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Precision Medicine in Pediatric Health

Precision Medicine in Pediatric Health
  • Author : Olaf Bodamer
  • Publisher :Unknown
  • Release Date :2020-03
  • Total pages :456
  • ISBN : 0128170166
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Summary : Precision Medicine in Pediatric Health is an invaluable resource on state-of-the-art tools, technologies and social and ethical issues involved in fully realizing precision medicine in new pediatric research and healthcare. The book adopts a holistic approach that is grounded in key learning points and practical case studies of interest to interdisciplinary teams of researchers and clinicians working in pediatrics. Chapters provide a thorough introduction to basic principles of precision medicine, its growing role in research and clinical care, relevant technologies and digital health. From there, the book examines best practices and offers support for implementing precision medicine in research and clinical settings. Chapters are devoted to varying specialties, such as prenatal and fetal health, oncology, cardiology, neurology, rare diseases, developmental disorders, and precision therapeutics, including small molecule and gene and cell-based therapies. These sections are followed by a close look at ethical, legal and social implications of precision medicine in pediatrics, patient perspectives and next steps in research and clinical translation. Presents succinct commentary and key learning points that support the translation of precision and genomic medicine Highlights the practical use of precision medicine in the management of pediatric patients Provides a comprehensive volume that is written and edited by leading researchers, clinicians and scientists

Precision Medicine for Investigators, Practitioners and Providers

Precision Medicine for Investigators, Practitioners and Providers
  • Author : Joel Faintuch,Salomao Faintuch
  • Publisher :Unknown
  • Release Date :2019-12-15
  • Total pages :350
  • ISBN : 0128191783
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Summary : Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date, authoritative and providing definitions and references. Health care providers will be served by being provided an unabridged, broad coverage of concerning disease groups, and ancillary information about techniques, resources and consequences. Moreover, each chapter will follow a structured blueprint, so that multiple essential items are not overlooked. Instead of concentrating in a limited number of extensive and pedantic coverages, equally scholarly diagrams will be offered regarding all the major pathways of precision medicine, with strategical references available for those seeking more details. A three-pronged approach to precision medicine focused on investigators, practitioners, and health-care providers More complete than the competition concerning disease groups and ancillary information about techniques, resources and consequences Each chapter follows a structured blueprint, ensuring essential items are not overlooked

Discovering Precision Health

Discovering Precision Health
  • Author : Lloyd Minor
  • Publisher :Unknown
  • Release Date :2020-01-23
  • Total pages :288
  • ISBN : 9781119672685
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Summary : Today we are on the brink of a much-needed transformative moment for health care. The U.S. health care system is designed to be reactive instead of preventive. The result is diagnoses that are too late and outcomes that are far worse than our level of spending should deliver. In recent years, U.S. life expectancy has been declining. Fundamental to realizing better health, and a more effective health care system, is advancing the disruptive thinking that has spawned innovation in Silicon Valley and throughout the world. That's exactly what Stanford Medicine has done by proposing a new vision for health and health care. In Discovering Precision Health, Lloyd Minor and Matthew Rees describe a holistic approach that will set health care on the right track: keep people healthy by preventing disease before it starts and personalize the treatment of individuals precisely, based on their specific profile. With descriptions of the pioneering work undertaken at Stanford Medicine, complemented by fascinating case studies of innovations from entities including the Chan Zuckerberg Biohub, GRAIL, and Impossible Foods, Minor and Rees present a dynamic vision for the future of individual health and health care. You'll see how tools from smartphone technology to genome sequencing to routine blood tests are helping avert illness and promote health. And you'll learn about the promising progress already underway in bringing greater precision to the process of predicting, preventing, and treating a range of conditions, including allergies, mental illness, preterm birth, cancer, stroke, and autism. The book highlights how biomedical advances are dramatically improving our ability to treat and cure complex diseases, while emphasizing the need to devote more attention to social, behavioral, and environmental factors that are often the primary determinants of health. The authors explore thought-provoking topics including: The unlikely role of Google Glass in treating autism How gene editing can advance precision in treating disease What medicine can learn from aviation liHow digital tools can contribute to health and innovation Discovering Precision Health showcases entirely new ways of thinking about health and health care and can help empower us to lead healthier lives.

