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Modern Supercritical Fluid Chromatography

Modern Supercritical Fluid Chromatography
  • Author : Larry M. Miller,J. David Pinkston,Larry T. Taylor
  • Publisher :Unknown
  • Release Date :2019-11-06
  • Total pages :416
  • ISBN : 9781119626008
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Summary : Explains why modern supercritical fluid chromatography (SFC) is the leading "green" analytical and purification separations technology. Modern supercritical fluid chromatography (SFC) is the leading method used to analyze and purify chiral and achiral chemical compounds, many of which are pharmaceuticals, pharmaceutical candidates, and natural products including cannabis-related compounds. This book covers current SFC instrumentation as it relates to greater robustness, better reproducibility, and increased analytical sensitivity. Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases covers the history, instrumentation, method development and applications of SFC. The authors provided readers with an overview of analytical and preparative SFC equipment, stationary phases, and mobile phase choices. Topics covered include: Milestones of Supercritical Fluid Chromatography; Physical Properties of Supercritical Fluids; Instrumentation for SFC; Detection in SFC; Achiral SFC Method Development; Chiral SFC Method Development; and Preparative Scale SFC. The book also includes highlights of modern applications of SFC in the final chapters—namely pharmaceuticals, consumer products, foods, polymers, petroleum-related mixtures, and cannabis—and discusses the future of SFC. Provides a clear explanation of the physical and chemical properties of supercritical fluids, which gives the reader a better understanding of the basis for improved performance in SFC compared to HPLC and GC Describes the advantages of SFC as a green alternative to HPLC and GC for the analysis of both polar, water-soluble, and non-polar analytes Details both achiral and chiral SFC method development, including modifiers, additives, the impact of temperature and pressure, and stationary phase choices Details why SFC is the premier modern preparative chromatographic technique used to purify components of mixtures for subsequent uses, both from performance and economic perspectives Covers numerous detectors, with an emphasis on SFC-MS, SFC-UV, and SFC-ELSD (evaporative light scattering detection) Describes the application of SFC to numerous high-value application areas Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases will be of great interest to professionals, students, and professors involved in analytical, bioanalytical, separations science, medicinal, petroleum, and environmental chemistries. It will also appeal to pharmaceutical scientists, natural-product scientists, food and consumer-products scientists, chemical engineers, and managers in these areas.

Supercritical Fluid Chromatography

Supercritical Fluid Chromatography
  • Author : Colin F. Poole
  • Publisher :Unknown
  • Release Date :2017-02-16
  • Total pages :572
  • ISBN : 9780128093672
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Summary : Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Significant improvements in instrumentation have rekindled interest in SFC in recent years and enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its strengths and weaknesses, but the possibilities brought to the table by SFC are less well-known and are underappreciated. Supercritical Fluid Chromatography is a thorough and encompassing reference that defines the concept of contemporary practice in SFC and how it should be implemented in laboratory science. Given the changes that have taken place in SFC, this book presents contemporary aspects and applications of the technique and introduces SFC as a natural solution in the larger field of separation science. The focus on state-of-the-art instrumental SFC distinguishes this work as the go-to reference work for those interested in implementing the technique at an advanced level. Edited and authored by world-leading chromatography experts Provides comprehensive coverage of SFC in a single source Extensive referencing facilitates identification of key research developments More than 200 figures and tables aid in the retention of key concepts

Supercritical Fluid Chromatography

Supercritical Fluid Chromatography
  • Author : Gregory K. Webster
  • Publisher :Unknown
  • Release Date :2014-02-04
  • Total pages :418
  • ISBN : 9789814463010
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Summary : Analytical chemists in the pharmaceutical industry are always looking for more-efficient techniques to meet the analytical challenges of today’s pharmaceutical industry. One technique that has made steady advances in pharmaceutical analysis is supercritical fluid chromatography (SFC). SFC is meeting the chromatography needs of the industry by providing efficient and selective testing capabilities on the analytical and preparative scale. The supercritical fluid mobile phase, consisting mainly of CO2, facilitates cost reduction costs and helps the industry in meeting green chemistry standards. This book provides a comprehensive overview of the use of SFC in pharmaceutical analysis. Supercritical Fluid Chromatography reviews the use of SFC in drug-discovery applications and describes its application in drug development. When a drug is developed and brought to market, it is tested many times for impurities and degradants, enantiomeric purity, and analytical and preparative isolations—it is tested during discovery and development and for under-regulated and unregulated methodologies. The book describes the use of SFC for each of these applications and discusses more in-depth topics, such as the use of SFC in mass spectrometric and polarographic detection. The book also sheds light on the role of SFC in drug development from natural products and the advancement of SFC with new technologies and its use in pilot-scale operations as a chromatographic technique.

