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Reactive Species Detection in Biology

Reactive Species Detection in Biology
  • Author : Frederick A. Villamena
  • Publisher :Unknown
  • Release Date :2016-10-23
  • Total pages :340
  • ISBN : 9780124200807
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Summary : Reactive Species Detection in Biology: From Fluorescence to Electron Paramagnetic Resonance Spectroscopy discusses the reactive oxygen species that have been implicated in the pathogenesis of various diseases, presenting theories, chemistries, methodologies, and various applications for the detection of reactive species in biological systems, both in-vitro and in-vivo. Techniques covered include fluorescence, high performance chromatography, mass spectrometry, immunochemistry, and electron paramagnetic resonance spectroscopy. Probe design and development are also reviewed in order to advance new approaches in radical detection through synthesis, computations, or experimental applications. Reviews all current advances in radical detection Emphasizes chemical structures and reaction schemes fundamental to radical detection and identification Describes the uses, advantages, and disadvantages of various probe designs Examines new approaches to radical probe development

Reactive Oxygen Species in Biology and Human Health

Reactive Oxygen Species in Biology and Human Health
  • Author : Shamim I. Ahmad
  • Publisher :Unknown
  • Release Date :2017-12-19
  • Total pages :543
  • ISBN : 9781498735469
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Summary : Unlike other narrowly focused books, Reactive Oxygen Species in Biology and Human Health provides a comprehensive overview of ROS. It covers the current status of research and provides pointers to future research goals. Additionally, it authoritatively reviews the impact of reactive oxygen species with respect to various human diseases and discusses antioxidants and other compounds that counteract oxidative stress. Comprised of seven sections, the first section describes the introduction, detection, and production of ROS, emphasizing phenolic compounds and vitamin E for their abilities to act as antioxidants. This section also highlights the role of lipoprotein-associated oxidative stress. Section two addresses the importance of iron accumulation in the brain resulting in the development of a group of neurodegenerative disorders (NDs) and identifies several causative genes for neurodegeneration with brain iron accumulation (NBIA) associated with Parkinsonism-related disorders. The third section discusses a number of NDs, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Huntington's disease (HD), epilepsy, and multiple sclerosis (MS). Section four addresses autoimmune diseases caused by ROS, including asthma, autoimmune liver diseases, rheumatoid arthritis, thyroid disease, primary biliary cirrhosis, and systemic lupus. Section five analyzes a number of different cancers, including lung cancer, breast cancer, and melanoma, along with possible treatment regimens. Section six discusses cardiovascular diseases (CVDs) induced by ROS, presents the ROS-associated complex biochemical processes inducing inflammation as an important cause of CVDs, and explains the roles carotenoids play in preventing CVDs. The final section addresses other human diseases induced by oxidative stress, including sickle cell disease, nonalcoholic steatohepatitis, retinopathy, fibromyalgia, chronic obstructive pulmonary disease, asthma, pulmonary hypertension, infertility, and aging of human skin.

Reactive Oxygen Species (ROS) in Living Cells

Reactive Oxygen Species (ROS) in Living Cells
  • Author : Filip Cristiana,Albu Elena
  • Publisher :Unknown
  • Release Date :2018-05-23
  • Total pages :216
  • ISBN : 9781789231342
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Summary : Oxygen represents only 20% of the Earth's atmosphere, yet it is vital for the survival of aerobic organisms. There is a dark part of the use of oxygen that consists in generating reactive species that are potentially harmful to living organisms. Moreover, reactive oxygen species can combine with nitrogen derivatives and generate many other reactive species. Thus, living organisms are continuously assaulted by reactive species from external or internal sources. However, the real danger comes in the case of high concentrations and prolonged exposure to these species. This book presents an image of the mechanisms of action of reactive species and emphasizes their involvement in diseases. Inflammation and cancer are examined to determine when and how reactive species turn the evolution of a benign process to a malignant one. Some answers may come from recent studies indicating that reactive species are responsible for epigenetic changes.

Peroxynitrite Detection in Biological Media

Peroxynitrite Detection in Biological Media
  • Author : Sabine Szunerits,Mekki Bayachou
  • Publisher :Unknown
  • Release Date :2015-10-21
  • Total pages :232
  • ISBN : 9781782620853
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Summary : Peroxynitrite is a powerful oxidiser which can damage a wide array of molecules within cells, including DNA and proteins, leading to apoptosis, inflammation or cancer. Peroxynitrite detection and quantification provides critical information in understanding its biological implications. Attempts to investigate the behavior of peroxynitrite in vivo and in vitro have been hampered by the difficulty in detecting this highly reactive oxygen species. This book presents the current state of the art in this research field with contributions from scientific leaders in the field. The chapters make clear the associated challenges and development for selective and sensitive detection of peroxynitrite. This book is a timely addition to the literature, as the first in the field, dedicated to detecting this molecule in vivo. It will be welcomed by the community particularly medicinal and analytical chemists, developers of sensors and probes and analytical equipment manufacturers.