Progress and Challenges in Precision Medicine

Progress and Challenges in Precision Medicine
  • Author : Mukesh Verma,Debmalya Barh
  • Publisher :Unknown
  • Release Date :2017-01-16
  • Total pages :450
  • ISBN : 0128094117
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Summary : Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. Provides an overview of the growing field of precision medicine Contains chapters from geographically diverse experts in their field Explores important aspects of precision medicine, including applications, ethics, and development

Implementing Precision Medicine in Best Practices of Chronic Airway Diseases

Implementing Precision Medicine in Best Practices of Chronic Airway Diseases
  • Author : Ioana Agache,Peter Hellings
  • Publisher :Unknown
  • Release Date :2018-09-19
  • Total pages :228
  • ISBN : 9780128134726
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Summary : Implementing Precision Medicine in Best Practices of Chronic Airway Diseases provides a comprehensive overview of the application of precision medicine in airway diseases with a goal of promoting optimal control of disease, higher patient satisfaction and disease prevention. As medical research continues to fund this area, the book highlights the need for implementation of the principles of precision medicine into the bedside management of chronic airway diseases. It is clear that chronic airway diseases are heterogeneous and that a personalized approach is warranted whereby treatment is tailored to the level of the individual patient. Written for basic researchers, medical doctors and other healthcare practitioners this book provides guidance on the implementation of the principles of precision medicine into further research and daily clinical practice. Bridges the gap between precision medicine research and the implementation of the principles into daily clinical practice Includes contributions from key opinion leaders in the field of airway disease giving a worldwide perspective Discusses precision medicine in terms of personalized and stratified medicine, biomarkers, prediction of success, participation of the patient and prevention of disease

Relevance of Health Literacy to Precision Medicine

Relevance of Health Literacy to Precision Medicine
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Roundtable on Health Literacy
  • Publisher :Unknown
  • Release Date :2016-11-04
  • Total pages :124
  • ISBN : 9780309447355
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Summary : On January 20, 2015, President Obama announced the Precision Medicine Initiative (PMI) in his State of the Union address. The PMI, by developing new approaches for detecting, measuring, and analyzing a wide range of biomedical information including molecular, genomic, cellular, clinical, behavioral, physiological, and environmental parameters, is intended to enable a new era of medicine in which researchers, providers, and patients work together to develop individualized care. Part of this effort included the creation of a national, large-scale research participant group, or cohort. The PMI Cohort Program is aimed at extending precision medicine to many diseases, including both rare and common diseases such as diabetes, heart disease, Alzheimer's disease, obesity, and mental illnesses such as depression, bipolar disorder, and schizophrenia, by building a national research cohort of 1 million or more U.S. participants. An important challenge to assembling the PMI Cohort will be to reach individuals who are socioeconomically disadvantaged. Individuals who are socioeconomically disadvantaged have lower health literacy; often belong to racial, ethnic, and minority communities; and are often less likely to participate in research studies and biorepositories. To explore possible strategies and messaging designs, the Roundtable on Health Literacy formed an ad hoc committee charged with planning and conducting a 1-day public workshop on the intersection of health literacy and precision medicine. The workshop participants discussed a variety of topics including an overview of precision medicine and its potential, the relevance of health literacy to the success of precision medicine efforts, and perspectives and understanding of different groups, such as health care providers, consumers, and insurers. This publication summarizes the presentations and discussions from the workshop.

Toward Precision Medicine

Toward Precision Medicine
  • Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
  • Publisher :Unknown
  • Release Date :2012-01-16
  • Total pages :142
  • ISBN : 9780309222228
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Summary : Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Precision Public Health

Precision Public Health
  • Author : Tarun Weeramanthri,Hugh Dawkins,Gareth Baynam,Matthew Bellgard,Ori Gudes,James Semmens
  • Publisher :Unknown
  • Release Date :2018-06-25
  • Total pages :229
  • ISBN : 9782889455010
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Summary : Precision Public Health is a new and rapidly evolving field, that examines the application of new technologies to public health policy and practice. It draws on a broad range of disciplines including genomics, spatial data, data linkage, epidemiology, health informatics, big data, predictive analytics and communications. The hope is that these new technologies will strengthen preventive health, improve access to health care, and reach disadvantaged populations in all areas of the world. But what are the downsides and what are the risks, and how can we ensure the benefits flow to those population groups most in need, rather than simply to those individuals who can afford to pay? This is the first collection of theoretical frameworks, analyses of empirical data, and case studies to be assembled on this topic, published to stimulate debate and promote collaborative work.