Supercritical Fluid Chromatography

Supercritical Fluid Chromatography
  • Author : Gérard Rossé
  • Publisher :Unknown
  • Release Date :2018-12-17
  • Total pages :213
  • ISBN : 9783110500776
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Summary : Supercritical Fluid Chromatography (SFC) provides a timely overview of SFC application areas which were unimaginable just a decade ago. This two-volume series opens with an overview of the history and expectant future of SFC and continues with recent applications in the pharmaceutical industry and other fascinating areas of science. SFC has found its place in the pharmaceutical industry with an increasing body of applications for chiral and achiral molecules in both the research and development phases of the drug discovery process. As illustrated in this two-volume series, the current interest in SFC extends well beyond the pharmaceutical industry. Chapters encompassing applications for polar and non-polar mixtures of importance are covering widely disparate areas in substance abuse, natural products including cannabinoids, bioactive lipids, flavor and fragrance. With its broad balance and coverage, this two-volume book constitutes a unique educational platform to students and scientists for many years to come. The major objective of this book editions is to inspire and stimulate readers to continue exploring the possibilities of exploiting supercritical fluids as a particular media for analysis, purifications and synthesis

Practical Supercritical Fluid Chromatography and Extraction

Practical Supercritical Fluid Chromatography and Extraction
  • Author : Thomas Caudell
  • Publisher :Unknown
  • Release Date :1999-03-08
  • Total pages :456
  • ISBN : 9057024098
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Summary : This book explores the fundamental and practical aspects of supercritical fluid chromatography (SFC) and extraction. It discusses packed columns in SFC; detection in SFC; supercritical fluid chromatography/mass spectroscopy; and evaporative light scattering detection in SFC.

Analysis with Supercritical Fluids: Extraction and Chromatography

Analysis with Supercritical Fluids: Extraction and Chromatography
  • Author : Bernd Wenclawiak
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :214
  • ISBN : 9783642774744
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Summary : The use of supercritical fluids in analytical chemistry is still grow ing. More and more analysts are discovering the favorable advan tages for a number of applications. Especially supercritical fluid extraction (SFE) has attracted a lot of interest in recent years due to its simplicity. Supercritical fluid chromatography (SFC) has become better established and the development of this technique has been accelerated by the many applications with capillary col umns which have been published in the literature. At first SFC equipment was based on instruments commonly used for liquid chromatography, and the first commercial in struments were derived from this technology. However, capillary columns can be much more easily interfaced to gas chromatogra phy equipment especially to the detectors commonly used for Oc. Many stationary phases both for packed micro columns and capillary columns have been designed for SFC purposes extending this technology to LC and OC. The most common fluid applied in SFC and SFE is carbon dioxide. The advantages of supercritical CO , such as having dif 2 fusivity like a gas and solvating power depending on temperature and pressure, are also valid for other fluids and modified fluids. Both properties are valuable for sample extraction and extraction selectivity.

Principles of Instrumental Analysis

Principles of Instrumental Analysis
  • Author : Douglas A. Skoog,F. James Holler,Stanley R. Crouch
  • Publisher :Unknown
  • Release Date :2017-01-27
  • Total pages :992
  • ISBN : 9781305577213
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Summary : PRINCIPLES OF INSTRUMENTAL ANALYSIS, 7th Edition, places an emphasis on operating principles of each type of instrument, its optimal area of application, its sensitivity, its precision, and its limitations. You'll also learn about elementary analog and digital electronics, computers, and the treatment of analytical data. The book companion website has supplemental tutorials on instrumental methods, Excel files of data analysis and simulations of analytical techniques to help you visualize important concepts in this course, and selected papers from the chemical literature to stimulate interest and provide background information for study.