Reactive Oxygen Species in Chemistry, Biology, and Medicine

Reactive Oxygen Species in Chemistry, Biology, and Medicine
  • Author : A. Quintanilha
  • Publisher :Unknown
  • Release Date :2013-06-29
  • Total pages :232
  • ISBN : 9781475704174
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Summary : A NATO Advanced Study Institute on "Oxygen Radicals in Biological Systems: Recent Progress and New Methods of Study" was held in Braga, Portugal between Sep tember 1 and September 14, 1985, in order to consider the basic chemistry and biochem istry of activated oxygen (both radical and non-radical species) and their effect in biolog ical systems. This book summarizes the main lectures given at this meeting. While there is no attempt to cover all the major topics in the expanding subject of oxidative mechanisms in biology, an effort has been made to provide overviews on some key aspects of this field. The authors have attempted to convey a clear picture of both what is known and what remains unclear in their respective subjects. Not only are some of the techniques used for detecting activated oxygen species described, but also their strengths and limi tations. The chemistry of many of these species is discussed and the biological and/or pathological implications are carefully reviewed. The medical and therapeutic aspects of some of the well established pathways of damage and protection are analyzed. It is our hope that the material included in this book might be useful for both researchers and teachers at the graduate level. The success of this meeting was to a large extent due to the tireless committment of Professor Alberto Amaral and Dr. Concei~a:o Rangel; without their outstanding efforts in dealing with all the aspects of the organization, this summer school would not have been possible.

Free Radicals in Biology and Medicine

Free Radicals in Biology and Medicine
  • Author : Barry Halliwell,John M. C. Gutteridge
  • Publisher :Unknown
  • Release Date :2015-07-16
  • Total pages :896
  • ISBN : 9780198717478
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Summary : Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Nitric Oxide, Part C: Biological and Antioxidant Activities

Nitric Oxide, Part C: Biological and Antioxidant Activities
  • Author : Lester Packer,Enrique Cadenas
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :589
  • ISBN : 0121822028
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Summary : General Description of the Volume: Nitric Oxide, recently designated "Molecule of the Year," impinges on a wide range of fields in biological research, particularly in the areas of biomedicine and cell and organismal biology, as well as in fundamental chemistry. This volume will be a valuable resource for the experienced researcher as well as for those newly entering the field. This volume continues the coverage of new and important tools for the elucidation of Nitric Oxide action initiated in Volumes 268 and 269 of Methods in Enzymology. Techniques for researching the physiology and toxicity of nitric oxide in cellular and organismal systems are highlighted. General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * Biological Activity * NO Donors: Nitrosothiols and Nitroxyls * Peroxynitrite * Oxidant and Antioxidant Action

Environmental Toxicology and Chemistry of Oxygen Species

Environmental Toxicology and Chemistry of Oxygen Species
  • Author : Irena Kruk
  • Publisher :Unknown
  • Release Date :2013-04-17
  • Total pages :265
  • ISBN : 9783540495710
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Summary : Properties, sources of formation, reactions, and detection of oxygen species form the first part of this volume. Biochemical, toxicological and environmental aspects are dealt with in detail in the following chapters. This information provides the basis for a state-of-the-art understanding of the role of oxygen species in environmental pollution and as a health hazard.

Singlet Oxygen

Singlet Oxygen
  • Author : Santi Nonell,Cristina Flors
  • Publisher :Unknown
  • Release Date :2016-01-27
  • Total pages :488
  • ISBN : 9781782620389
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Summary : Meeting the desire for a comprehensive book that collects and curates the vast amount of knowledge gained in the field of singlet oxygen, this title covers the physical, chemical and biological properties of this reactive oxygen species and also its increasingly important applications across chemical, environmental and biomedical areas.The editors have a long and distinguished background in the field of singlet oxygen chemistry and biomedical applications, giving them a unique insight and ensuring the contributions attain the highest scientific level.The book provides an up to date reference resource for both the beginner and experienced researcher and crucially for those working across disciplines such as photochemistry, photobiology and photomedicine.

Frontiers of Reactive Oxygen Species in Biology and Medicine

Frontiers of Reactive Oxygen Species in Biology and Medicine
  • Author : Kozi Asada,Toshikazu Yoshikawa
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :578
  • ISBN : UOM:39015017427181
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Summary : Reflecting upon the progress since the discovery of superoxide dismutase, these papers cover such topics as: reactive species of oxygen and its detection in vivo and in vitro; antioxidative enzymes and compounds; and the molecular mechanisms for adaption to oxidative stress.