The Essential Guide to N-of-1 Trials in Health

The Essential Guide to N-of-1 Trials in Health
  • Author : Jane Nikles,Geoffrey Mitchell
  • Publisher :Unknown
  • Release Date :2015-10-05
  • Total pages :245
  • ISBN : 9789401772006
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Summary : N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced. Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials. Written and edited by some of the world’s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.

Personalizing Precision Medicine

Personalizing Precision Medicine
  • Author : Kristin Ciriello Pothier
  • Publisher :Unknown
  • Release Date :2017-10-02
  • Total pages :272
  • ISBN : 9781118792117
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Summary : The author uses decades of experience and interviews with experts in precision medicine to explain past, present, and future of precision medicine. She reviews the full continuum of personalizing precision medicine, including diagnostics, therapeutics, big data, supportive care, regulation, and reimbursement and innovation in precision medicine worldwide. • Combines a unique cross section of history, current technologies, and future directions for how precision medicine has and will affect people worldwide • Reviews precision medicine around the world, including the US, China, Japan, the Middle East, India, Europe, and Latin America • Discusses a number of diseases areas – cancer, cardiovascular, neurodegenerative, infectious disease, pain, immunology, rare diseases • Includes information and quotes from over 100 interviews with key industry experts in biotech, pharma, informatics, diagnostics, health providers, advocacy groups, and more. • Includes stories illustrating current issues and future promises in precision medicine for a human touch

Precision Medicine: A Guide to Genomics in Clinical Practice

Precision Medicine: A Guide to Genomics in Clinical Practice
  • Author : Jeanette J. McCarthy,Bryce A. Mendelsohn
  • Publisher :Unknown
  • Release Date :2017-01-05
  • Total pages :304
  • ISBN : 9781259644146
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Summary : Incorporate genomics into every applicable area of your clinical practice with this complete how-to guide Precision Medicine: A Guide to Genomics in Clinical Practice is a comprehensive, yet succinct overview of the practice of genomic medicine. It is written for general healthcare practitioners, specialists, and trainees with the goal of providing detailed guidance on how to incorporate genomic medicine into daily practice. Features that make this book valuable to every practice: •Intentionally avoids excessive technical content and consistently emphasizes real-life patient care and decision support •Follows the course of a human life, beginning before conception through pregnancy, childhood, and adulthood, discussing the current and future applications of genomics and precision medicine at each stage •Organization allows healthcare providers to quickly and easily find the information relevant to their practice. •The authors highlight common pitfalls – technical and ethical – that might complicate the delivery of quality genomic healthcare •Enhanced by eleven valuable appendices that cover important topics ranging from the basics of genetics to ethical issues to regulation and reimbursement If you are searching for a clinically relevant, non-technical resource that will teach you how genomic medicine can and should be practiced in your specific field of interest, Precision Medicine: A Guide to Genomics in Clinical Practicebelongs on your desk.

