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Stem Cells and Aging

Stem Cells and Aging
  • Author : Surajit Pathak,Antara Banerjee
  • Publisher :Unknown
  • Release Date :2021-03-26
  • Total pages :320
  • ISBN : 9780128204139
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Summary : Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Adult Stem Cells in Aging, Diseases and Cancer

Adult Stem Cells in Aging, Diseases and Cancer
  • Author : K.L. Rudolph
  • Publisher :Unknown
  • Release Date :2014-12-22
  • Total pages :88
  • ISBN : 9783318027327
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Summary : The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.

Stem Cells and Aging

Stem Cells and Aging
  • Author : Kursad Turksen
  • Publisher :Unknown
  • Release Date :2013-02-13
  • Total pages :179
  • ISBN : 1627033165
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Summary : Over time, it has become clear that changes in stem cells do occur during aging, not only in their number but also in their relationship to their microenvironment and their functionality as reflected in changes to their metabolome. Stem Cells and Aging: Methods and Protocols brings together chapters from expert contributors with protocols critical for exploring the biology of stem cell aging, all of which is key for understanding these age-related stem cell changes at a basic biology level and at the level of their impacts for regenerative medicine. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy to use, Stem Cells and Aging: Methods and Protocols serves as an ideal reference to guide investigators toward further valuable answers to the problems of our aging population.

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering
  • Author : Rakesh Sharma
  • Publisher :Unknown
  • Release Date :2018-05-02
  • Total pages :352
  • ISBN : 9781789230109
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Summary : Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation
  • Author : Hartmut Geiger,Heinrich Jasper,Maria Carolina Florian
  • Publisher :Unknown
  • Release Date :2015-07-06
  • Total pages :354
  • ISBN : 9783709112328
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Summary : Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

Advances in Stem Cell Aging

Advances in Stem Cell Aging
  • Author : K.L. Rudolph
  • Publisher :Unknown
  • Release Date :2012-09-27
  • Total pages :134
  • ISBN : 9783318021714
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Summary : Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells.This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kröner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.

The Stem Cell Niche during Ageing

The Stem Cell Niche during Ageing
  • Author : Susie Prof. Nilsson
  • Publisher :Unknown
  • Release Date :2020-08-22
  • Total pages :258
  • ISBN : 9780128220207
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Summary : Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Telomeres and Telomerase in Aging, Disease, and Cancer

Telomeres and Telomerase in Aging, Disease, and Cancer
  • Author : K. Lenhard Rudolph
  • Publisher :Unknown
  • Release Date :2007-11-07
  • Total pages :330
  • ISBN : 9783540737094
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Summary : Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Progress in Stem Cell Transplantation

Progress in Stem Cell Transplantation
  • Author : Taner Demirer
  • Publisher :Unknown
  • Release Date :2015-12-02
  • Total pages :208
  • ISBN : 9789535122272
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Summary : This book documents the increased amount of stem cell-related research, basic and clinical applications as well as views for the future. The book covers a wide range of issues related to new developments and innovations in cell-based therapies discussed in basic and clinical chapters from authors around the world involved in stem cell studies and research. It thereby complements and extends the basic coverage of stem cells, such as mesenchymal stem cells, effect of stem cells on aging, cover hematopoietic stem cells, storage and cryopreservation, issues related to clinical applications such as haploidentical transplants and use of stem cells for the treatment of Huntingtons disease. Clearly, the treatment of various malignant and nonmalignant diseases depends heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments.

Stem Cells and Aging

Stem Cells and Aging
  • Author : Surajit Pathak,Antara Banerjee
  • Publisher :Unknown
  • Release Date :2021-04-09
  • Total pages :320
  • ISBN : 9780128200711
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Summary : Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
  • Author : Lucas G. Chase,Mohan C Vemuri
  • Publisher :Unknown
  • Release Date :2012-12-12
  • Total pages :456
  • ISBN : 9781627032001
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Summary : Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Exosomes, Stem Cells and MicroRNA

Exosomes, Stem Cells and MicroRNA
  • Author : Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar
  • Publisher :Unknown
  • Release Date :2018-04-07
  • Total pages :152
  • ISBN : 9783319744704
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Summary : This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

How and why We Age

How and why We Age
  • Author : Leonard Hayflick
  • Publisher :Unknown
  • Release Date :1996-01-01
  • Total pages :377
  • ISBN : 0345401557
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Summary : A cell biologist who has studied the aging process for thirty years answers the big questions about aging, dispels the myths, and discusses the desirability of living longer

Frailty and Sarcopenia

Frailty and Sarcopenia
  • Author : Yannis Dionyssiotis
  • Publisher :Unknown
  • Release Date :2017-08-30
  • Total pages :254
  • ISBN : 9789535134831
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Summary : Frailty is considered a multisystem impairment that makes an individual vulnerable to external or internal stressors. Sarcopenia, the age-dependent loss of muscle mass and function, is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. These syndromes are associated with a negative impact in quality of life and can lead to the occurrence of disability, institutionalization, and even mortality. The book focuses upon all the related aspects of frailty and sarcopenia and the new advancements in the related treatments including complex issues and research. It includes high-quality chapters in all related aspects for the syndromes of sarcopenia and frailty, which adversely affect the function and overall effectiveness of the musculoskeletal system and interventions to promote rehabilitation.

