of interest to both gastroenterologists and colon and rectal surgeons, whether concerned with basic science or clinical practice.

Molecular Genetics of Inflammatory Bowel Disease

Molecular Genetics of Inflammatory Bowel Disease
  • Author : Mauro D'Amato,John D Rioux
  • Publisher :Unknown
  • Release Date :2013-10-05
  • Total pages :343
  • ISBN : 9781461482567
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Summary : Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisposing and protective roles (e.g. the multiple variants in the receptor for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these diseases and other chronic inflammatory diseases (e.g. psoriasis, multiple sclerosis, type 1 diabetes and many others).

Surgical Pathology of Non-neoplastic Gastrointestinal Diseases

Surgical Pathology of Non-neoplastic Gastrointestinal Diseases
  • Author : Lizhi Zhang,Vishal S. Chandan,Tsung-Teh Wu
  • Publisher :Unknown
  • Release Date :2019-06-24
  • Total pages :572
  • ISBN : 9783030155735
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Summary : This book covers the entire spectrum of non-neoplastic diseases within the gastrointestinal (GI) tract including new entities, recent developments, and questions that arise in the practice of GI pathology. The text is organized by specific organ site, with related disorders of each organ site subgrouped into several chapters based on their common features. Pathologists can quickly find the disorders they are interested and review similar disorders in the same chapter to help them make a correct diagnosis. Each major and common entity is described in detail with its definition, clinical features, pathological features (covering both the gross and microscopic details), differential diagnosis and treatment/prognosis. All chapters also highlight the use of special/immunohistochemical stains and other supporting studies as needed with a focus on providing a practical differential diagnosis rather than just a list of potential associations. This book is extensively illustrated with both gross and microscopic images that act as an integral part of the information provided in the text. Written by practicing GI/liver pathologists and gastroenterologists from the Mayo Clinic, Surgical Pathology of Non-neoplastic Gastrointestinal Diseases serves as a comprehensive yet practical guide for diagnostic surgical pathologists with a passion for GI pathology.

New Insights into Inflammatory Bowel Disease

New Insights into Inflammatory Bowel Disease
  • Author : Samuel Huber
  • Publisher :Unknown
  • Release Date :2016-10-26
  • Total pages :264
  • ISBN : 9789535127543
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Summary : The incidence of chronic inflammatory and autoimmune diseases is steadily increasing. Inflammatory bowel disease (IBD) is one example of a chronic inflammatory disease, which primarily affects the intestine but may also affect extraintestinal organs. The exact pathogenesis of IBD is currently unknown. However, it is clear that the pathogenesis is complex, involving barrier defects, changes in the intestinal microbiome, and chronic immune activation. This book aims to summarize basic aspects of these complex interactions between barrier function, microbiome, and the immune system. Of note, there is currently no cure for IBD. However, several therapies have evolved in the last years, which are overall able to-at least temporarily-suppress IBD. These therapies and the underlying mechanism are discussed.