Supercritical Fluid Chromatography And Micro-hplc

Supercritical Fluid Chromatography And Micro-hplc
  • Author : M. Yoshioka
  • Publisher :Unknown
  • Release Date :1989
  • Total pages :300
  • ISBN : 9067641138
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Summary :

Chiral Separations

Chiral Separations
  • Author : Bezhan Chankvetadze
  • Publisher :Unknown
  • Release Date :2001-01-01
  • Total pages :489
  • ISBN : 0444506985
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Summary : From the contents: Chiral chromatographic separations based on ligand exchange (A. Kurganov). - Chiral separations using the macrocyclic antibiotics: a review (T.J. Ward, A.B. Farris III). - High-performace liquid chromatographic and capillary electrophoretic enantioseparation of plant growth regulators and related indole conpounds using macrocyclic antibiotics as chiral selectors (Review) (F. Hui et al.). -Polysaccaride-based chiral stationary phases for high-performance liquid chromtaographic enantioseparation (Review) (E. Yashima).

Supercritical Fluid Chromatography with Patked Columns

Supercritical Fluid Chromatography with Patked Columns
  • Author : Klaus Anton,Claire Berger
  • Publisher :Unknown
  • Release Date :1997-09-19
  • Total pages :472
  • ISBN : 0824700139
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Summary : From the analytical to industrial preparative scale, this work provides a praxis-oriented overview of packed column supercritical fluid chromatography. It discusses and evaluates established applications and techniques, up-to-date and promising developments, and commercial instrumentation devices for use in industry. The book also reveals possibilities for problem solving and future innovations.

Supercritical Fluid Chromatography

Supercritical Fluid Chromatography
  • Author : Roger Malcolm Smith,Smith
  • Publisher :Unknown
  • Release Date :1988
  • Total pages :238
  • ISBN : UCAL:B4456441
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Summary : Theory and principles of supercritical fluid cgromatography. The emergence and instrumentation of SFC. Selection of conditions for an SFC separation. Opens columns or pachked columns for supercritical fluid chromatography. HT-CGC and CSFC for the analysis of relatively high molecular weight compounds. Supercritical fluid chromatography mass spectrometry. SFC-MS in the pharmaceutical industry. Fractionation by coupled micro-supercritical fluid extraction and supercritical fluid chromatogrpahy.

Hyphenated Techniques in Supercritical Fluid Chromatography and Extraction

Hyphenated Techniques in Supercritical Fluid Chromatography and Extraction
  • Author : K. Jinno
  • Publisher :Unknown
  • Release Date :1992-07-21
  • Total pages :328
  • ISBN : 0080858619
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Summary : This is the first book to focus on the latest developments in hyphenated techniques using supercritical fluids. The advantages of SFC in hyphenation with various detection modes, such as FTIR, MS, MPD and ICP and others are clearly featured throughout the book. Special attention is paid to coupling of SFE with GC or SFC. In this edited volume, chapters are written by leading experts in the field. The book will be of interest to professionals in academia, as well as to those researchers working in an industrial environment, such as analytical instrumentation, pharmaceuticals, agriculture, food, petrochemicals and environmental.

Applications of Supercritical Fluids in Industrial Analysis

Applications of Supercritical Fluids in Industrial Analysis
  • Author : J.R. Dean
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :224
  • ISBN : 9789401121460
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Summary : The continued search for rapid, efficient and cost-effective means of analytical measurement has introduced supercritical fluids into the field of analytical chemistry. Two areas are common: supercritical fluid chroma tography and supercritical fluid extraction. Both seek to exploit the unique properties of a gas at temperatures and pressures above the critical point. The most common supercritical fluid is carbon dioxide, employed because of its low critical temperature (31 °C), inertness, purity, non-toxicity and cheapness. Alternative supercritical fluids are also used and often in conjunction with modifiers. The combined gas-like mass transfer and liquid-like solvating characteristics have been used for improved chroma tographic separation and faster sample preparation. Supercritical fluid chromatography (SFC) is complementary to gas chro matography ( GC) and high performance liquid chromatography (HPLC), providing higher efficiency than HPLC, together with the ability to analyse thermally labile and high molecular weight analytes. Both packed and open tubular columns can be employed, providing the capability to analyse a wide range of sample types. In addition, flame ionization detection can be used, thus providing 'universal' detection.