Biomarker Tests for Molecularly Targeted Therapies

Biomarker Tests for Molecularly Targeted Therapies
  • Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,Committee on Policy Issues in the Clinical Development and Use of Biomarkers for Molecularly Targeted Therapies
  • Publisher :Unknown
  • Release Date :2016-07-30
  • Total pages :292
  • ISBN : 9780309381345
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Summary : Every patient is unique, and the evolving field of precision medicine aims to ensure the delivery of the right treatment to the right patient at the right time. In an era of rapid advances in biomedicine and enhanced understanding of the genetic basis of disease, health care providers increasingly have access to advanced technologies that may identify molecular variations specific to an individual patient, which subsequently can be targeted for treatment. Known as biomarker tests for molecularly targeted therapies, these complex tests have the potential to enable the selection of the most beneficial treatment (and also to identify treatments that may be harmful or ineffective) for the molecular underpinnings of an individual patient's disease. Such tests are key to unlocking the promise of precision medicine. Biomarker tests for molecularly targeted therapies represent a crucial area of focus for developing methods that could later be applicable to other areas of precision medicine. The appropriate regulatory oversight of these tests is required to ensure that they are accurate, reliable, properly validated, and appropriately implemented in clinical practice. Moreover, common evidentiary standards for assessing the beneficial impact of biomarker-guided therapy selection on patient outcomes, as well as the effective collection and sharing of information related to those outcomes, are urgently needed to better inform clinical decision making. Biomarker Tests of Molecularly Targeted Therapies examines opportunities for and challenges to the use of biomarker tests to select optimal therapy and offers recommendations to accelerate progress in this field. This report explores regulatory issues, reimbursement issues, and clinical practice issues related to the clinical development and use of biomarker tests for targeting therapies to patients. Properly validated, appropriately implemented biomarker tests hold the potential to enhance patient care and improve outcomes, and therefore addressing the challenges facing such tests is critical.

Managing Health in the Genomic Era

Managing Health in the Genomic Era
  • Author : Vincent Henrich,Lori A. Orlando,Brian H. Shirts
  • Publisher :Unknown
  • Release Date :2020-06-27
  • Total pages :238
  • ISBN : 9780128160169
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Summary : In Managing Health in the Genomic Era: A Guide to Family Health History and Disease Risk, Drs. Vincent C. Henrich, Lori A. Orlando, and Brian H. Shirts discuss the practical considerations surrounding the use of genomic and genetic tests to manage patient health, to provide adult disease risk assessment, to improve diagnosis, and to support effective interventions and treatment. In 10 chapters, evidence-based information and case studies are described and examine the central place of family health history (FHH) in genomic medicine, tools and strategies for compiling and analyzing family health history, how to identify existing and novel genetic markers, how to identify lineage specific (or rare) variants within families, and how to find effective interventions based on genetic testing results and FHH. Factors that influence clinical practice, including gene-environment interactions, FHH social networking, direct to consumer (DTC) genetic testing and data sharing, algorithms for analyzing genetic data, and patient counseling are discussed from the standpoint of clinical practice. Here, frontline healthcare providers will discover succinct commentary and key examples to assist with their local needs. Relevant principles of genetic biology and inheritance are explored and guidance on available support networks and online resources is also provided Presents a practical, accessible resource for primary care providers, allied health professionals, pharmacologists, public health professionals, students and clinical researchers Addresses genetic and genomic approaches in managing patient health, conducting and analyzing family health histories, and assessing adult disease risk Features an expert author team with direct experience integrating genetics and genomics in primary care and family medicine settings Examines the attributes and limitations of family health history, genetic testing, and genomic testing in clinical practice Includes detailed explanations following practice-based examples

Precision Health and Medicine

Precision Health and Medicine
  • Author : Arash Shaban-Nejad,Martin Michalowski
  • Publisher :Unknown
  • Release Date :2019-08-01
  • Total pages :197
  • ISBN : 9783030244095
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Summary : This book highlights the latest advances in the application of artificial intelligence to healthcare and medicine. It gathers selected papers presented at the 2019 Health Intelligence workshop, which was jointly held with the Association for the Advancement of Artificial Intelligence (AAAI) annual conference, and presents an overview of the central issues, challenges, and potential opportunities in the field, along with new research results. By addressing a wide range of practical applications, the book makes the emerging topics of digital health and precision medicine accessible to a broad readership. Further, it offers an essential source of information for scientists, researchers, students, industry professionals, national and international public health agencies, and NGOs interested in the theory and practice of digital and precision medicine and health, with an emphasis on risk factors in connection with disease prevention, diagnosis, and intervention.

