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Stem Cells and Cancer in Hepatology

Stem Cells and Cancer in Hepatology
  • Author : Yun-Wen Zheng
  • Publisher :Unknown
  • Release Date :2018-05-18
  • Total pages :382
  • ISBN : 9780128123027
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Summary : Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed. As the field of stem cells and cancer stem cells in hepatology is new and dynamic, thus making it difficult for researchers and clinicians to understand the most relevant historic and novel studies, this volume addresses that challenge. Addresses both the basic and clinical perspectives of the topic, including sections on normal and cancer stem cells of the liver Provides coverage of the molecular mechanisms of liver development, the proliferation of hepatic progenitor cells during development, epithelial cell plasticity, generation of hepatocytes by transdifferentiation, liver tissue engineering, and more Presents a study of hepatic stem cells that will help readers understand critical events during development, stem cell differentiation towards functional liver cell fate, and tumor initiation

Exam Prep for: Stem Cells and Cancer in Hepatology

Exam Prep for: Stem Cells and Cancer in Hepatology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 1230987654XX
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Summary :

Stem Cells and Cancer

Stem Cells and Cancer
  • Author : Sudhir Srivastava,Lopa Mishra
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :106
  • ISBN : 1586038028
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Summary : Describes the role of cancer stem cells and progenitor cells in the progression to cancer. This volume refers to the role of stem cells in well-characterized diseases such as prostate and hepatocellular cancer, melanoma, chronic myeloid leukaemia and stem cell/cancer stem cell properties.

Innovative Medicine

Innovative Medicine
  • Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
  • Publisher :Unknown
  • Release Date :2015-10-13
  • Total pages :339
  • ISBN : 9784431556510
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Summary : This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Hepatic Stem Cells

Hepatic Stem Cells
  • Author : Naoki Tanimizu
  • Publisher :Unknown
  • Release Date :2019-02-04
  • Total pages :248
  • ISBN : 149398960X
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Summary : This volume looks at the liver’s epithelial cells—hepatocytes and cholangiocytes—and their progenitors. This book is divided into five parts: isolation of progenitor cells; characterization of liver progenitors in vivo; generation of hepatocytes, cholangiocytes, and their progenitors; reconstitution of liver tissue structures; and liver injury models. The chapters in this book cover topics such as expansion of bipotential liver stem/progenitor cells (LPCs) from fetal and neonatal liver; identifying progenitor cells involved in liver regeneration in vivo; methods for generating hepatocytes and cholangiocytes from multiple cellular sources; 3D tissue structures ex vivo; and resolving hepatic fibrosis by bone marrow transplantation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Hepatic Stem Cells: Methods and Protocols is a valuable resource to help researchers understand the current theories used to study hepatic stem/progenitor cells, and aid them in performing experiments related to liver biology and pathophysiology.

Principles of Stem Cell Biology and Cancer

Principles of Stem Cell Biology and Cancer
  • Author : Tarik Regad,Thomas Sayers,Robert Rees
  • Publisher :Unknown
  • Release Date :2015-04-01
  • Total pages :376
  • ISBN : 9781118670583
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Summary : Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.

Atlas of Tumor Pathology

Atlas of Tumor Pathology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :229
  • ISBN : UCLA:L0082341900
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Summary :

Journal of the National Cancer Institute

Journal of the National Cancer Institute
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2011-07
  • Total pages :229
  • ISBN : NYPL:33433078242538
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Summary :

Liver Stem Cells

Liver Stem Cells
  • Author : Stewart Sell
  • Publisher :Unknown
  • Release Date :1997
  • Total pages :349
  • ISBN : OCLC:1176261005
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Summary :

Hepatology

Hepatology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1997-07
  • Total pages :229
  • ISBN : NWU:35558003866940
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Summary :

Advances in Cancer Stem Cell Biology

Advances in Cancer Stem Cell Biology
  • Author : Roberto Scatena,Alvaro Mordente,Bruno Giardina
  • Publisher :Unknown
  • Release Date :2011-10-06
  • Total pages :343
  • ISBN : 1461408091
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Summary : In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.

Stem Cells and Cancer

Stem Cells and Cancer
  • Author : Devon W. Parsons
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :284
  • ISBN : PSU:000061070899
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Summary : Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book brings together leading research from throughout the world with particular focus on stem cells and cancer research.

Liver Pathophysiology

Liver Pathophysiology
  • Author : Pablo Muriel
  • Publisher :Unknown
  • Release Date :2017-03-02
  • Total pages :914
  • ISBN : 9780128043219
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Summary : Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.

