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Biased Signaling in Physiology, Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics
  • Author : Brian J Arey
  • Publisher :Unknown
  • Release Date :2014-06-05
  • Total pages :316
  • ISBN : 9780124115071
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Summary : Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Biomedical Index to PHS-supported Research: pt. A. Subject access A-H

Biomedical Index to PHS-supported Research: pt. A. Subject access A-H
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :229
  • ISBN : MINN:31951P002070717
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Summary :

NIH Almanac

NIH Almanac
  • Author : National Institutes of Health (U.S.). Division of Public Information
  • Publisher :Unknown
  • Release Date :1992
  • Total pages :229
  • ISBN : MINN:31951D00759747L
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Summary :

Regulation of Signal Transduction in Human Cell Research

Regulation of Signal Transduction in Human Cell Research
  • Author : Nariyoshi Shinomiya,Hiroaki Kataoka,Qian Xie
  • Publisher :Unknown
  • Release Date :2018-02-15
  • Total pages :218
  • ISBN : 9789811072963
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Summary : This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on. This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area. This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.

Physiological Research

Physiological Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :229
  • ISBN : UCLA:L0090275884
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Summary :

Signal Transduction

Signal Transduction
  • Author : Lewis C Cantley,Tony Hunter,Jeremy Thorner,Richard Sever
  • Publisher :Unknown
  • Release Date :2013-10-31
  • Total pages :452
  • ISBN : 1621821811
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Summary : Cells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex network of signal transduction pathways within the cell ensures that these signals are relayed to the correct molecular targets and that the cell responds appropriately. This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. Taking a novel approach, it first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function. The book is essential reading for students learning about signal transduction for the first time. It will also be a vital reference for all cell, molecular, and developmental biologists and pharmacologists, neurobiologists, and immunologists studying processes regulated by cell signaling.

The Journal of NIH Research

The Journal of NIH Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :229
  • ISBN : UCSC:32106013138844
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Summary :

New Scientist

New Scientist
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :229
  • ISBN : UOM:39015058989867
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Summary :

Physiology and Pathophysiology of the Heart

Physiology and Pathophysiology of the Heart
  • Author : Nick Sperelakis,Nicholas Sperelakis
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :1173
  • ISBN : UOM:39015032088919
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Summary : The third edition includes 14 new chapters covering topics that were not covered in the second edition. These include two new chapters on the molecular structure of ion channels and several new chapters on the ionic channels of myocardial cells, vascular smooth muscle cells, and endothelial cells. New chapters are also included on release of Ca[superscript 2+] from the SR, and on the action of phospholipids released during ischemia on ion channels and production of disrhythmias. These new additions make Physiology and Pathophysiology of the Heart, Third Edition substantially more complete and up-to-date with respect to recent developments in cardiovascular science.

Cancer Research

Cancer Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :229
  • ISBN : CORNELL:31924090576319
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Summary :

Hormonal Signaling in Biology and Medicine

Hormonal Signaling in Biology and Medicine
  • Author : Gerald Litwack
  • Publisher :Unknown
  • Release Date :2019-10-24
  • Total pages :738
  • ISBN : 9780128138151
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Summary : Hormonal Signaling in Biology and Medicine: Comprehensive Modern Endocrinology covers the endocrine secretions produced by every organ. This extensive collection of knowledge is organized by tissue, addressing how certain hormones are synthesized in multiple tissues, along with their structure, function and pathways, which are very applicable for researchers in drug design who need to focus on a specific step along the pathway. This is a must have reference for researchers in endocrinology and practicing endocrinologists, but it is also ideal for biochemists, pharmacologists, biologists and students. Serves as a valuable desk reference for researchers Provides information on the structure of a given hormone, its receptor(s), and the pathways that become activated Includes extensive citations to the literature that will enable the reader to dig more deeply into the effects of a given hormone

Signal Transduction: Pathways, Mechanisms and Diseases

Signal Transduction: Pathways, Mechanisms and Diseases
  • Author : Ari Sitaramayya
  • Publisher :Unknown
  • Release Date :2009-12-02
  • Total pages :437
  • ISBN : 3642021123
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Summary : Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

European Research Centres: A-N

European Research Centres: A-N
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1994-11
  • Total pages :1219
  • ISBN : 1561591173
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Summary :

Directory of American Research and Technology

Directory of American Research and Technology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :229
  • ISBN : UOM:39015039838662
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Summary : Identifies non-government facilities active in commercial research, including development of products and processes. Arrangement is alphabetic, geographic, and by concept classification.

Molecular Pharmacology

Molecular Pharmacology
  • Author : John Dickenson,Fiona Freeman,Chris Lloyd Mills,Christian Thode,Shiva Sivasubramaniam
  • Publisher :Unknown
  • Release Date :2012-11-30
  • Total pages :424
  • ISBN : 9781118451953
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Summary : This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.

Nature

Nature
  • Author : Sir Norman Lockyer
  • Publisher :Unknown
  • Release Date :1869
  • Total pages :229
  • ISBN : UIUC:30112075228673
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Summary :

The Directory of Graduate Studies

The Directory of Graduate Studies
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1996
  • Total pages :229
  • ISBN : STANFORD:36105020039595
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Summary :

Program & Abstracts, 10th International Congress of Endocrinology (ICE 96)

Program & Abstracts, 10th International Congress of Endocrinology (ICE 96)
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1996
  • Total pages :229
  • ISBN : NWU:35558003609480
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Summary :

Kyoto University Bulletin

Kyoto University Bulletin
  • Author : Kyōto Daigaku
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :229
  • ISBN : IND:30000048871416
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Summary :

Peterson's Graduate Programs in the Biological Sciences 2008

Peterson's Graduate Programs in the Biological Sciences 2008
  • Author : Peterson's
  • Publisher :Unknown
  • Release Date :2007-12
  • Total pages :1239
  • ISBN : 0768924065
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Summary : Lists over 3,700 graduate programs in 37 disciplines in the biological sciences

Handbook of Cell Signaling

Handbook of Cell Signaling
  • Author : Ralph A. Bradshaw,Edward A. Dennis
  • Publisher :Unknown
  • Release Date :2009-11-03
  • Total pages :3048
  • ISBN : 9780080920917
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Summary : Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field