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• Author : Alirio Rodrigues
• Publisher :Unknown
• Release Date :2015-05-23
• Total pages :304
• ISBN : 9780128020517

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Summary : Simulated Moving Bed Technology is one of only a few books solely dedicated to SMB. It aims to equip you with the tools and skills needed for SMB modelling, simulation, design and operation. The theory presented is supported by real-world examples from the petrochemical, sugar and pharma industries. The core of the book focuses on SMB process development and model validation. It explains basic process concepts and definitions, fundamental principles and equations, as well as typical applications and recent advances made to address challenges. Its specialist content makes it a must have book for people working with SMB technology, chemical engineering post-graduate students and process and R&D engineers in industry. Will provide you with the tools and predictive approaches for use in SMB design and performance assessment Covers SMB modelling, simulation, design and operation as applied to separation and reaction processes Discusses process intensification through coupling SMB and reaction in SMBR, membrane permeation and SMBR in PermSMBR and introduces the design of SCPC

• Author : Nesma Nehad Hashem
• Publisher :Unknown
• Release Date :2012
• Total pages :229
• ISBN : OCLC:1069580631

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Summary : Simulated Moving Bed (SMB) technology has gained increasing attention as one of the most powerful techniques for chromatographic separations due to its cost-effectiveness and efficiency. Application of SMB technology is especially important in the pharmaceutical industry for production of enantiopure drugs, as required under strict FDA regulations, to avoid possible adverse effects of racemic drugs. In this study, the performance of the SMB process in separation of racemic nadolol on a perphenyl carbamoylated beta cyclodextrin ( -CD) stationary phase was investigated. The equilibrium dispersive model coupled with bi-Langmuir adsorption isotherm and lumped kinetic approximation, constitute the mathematical model used to simulate the dynamic behavior of SMB. Multi-objective optimization was carried out using a robust state-of-the-art optimization technique, non-dominated sorting genetic algorithm (NSGA). Two optimization problems were solved to simultaneously maximize productivity and purity of the product and minimize consumption of desorbent. The generated Pareto optimal solutions showed that selection of operating conditions can significantly affects the performance of SMB to meet the desired objectives.

• Author : Jinglan Wu
• Publisher :Unknown
• Release Date :2009
• Total pages :169
• ISBN : OCLC:624525994

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Summary :

• Author : Shri Ramaswamy,Hua-Jiang Huang,Bandaru V. Ramarao
• Publisher :Unknown
• Release Date :2013-02-04
• Total pages :608
• ISBN : 9781118493465

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Summary : Separation and purification processes play a critical role in biorefineries and their optimal selection, design and operation to maximise product yields and improve overall process efficiency. Separations and purifications are necessary for upstream processes as well as in maximising and improving product recovery in downstream processes. These processes account for a significant fraction of the total capital and operating costs and also are highly energy intensive. Consequently, a better understanding of separation and purification processes, current and possible alternative and novel advanced methods is essential for achieving the overall techno-economic feasibility and commercial success of sustainable biorefineries. This book presents a comprehensive overview focused specifically on the present state, future challenges and opportunities for separation and purification methods and technologies in biorefineries. Topics covered include: Equilibrium Separations: Distillation, liquid-liquid extraction and supercritical fluid extraction. Affinity-Based Separations: Adsorption, ion exchange, and simulated moving bed technologies. Membrane Based Separations: Microfiltration, ultrafiltration and diafiltration, nanofiltration, membrane pervaporation, and membrane distillation. Solid-liquid Separations: Conventional filtration and solid-liquid extraction. Hybrid/Integrated Reaction-Separation Systems: Membrane bioreactors, extractive fermentation, reactive distillation and reactive absorption. For each of these processes, the fundamental principles and design aspects are presented, followed by a detailed discussion and specific examples of applications in biorefineries. Each chapter also considers the market needs, industrial challenges, future opportunities, and economic importance of the separation and purification methods. The book concludes with a series of detailed case studies including cellulosic bioethanol production, extraction of algae oil from microalgae, and production of biopolymers. Separation and Purification Technologies in Biorefineries is an essential resource for scientists and engineers, as well as researchers and academics working in the broader conventional and emerging bio-based products industry, including biomaterials, biochemicals, biofuels and bioenergy.

