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• Author : Alys E. Bradley,Jennifer Chilton
• Publisher :Unknown
• Release Date :2020-11-01
• Total pages :575
• ISBN : 9780128130896

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Summary : Spontaneous Pathology of the Laboratory Nonhuman Primate serves as a "go to" resource for all pathologists working on primates in safety assessment studies. In addition, it helps diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathologies when assigning cause of death to species in zoological collections. Primate species included are rhesus, cynomolgus macaques and marmosets. Multi-authored chapters are arranged by organ system, thus providing the necessary information for continued research. Pathologists often face a lack of suitable reference materials or historical data to determine if pathologic changes they are observing in monkeys are spontaneous or a consequence of other treatments or factors. Contains color illustrations that depict the most common lesions to augment descriptions Covers descriptions that are compliant with the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) guidelines set forth by the Society of Toxicologic Pathology (STP) Provides pathologists with common terms that are compliant with the FDA’s Standard for Exchange of Nonclinical Data (SEND) guidelines

• Author : Alys E Bradley,Jennifer Chilton
• Publisher :Unknown
• Release Date :2019-06-15
• Total pages :575
• ISBN : 0128130881

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Summary : Pathologists often face a lack of suitable reference materials or historical data to determine if pathologic changes they are observing in monkeys are spontaneous or a consequence of other treatments or factors. By providing that background information, this text solves that problem. This book serves as a "go to" text for all pathologists working on primates in safety assessment studies, and to help diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathology when assigning cause of death to these species in zoological collections. Primate species included are rhesus and cynomolgus macaques, and marmosets. Multi-authored chapters are arranged by organ system. Comprehensive text that describes the spontaneous pathology seen in the common laboratory primate species: rhesus and cynomolgus macaques, and marmosets Color illustrations depict the most common lesions to augment the descriptions Descriptions are compliant with the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) guidelines set forth by the Society of Toxicologic Pathology (STP), and currently utilized in rodent manuscripts published in the Japanese Journal of Toxicological Pathology and the Journal of Toxicologic Pathology Provides pathologists with common terms that are compliant with the FDA's Standard for Exchange of Nonclinical Data (SEND) guidelines

• Author : John L. VandeBerg,Sarah Williams-Blangero,Suzette D. Tardif
• Publisher :Unknown
• Release Date :2009-06-04
• Total pages :392
• ISBN : 0387759913

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Summary : Nonhuman primates have played critical roles in biomedical research, and they are among the few animals whose use in research continues to increase. The scienti?c value of nonhuman primates derives from their close phylogenetic proximity to man and their consequent anatomic, physiologic, and genetic similarities to man. Only nonhuman primates can provide adequate models for many complex physiological and disease processes of humans. The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its ?rst use in the U. S. , it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used models for the genetics of susceptibility to complex diseases and they are the ?rst nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased.

• Author : Alys Bradley
• Publisher :Unknown
• Release Date :2022-01-17
• Total pages :575
• ISBN : 0128225289

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Summary : Provides a comprehensive text describing the spontaneous pathology seen in the common laboratory rabbit strains. This is the first book collating information on all organ systems in these strains. Rabbits are widely used for experimentation and testing mainly due to practical, rather than scientific, considerations. They are small and usually docile, easily restrained, cheap to maintain, and breed prodigious. Spontaneous Pathology of the Laboratory Rabbit serves as a "go to” text for all pathologists working on laboratory rabbits in safety assessment studies, and to help diagnostic veterinary pathologists rule out spontaneous non-clinical disease pathology when assigning cause of death to these animals which are also kept as domestic pets. Consist of multi-author chapters arranged by Organ systems Provides color illustrations that depict the most common lesions to augment the descriptions provides pathologists with common terms that are compliant with the FDA's Standard for Exchange of Nonclinical Data (SEND) guidelines Gives references for recommended tissue trimming planes

• Author : Angela Courtney
• Publisher :Unknown
• Release Date :2012-10-18
• Total pages :251
• ISBN : 9781439867280

