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Tissue Regeneration

Tissue Regeneration
  • Author : Hussein Abdelhay Essayed Kaoud
  • Publisher :Unknown
  • Release Date :2018-06-06
  • Total pages :206
  • ISBN : 9781789232608
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Summary : Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).

Calcific Aortic Valve Disease

Calcific Aortic Valve Disease
  • Author : Elena Aikawa
  • Publisher :Unknown
  • Release Date :2013-06-12
  • Total pages :542
  • ISBN : 9789535111504
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Summary : Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

The Extracellular Matrix: an Overview

The Extracellular Matrix: an Overview
  • Author : Robert Mecham
  • Publisher :Unknown
  • Release Date :2011-02-16
  • Total pages :426
  • ISBN : 3642165559
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Summary : Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Composition and Function of the Extracellular Matrix in the Human Body

Composition and Function of the Extracellular Matrix in the Human Body
  • Author : Francesco Travascio
  • Publisher :Unknown
  • Release Date :2016-06-15
  • Total pages :374
  • ISBN : 9789535124153
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Summary : The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Extracellular Matrix

Extracellular Matrix
  • Author : A. H. Reddi
  • Publisher :Unknown
  • Release Date :1985
  • Total pages :436
  • ISBN : UOM:39015010138272
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Summary :

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : 0815332181
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Summary :

Evolution of Extracellular Matrix

Evolution of Extracellular Matrix
  • Author : Fred W. Keeley,Robert Mecham
  • Publisher :Unknown
  • Release Date :2013-03-15
  • Total pages :290
  • ISBN : 9783642360022
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Summary : The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.

Extracellular Matrix Assembly and Structure

Extracellular Matrix Assembly and Structure
  • Author : Peter D. Yurchenco
  • Publisher :Unknown
  • Release Date :2013-10-22
  • Total pages :468
  • ISBN : 9781483289427
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Summary : The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix. Addresses assembly of most of the known classes of extracellular matrix macromolecules Discusses higher order structures produced by ECM Gives important concepts in ECM and cell-matrix interactions, Protein structure and protein-protein interactions, Development and tissue remodeling

Extracellular Matrix and Egg Coats

Extracellular Matrix and Egg Coats
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2018-05-28
  • Total pages :502
  • ISBN : 9780128098035
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Summary : Extracellular Matrix and Egg Coats, Volume 130, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on The Human Egg’s Zona Pellucida, the Structure of Zona Pellucida Module Proteins, The Fish Egg’s Zona Pellucidam The Chicken Egg’s Zona Pellucidam The Marsupial Egg’s Zona Pellucida, the Evolution of Zona Pellucida Proteins, The Mouse Egg’s Zona Pellucida, Aspects of ECM, ECM and Morphogenesis, Collagen fibril assembly and function, The Ear's Tectorial Membrane, ECM and Cell Fate, and the Aspects of ECM. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on the Extracellular Matrix in Development

Decellularized Extracellular Matrix

Decellularized Extracellular Matrix
  • Author : Takashi Hoshiba,Tetsuji Yamaoka
  • Publisher :Unknown
  • Release Date :2019-12-05
  • Total pages :352
  • ISBN : 9781788014670
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Summary : Takashi Hoshiba and Tetsuji Yamaoka have brought together, for the first time, leading contributors to provide a fundamental guide to the decellularized extracelluar matrix. Focussing on the sources of dECM, preparation, characterization and applications of dECM in regenerative medicine and biological systems, this is a must-have resource for those working in regenerative medicine and tissue engineering.

Brain Extracellular Matrix in Health and Disease

Brain Extracellular Matrix in Health and Disease
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2014-10-30
  • Total pages :506
  • ISBN : 9780444634948
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Summary : In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells. Authors are the leading experts in the field of brain extracellular matrix in health and disease Book covers the most important aspects of brain extracellular matrix in health and disease Interesting for both scientists and clinicians

Extracellular Matrix: Pathobiology and Signaling

Extracellular Matrix: Pathobiology and Signaling
  • Author : Nikos Karamanos
  • Publisher :Unknown
  • Release Date :2012-08-31
  • Total pages :938
  • ISBN : 9783110258776
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Summary : Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellular matrix is organized into seven thematic sections, giving an overview of the current state of knowledge of matrix components (structure and function), their roles in health and disease (matrix pathobiology) as well as new concepts of pharmacological targeting.

Cell Surface and Extracellular Glycoconjugates

Cell Surface and Extracellular Glycoconjugates
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2012-12-02
  • Total pages :314
  • ISBN : 9780323138093
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Summary : This book serves as a much-needed guide for new investigators in the field of glycobiology as well as researchers in other disciplines attempting to define the role of glycoconjugates in their biological systems. Cell Surface and Extracellular Glycoconjugates: Structure and Function describes the determination of structure and function of glycoconjugates that occur on the cell surface and in molecules involved in cell-matrix interactions. The broad scope of thebook covers basic background and technical information in this rapidly expanding field. The text is specifically designed to inform researchers in diverse disciplines of the approaches and resources that can be employed to address problems in glycoconjugate biology. Includes coverage of the: * Structure of cell surface carbohydrates * Biosynthesis of glycoproteins * Biological signals associated with glycoproteins * Diversity of glycoprotein structure