Photomedicine and Stem Cells

Photomedicine and Stem Cells
  • Author : Heidi Abrahamse,Michael R Hamblin
  • Publisher :Unknown
  • Release Date :2017-12-20
  • Total pages :135
  • ISBN : 9781681743226
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Summary : Janus, the ancient Roman god depicted with two faces is an appropriate metaphor for light therapy. In the right photodynamic therapy conditions, light is able to kill nearly anything that is living such as cancers, microorganisms, parasites, and more. On the opposite face, light of the correct wavelength and proper dose (photobiomodulation) can heal, regenerate, protect, revitalize and restore any kind of dead, damaged, stressed, dying, degenerating cells, tissue, or organ system. This book discusses both sides of Janus' face in regards to light therapy.

Stem Cell Therapeutics for Cancer

Stem Cell Therapeutics for Cancer
  • Author : Khalid Shah
  • Publisher :Unknown
  • Release Date :2013-08-01
  • Total pages :304
  • ISBN : 9781118660621
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Summary : Stem Cell Therapeutics for Cancer covers theapplication of stem cells in various cancers, with an emphasis onthe aspects of these strategies that are critical to the success offuture stem cell-based therapies for cancer. Topics covered in thebook include stem cell sources, tumor specificity, targetedtherapeutics, visualizing the stem cell, and therapeutic agentpharmacokinetics. Each chapter contains a brief introduction to thecancer, followed by an exploration of how engineered stem cellshave been utilized to cure the disease in mouse models and in earlyphase clinical trials. Comprises of sections on stem cell therapy in brain cancers,lung cancers, breast cancers, as well as stem cells incombination with other therapies Focuses on the practical applications of using stem cells asgene delivery agents to treat cancer Includes coverage of cutting-edge molecular imaging techniquesin stem cell therapeutics for a variety of tumour types

Stem Cell Research Advances

Stem Cell Research Advances
  • Author : Lydia P. Davenport
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :286
  • ISBN : UVA:X030102780
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Summary : Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book presents leading-edge research in this rapidly-growing field.

Stem Cell Research Trends

Stem Cell Research Trends
  • Author : Josse R. Braggina
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :349
  • ISBN : UVA:X030262805
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Summary : Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, auto-immune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book presents important research from around the globe.

Scientific Engineering of Distributed Java Applications.

Scientific Engineering of Distributed Java Applications.
  • Author : Nicoals Guelfi,Egidio Astesiano,Gianna Reggio
  • Publisher :Unknown
  • Release Date :2004-02-18
  • Total pages :154
  • ISBN : 3540210911
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Summary : This book constitutes the thoroughly refereed post-proceedings of the Third International Workshop on Scientific Engineering of Distributed Java Applications, FIDJI 2003, held in Luxembourg-Kirchberg, Luxembourg in November 2003. The 213 revised full papers presented together with abstracts of two invited contributions were carefully selected during two round of reviewing and revision from 29 submissions. Among the topics addressed are Java-enabled service gateways, mobility in distributed settings, XML, embedded Java software, interception services, mobile agents, error management, software model engineering, distributed composite objects, cooperative applications, distributed mobile applications, service-based software architectures, and distributed Java programs.

Cancer Stem Cells in Solid Tumors

Cancer Stem Cells in Solid Tumors
  • Author : Alison L. Allan
  • Publisher :Unknown
  • Release Date :2011-08-12
  • Total pages :478
  • ISBN : 9781617792465
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Summary : The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

Therapeutic Targeting of Cancer Stem-Like Cells (CSC) – The Current State of the Art

Therapeutic Targeting of Cancer Stem-Like Cells (CSC) – The Current State of the Art
  • Author : Cyril Corbet,Alexandre Prieur
  • Publisher :Unknown
  • Release Date :2020-04-03
  • Total pages :229
  • ISBN : 9782889636471
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Summary :

Stem Cells and Cancer

Stem Cells and Cancer
  • Author : Sadhan Majumder
  • Publisher :Unknown
  • Release Date :2009-06-07
  • Total pages :296
  • ISBN : 0387896112
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Summary : Cancer is a primary cause of human mortality worldwide. Despite decades of basic and clinical research, the outcome for most cancer patients is still dismal. Some stumbling blocks to developing effective therapy include the heterogeneity of cancer tissues, the lack of knowledge about the critical molecular mechanisms in cancer tissues (which are typically aberrant compared with mechanisms in normal tissue), and the lack of good mechanism-based therapeutic approaches. The recent findings that most cancers contain a small fraction of self-renewing, differentiation-blocked stem cell-like cells (cancer stem cells) and that it is these cells—and not the major bulk of the tissue—that are the root cause for cancer initiation and metastasis have also highlighted the need to change our approach to cancer therapy. The objectives of this book, therefore, would be to impart up-to-date information about the role of stem cells in the development of normal and cancerous tissue, the mechanisms that differentiate normal from cancerous functions, and the use of these findings in developing mechanism-based therapies.