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Summary : Sources of clinical treatment information on nonhuman primates are generally scattered across journals, textbooks, conferences, personal conversations, and more. However, when a clinician on the treatment floor is faced with a patient requiring an immediate treatment decision, time spent on making an informed decision becomes a critical factor. An alternative to conducting a literature search in time-sensitive situations, the Pocket Handbook of Nonhuman Primate Clinical Medicine supplies guidance and initial direction on diagnosis and treatment, including working doses based on past case experience. It is the frank, to-the-point nature of the writing that makes readers feel as if they had just asked a colleague how to approach a clinical problem and obtained a quick, "what you need to know" answer. The chapter authors draw on personal experience to describe commonly encountered clinical conditions and how to treat these cases—including not only the "dos" but also the "don’ts." This format gives readers easy access to clinical signs, diagnostic criteria, and options for treatment. The Pocket Handbook of Nonhuman Primate Clinical Medicine is a convenient, concise, case-based handbook written by and for clinicians in charge of the diagnosis and treatment of nonhuman primate patients. Available in both print and electronic formats, this handbook saves readers from having to wade through pages of data and case studies to find answers when time is a factor on the clinic floor.

• Author : Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt
• Publisher :Unknown
• Release Date :2012-12-06
• Total pages :248
• ISBN : 9783642849244

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Summary : The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The M on ographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stud ies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book on nonhuman primate pathology is the 12th volume of a set of monographs prepared under the sponsorship of the International Life Sciences Institute (ILSI).

• Author : Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt
• Publisher :Unknown
• Release Date :2012-12-06
• Total pages :221
• ISBN : 9783642849060

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Summary : The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The Mo nographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stu dies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors -strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on Nonhuman Primates, is the eleventh volume of a set pre pared under the sponsorship of the International Life Sciences Institute (ILSI).

• Author : Anonim
• Publisher :Unknown
• Release Date :1998-07-24
• Total pages :512
• ISBN : 0080537634

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Summary : This volume and its companion Nonhuman Primates in Biomedical Research: Biology and Management represent the most comprehensive publications of their type on nonhuman primates. This volume addresses the diseases of nonhuman primates with an emphasis on the etiological factors, clinical signs, diagnostic pathology, therapy, and management. Its companion volume serves as a general reference for those who provide care for these animals and for those who use them in biomedical research.

• Author : Elizabeth Fiona McInnes
• Publisher :Unknown
• Release Date :2011-10-24
• Total pages :256
• ISBN : 9780702049248

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Summary : Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals a chapter on common artifacts that may be observed in histological glass slides extensive references to each lesion described aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies

• Author : Kurt Benirschke
• Publisher :Unknown
• Release Date :2012-12-06
• Total pages :1044
• ISBN : 9781461249184

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Summary : This conference represents the first time in my life when I felt it was a misfor tune, rather than a major cause of my happiness, that I do conservation work in New Guinea. Yes, it is true that New Guinea is a fascinating microcosm, it has fascinating birds and people, and it has large expanses of undisturbed rainforest. In the course of my work there, helping the Indonesian government and World Wildlife Fund set up a comprehensive national park system, I have been able to study animals in areas without any human population. But New Guinea has one serious drawback: it has no primates, except for humans. Thus, I come to this conference on primate conservation as an underprivileged and emotionally deprived observer, rather than as an involved participant. Nevertheless, it is easy for anyone to become interested in primate conserva tion. The public cares about primates. More specifically, to state things more realistically, many people care some of the time about some primates. Primates are rivaled only by birds, pandas, and the big cats in their public appeal. For some other groups of animals, the best we can say is that few people care about them, infrequently. For most groups of animals, no one cares about them, ever.

• Author : Kurt Benirschke,F.M. Garner,T.C. Jones
• Publisher :Unknown
• Release Date :2012-12-06
• Total pages :1050
• ISBN : 9781461299424

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Summary : Laboratory Animal Medicine has made enor We deeply appreciate the efforts of each of the mous strides in the 47 years since R. Jaffe published authors and co-authors of the 23 chapters in this his "Anatomy and Pathology of Spontaneous Dis two volume work. In some instances the reader will eases of Small Laboratory Animals" in 1931. So note what appears to be repetition in certain chap ters. This repetition was allowed to stand in some much new information had accumulated that in a cases because different approaches seemed useful, new edition in 1958, Jaffe, aided by Cohrs and Meessen, needed the assistance of 46 colleagues to although efforts were made to delete most of the do the subject justice. Like its predecessor, this two redundancy which inevitably arises in a venture of volume comprehensive treatise on "Pathologie der this kind. We will be grateful if our colleagues point out errors and send us specific and general Laboratoriumstiere" was written in German and criticism of this work to allow corrections in the thus not readily available to the widening circle of event of reprinting or a next edition. veterinarians and pathologists who now are inter One objective has been to assemble current in ested in laboratory animals. Aside from the need to have a comprehensive formation in the pathologic aspects of diseases of review of laboratory animal pathology in English, laboratory animals.