Packed Column SFC

Packed Column SFC
  • Author : T A Berger
  • Publisher :Unknown
  • Release Date :2007-10-31
  • Total pages :266
  • ISBN : 9781847551603
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Summary : Packed Column SFC is the third title to be published in this series and has been produced as a result of the dramatic re-emergence, in the last three years, of packed column instrumentation. This has led to a redefinition of the technique and an urgent need for a practical guide that deals with its subtleties. This book fulfils that need and deals exclusively with packed column SFC. It places the emphasis on understanding the underlying chemistry in order to perform rapid, systematic optimizations and provides many practical tips to help the new user avoid problems unique to SFC. It also proposes a detailed scheme for method development and provides lists of prioritized guidelines. The book clears up some of the confusion that surrounds the analytical use of supercritical fluids and assists the user in understanding the power and utility of this technique. Detailed chapters cover the most promising new application areas for packed column SFC, which are often overlooked in the mainstream chromatography literature. Like the other books in this popular series, Packed Column SFC will prove an invaluable guide and is essential reading for graduates, postgraduates and researchers with interests in pharmaceuticals, agricultural chemistry, small polar drug molecules, chiral analysis, environmental chemistry, and chromatography/instrumentation.

Analytical Supercritical Fluid Extraction Techniques

Analytical Supercritical Fluid Extraction Techniques
  • Author : E.D. Ramsey
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :432
  • ISBN : 9789401149488
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Summary : During the past decade supercritical fluid extration (SFE) has attracted considerable attention as a sample preparation procedure in analytical chemistry. The successful implementation of this technique can lead to improved sample throughput, more efficient recovery of analytes, cleaner extracts, economic replacement of halogenated solvents and a high level of automation, compared to conventional sample preparation procedures. This book provides an overview of basic principles of SFE as well as in-depth reviews of both on- and off-line SFE methods. The on-line coupling of SFE with both chromatographic and spectroscopics techniques has been the subject of a great deal of research effort and is dealt with in detail. Newer developments, such as off-line SFE of solid and liquid matrices, are starting to attract a great deal of interest, and the coverage of these areas will prove of particular value to the analytical chemist. The international team of authors has illustrated these topics with many `state-of-the-art' applications, and each chapter provides a comprehensive list of references. For the convenience of the reader, an appendix which contains pressure conversion scales and supercritical fluid carbon dioxide density tables appears at the end of the book. The volume's extensive coverage of both on-line and off-line extraction will be particularly useful to analytical chemists, in a wide range of environments, seeking to develop high quality, simple and robust SFE methods.

Encyclopedia of Separation Science

Encyclopedia of Separation Science
  • Author : Michael Cooke,C. F. Poole
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :4954
  • ISBN : UOM:39015043253445
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Supercritical Fluid Methods and Protocols

Supercritical Fluid Methods and Protocols
  • Author : Tony Clifford
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :256
  • ISBN : 9781592590308
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Summary : Because of their unique properties and relatively low environmental impact, supercritical fluids have proven highly useful in the extraction and separation of organic compounds, in particle production, as reaction media, and for the destruction of toxic waste. In Supercritical Fluid Methods and Protocols, experienced practitioners present detailed accounts of a wide variety of techniques using supercritical fluids. These range from the supercritical fluid extraction methods for numerous compounds to the ninhydrin staining of fingerprints on checks and banknotes, and from the detection of impurities in pharmaceuticals to a wide variety of applications throughout environmental and food science, and across analytical, clinical, and medicinal chemistry. Detailed step-by-step instructions enable users to apply these essential techniques successfully the first time, and include modifications that permit their effective adaptation to novel experimental or process conditions. For each application, additional discussions provide needed background information, lists of materials and apparatus, and advice about common pitfalls and how to avoid them. Versatile and comprehensive, Supercritical Methods and Protocols offers both novice and experienced investigators and laboratory analysts powerful tools that will enable successful biological and bioprocess analyses and optimizations today.

