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Biased Signaling in Physiology, Pharmacology and Therapeutics

Biased Signaling in Physiology, Pharmacology and Therapeutics
  • Author : Brian J Arey
  • Publisher :Unknown
  • Release Date :2014-06-05
  • Total pages :316
  • ISBN : 0124115071
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Summary : Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

RGS Protein Physiology and Pathophysiology

RGS Protein Physiology and Pathophysiology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2015-06-23
  • Total pages :226
  • ISBN : 0128029544
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Summary : RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. Brings together information on the current state of the RGS protein field Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery

Receptor-Receptor Interactions

Receptor-Receptor Interactions
  • Author : P. Michael Conn
  • Publisher :Unknown
  • Release Date :2013-10-18
  • Total pages :538
  • ISBN : 0124104703
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Summary : This new volume of Methods in Cell Biology looks at receptor-receptor interactions, with sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes. With cutting-edge material, this comprehensive collection is intended to guide researchers of receptor-receptor interactions for years to come. Covers sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes Chapters are written by experts in the field Cutting-edge material

Pulmonary Vasculature Redox Signaling in Health and Disease

Pulmonary Vasculature Redox Signaling in Health and Disease
  • Author : Yong-Xiao Wang
  • Publisher :Unknown
  • Release Date :2017-10-18
  • Total pages :422
  • ISBN : 3319632450
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Summary : The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field. The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.

Heart Physiology and Pathophysiology

Heart Physiology and Pathophysiology
  • Author : Yoshihisa Kurachi,Andre Terzic,Michael V. Cohen
  • Publisher :Unknown
  • Release Date :2000-10-09
  • Total pages :1261
  • ISBN : 0080533884
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Summary : Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features * The most comprehensive book available on this topic * Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology * Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology * Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology

Sex Differences in Cardiovascular Physiology and Pathophysiology

Sex Differences in Cardiovascular Physiology and Pathophysiology
  • Author : Babbette LaMarca, Ph.D.,Barbara T. Alexander, PhD, FAHA, FAPS
  • Publisher :Unknown
  • Release Date :2019-06-15
  • Total pages :320
  • ISBN : 0128131977
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Summary : Sex Differences in Cardiovascular Physiology and Pathophysiology is a comprehensive look into the often overlooked and underappreciated fundamental sex differences between men and women and how those differences affect the cardiovascular system. It covers cardiovascular function, anatomy, cell signaling and the development of pathology. With contributions from world-renowned research investigators, this up-to-date reference compiles critical knowledge on cardiovascular sex differences, providing researchers and clinicians with a better understanding of the diagnosis, prevention and treatment of cardiovascular diseases in both men and women. Identifies the fundamental sex differences in the physiology and pathophysiology of the cardiovascular system Describes cell signaling pathways involved in sex-associated cardiovascular function and diseases Puts the sex differences in cardiovascular diseases in the forefront to improve cardiovascular prognoses

Signal Transduction

Signal Transduction
  • Author : Lewis C Cantley,Tony Hunter,Jeremy Thorner,Richard Sever
  • Publisher :Unknown
  • Release Date :2013-10-31
  • Total pages :452
  • ISBN : 9781621821816
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Summary : Cells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex network of signal transduction pathways within the cell ensures that these signals are relayed to the correct molecular targets and that the cell responds appropriately. This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. Taking a novel approach, it first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function. The book is essential reading for students learning about signal transduction for the first time. It will also be a vital reference for all cell, molecular, and developmental biologists and pharmacologists, neurobiologists, and immunologists studying processes regulated by cell signaling.

Murray and Nadel's Textbook of Respiratory Medicine E-Book

Murray and Nadel's Textbook of Respiratory Medicine E-Book
  • Author : Robert J. Mason,V.Courtney Broaddus,Thomas R Martin,Talmadge E King,Dean Schraufnagel,John F. Murray,Jay A. Nadel
  • Publisher :Unknown
  • Release Date :2010-06-09
  • Total pages :2440
  • ISBN : 1437735533
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Summary : Murray and Nadel’s Textbook of Respiratory Medicine has long been the definitive and comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition in full color with new images and highlighted clinical elements. The fully searchable text is also online at www.expertconsult.com, along with regular updates, video clips, additional images, and self-assessment questions. This new edition has been completely updated and remains the essential tool you need to care for patients with pulmonary disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Search the full text online at expertconsult.com, along with downloadable images, regular updates, more than 50 videos, case studies, and self-assessment questions. Consult new chapters covering Ultrasound, Innate Immunity, Adaptive Immunity, Deposition and Clearance, Ventilator-Associated Pneumonia. Find critical information easily using the new full-color design that enhances teaching points and highlights challenging concepts. Apply the expertise and fresh ideas of three new editors—Drs. Thomas R. Martin, Talmadge E. King, Jr., and Dean E. Schraufnagel. Review the latest developments in genetics with advice on how the data will affect patient care.

Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels

Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels
  • Author : George S. Baillie,Frank Christian,Apostolos Zarros
  • Publisher :Unknown
  • Release Date :2016-04-08
  • Total pages :229
  • ISBN : 2889198154
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Summary : Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions.

