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Biology and Engineering of Stem Cell Niches

Biology and Engineering of Stem Cell Niches
  • Author : Ajaykumar Vishwakarma,Jeffrey M Karp
  • Publisher :Unknown
  • Release Date :2017-03-22
  • Total pages :642
  • ISBN : 9780128027561
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Summary : Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points

Epidermal Stem Cell Niche

Epidermal Stem Cell Niche
  • Author : Mirna Perez-Moreno
  • Publisher :Unknown
  • Release Date :2019-08-09
  • Total pages :230
  • ISBN : 9780128184479
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Summary : Advances in Stem Cells and Their Niches, Volume Three, comprises a compilation of the latest findings on our understanding of skin biology. It extends the current knowledge on skin stem cells and provides in-depth discussions on their unique settings, niches and properties. Chapters in this new release include The biophysical regulation of epidermal fate and function, Epidermal stem cell lineages, Hair shaft progenitors that create a niche for hair pigmentation, Dermal papilla cells control of hair follicle growth and pigmentation, Molecular mechanisms regulating the hair follicle niche, Dermal fibroblasts and their niches and interactions with epidermal stem cells. Contains chapters written by international leaders in skin biology Provides a unique compilation of the latest findings and technologies in basic and translational skin biology Expands current knowledge on the regulation of skin stem cells as isolated entities, focusing on how skin stem cells and lineages of stem cells function in a coordinated manner Provides illustrations and comprehensive analyses of each subject

Adult Stem Cell Niches

Adult Stem Cell Niches
  • Author : Sabine Wislet
  • Publisher :Unknown
  • Release Date :2014-08-01
  • Total pages :330
  • ISBN : 9789535117186
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Summary : Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.

Hematopoietic Stem Cell Niche

Hematopoietic Stem Cell Niche
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2017-03-10
  • Total pages :186
  • ISBN : 9780128113769
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Summary : Hematopoietic Stem Cell Niche focuses on an individual organ, looking at the stem cells in the organ itself (if they exist), their niches, and how to use them alongside relevant methods and protocols. This series addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

The Stem Cell Niche during Ageing

The Stem Cell Niche during Ageing
  • Author : Susie Prof. Nilsson
  • Publisher :Unknown
  • Release Date :2020-08-22
  • Total pages :258
  • ISBN : 9780128220207
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Summary : Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Biomaterials as Stem Cell Niche

Biomaterials as Stem Cell Niche
  • Author : Krishnendu Roy
  • Publisher :Unknown
  • Release Date :2010-09-30
  • Total pages :309
  • ISBN : 3642138934
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Summary : Recent developments in stem cell biology have opened new directions in cell therapy. This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering stem cells, both for the purpose of better understanding their biology under 3D biomimetic conditions as well as for developing new strategies for efficient long term maintenance and directed differentiation of stem cells into various therapeutic lineages. Animal and human stem cells of both embryonic and adult origin are discussed with applications ranging from nerve regeneration, orthopedics, cardiovascular therapy, blood cell generation and cancer therapy. Both synthetic and natural biomaterials are reviewed with emphasis on how material-stem cell interactions direct specific signaling pathways and ultimately modulate the cell fate. This book is valuable for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells.

Stem Cell Microenvironments and Beyond

Stem Cell Microenvironments and Beyond
  • Author : Alexander Birbrair
  • Publisher :Unknown
  • Release Date :2017-12-03
  • Total pages :270
  • ISBN : 9783319691947
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Summary : This book discusses the main stem cell niches under distinct pathophysiological conditions. The role of tissue microenvironments in stem cell regulation, as well as modern methodologies and new techniques for the identification and characterization of stem cell niches, are discussed by leading experts in the field. Chapters describe the major components of various stem cell microenvironments, such as cellular components, soluble factors, cell-cell interactions, extra-cellular matrix proteins, and physical forces. Stem Cell Microenvironments and Beyond is part of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students and researchers in the field of stem cells or cell biology as well as clinicians.

Tissue-Specific Stem Cell Niche

Tissue-Specific Stem Cell Niche
  • Author : Kursad Turksen
  • Publisher :Unknown
  • Release Date :2015-10-05
  • Total pages :328
  • ISBN : 9783319217055
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Summary : This timely volume explores tissue-derived stem cells, summarizing and evaluating the current body of knowledge. Sixteen chapters cover hematopoietic, osteoblast, skeletal, cardiac, pancreatic, epithelial, corneal, hepatic, renal, testicular, ovarian, fingernail, hair follicle and other stem cells- discussing their individual development, functions and pathologies, as well as the commonalities and interdependence between niches. This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Tissue-Specific Stem Cell Niche is an ideal complementary volume to Biology of Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.