Methods in Biological Oxidative Stress

Methods in Biological Oxidative Stress
  • Author : Kenneth Hensley,Robert A. Floyd
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :215
  • ISBN : 9781592594245
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Summary : Methods in Biological Oxidative Stress is practical in scope, and outlines modern techniques for measuring oxidative stress and detecting oxidizing agents both in vitro and in vivo. Free radicals and reactive oxidizing agents, once ignored as meaningful biochemicals entities, are now recognized as causes or contributing factors in dozens if not hundreds of disease states, and free radical metabolism of xenobiotics is increasingly important to pharmacologists. This is the first book to detail experimental methods for detecting free radicals and reactive oxygen species or their byproducts. Subjects covered include techniques used routinely in laboratories developed by the authors, as well as HPLC-electrochemical measurement of protein oxidation products, particularly nitrotyrosine and dityrosine; HPLC-electrochemical detection of DNA oxidation products; HPLC measurement of salicylate products, a means of detecting OH radicals in vivo; electron paramagnetic resonance. Contributions are from recognized experts in the field of oxidative stress, who have developed novel strategies for studying biological oxidations.

Biological Reactive Intermediates Vi

Biological Reactive Intermediates Vi
  • Author : Patrick Dansette,Robert R. Snyder,Terrence J. Monks,David J. Jollow,I. Glenn Sipes,Helmut Greim,G. Gordon Gibson,Marcel Delaforge
  • Publisher :Unknown
  • Release Date :2001-11-30
  • Total pages :728
  • ISBN : 0306466597
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Summary : This volume presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites, i.e., toxic and carcinogenic effects, which have been the basis of all five earlier volumes in this series. In particular, this volume devotes sections to structure-activity relationships, recent advances in the understanding of the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide. There are also segments on DNA damage by reactive metabolites and DNA repair, tissue specific responses to BRIs, and human health effects of BRIs. The papers that comprise this volume were submitted by world class scientists who were in attendance at The Symposium on Biological Reactive Intermediates VI at the Universite Rene Descartes, July 16-20, 2000.

Plant Signal Transduction

Plant Signal Transduction
  • Author : Thomas Pfannschmidt
  • Publisher :Unknown
  • Release Date :2014-12-04
  • Total pages :360
  • ISBN : 1627038027
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Summary : During recent years, research has greatly expanded our understanding of the sophisticated molecular network of responses which enable plants to develop, survive and propagate under a wide range of conditions. In Plant Signal Transduction: Methods and Protocols, an international panel of experts provide well-established methods vital to analyzing plant signal transduction on the molecular level. Featuring experimental procedures on several of the most popular model organisms, the volume focuses on in planta analyses and the proteins involved in signal transduction in order to aid with the establishment of laboratory techniques or the modification of the protocols for other plants. As part of the highly successful Methods in Molecular BiologyTM series, the chapters include brief introductions to the subject, lists of necessary materials, readily reproducible laboratory protocols, and tips on trouble-shooting and avoiding known pitfalls. Comprehensive and cutting-edge, Plant Signal Transduction: Methods and Protocols will benefit plant scientists wishing to improve their experimental approaches and delve further into this exciting and important field of study

Oxidative Stress in Human Reproduction

Oxidative Stress in Human Reproduction
  • Author : Ashok Agarwal,Rakesh Sharma,Sajal Gupta,Avi Harlev,Gulfam Ahmad,Stefan S. du Plessis,Sandro C. Esteves,Siew May Wang,Damayanthi Durairajanayagam
  • Publisher :Unknown
  • Release Date :2017-05-03
  • Total pages :190
  • ISBN : 9783319484273
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Summary : This book discusses the role of oxidative stress in the reproductive system. The book reviews endogenous sources, methods of determining its levels in body fluid/tissues, the physiological roles of ROS, as well as its negative effects on the human reproductive processes. Also discussed are multiple extrinsic factors that could induce oxidative stress in the reproductive system. This volume covers various clinical pathologies related to the reproductive system that arise from or produce oxidative stress, both in the male and female. The use of antioxidants as a therapeutic measure to keep ROS levels in check are highlighted, describing the outcome of various clinical studies involving antioxidant supplementation in infertile patients. Infertility is a global disease that affects 15-25% of all couples, and oxidative stress arising from a multitude of sources has been implicated as one of the major contributing factors to the decline in human fertility. As such, this book provides an up-to-date review on the significance of ROS in human reproduction.