Cancer

Cancer
  • Author : Vincent T. DeVita,Samuel Hellman,Steven A. Rosenberg
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :3217
  • ISBN : 9780397515752
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Summary :

Pediatric Critical Care E-Book

Pediatric Critical Care E-Book
  • Author : Bradley P. Fuhrman,Jerry J. Zimmerman
  • Publisher :Unknown
  • Release Date :2011-03-24
  • Total pages :1776
  • ISBN : 0323081703
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Summary : Provide the latest in superior quality care for critically ill children with the full-color, updated 4th Edition of Fuhrman and Zimmerman’s Pediatric Critical Care. In print, and now online, Drs. Bradley P. Fuhrman and Jerry J. Zimmerman use a comprehensive, organ-systems approach to help you manage a full range of disease entities. Get up-to-the-minute knowledge of topics such as acute lung injury, multiple organ dysfunction syndrome, and more. Implement new clinical techniques and diagnostic tests, weigh the varying perspectives of six associate editors with expertise in the field, reference 1,000+ illustrations to aid diagnosis, and keep sharp with online access to board-style review questions. This definitive title will ensure that you consistently deliver the very best intensive care to your pediatric patients. Focus on the development, function, and treatment of a wide range of disease entities with the text’s clear, logical, organ-system approach. Keep all members of the pediatric ICU team up to date with coverage of topics particularly relevant to their responsibilities. Keep current with the latest developments in palliative care, mass casualty/epidemic disease, acute respiratory failure, non-invasive ventilation, neurocritical care, neuroimaging, hypoxic-ischemic encephalopathy, stroke and intracerebral hemorrhage, systemic inflammatory response syndrome, acute lung injury, multiple organ dysfunction syndrome, and much more. Quickly find the information you need with sections newly reorganized for easier access. Gain the perspectives of six expert associate editors on all the new developments in the field. Understand complex concepts quickly and conclusively with a brand new full-color format and more than 1,000 illustrations. Search the full text, download the image library, and access online board review questions targeting every relevant topic, all at www.expertconsult.com.

Abeloff's Clinical Oncology E-Book

Abeloff's Clinical Oncology E-Book
  • Author : John E. Niederhuber,James O. Armitage,James H Doroshow,Michael B. Kastan,Joel E. Tepper
  • Publisher :Unknown
  • Release Date :2013-09-12
  • Total pages :2224
  • ISBN : 1455728810
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Summary : Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

Perspectives in Receptor Research

Perspectives in Receptor Research
  • Author : Dario Giardina,Alessandro Piergentili,Maria Pigini
  • Publisher :Unknown
  • Release Date :1996-06-07
  • Total pages :422
  • ISBN : 9780080545011
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Summary : Perspectives in Receptor Research

The Journal of NIH Research

The Journal of NIH Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :229
  • ISBN : 09876543XX
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Summary :

Anatomy ;Ocular physiology ;Biochemistry and genetics ;Pathology ;Microbiology ;Immunology ;Growth and senescence ;Optics ;Therapeutics ;Lasers and instrument technology ;Basic biostatistical and epidemiological terms

Anatomy ;Ocular physiology ;Biochemistry and genetics ;Pathology ;Microbiology ;Immunology ;Growth and senescence ;Optics ;Therapeutics ;Lasers and instrument technology ;Basic biostatistical and epidemiological terms
  • Author : Louise Bye,Neil Modi,Miles Stanford
  • Publisher :Unknown
  • Release Date :2013-05-23
  • Total pages :288
  • ISBN : 0199584990
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Summary : An indispensable and fully comprehensive textbook, this covers the basic sciences in ophthalmology and is the only book you need to pass the FRCOphth Part 1 exam.

Cellular Signal Transduction in Toxicology and Pharmacology

Cellular Signal Transduction in Toxicology and Pharmacology
  • Author : Jonathan W. Boyd,Richard R. Neubig
  • Publisher :Unknown
  • Release Date :2019-04-16
  • Total pages :336
  • ISBN : 1119060265
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Summary : Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques

Peterson's Guide to Graduate Programs in the Biological Sciences 1997

Peterson's Guide to Graduate Programs in the Biological Sciences 1997
  • Author : Peterson's Guides Staff,Peterson's Guides, Inc
  • Publisher :Unknown
  • Release Date :1997-01-05
  • Total pages :2672
  • ISBN : 9781560796534
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Summary : Graduate students depend on this series and ask for it by name. Why? For over 30 years, it's been the only one-stop source that supplies all of their information needs. The new editions of this six-volume set contain the most comprehensive information available on more than 1,500 colleges offering over 31,000 master's, doctoral, and professional-degree programs in more than 350 disciplines.New for 1997 -- Non-degree-granting research centers, institutes, and training programs that are part of a graduate degree program.Five discipline-specific volumes detail entrance and program requirements, deadlines, costs, contacts, and special options, such as distance learning, for each program, if available. Each Guide features "The Graduate Adviser", which discusses entrance exams, financial aid, accreditation, and more.The only source that covers nearly 4,000 programs in such areas as oncology, conservation biology, pharmacology, and zoology.

Transforming Growth Factor-Beta in Cancer Therapy, Volume I

Transforming Growth Factor-Beta in Cancer Therapy, Volume I
  • Author : Sonia B. Jakowlew
  • Publisher :Unknown
  • Release Date :2010-01-01
  • Total pages :735
  • ISBN : 1597452920
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Summary : Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Perspectives on Pathophysiology

Perspectives on Pathophysiology
  • Author : Lee Ellen Copstead
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :1222
  • ISBN : 09876543XX
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Summary : This textbook offers students an introduction to the aetiology, pathogenesis, clinical manifestation, and treatment of disease. Its reviews of individual structures and function prepare students for the study of human disease. It aims to stimulate critical thinking skills of the student.

Handbook of Cell Signaling

Handbook of Cell Signaling
  • Author : Ralph A. Bradshaw,Edward A. Dennis
  • Publisher :Unknown
  • Release Date :2009-11-03
  • Total pages :3048
  • ISBN : 0080920918
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Summary : Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field

Signal Transduction: Pathways, Mechanisms and Diseases

Signal Transduction: Pathways, Mechanisms and Diseases
  • Author : Ari Sitaramayya
  • Publisher :Unknown
  • Release Date :2009-12-02
  • Total pages :437
  • ISBN : 9783642021121
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Summary : Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.