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Rio-Hortega's Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia

Rio-Hortega's Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia
  • Author : Jose R. Iglesias-Rozas,Manuel Garrosa
  • Publisher :Unknown
  • Release Date :2013-06-17
  • Total pages :124
  • ISBN : 0124116175
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Summary : Pío del Rio-Hortega, one of the pioneering neuroscientists and discoverer of microglia, has been recognized as one of the most important Spanish neurohistogists of the past century. His landmark research on oligodendroglia, originally published in Spanish in 1928, has been translated into English for the first time by Dr. José R. Iglesias-Rozas and Prof. Manuel Garrosa. The book establishes definitively the concept of oligodendroglia and describes in great detail its structure, varieties, function, origin and pathology, providing a thorough review. The entire 1928 writing is presented, including the 79 excellent drawings and photographs from the original publication. To complement the original book and provide historical context, the translators have also included an introduction to the research and a biography of Pío del Rio-Hortega. This book constitutes a milestone in the history of neuroscience, biology and medicine, and it will be valuable reading for researchers and practitioners in these fields. First English translation of seminal 1928 research Contains the broad descriptions and interpretations of the normal and pathological oligodendroglia Full original text and new introductory sections

Rio-Hortega's Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia

Rio-Hortega's Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia
  • Author : Jose R. Iglesias-Rozas,Manuel Garrosa
  • Publisher :Unknown
  • Release Date :2013-06-05
  • Total pages :124
  • ISBN : 9780124116085
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Summary : Pío del Rio-Hortega, one of the pioneering neuroscientists and discoverer of microglia, has been recognized as one of the most important Spanish neurohistogists of the past century. His landmark research on oligodendroglia, originally published in Spanish in 1928, has been translated into English for the first time by Dr. José R. Iglesias-Rozas and Prof. Manuel Garrosa. The book establishes definitively the concept of oligodendroglia and describes in great detail its structure, varieties, function, origin and pathology, providing a thorough review. The entire 1928 writing is presented, including the 79 excellent drawings and photographs from the original publication. To complement the original book and provide historical context, the translators have also included an introduction to the research and a biography of Pío del Rio-Hortega. This book constitutes a milestone in the history of neuroscience, biology and medicine, and it will be valuable reading for researchers and practitioners in these fields. First English translation of seminal 1928 research Contains the broad descriptions and interpretations of the normal and pathological oligodendroglia Full original text and new introductory sections

Rio-Hortega's Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia

Rio-Hortega's Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia
  • Author : José R. Iglesias-Rozas,Paio Del Raio-Hortega,Manuel Garrosa
  • Publisher :Unknown
  • Release Date :2013-06-17
  • Total pages :126
  • ISBN : 0323282970
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Summary : P o del Rio-Hortega, one of the pioneering neuroscientists and discoverer of microglia, has been recognized as one of the most important Spanish neurohistogists of the past century. His landmark research on oligodendroglia, originally published in Spanish in 1928, has been translated into English for the first time by Dr. Jos(r) R. Iglesias-Rozas and Prof. Manuel Garrosa. The book establishes definitively the concept of oligodendroglia and describes in great detail its structure, varieties, function, origin and pathology, providing a thorough review. The entire 1928 writing is presented, including the 79 excellent drawings and photographs from the original publication. To complement the original book and provide historical context, the translators have also included an introduction to the research and a biography of P o del Rio-Hortega. This book constitutes a milestone in the history of neuroscience, biology and medicine, and it will be valuable reading for researchers and practitioners in these fields. First English translation of seminal 1928 researchContains the broad descriptions and interpretations of the normal and pathological oligodendrogliaFull original text and new introductory sections"

The Major Discoveries of Cajal and His Disciples: Consolidated Milestones for the Neuroscience of the XXIst Century