Basic Principles and Clinical Significance of Oxidative Stress

Basic Principles and Clinical Significance of Oxidative Stress
  • Author : Sivakumar Joghi Thatha Gowder
  • Publisher :Unknown
  • Release Date :2015-11-11
  • Total pages :328
  • ISBN : 9789535122005
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Summary : It is a natural phenomenon for all living organisms in the world to undergo different kinds of stress during their life span. Stress has become a common problem for human beings in this materialistic world. In this period, a publication of any material on stress will be helpful for the human society. The book Basic Principles and Clinical Significance of Oxidative Stress targets all aspects of oxidative stress, including principles, mechanisms, and clinical significance. This book covers four sections: Free Radicals and Oxidative Stress, Natural Compounds as Antioxidants, Antioxidants - Health and Disease, and Oxidative Stress and Therapy. Each of these sections is interwoven with the theoretical aspects and experimental techniques of basic and clinical sciences. This book will be a significant source to scientists, physicians, healthcare professionals, and students who are interested in exploring the effect of stress on human life.

Free Radicals in Biology and Environment

Free Radicals in Biology and Environment
  • Author : F. Minisci
  • Publisher :Unknown
  • Release Date :1997-03-31
  • Total pages :500
  • ISBN : 0792345029
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Summary : Our understanding of the quantitative aspects of free radical chemistry and the involvement of radicals in such areas as biology, medicine, the environment, etc., has developed spectacularly over recent years, yet the various topics are commonly discussed separately, in specific meetings and specialised publications. Free Radicals in Biology and Environment draws together two important areas of free radical chemistry, using as a bridge the fundamental physical chemistry of free radicals (spectroscopic detection of free radicals, evaluation of absolute rate constants, elucidation of mechanisms of free radical reactions and catalysis, photochemical and radiation processes, etc.). The most relevant topics covered are the EPR detection of radicals in biochemical systems and in pollutant formation and degradation, oxidation processes in biology and in the troposphere, radiation and induced damage, and atmospheric pollutants arising from incomplete combustion. Also covered are the chemistry and biochemistry of nitric oxide and peroxynitrite, the chemistry and biochemistry of DNA radicals, the role of radicals in myeloperoxidase, lignineperoxidase, radicals and cardiovascular injury, radiation and the fragmentation of cells and tissues.

Oxidative Stress and Biomaterials

Oxidative Stress and Biomaterials
  • Author : Thomas Dziubla,D Allan Butterfield
  • Publisher :Unknown
  • Release Date :2016-05-31
  • Total pages :404
  • ISBN : 9780128032701
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Summary : Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death Brings together the two fields of biomaterials and the biology of oxidative stress Provides approaches for the design of biomaterials with improved biocompatibility

Systems Biology of Free Radicals and Antioxidants

Systems Biology of Free Radicals and Antioxidants
  • Author : Ismail Laher
  • Publisher :Unknown
  • Release Date :2014-06-16
  • Total pages :4178
  • ISBN : 3642300170
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Summary : The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.

Protein Sensors and Reactive Oxygen Species

Protein Sensors and Reactive Oxygen Species
  • Author : Helmut Sies,Lester Packer
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :511
  • ISBN : 9780121822484
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Summary : This volume of Methods in Enzymology is concerned with the rapidly developing field of selenoprotein synthesis and its related molecular genetics. Progressive information on the topics of proteins as redox sensors, selenoproteins, and the thioredoxin system is studied using methods such as bioinformatics, DNA chip technology, cell biology, molecular genetics, and enzymology. The information on novel selenoproteins identified from genomic sequence data, as well as current knowledge on glutathione peroxidases, selenoprotein P, iodothyronine deiodinases, and thioredoxin reductases, is presented in a method-based approach.

Oxygen Radicals in Biological Systems

Oxygen Radicals in Biological Systems
  • Author : Lester Packer
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :711
  • ISBN : 012182134X
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Summary : Since biological tissues are unstable in an oxygen atmosphere, a great deal of effort is expended by organisms to metabolically limit or repair oxidative tissue damage. This volume of Methods in Enzymology and its companion Volume 234 present methods developed to investigate the roles of oxygen radicals and antioxidants in disease. Key Features * Generation, detection, and characterization of oxygen radicals, chemistry, biochemistry, and intermediate states of reductio* Isolation, characterization, and assay of enzymes or substrates involved in formation or removal of oxygen radical * Methods for assessing molecular, cell, and tissue damage; assays and repair of oxidative damage

Free Radicals

Free Radicals
  • Author : Gerald M. Rosen
  • Publisher :Unknown
  • Release Date :1999-12-02
  • Total pages :482
  • ISBN : 0195095057
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Summary : Free radicals, molecules with unpaired electrons, are highly reactive and play key roles in physiologic regulation and in many degenerative and pathologic processes, making them a fertile area of research. This book focuses on spin trapping, a sophisticated technique for the identification of free radicals in biological systems. The method is complex, and this book offers an in-depth guide to all of the critical aspects needed for its application to free radicals in biology. This includes advice on interpreting results, trouble-shooting, and experimental designs. The book looks at future directions in the field and will prove an invaluable resource for investigators working in the biology of free radicals, regardless of whether they are new or highly experienced in the applications of spin trapping.