• Author : Nelu Grinberg,Peter W. Carr
• Publisher :Unknown
• Release Date :2020-08-05
• Total pages :304
• ISBN : 9781000062014

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Summary : For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to date information on a wide range of developments in chromatographic methods and applications. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill. This volume considers the achievements and legacy of Lloyd R. Snider in separation science and analytical chemistry. Key Features: • Provides a historical perspective of the evolution of SMB technology together with a theoretical analysis of the most relevant underlying phenomena. • Presents a brief survey of the polar columns suitable for HILIC separations and pays special attention to the role of the mobile phase in RP and HILIC modes. • Describes recent strategies of method development in Kosmotropic chromatography. • Surveys the many approaches to avert the effects of temperature in reversed-phase liquid chromatographic separations. • Reviews separation of isotopic compounds by HPLC in relation to the advances of columns and stationary phases.

• Author : Andrzej Stankiewicz,Jacob A. Moulijn
• Publisher :Unknown
• Release Date :2018-12-14
• Total pages :368
• ISBN : 9780203913291

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Summary : The first guide to compile current research and frontline developments in the science of process intensification (PI), Re-Engineering the Chemical Processing Plant illustrates the design, integration, and application of PI principles and structures for the development and optimization of chemical and industrial plants. This volume updates professionals on emerging PI equipment and methodologies to promote technological advances and operational efficacy in chemical, biochemical, and engineering environments and presents clear examples illustrating the implementation and application of specific process-intensifying equipment and methods in various commercial arenas.

• Author : Kai Knoerzer,Pablo Juliano,Geoffrey W Smithers
• Publisher :Unknown
• Release Date :2016-06-29
• Total pages :510
• ISBN : 9780081002988

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Summary : Innovative Food Processing Technologies: Extraction, Separation, Component Modification and Process Intensification focuses on advances in new and novel non-thermal processing technologies which allow food producers to modify and process food with minimal damage to the foodstuffs. The book is highly focused on the application of new and novel technologies, beginning with an introductory chapter, and then detailing technologies which can be used to extract food components. Further sections on the use of technologies to modify the structure of food and the separation of food components are also included, with a final section focusing on process intensification and enhancement. Provides information on a variety of food processing technologies Focuses on advances in new and novel non-thermal processing technologies which allow food producers to modify and process food with minimal damage to the foodstuffs Presents a strong focus on the application of technologies in a variety of situations Created by editors who have a background in both the industry and academia

• Author : Kai Knoerzer, PhD,Pablo Juliano, PhD,Peter Roupas, PhD,Cornelis Versteeg, PhD
• Publisher :Unknown
• Release Date :2011-01-31
• Total pages :300
• ISBN : 0470959428

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Summary : Part of the IFT (Institute of Food Technologists) series, this book discusses multiphysics modeling and its application in the development, optimization, and scale-up of emerging food processing technologies. The book covers recent research outcomes to demonstrate process efficiency and the impact on scalability, safety, and quality, and technologies including High Pressure Processing, High Pressure Thermal Sterilization, Radiofrequency, Ultrasound, Ultraviolet, and Pulsed Electric Fields Processing. Ideal for food and process engineers, food technologists, equipment designers, microbiologists, and research and development personnel, this book covers the importance and the methods for applying multiphysics modeling for the design, development, and application of these technologies.

• Author : Dr. Inamuddin,Mohammad Luqman
• Publisher :Unknown
• Release Date :2012-06-05
• Total pages :440
• ISBN : 9789400740266

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Summary : Ion-exchange Technology II: Applications presents an overview of the numerous industrial applications of ion-exchange materials. In particular, this volume focuses on the use of ion-exchange materials in various fields including chemical and biochemical separations, water purification, biomedical science, toxic metal recovery and concentration, waste water treatment, catalysis, alcohol beverage, sugar and milk technologies, pharmaceuticals industry and metallurgical industries. This title is a highly valuable source not only to postgraduate students and researchers but also to industrial R&D specialists in chemistry, chemical, and biochemical technology as well as to engineers and industrialists.

• Author : Ruth Freitag,R.W. Allington
• Publisher :Unknown
• Release Date :2002-05-28
• Total pages :271
• ISBN : 9783540430421

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Summary : Chromatography is the separation method for biological molecules from the analytical to the preparative scale. Few of the recent advances in life science, whether in "proteomics" or in the industrial production of recombinant therapeutics, would have been possible without the help of chromatographic separations. Concomitantly, chromatography nowadays stands for much more than a batch column packed with porous particles. In this book eminent experts from academia and industry introduce the reader to some of the recent new developments in this exciting area. Ranging from evolving nanoanalytical techniques to advances in the material sciences and artificial antibodies and finally continuous large scale separations of the most fragile biologicals, this book should provide interesting reading material for students and practitioners from various fields.