Pluripotent Stem Cells

Pluripotent Stem Cells
  • Author : Minoru Tomizawa
  • Publisher :Unknown
  • Release Date :2016-07-20
  • Total pages :532
  • ISBN : 9789535124719
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Summary : Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

The Cell Biology of Stem Cells

The Cell Biology of Stem Cells
  • Author : Eran Meshorer,Kathrin Plath
  • Publisher :Unknown
  • Release Date :2011-01-11
  • Total pages :229
  • ISBN : 1441970371
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Summary : Stem cells have been gaining a lot of attention in recent years. Their unique potential to self-renew and differentiate has turned them into an attractive model for the study of basic biological questions such as cell division, replication, transcription, cell fate decisions, and more. With embryonic stem (ES) cells that can generate each cell type in the mammalian body and adult stem cells that are able to give rise to the cells within a given lineage, basic questions at different developmental stages can be addressed. Importantly, both adult and embryonic stem cells provide an excellent tool for cell therapy, making stem cell research ever more pertinent to regenerative medicine. As the title The Cell Biology of Stem Cells suggests, our book deals with multiple aspects of stem cell biology, ranging from their basic molecular characteristics to the in vivo stem cell trafficking of adult stem cells and the adult stem-cell niche, and ends with a visit to regeneration and cell fate reprogramming. In the first chapter, “Early embryonic cell fate decisions in the mouse”, Amy Ralson and Yojiro Yamanaka describe the mechanisms that support early developmental decisions in the mouse pre-implantation embryo and the current understanding of the source of the most immature stem cell types, which includes ES cells, trophoblast stem (TS) cells and extraembryonic endoderm stem (XEN) cells.

Intestinal Stem Cell Niche

Intestinal Stem Cell Niche
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2018-04-24
  • Total pages :150
  • ISBN : 012813481X
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Summary : Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Stem Cell Biology in Normal Life and Diseases

Stem Cell Biology in Normal Life and Diseases
  • Author : Kamran Alimoghaddam
  • Publisher :Unknown
  • Release Date :2013-05-08
  • Total pages :196
  • ISBN : 9789535111078
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Summary : Stem cells have a prominent role in normal life and also in pathogenesis of disorders. Today, these cells are clinically applicable in hematopoietic stem cell transplantation but expansion of their application in many more disorders needs more work. For safe and effective application of these cells, we need better knowledge of their biology, their interaction with other cells (especially supporting niche cells), growth, maturation and also immigration of stem cells through body in normal and abnormal conditions. Also for clinical application we need to understand better, their separation methods and safe manipulation. This book is written to clarify some aspects of stem cell biology, their characteristics, assessment of damage to cells during ex vivo manipulation and also their role in a model of cancers (chronic myeloid leukemia).

Cancer Metastasis and Cancer Stem Cell/Niche

Cancer Metastasis and Cancer Stem Cell/Niche
  • Author : Takanori Kawaguchi
  • Publisher :Unknown
  • Release Date :2016-11-04
  • Total pages :157
  • ISBN : 9781681083476
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Summary : A malignant tumor is an actively growing tissue, composed of cells derived from a single cell line that has undergone irreversible differentiation. These cells are invasive and also metastasize in the body, resulting in malignant cancer. Recent research suggests that a malignant tumor originates from cancer stem cells (CSC) accompanied with physiological niches. Cancer Metastasis and Stem Cell/Niche explains the invasiveness and metastasis of cancer cells I the light of information gained from the CSC / niche theory. Five chapters present a review on the fundamental relationships between CSCs, their niche and metastasis, the regulation of cell surface glycan expression in CSCs, tumor endothelial cells and metastasis, toll-like receptor 4 (TLR4)-mediated premetastatic microenvironment, and in surgical cancer metastasis. This monograph is intended as a primary reference on CSC research for physiologists, clinical oncologists, stem cell researchers and molecular biologists.