Mimicking the Extracellular Matrix

Mimicking the Extracellular Matrix
  • Author : Gregory A Hudalla,William L Murphy
  • Publisher :Unknown
  • Release Date :2019-03-15
  • Total pages :405
  • ISBN : 9781788018159
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Summary : The extracellular matrix (ECM) is the focus of much interest in biology and bioengineering. Increasing understanding of the influence of the ECM on cell behaviour has led to the exciting possibilities of tissue engineering. Aside from new therapeutic tools, understanding the ECM is of course fundamental to basic cell biology research. Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Seven topics are approached each in a pair of chapters, one with a biological approach and its partner with a bioengineering approach. Topics include the mechanical properties of the ECM, which outlines current knowledge of the ECM physical structure and reviewing state-of-the-art strategies to mimic its native microenvironments. The organisational characteristics of the ECM form the focus of another pair of chapters, where the collagen triple helix is discussed, followed by a review of advances in artificial reproduction of well-ordered systems using self-assembling peptides, or peptide amphiphiles. The balanced approach of this text gives it a broad appeal to those interested in the ECM from a range of backgrounds and disciplines. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.

Extracellular Matrix and The Liver

Extracellular Matrix and The Liver
  • Author : Isao Okazaki,Yosifumi Ninomiya,Tanikawa Kyuichi,Scott I. Friedman
  • Publisher :Unknown
  • Release Date :2003-02-20
  • Total pages :512
  • ISBN : 012525251X
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Summary : Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches. The chapters are divided into six sections as follows: Basic Science of Extracellular Matrix Cells Responsible for Extracellular Matrix Production Activation Mechanism of Hepatic Cells and Signal Transduction Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases New Strategies for the treatment of Liver Cirrhosis Discusses the possibility of gene therapy for liver cirrhosis Includes information on new aspects of hepatic stellate cells Written by top experts in basic science and clinical hepatology

Extracellular Matrix Protocols

Extracellular Matrix Protocols
  • Author : Charles H. Streuli,Michael E. Grant
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :370
  • ISBN : 9781592590636
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Summary : It is now widely accepted that much of the dynamic function of cells and tissues is regulated from outside the cell by the extracellular matrix (ECM). In Extracellular Matrix Protocols, leading bench-top experimentalists from around the world present in a proven format their state-of-the-art methods for probing the extracellular matrix, its mechanisms of assembly, and how it influences cell behavior. These carefully detailed biochemical, biophysical, molecular biological, and cell biological techniques have been optimized for the study ECM structure and assembly, the mechanisms of cell-ECM interactions, and the molecular genetics of ECM proteins and defects in human disease, and bring to a wider audience a range of highly sophisticated methods that have hitherto been difficult even for a few specialized laboratories. Cutting-edge and highly practical, Extracellular Matrix Protocols offers today's ECM researchers a gold-standard collection of powerful, readily reproducible methods to investigate the extracellular matrix and the altered cell-ECM interactions that play so important a role in human health and disease.

Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 11 Volume Set

Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 11 Volume Set
  • Author : Munmaya Mishra
  • Publisher :Unknown
  • Release Date :2015-04-28
  • Total pages :10444
  • ISBN : 1439898790
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Summary : The Encyclopedia of Biomedical Polymers & Polymeric Biomaterials presents state-of-the-art research and development on the application of novel polymers in a vital area. This groundbreaking work includes the insight of a large number of contributors from around the world who offer a broad-based perspective on a multitude of topics. Authoritative, dynamic, and comprehensive, this multi-volume reference covers the broad subject area of polymer applications in the medical field, providing readers with an enriching experience and targeted knowledge in this evolving arena. The materials presented convey important overviews to help stimulate further advancements in all areas of biomaterials and biomedical polymers. Additionally, they address and identify new breakthroughs and emerging technologies. Designed for novices to experienced researchers, the encyclopedia caters to engineers and scientists (polymer and materials scientists, biomedical engineers, biochemists, molecular biologists, macromolecular chemists), pharmacists, doctors, cardiovascular and plastic surgeons, and students, as well as general readers in academia, industry, research institutions, etc. It is envisioned that the encyclopedia will serve as the most respected reference work on the application of polymers in the medical field.

Structure-function Relationship of the Cartilage Extracellular Matrix Assessed by Atomic Force Microscopy

Structure-function Relationship of the Cartilage Extracellular Matrix Assessed by Atomic Force Microscopy
  • Author : Carina Prein
  • Publisher :Unknown
  • Release Date :2016
  • Total pages :229
  • ISBN : OCLC:968238517
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Summary :

Extracellular Matrix Biology

Extracellular Matrix Biology
  • Author : Richard O. Hynes,Kenneth M. Yamada
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :397
  • ISBN : 1936113384
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Summary : In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in the regulation of cell function. ECM proteins bind to cell surface receptors such as integrins, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis. This book covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during tumorigenesis and other disease states. The editors are both giants in the field (Dr. Hynes discovered fibronectin), who are highly respected through the cell, molecular, and cancer biology communities.

Biochemistry of Collagens, Laminins and Elastin

Biochemistry of Collagens, Laminins and Elastin
  • Author : Morten Karsdal
  • Publisher :Unknown
  • Release Date :2016-07-29
  • Total pages :272
  • ISBN : 9780128098998
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Summary : Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states

Extracellular Matrix

Extracellular Matrix
  • Author : W.D. Comper
  • Publisher :Unknown
  • Release Date :1996-06-30
  • Total pages :464
  • ISBN : 3718658429
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Summary :