• Author : Anonim
• Publisher :Unknown
• Release Date :1990
• Total pages :229
• ISBN : UCAL:B4444515

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Summary :

• Author : G. Ganetsos,P.E. Barker
• Publisher :Unknown
• Release Date :2019-11-11
• Total pages :816
• ISBN : 9781000715682

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Summary : Describes the latest developments in the scaling-up and application of chromatographic operations and demonstrates that production-scale chromatography is a powerful and invaluable separation process. The book covers every important process design and reveals actual, immediately applicable techniques and is designed to appeal to design, chemical/biochemical, and research and development engineers, process development managers, bioprocess technologists, analytical and clinical chemists and biochemists, pharmacists, and upper-level undergraduate, graduate, and continuing-education students in these disciplines.

• Author : Kai Sundmacher,Achim Kienle,Andreas Seidel-Morgenstern
• Publisher :Unknown
• Release Date :2006-03-06
• Total pages :556
• ISBN : 9783527605552

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Summary : This is the first book dedicated to the entire field of integrated chemical processes, covering process design, analysis, operation and control of these processes. Both the editors and authors are internationally recognized experts from different fields in industry and academia, and their contributions describe all aspects of intelligent integrations of chemical reactions and physical unit operations such as heat exchange, separational operations and mechanical unit operations. As a unique feature, the book also introduces new concepts for treating different integration concepts on a generalized basis. Of great value to a broad audience of researchers and engineers from industry and academia.

• Author : Kevin R. Wood,Y. A. Liu,Yueying Yu
• Publisher :Unknown
• Release Date :2018-07-16
• Total pages :432
• ISBN : 9783527344697

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Summary : A comprehensive resource to the construction, use, and modification of the wide variety of adsorptive and chromatographic separations Design, Simulation and Optimization of Adsorptive and Chromatographic Separations offers the information needed to effectively design, simulate, and optimize adsorptive and chromatographic separations for a wide range of industrial applications. The authors?noted experts in the field?cover the fundamental principles, the applications, and a range of modeling techniques for the processes. The text presents a unified approach that includes the ideal and intermediate equations and offers a wealth of hands-on case studies that employ the rigorous simulation packages Aspen Adsorption and Aspen Chromatography. The text reviews the effective design strategies, details design considerations, and the assumptions which the modelers are allowed to make. The authors also cover shortcut design methods as well as mathematical tools that help to determine optimal operating conditions. This important text: -Covers everything from the underlying pheonmena to model optimization and the customization of model code -Includes practical tutorials that allow for independent review and study -Offers a comprehensive review of the construction, use, and modification of the wide variety of adsorptive and chromatographic separations -Contains contributions from three noted experts in the field Written for chromatographers, process engineers, ehemists, and other professionals, Design, Simulation and Optimization of Adsorptive and Chromatographic Separations offers a comprehensive review of the construction, use, and modification of adsorptive and chromatographic separations.

• Author : Ganapathy Subramanian
• Publisher :Unknown
• Release Date :2014-12-03
• Total pages :528
• ISBN : 9783527673704

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Summary : With contributions from biotechnologists and bioengineers, this ready reference describes the state of the art in industrial biopharmaceutical production, with a strong focus on continuous processes. Recent advances in single-use technology as well as application guidelines for all types of biopharmaceutical products, from vaccines to antibodies, and from bacterial to insect to mammalian cells are covered. The efficiency, robustness, and quality control of continuous production processes for biopharmaceuticals are reviewed and compared to traditional batch processes for a range of different production systems.

• Author : Ganapathy Subramanian
• Publisher :Unknown
• Release Date :2018-01-04
• Total pages :628
• ISBN : 9783527340637

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Summary : This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities.

• Author : H. Schmidt-Traub,Michael Schulte,Andreas Seidel-Morgenstern
• Publisher :Unknown
• Release Date :2020-02-12
• Total pages :648
• ISBN : 9783527816316

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Summary : The third edition of this popular work is revised to include the latest developments in this fast-changing field. Its interdisciplinary approach elegantly combines the chemistry and engineering to explore the fundamentals and optimization processes involved.