The Major Discoveries of Cajal and His Disciples: Consolidated Milestones for the Neuroscience of the XXIst Century
  • Author : Fernando de Castro,Miguel A. Merchán
  • Publisher :Unknown
  • Release Date :2017-04-25
  • Total pages :229
  • ISBN : 9782889450664
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Summary : When Santiago Ramón y Cajal started to unravel the fine structure of the nervous system in the last decades of the XIXth century maybe only his unbeatable soul of brave Spaniard imagined that most of the descriptions were scientific truths that lasted to date. Simple histological stainings, curiosity to ameliorate these, monocular microscopes, patience for drawing his observations and a rich imaginative open mind: this is the recipy for Cajal success. His descriptions of connectivity in the nervous system, compiled in Cajal's opus magna published in 1904 ("Textura del sistema nervioso del hombre y los vertebrados") and 1911 ("Histologie du systeme nerveux"), have been corroborated by modern techniques decade after decade. Even more, the main hypothesis that Cajal raised are universally recognised as biological laws, today: the neuron theory, the law on the dynamic polarization of the neuron and the chemotropic hypothesis. That is: the nervous system is not a sincitial network but is formed by individual cells; the transmission of the nerve impulses follow a main direction within a given neuron; the axons are guided by chemical substances in a chemotropic way, till form synapses with their targets. Attracted by Cajal's strong personality and scientific success, a number of medical students and doctors join him in the crusade to explore the nervous system. And the seed planted by the universal savant was really successful: Francisco Tello described interesting aspects of the regeneration of peripheral nerves which are very useful for neuroscientist currently working in this topic; Nicolás Achúcarro significantly contributed to study neuroglia and future microglia; Pío del Río-Hortega identified two out of the four main nervous cell types, the oligodendrocytes and microglia, and proposed an almost still valid classification for the CNS tumours; Fernando de Castro made was the first description of arterial chemoreceptors in the carotid body; Rafael Lorente de Nó was a dominant figure of Neuroscience for decades after the IInd World War, first describing the columnar organization of the cerebral cortex well before Mountcastle, Hubbel and Wiesel. Even less recognised co-workers and disciples of Cajal (his brother Pedro Ramón y Cajal, Domingo Sánchez, the neurologist Rodríguez-Lafora... protagonised discoveries that are consolidated scientific truths today). Altogether, it is difficult (if not impossible) to find a school in biology contributing in such a fundamental and variated way to the common acervo like the collectively known as Cajal School or Spanish Neurological School. Although the particular way to work of the Maestro, selecting a pleiade of brilliant collaborators with whom accomplish such a titanic feat, giving them freedom for their studies, has been recognised and confronted to antagonic systems followed by other relevant scientists and scientific schools, the general recognition of such a significant major milestones for Neuroscience and their vigency in the well-marched XXIst century is not: this is the purpose of this Ebook, to remind all these examples of how successful can be the scientific work when it is minutious, constant and performed by brilliant, imaginative and skilled scientists with a minimal conditions supporting their efforts.

Never-resting microglia: physiological roles in the healthy brain and pathological implications

Never-resting microglia: physiological roles in the healthy brain and pathological implications
  • Author : Amanda Sierra,Marie-Eve Tremblay,Hiroaki Wake
  • Publisher :Unknown
  • Release Date :2015-02-11
  • Total pages :172
  • ISBN : 9782889193691
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Summary : Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic reviewed the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic discussed the cellular and molecular mechanisms by which microglia contribute to the formation, pruning and plasticity of synapses; the regulation of adult neurogenesis as well as hippocampal learning and memory; among other important roles. Because these novel findings defy our understanding of microglial function in health as much as in disease, this Research Topic also summarized the current view of microglial nomenclature, phenotypes, origin and differentiation, and contribution to various brain pathologies. Additionally, novel imaging approaches and molecular tools to study microglia in their non-activated state have been discussed. In conclusion, this Research Topic seeked to emphasize how the current research in neuroscience is challenged by never-resting microglia.

Microglia in Health and Disease: A Unique Immune Cell Population

Microglia in Health and Disease: A Unique Immune Cell Population
  • Author : Alessandro Michelucci,Michel Mittelbronn,Diego Gomez-Nicola
  • Publisher :Unknown
  • Release Date :2018-10-05
  • Total pages :229
  • ISBN : 9782889456017
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Summary : Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.