Supercritical Fluid Technology for Drug Product Development

Supercritical Fluid Technology for Drug Product Development
  • Author : Peter York,Uday B. Kompella,Boris Y. Shekunov
  • Publisher :Unknown
  • Release Date :2004-03-23
  • Total pages :632
  • ISBN : 9780824751029
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Summary : Interconnecting the fundamentals of supercritical fluid (SCF) technologies, their current and anticipated utility in drug delivery, and process engineering advances from related methodological domains and pharmaceutical applications, this volume unlocks the potential of supercritical fluids to further the development of improved pharmaceutical products-from drug powders for respiratory delivery to drug delivery systems for controlled release.

Supercritical Fluids

Supercritical Fluids
  • Author : E. Kiran,Pablo G. Debenedetti,Cor J. Peters
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :596
  • ISBN : 9789401139298
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Summary : Supercritical fluids are neither gas nor liquid, but can be compressed gradually from low to high density and they are therefore interesting and important as tunable solvents and reaction media in the chemical process industry. By adjusting the density the properties of these fluids can be customised and manipulated for a given process - physical or chemical transformation. Separation and processing using supercritical solvents such as CO2 are currently on-line commercially in the food, essential oils and polymer industries. Many agencies and industries are considering the use of supercritical water for waste remediation. Supercritical fluid chromatography represents another, major analytical application. Significant advances have recently been made in materials processing, ranging from particle formation to the creation of porous materials. The chapters in this book provide tutorial accounts of topical areas centred around: (1) phase equilibria, thermodynamics and equations of state; (2) critical behaviour, crossover effects; (3) transport and interfacial properties; (4) molecular modelling, computer simulation; (5) reactions, spectroscopy; (6) phase separation kinetics; (7) extractions; (8) applications to polymers, pharmaceuticals, natural materials and chromatography; (9) process scale-up.

Supercritical Fluid Chromatography

Supercritical Fluid Chromatography
  • Author : The Open The Open Courses Library
  • Publisher :Unknown
  • Release Date :2019-12-02
  • Total pages :27
  • ISBN : 1670679268
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Summary : Supercritical Fluid Chromatography Physical Methods in Chemistry and Nano Science Supercritical fluid chromatography (SFC) begins its history in 1962 under the name "high pressure gas chromatography". It started off slow and was quickly overshadowed by the development of high performance liquid chromatography (HPLC) and the already developed gas chromatography. SFC was not a popular method of chromatography until the late 1980s, when more publications began exemplifying its uses and techniques. Chapter Outline: Supercritical fluids The instrument Advantages of supercritical fluid chromatography Applications The Open Courses Library introduces you to the best Open Source Courses.

The Application of Green Solvents in Separation Processes

The Application of Green Solvents in Separation Processes
  • Author : Francisco Pena-Pereira,Marek Tobiszewski
  • Publisher :Unknown
  • Release Date :2017-02-28
  • Total pages :560
  • ISBN : 9780128054437
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Summary : The Application of Green Solvents in Separation Processes features a logical progression of a wide range of topics and methods, beginning with an overview of green solvents, covering everything from water and organic solvents, to ionic liquids, switchable solvents, eutectic mixtures, supercritical fluids, gas-expanded solvents, and more. In addition, the book outlines green extraction techniques, such as green membrane extraction, ultrasound-assisted extraction, and surfactant-mediated extraction techniques. Green sampling and sample preparation techniques are then explored, followed by green analytical separations, including green gas and liquid capillary chromatography, counter current chromatography, supercritical fluid chromatography, capillary electrophoresis, and other electrical separations. Applications of green chemistry techniques that are relevant for a broad range of scientific and technological areas are covered, including the benefits and challenges associated with their application. Provides insights into recent advances in greener extraction and separation processes Gives an understanding of alternatives to harmful solvents commonly used in extraction and separation processes, as well as advanced techniques for such processes Written by a multidisciplinary group of internationally recognized scientists