• Author : Arne Staby,Anurag S. Rathore,Satinder Ahuja
• Publisher :Unknown
• Release Date :2017-02-02
• Total pages :608
• ISBN : 9781119031178

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Summary : Preparative Chromatography for Separation of Proteins addresses a wide range of modeling, techniques, strategies, and case studies of industrial separation of proteins and peptides. • Covers broad aspects of preparative chromatography with a unique combination of academic and industrial perspectives • Presents Combines modeling with compliantce useing of Quality-by-Design (QbD) approaches including modeling • Features a variety of chromatographic case studies not readily accessible to the general public • Represents an essential reference resource for academic, industrial, and pharmaceutical researchers

• Author : Bertrand Braunschweig,Xavier Joulia
• Publisher :Unknown
• Release Date :2008
• Total pages :1205
• ISBN : 9780444532275

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Summary : The 18th European Symposium on Computer Aided Process Engineering contains papers presented at the 18th European Symposium of Computer Aided Process Engineering (ESCAPE 18) held in Lyon, France, from 1-4 June 2008. The ESCAPE series brings the latest innovations and achievements by leading professionals from the industrial and academic communities. The series serves as a forum for engineers, scientists, researchers, managers and students from academia and industry to: - present new computer aided methods, algorithms, techniques related to process and product engineering, - discuss innovative concepts, new challenges, needs and trends in the area of CAPE. This research area bridges fundamental sciences (physics, chemistry, thermodynamics, applied mathematics and computer sciences) with the various aspects of process and product engineering. The special theme for ESCAPE-18 is CAPE for the Users! CAPE systems are to be put in the hands of end users who need functionality and assistance beyond the scientific and technological capacities which are at the core of the systems. The four main topics are: - off-line systems for synthesis and design, - on-line systems for control and operation, - computational and numerical solutions strategies, - integrated and multi-scale modelling and simulation, Two general topics address the impact of CAPE tools and methods on Society and Education. * CD-ROM that accompanies the book contains all research papers and contributions * International in scope with guest speeches and keynote talks from leaders in science and industry * Presents papers covering the latest research, key top areas and developments in Computer Aided Process Engineering

• Author : Georges Guiochon,Dean G. Shirazi,Attila Felinger,Anita M. Katti
• Publisher :Unknown
• Release Date :2006
• Total pages :975
• ISBN : 9780123705372

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Summary : The second edition of Fundamentals of Preparative and Nonlinear Chromatographyis book that discusses all the physico-chemical issues related to linear and nonlinear chromatography. It summarizes the essential issues involved in thermodynamics (single-component and competitive liquid-solid equilibrium isotherms, influence of the temperature, the pressure, and the mobile phase composition on these isotherms, heterogeneity of the surface of adsorbents), mass transfer kinetics (diffusion through bulk liquids, through particle beds, and through particles, surface diffusion, competitive diffusion), and flow through porous media (pressure drop, permeability, viscosity of mixtures, viscous fingering). It presents the different models used in chromatography (ideal, nonlinear model, linear, nonideal model, equilibrium-dispersive model, transport and transport-dispersive models, general rate model, POR model), their algebraic and numerical solutions, and the practical applications made of these solutions (elution, frontal analysis and displacement chromatography, gradient elution, system peaks). Also discussed are the various processes derived from chromatography, particularly the different modes of recycling, the true and the simulated moving bed separators, including the recent variants of this SMB process. Finally, it describes and illustrates the different methods used for the optimization of the experimental conditions with different objective functions.

• Author : Frerich J. Keil
• Publisher :Unknown
• Release Date :2007-06-27
• Total pages :422
• ISBN : 9783527610594

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Summary : Combining the knowledge involved in process engineering and process modeling, this is the first book to cover all modeling methods applicable to process intensification. Both the editors and authors are renowned experts from industry and academia in the various fields of process modeling and integrated chemical processes. Following an introduction to the topic, the book goes on to look at equipment and operational methods, monolithic catalysis, HEX, micro- and reverse flow reactors, catalytic and reactive distillation, the simulated-moving bed and vibration bubble column as well as ultrasound and ultrasonic reactors. A final chapter is devoted to processes under supercritical conditions. In its treatment of hot topics of multidisciplinary interest, this book is of great value to researchers and engineers alike.