Microglia in Health and Disease

Microglia in Health and Disease
  • Author : Marie-Ève Tremblay,Amanda Sierra
  • Publisher :Unknown
  • Release Date :2014-09-22
  • Total pages :486
  • ISBN : 9781493914296
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Summary : These past few years have witnessed a revolution in our understanding of microglia, especially since their roles in the healthy central nervous system (CNS) have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their involvement with diseases. Edited by two pioneers in the field, Marie-Ève Tremblay and Amanda Sierra, Microglia in health and disease aims to share with the broader scientific community some of the recent discoveries in microglia research, from a broad perspective, with a collection of 19 chapters from 52 specialists working in 11 countries across 5 continents. To set microglia on the stage, the book begins by explaining briefly who they are, what they do in the healthy and diseased CNS, and how they can be studied. The first section describes in more details their physiological roles in the maturation, function, and plasticity of the CNS, across development, adolescence, adulthood, neuropathic pain, addiction, and aging. The second section focuses on their implication in pathological conditions impairing the quality of life: neurodevelopmental and neuropsychiatric disorders, AIDS, and multiple sclerosis; and in leading causes of death: ischemia and stroke, neurodegenerative diseases, as well as trauma and injury.

NG2-Glia (Polydendrocytes)

NG2-Glia (Polydendrocytes)
  • Author : Arthur M. Butt
  • Publisher :Unknown
  • Release Date :2016-10-31
  • Total pages :43
  • ISBN : 9781615047314
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Summary : Classically, the central nervous system (CNS) was considered to contain neurons and three main types of glial cells—astrocytes, oligodendrocytes, and microglia. Now, it has been clearly established that NG2-glia are a fourth glial cell type that are identified and defined by their expression of the NG2 chondroitin sulfate proteoglycan (Cspg4). NG2-glia differentiate into oligodendrocytes, the myelin-forming cells of the CNS, under the control of multiple extacellular and intrinsic factors. Due to this, NG2-glia are often referred to in the literature as oligodendrocyte progenitor cells (OPCs). The name polydendrocytes has been suggested for NG2-glia (OPCs), to emphasize their nature as a fourth distinct glial cell type. NG2-glia respond rapidly to neurotransmission via their synaptic connections with neurons and their repertoire of neurotransmitter receptors and ion channels. Bidirectional interactions between NG2-glia and neurons are also important for synaptic function and neuronal integrity. NG2-glia respond to most neuropathologies by increased proliferation and differentiation into oligodendrocytes, which is critical for replacing damaged myelin after injury and in demyelinating diseases, such as multiple sclerosis. There is also evidence NG2-glia are capable of generating astrocytes and neurons under some circumstances. The full capacity of NG2-glia is not yet clear, but their key function is the lifelong generation of oligodendrocytes, which is absolutely critical for CNS function and integrity.

Neuroglia

Neuroglia
  • Author : Helmut Kettenmann,Bruce R. Ransom
  • Publisher :Unknown
  • Release Date :2004-09-30
  • Total pages :624
  • ISBN : 9780198034742
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Summary : Neuroglia is the only comprehensive reference book on the basic biology and function of glial cells. This long-awaited second edition has been completely reorganized and rewritten to include the dramatic advances in this field since the first edition was published ten years ago. The impact of the second edition will be greater than that of the first because the majority of neuroscientists now acknowledge that neuroglia are elemental to most, if not all, brain functions. The second edition covers the entire field of glial research from the basic molecular and cellular principles of these cells to their involvement in neurological diseases including stroke, Alzheimer's disease, and multiple sclerosis. It includes new chapters on transmitter release from exocytosis from glia, glia derived stem cells, glia and synaptic transmission, glia and axon guidance, an entirely new section on mechanisms of glial injury, and several new chapters on the roles of glia in different diseases. The new edition was written with both students and experts in mind. It provides a basic introduction to the entire range of glial topics and detailed information with critical assessment of the research literature. Neuroscience textbooks focus on the properties of neurons, whereas this book fills the information void about the brain's other cells. Neuroglia, Second Edition, is an essential reference source for newcomers, including graduate students, to neuroanatomy, neurochemistry, neurophysiology, and molecular neurobiology. It is also a vital companion for established researchers in these fields as well as clinicians in neurology, neurosurgery, psychiatry, neuropathology, and neuro-oncology.