Stem Cells: A Cellular Fountain of Youth

Stem Cells: A Cellular Fountain of Youth
  • Author : M.P. Mattson,G. van Zant
  • Publisher :Unknown
  • Release Date :2002-09-04
  • Total pages :225
  • ISBN : 0444507310
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Summary : This volume provides a timely and thorough review of the current state of understanding of a fascinating type of cell that is capable of forming many or all cells in the body. In humans and other mammals embryonic stem cells, the immediate offspring of the fertilized egg, are capable of forming any type of cell in the body. Moreover stem cells are present in many different tissues in adults that are capable of dividing and differentiating into the specific cell types that comprise the organ in which they reside. A major focus of the book is to provide the reader with up-to-date information on the molecular mechanisms that regulate the proliferation, differentiation and survival of stem cells, and how aging and age-related disease impacts on stem cells. Leading authorities detail the properties and therapeutic potential of embryonic stem cells and stem cells of the nervous and immune systems, muscle and bone. Particularly exciting are emerging technologies for using stem cells to treat human age-related diseases including cardiovascular disease, diabetes, neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. This book will be a valuable reference for developmental biologists and for scientists and clinicians who study and treat a variety of diseases.

Aging

Aging
  • Author : Shamim I. Ahmad
  • Publisher :Unknown
  • Release Date :2017-10-30
  • Total pages :658
  • ISBN : 9781315283883
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Summary : This book is a detailed and comprehensive synthesis of the scientific study of aging. Dozens of contributions from leading scholars review various theories of aging, and molecular, cellular, biochemical and microbial aspects of aging, among just a few of the topics included. Authoritative, wide ranging and thorough, this book will act as a source for experimental design, a comprehensive description of age related diseases, and provide information of the latest molecular theories underlying their causes. Additionally, it will target industries involved in developing anti-aging drugs, post-graduate medical students, and university libraries.

Cellular Ageing and Replicative Senescence

Cellular Ageing and Replicative Senescence
  • Author : Suresh I.S. Rattan,Leonard Hayflick
  • Publisher :Unknown
  • Release Date :2016-05-09
  • Total pages :364
  • ISBN : 9783319262390
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Summary : This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

The Uniqueness of the Individual

The Uniqueness of the Individual
  • Author : P.B. Medawar
  • Publisher :Unknown
  • Release Date :2019-08-31
  • Total pages :188
  • ISBN : 9781000063844
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Summary : Originally published in 1957, The Uniqueness of the Individual is a collection of 9 essays published from the ten years preceding publication. The essays deal with some of the central problems of biology. These are among the questions put and answered from the standpoint of modern experimental biology. What is ageing and how is it measured? What theories have been held to account for it, and with what success? Did ageing evolve, and if so how? Is Lamarckism and adequate explanation of evolutionary process? Does evolution sometimes go wrong? Do human beings evolve in a way peculiar to themselves? Other essays touch upon the problems of scientific method and of growth and transformation. This book will be of interest to natural historians, evolutionists and anthropologists.

Stem Cells: An Insider's Guide

Stem Cells: An Insider's Guide
  • Author : Paul Knoepfler
  • Publisher :Unknown
  • Release Date :2013-07-30
  • Total pages :368
  • ISBN : 9789814508827
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Summary : Stem Cells: An Insider's Guide is an exciting new book that takes readers inside the world of stem cells guided by international stem cell expert, Dr. Paul Knoepfler. Stem cells are catalyzing a revolution in medicine. The book also tackles the exciting and hotly debated area of stem cell treatments that are capturing the public's imagination. In the future they may also transform how we age and reproduce. However, there are serious risks and ethical challenges, too. The author's goal with this insider's guide is to give readers the information needed to distinguish between the ubiquitous hype and legitimate hope found throughout the stem cell world. The book answers the most common questions that people have about stem cells. Can stem cells help my family with a serious medical problem such as Alzheimer's, Multiple Sclerosis, or Autism? Are such treatments safe? Can stem cells make me look younger or even literally stay physically young? These questions and many more are answered here.A number of ethical issues related to stem cells that spark debates are discussed, including risky treatments, cloning and embryonic stem cells. The author breaks new ground in a number of ways such as by suggesting reforms to the FDA, providing a new theory of aging based on stem cells, and including a revolutionary Stem Cell Patient Bill of Rights. More generally, the book is your guide to where the stem cell field will be in the near future as well as a thoughtful perspective on how stem cell therapies will ultimately change your life and our world.

Models, Molecules and Mechanisms in Biogerontology

Models, Molecules and Mechanisms in Biogerontology
  • Author : Pramod C. Rath
  • Publisher :Unknown
  • Release Date :2019-07-30
  • Total pages :436
  • ISBN : 9789811335853
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Summary : This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.

Bone Marrow-Derived Progenitors

Bone Marrow-Derived Progenitors
  • Author : Katalin Kauser,Andreas-Michael Zeiher
  • Publisher :Unknown
  • Release Date :2007-06-07
  • Total pages :289
  • ISBN : 9783540689768
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Summary : The ambitious goal of this volume is to provide – in chapters written by accomplished scientists and experts in their field – a comprehensive overview of the currently available information related to the therapeutic utility of adult bone marrow-derived cells. With excitement generated almost daily about the possible uses of stem cells to treat human disease, but the controversy surrounding their use still raging, adult bone-marrow derived cells are more readily available, and have a staggering range of uses.