Precision Medicine: A Multidisciplinary Approach , EBK

Precision Medicine: A Multidisciplinary Approach , EBK
  • Author : Joel J. Heidelbaugh
  • Publisher :Unknown
  • Release Date :2020-12-18
  • Total pages :240
  • ISBN : 9780323789486
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Summary : The Clinics Collections titles take a multidisciplinary approach to today’s practice of medicine, selecting the most recent and relevant articles from the Clinics series and combining them into a single source of information on a focused topic. Articles are chosen from multiple Clinics to highlight the range of specialties covering major medical issues, delivering the information needed for successful interdisciplinary teamwork and effective patient care. Written from a variety of medical perspectives, these articles offer deeper insight into how each specialty cares for its patients and provide a unique entry into sharing best concepts for the entire medical team. Clinics Collections: Precision Medicine draws from Elsevier’s Clinics Review Articles database to provide today’s medical teams with practical clinical advice and insights on this timely medical model. It guides readers on how to apply current primary research findings to everyday practice, keep up with new and improved treatment methods, and improve patient outcomes. Areas of focus include breast cancer, lung cancer, melanoma, arthritis, sleep medicine, and pediatric oncology. Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format.

Clinical Precision Medicine

Clinical Precision Medicine
  • Author : Judy S. Crabtree
  • Publisher :Unknown
  • Release Date :2019-11-29
  • Total pages :112
  • ISBN : 0128198346
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Summary : Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource

Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease

Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease
  • Author : Fumihiro Sata,Hideoki Fukuoka,Mark Hanson
  • Publisher :Unknown
  • Release Date :2018-12-11
  • Total pages :217
  • ISBN : 9789811321948
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Summary : This book reviews public health activities such as awareness campaigns, health education, and strategies for health policy based on recent epidemiological studies that provide insights into epigenetic processes caused by environmental factors and developmental plasticity. It provides the latest concepts and findings on the public health aspects of Developmental Origins of Health and Disease (DOHaD) research regarding early prevention of non-communicable diseases (NCDs). Attention is especially paid to key issues, including strategies for the effective prevention of NCDs in developmental stages of life and younger generations rather than in adults and the elderly. Public Health Aspects in Developmental Origins of Health and Disease (DOHaD) is structured in two parts; the first focuses on general remarks reviewing specific recommendations, practical methods and protocols, and future goals regarding public health aspects, while the second presents brief profiles of individual cohorts and consortia studies. This collection will benefit both new and established researchers, as well as students in the fields of epidemiology, clinical medicine, nutrition, education, and public health who are seeking comprehensive information on DOHaD and preemptive medicine.

Personalizing Asthma Management for the Clinician

Personalizing Asthma Management for the Clinician
  • Author : Stanley J. Szefler,Fernando Holguin,Michael E Wechsler
  • Publisher :Unknown
  • Release Date :2017-09-22
  • Total pages :250
  • ISBN : 9780323497084
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Summary : Personalized medicine is a rapidly emerging area in health care, and asthma management lends itself particularly well to this new development. This practical resource by Dr. Stanley J. Szefler helps you navigate the many asthma medication options available to your patients, as well as providing insights into those which may be introduced within the next several years. Features a wealth of information on available asthma medications, including new immunomodulators, new responses to treatment, and new treatment strategies at all levels of asthma care. Prepares you to meet your patients’ needs regarding asthma exacerbation prevention and asthma prevention. Consolidates today’s available information and guidance in this timely area into one convenient resource.

Genomics and Personalized Medicine

Genomics and Personalized Medicine
  • Author : Michael Snyder
  • Publisher :Unknown
  • Release Date :2016-02-25
  • Total pages :184
  • ISBN : 9780190234768
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Summary : In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence -- their genome -- against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms, consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs.

Evidence-based Pediatrics and Child Health

Evidence-based Pediatrics and Child Health
  • Author : Virginia Moyer,Elizabeth Elliott
  • Publisher :Unknown
  • Release Date :2008-04-15
  • Total pages :544
  • ISBN : 9781405140256
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Summary : Evidence Based Pediatrics and Child Health is a ground-breaking new text on pediatrics and child care management, using evidence based approach. It covers all the major childhood conditions and contains the features of both a handbook and a reference text. Each chapter combines both advice on management and how best to practice evidence based medicine with reviews of all the available evidence in a specific area. The goal of the book is to help pediatricians and others who care for children to provide the best possible care by combining the best, most current evidence with special circumstances of each individual patient.

Cancer Genomics

Cancer Genomics
  • Author : Graham Dellaire,Jason N Berman,Robert J. Arceci
  • Publisher :Unknown
  • Release Date :2013-11-21
  • Total pages :510
  • ISBN : 9780123972743
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Summary : Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.