Glial Physiology and Pathophysiology

Glial Physiology and Pathophysiology
  • Author : Alexei Verkhratsky,Arthur Butt
  • Publisher :Unknown
  • Release Date :2013-01-31
  • Total pages :560
  • ISBN : 9781118402054
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Summary : Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells. Coverae includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems the cellular physiology of the different kinds of glial cells the mechanisms of intra- and inter-cellular signalling in glial networks the mechanisms of glial-neuronal communications the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system the cellular and molecular mechanisms of metabolic neuronal-glial interactions the role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brain Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system Describes the role og glial cells in neuropathology Focus boxes highlight key points and summarise important facts Companion website with downloadable figures and slides

Fundamental Neuroscience

Fundamental Neuroscience
  • Author : Larry Squire,Floyd E. Bloom,Nicholas C. Spitzer,Larry R. Squire,Darwin Berg,Sascha du Lac,Anirvan Ghosh
  • Publisher :Unknown
  • Release Date :2008-04-02
  • Total pages :1280
  • ISBN : 0080561020
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Summary : Fundamental Neuroscience, 3rd Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts. Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! New to this edition: 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness Additional text boxes describing key experiments, disorders, methods, and concepts Multiple model system coverage beyond rats, mice, and monkeys Extensively expanded index for easier referencing

Glial Neurobiology

Glial Neurobiology
  • Author : Alexei Verkhratsky,Arthur Butt
  • Publisher :Unknown
  • Release Date :2007-08-20
  • Total pages :230
  • ISBN : 0470513071
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Summary : "This volume is a very valuable and much needed contribution." –Quarterly Review of Biology AT LAST - A comprehensive, accessible textbook on glial neurobiology! Glial cells are the most numerous cells in the human brain but for many years have attracted little scientific attention. Neurophysiologists concentrated their research efforts instead, on neurones and neuronal networks because it was thought that they were the key elements responsible for higher brain function. Recent advances, however, indicate this isn’t exactly the case. Not only are astroglial cells the stem elements from which neurones are born, but they also control the development, functional activity and death of neuronal circuits. These ground-breaking developments have revolutionized our understanding of the human brain and the complex interrelationship of glial and neuronal networks in health and disease. Features of this book: an accessible introduction to glial neurobiology including an overview of glial cell function and its active role in neural processes, brain function and nervous system pathology an exploration of all the major types of glial cells including: the astrocytes, oligodendrocytes and microglia of the ACNS and Schwann cells of the peripheral nervous system; the book also presents a broad overview of glial receptors and ion channels an investigation into the role of glial cells in various types of brain diseases including stroke, neurodegenerative diseases such as Alzheimer's, Parkinson's and Alexander's disease, brain oedema, multiple sclerosis and many more a wealth of illustrations, including unique images from the authors' own libraries of images, describing the main features of glial cells Written by two leading experts in the field, Glial Neurobiology provides a concise, authoritative introduction to glial physiology and pathology for undergraduate/postgraduate neuroscience, biomedical, medical, pharmacy, pharmacology, and neurology, neurosurgery and physiology students. It is also an invaluable resource for researchers in neuroscience, physiology, pharmacology and pharmaceutics.

Astrocyte

Astrocyte
  • Author : Maria Teresa Gentile,Luca Colucci D’Amato
  • Publisher :Unknown
  • Release Date :2018-03-21
  • Total pages :242
  • ISBN : 9789535138853
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Summary : A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.

Spinal Cord Injury (SCI) Repair Strategies

Spinal Cord Injury (SCI) Repair Strategies
  • Author : Giuseppe Perale,Filippo Rossi
  • Publisher :Unknown
  • Release Date :2019-10-30
  • Total pages :346
  • ISBN : 9780081028087
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Summary : Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering

Neuroglia in Neurodegenerative Diseases

Neuroglia in Neurodegenerative Diseases
  • Author : Alexei Verkhratsky,Margaret S. Ho,Robert Zorec,Vladimir Parpura
  • Publisher :Unknown
  • Release Date :2019-10-03
  • Total pages :405
  • ISBN : 9789811399138
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Summary : This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.