Essentials of Stem Cell Biology

Essentials of Stem Cell Biology
  • Author : Robert Lanza,John Gearhart,Brigid Hogan,Douglas Melton,Roger Pedersen,E. Donnall Thomas,James A. Thomson,Ian Sir Wilmut
  • Publisher :Unknown
  • Release Date :2009-06-05
  • Total pages :680
  • ISBN : 0080884970
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Summary : First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries Contributions by Nobel Laureates and leading international investigators Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references

Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other?

Crosstalk between the osteogenic and neurogenic stem cell niches: how far are they from each other?
  • Author : Wanda Lattanzi,Maria Concetta Geloso
  • Publisher :Unknown
  • Release Date :2016-03-14
  • Total pages :102
  • ISBN : 9782889197774
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Summary : Somatic stem cells reside in definite compartments, known as "niches", within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic stem cells have been found in almost every human organism, including brain and heart. (HSCs) and mesenchymal stem cells (MSCs), that intensely interacts. HSCs represent the common precursors of all mature blood cells. (Bone, cartilage, blood vessels, adipose tissue, and.), And in the case of the skeletal muscle Supporting connective stroma). Despite this high plasticity, the claim that MSCs could be capable of transdifferentiation along non-mesodermal linesages, including neurons, has been strongly argued. Adult osteogenic and neurogenic niches display wide differences: embryo origin, microenvironment, progenitors' lifespan, lineages of supporting cells. Although similar pathways may be involved, it is hard to believe that the osteogenic and neurogenic lineages can share functional features. The outbreak of the disease is the most important cause of neurodegeneration and neurological disorders, including the development of neurological disorders. Based on this research, the research group is interested in the development of new technologies, and in the field of research and development. The results of the study are summarized in the following sections: In vivo transplantation, has been covered.

The Cancer Stem Cell Niche

The Cancer Stem Cell Niche
  • Author : Susie Nilsson
  • Publisher :Unknown
  • Release Date :2021-02-01
  • Total pages :246
  • ISBN : 9780323853262
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Summary : The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

Stem Cell Engineering

Stem Cell Engineering
  • Author : Gerhard M. Artmann,Stephen Minger,Jürgen Hescheler
  • Publisher :Unknown
  • Release Date :2010-10-29
  • Total pages :547
  • ISBN : 3642118658
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Summary : The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.

Germline Stem Cells

Germline Stem Cells
  • Author : Steven X. Hou,Shree Ram Singh
  • Publisher :Unknown
  • Release Date :2014-03-14
  • Total pages :273
  • ISBN : 1617378801
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Summary : In this comprehensive and cutting-edge book, leading experts explore the parameters that define germline stem cells and the mechanisms that regulate the cell behavior in order to better isolate, characterize and maintain them. The volume begins by providing protocols for germline stem cell identification and regulation in model organisms, and concludes with detailed chapters covering current techniques involving in vitro culture and the applications of the cells.

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering
  • Author : Rakesh Sharma
  • Publisher :Unknown
  • Release Date :2018-05-02
  • Total pages :352
  • ISBN : 9781789230109
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Summary : Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

Innovations in Biomedical Engineering

Innovations in Biomedical Engineering
  • Author : Marek Gzik,Zbigniew Paszenda,Ewa Pietka,Ewaryst Tkacz,Krzysztof Milewski
  • Publisher :Unknown
  • Release Date :2020-10-10
  • Total pages :393
  • ISBN : 9783030521806
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Summary : This book presents a compact study on recent concepts and advances in biomedical engineering. The ongoing advancement of civilization and related technological innovations are increasingly affecting many aspects of our lives. These changes are also visible in the development and practical application of new methods for medical diagnosis and treatment, which in turn are closely linked to expanding knowledge of the functions of the human body. This development is possible primarily due to the increasing cooperation of scientists from various disciplines, and related activities are referred to as “biomedical engineering.” The combined efforts of doctors, physiotherapists and engineers from various fields of science have helped achieve dynamic advances in medicine that would have been impossible in the past. The reader will find here papers on biomaterials, biomechanics, as well as the use of information technology and engineering modeling methods in medicine. The respective papers will promote the development of biomedical engineering as a vital field of science, based on cooperation between doctors, physiotherapists and engineers. The editors would like to thank all the people who contributed to the creation of this book – both the authors, and those involved in technical aspects.

Pluripotent Stem Cells

Pluripotent Stem Cells
  • Author : Deepa Bhartiya,Nibedita Lenka
  • Publisher :Unknown
  • Release Date :2013-08-28
  • Total pages :640
  • ISBN : 9789535111924
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Summary : Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.