• Author : B. Taylor Bennett,Christian R. Abee,Roy Henrickson
• Publisher :Unknown
• Release Date :1998
• Total pages :512
• ISBN : 9780120886654

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Summary : This volume addresses the diseases of nonhuman primates with an emphasis on the etiological factors, clinical signs, diagnostic pathology, therapy, and management.

• Author : Sam Silverman
• Publisher :Unknown
• Release Date :1983
• Total pages :136
• ISBN : UCAL:X16326

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Summary :

• Author : Thomas Burbacher,Kimberly Grant,Gene P. Sackett
• Publisher :Unknown
• Release Date :2011-10-10
• Total pages :472
• ISBN : 0080554067

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Summary : The rate of neurodevelopmental disabilities, including autism, mental retardation, hearing loss and attention deficit hyperactivity disorder is rising in the United States. Although estimates of the prevalence of these disorders vary, figures from the CDC indicate that 4% of all school age children are developmentally disabled. During infancy, many important milestones in behavioral development are shared between human and nonhuman primates. Learning more about the causes of abnormal development in monkeys has provided important insights into the mechanisms underlying neurodevelopmental disabilities in human infants. This book documents the latest research not commonly found in other references, and provides a comprehensive look at the results from decades of work with nonhuman primates as it relates to child development and disability. Includes hot topics such as early chemical exposures, immunological influences on development, low birth weight, endocrine disrupters, pediatric AIDS, origin of childhood psychopathologies and assisted reproductive technology Represents the significant body of work accumulated since funding for research on developmental disabilities has increased substantially in recent years

• Author : Elizabeth McInnes
• Publisher :Unknown
• Release Date :2017-03-16
• Total pages :216
• ISBN : 9781118755310

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Summary : Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity. Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes: Colour diagrams explaining how lesions are caused by either external compounds or spontaneously The anatomic variations and background lesions of laboratory animals Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data A chapter on the haematology and biochemistry of laboratory animals Full colour photographs of common macroscopic lesions encountered in laboratory animals A comprehensive glossary

• Author : Christian R. Abee,Keith Mansfield,Suzette D. Tardif,Timothy Morris
• Publisher :Unknown
• Release Date :2012-04-12
• Total pages :868
• ISBN : 9780123813664

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Summary : The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information Includes four color images throughout

• Author : Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer
• Publisher :Unknown
• Release Date :2015-03-13
• Total pages :716
• ISBN : 9780124171466

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Summary : The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

• Author : Anonim
• Publisher :Unknown
• Release Date :1996
• Total pages :229
• ISBN : UCSC:32106014500497

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Summary :

• Author : National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Well-Being of Nonhuman Primates
• Publisher :Unknown
• Release Date :1998-11-03
• Total pages :184
• ISBN : 9780309176507

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Summary : A 1985 amendment to the Animal Welfare Act requires those who keep nonhuman primates to develop and follow appropriate plans for promoting the animals' psychological well-being. The amendment, however, provides few specifics. The Psychological Well-Being of Nonhuman Primates recommends practical approaches to meeting those requirements. It focuses on what is known about the psychological needs of primates and makes suggestions for assessing and promoting their well-being. This volume examines the elements of an effective care program--social companionship, opportunities for species-typical activity, housing and sanitation, and daily care routines--and provides a helpful checklist for designing a plan for promoting psychological well-being. The book provides a wealth of specific and useful information about the psychological attributes and needs of the most widely used and exhibited nonhuman primates. Readable and well-organized, it will be welcomed by animal care and use committees, facilities administrators, enforcement inspectors, animal advocates, researchers, veterinarians, and caretakers.

• Author : Medbh McGuckian
• Publisher :Unknown
• Release Date :1998-01-01
• Total pages :120
• ISBN : 1852352213

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Summary : Taking her title from the Wexford fishermen who became gunmen in the Irish rising of 1798, Medbh McGuckian warms history into a living and breathing voice.

• Author : Anonim
• Publisher :Unknown
• Release Date :1984
• Total pages :229
• ISBN : UCAL:B4490564

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Summary :