Sex and the Developing Brain

Sex and the Developing Brain
  • Author : Margaret McCarthy
  • Publisher :Unknown
  • Release Date :2010-11-01
  • Total pages :110
  • ISBN : 9781615040629
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Summary : The brains of males and females, men and women, are different—that is a fact. What is debated is how different and how important those differences are. Sex differences in the brain are determined by genetics, hormones, and experience, which in humans includes culture, society, and parental and peer expectations. The importance of nonbiological variables to sex differences in humans is paramount, making it difficult if not impossible to parse out those contributions that are truly biological. The study of animals provides us the opportunity to understand the magnitude and scope of biologically based sex differences in the brain and understanding the cellular mechanisms provides us insight into novel sources of brain plasticity. Many sex differences are established during a developmental sensitive window by differences in the hormonal milieu of males versus females. The neonatal testis produces large amounts of testosterone, which gains access to the brain and is further metabolized into active androgens and estrogens, which modify brain development. Major parameters that are influenced by hormones include neurogenesis, cell death, neurochemical phenotype, axonal and dendritic growth, and synaptogenesis. Variance in these parameters results in sex differences in the size of particular brain regions, the projections between brain regions, and the number and type of synapses within particular brain regions. The cellular mechanisms are both region and endpoint specific and invoke many surprising systems such as prostaglandins, endocannabinoids, and cell death proteins. By understanding when, why, and how sex differences in the brain are established, we may also learn the source of strong gender biases in the relative risk and severity of numerous neurological diseases and disorders of mental health, including but not limited to autism, dyslexia, attention deficit disorder, schizophrenia, Alzheimer’s, multiple sclerosis, Parkinson’s, and major depressive disorder.

Plastic Reason

Plastic Reason
  • Author : Tobias Rees
  • Publisher :Unknown
  • Release Date :2016-05-03
  • Total pages :352
  • ISBN : 9780520288126
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Summary : Throughout the twentieth century, neuronal researchers knew the adult human brain to be a thoroughly fixed and immutable cellular structure, devoid of any developmental potential. Plastic Reason is a study of the efforts of a few Parisian neurobiologists to overturn this rigid conception of the central nervous system by showing that basic embryogenetic processes—most spectacularly the emergence of new cellular tissue in the form of new neurons, axons, dendrites, and synapses—continue in the mature brain. Furthermore, these researchers sought to demonstrate that the new tissues are still unspecific and hence literally plastic, and that this cellular plasticity is constitutive of the possibility of the human. Plastic Reason, grounded in years of fieldwork and historical research, is an anthropologist’s account of what has arguably been one of the most sweeping events in the history of brain research—the highly contested effort to consider the adult brain in embryogenetic terms. A careful analysis of the disproving of an established truth, it reveals the turmoil that such a disruption brings about and the emergence of new possibilities of thinking and knowing.

Neuroimmune Pharmacology

Neuroimmune Pharmacology
  • Author : Tsuneya Ikezu,Howard E. Gendelman
  • Publisher :Unknown
  • Release Date :2016-12-22
  • Total pages :1035
  • ISBN : 9783319440224
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Summary : The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.

Neuroinflammation in Stroke

Neuroinflammation in Stroke
  • Author : Ulrich Dirnagl,Bernd Elger
  • Publisher :Unknown
  • Release Date :2013-04-17
  • Total pages :224
  • ISBN : 9783662054260
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Summary : The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.

Neuroanatomy of the Mouse

Neuroanatomy of the Mouse
  • Author : Hannsjörg Schröder,Natasha Moser,Stefan Huggenberger
  • Publisher :Unknown
  • Release Date :2020-02-28
  • Total pages :350
  • ISBN : 9783030198985
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Summary : This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse’s central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories.

The Biology of Oligodendrocytes

The Biology of Oligodendrocytes
  • Author : Patricia Armati,Emily Mathey
  • Publisher :Unknown
  • Release Date :2010-10-21
  • Total pages :229
  • ISBN : 9781139491716
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Summary : Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.