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Systems Immunology and Infection Microbiology

Systems Immunology and Infection Microbiology
  • Author : Bor-Sen Chen
  • Publisher :Unknown
  • Release Date :2021-03-16
  • Total pages :672
  • ISBN : 9780128173350
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Summary : Systems Immunology and Infection Microbiology provides a large amount of biological system models, diagrams and flowcharts to illustrate development procedures and help users understand the results of systems immunology and infection microbiology. Chapters discuss systems immunology, systems infection microbiology, systematic inflammation and immune responses in restoration and regeneration process, systems' innate and adaptive immunity in infection process, systematic genetic and epigenetic pathogenic/defensive mechanism during bacterial infection on human cells is introduced, and the systematic genetic and epigenetic pathogenic/defensive mechanisms during viral infection on human cells. This book provides new big data-driven and systems-driven systems immunology and infection microbiology to researchers applying systems biology and bioinformatics in their work. It is also invaluable to several members of biomedical field who are interested in learning more about those approaches. Encompasses one applicable example in every chapter to illustrate the solution procedure from big data mining, network modeling, host/pathogen cross-talk detection, drug target identification and systems drug design Presents flowcharts to represent the development procedure of systematic immunology and infection in a very clear format Contains 100 color diagrams to help readers understand the related biological networks, their corresponding mechanisms, and significant network biomarkers for therapeutic drug design

Immunology, Infection, and Immunity

Immunology, Infection, and Immunity
  • Author : Gerald B. Pier,Jeffrey B. Lyczak,Lee M. Wetzler
  • Publisher :Unknown
  • Release Date :2004-04
  • Total pages :718
  • ISBN : 155581283X
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Summary : TEXT WITH CD STUDY GUIDE With a focus on the relatedness of immunology and microbiology, Immunology, Infection, and Immunity covers both the foundation concepts of immunology, among the most exciting in modern biology and medicine, and their application to the real world of diseases and health. This new text combines clear narratives of how the immune system functions relying in many instances on supporting data from experiments. The editors use examples and illustrations depicting basic immunologic processes in conjunction with their role in infectious or other diseases in order to teach both basic and applied aspects of immunology. A chapter on antibody–antigen interactions and measurements of immunologic reactions familiarizes students with the tools of experimental immunology. In addition to an emphasis on infectious diseases, the book focuses strongly on those areas where the immune system does not act when it should – primary and acquired immunodeficiency, and the failure to control cancer – as well as areas where the over–activity or dysregulation of the immune system is a cause of pathology – hypersensitivity reactions, including allergy and asthma, autoimmunity and the unwanted immune responses to transplanted tissues and organs. To bring the full flavor and excitement of immunology to new students, the editors have assembled an outstanding group of contributors with expertise in the multiple areas of immunology who provide the most up–to–date information in this quickly moving field. All of the chapters have standardized thematic and structural aspects to provide critical information in a comprehensive style. Immunology, Infection, and Immunity is ideally suited for upper division and graduate level students as well as medical and dental students with a good background in basic biology, biochemistry, genetics, and cell biology. The text complements traditional views and dogmas about immunology with today′s cutting edge ideas and experimental data describing how the immune system works, some of which are challenging and changing some long–held beliefs about the function of the immune system. Key Features Examines the basic molecular and cellular components of the immune system relative to the pathogenesis and prevention of infectious diseases Concentrates on the way in which the immune system is critical to the pathogenesis and prevention of infectious diseases Focuses on primary and acquired immunodeficiency and immune system dysregulation as causes of pathology Contributions from multiple areas of immunology present current information in a rapidly moving field All chapters have standardized thematic and structural aspects to provide critical information in a comprehensible style Examples and illustrations depict basic immunologic processes in conjunction with their role in infectious or other diseases About the Electronic Study Guide The DLG CD—ROM is an interactive, automated program that organizes each chapter from Immunology, Infection and Immunity into questions, answers, and extensive explanations. The software helps students first through reviewing the book and then helps them quiz themselves and assess their progress. Students can print out or even stop a study session and resume exactly where they left off at their convenience. With the DLG, students will be able to quickly learn new information, retain it longer, and improve their test scores. Students can work at their own pace, measure their performance, and make the most efficient use of their study time. Prepared by Mary J. Ruebush Recommended system requirements: Windows 98/98SE/ME/NT4/2000/XP Pentium Class Processor, 166 MHz or greater 64 MB of RAM 300 MB free disk space Internet connection for registration/activation only

Immunology of Infection

Immunology of Infection
  • Author : Stefan H.E. Kaufmann,Dieter Kabelitz
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :806
  • ISBN : 0125215320
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Summary : Immunology of Infection, 2nd Edition, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the Microbiologist interested in analysing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology. This new edition of Immunology of Infection provides ready-to-use "recipes", and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition. Methods in Microbiologyis the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your research. Includes techniques for genome-wide expression profiling of both the pathogen and host and of the host response to infection Cytometric analysis of cytokine secretion by immune cells Describes tetramer technology for the quantitative analysis of antigen specific T cell responses Analysis of host cells and pathogens involved in the host-microbe interplay Covers techniques useful for the analysis of human and murine systems Includes techniques for the prediction and determination of MHC ligands and T cell epitopes Covers the fundamentals and practice of DNA vaccines Describes methods for the isolation and propagation of human dendritic cells

Immunology of Infectious Diseases

Immunology of Infectious Diseases
  • Author : Stefan H. E. Kaufmann,Alan Sher,Rafi Ahmed
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :495
  • ISBN : UOM:39015054162923
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Summary : An integrated view of the principal aspects of immune response to all types of infectious agents, emphasizing the immune system as a host defense system. * Illustrates how the dialogue between different types of pathogens and the host immune system, as well as the cross-talk between the different members of the immune response, works. * Serves as valuable reading for microbiologists interested in pathogenesis and immunology; clinicians with an interest in immunology, virology, vaccine development, infectious diseases, bacteriology, parasitology, pathology, and cell biology; and immunologists wanting to expand their knowledge of infectious diseases and their causative agents.

Systems Biology of Microbial Infection

Systems Biology of Microbial Infection
  • Author : Reinhard Guthke,Jörg Linde,Marc Thilo Figge,Franziska Mech
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 9782889190607
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Summary : The systems biology of microbial infections aims at describing and analysing the confrontation of the host with bacterial and fungal pathogens. It intends to understand and to model the interaction of the host, in particular the immune system of humans or animals, with components of pathogens. This comprises experimental studies that provide spatio-temporal data from monitoring the response of host and pathogenic cells to perturbations or when interacting with each other, as well as the integrative analysis of genome-wide data from both the host and the pathogen. In perspective, the host-pathogen interaction should be described by a combination of spatio-temporal models with interacting molecular networks of the host and the pathogen. The aim is to unravel the main mechanisms of pathogenicity, to identify diagnostic biomarkers and potential drug targets, and to explore novel strategies for personalized therapy by computer simulations. Some microorganisms are part of the normal microbial flora, existing either in a mutualistic or commensal relationship with the host. Microorganisms become pathogenic if they posses certain physiological characteristics and virulence determinants as well as capabilities for immune evasion. Despite the different pathogenesis of infections, there are several common traits: (1) Before infection, pathogens must be able to overcome (epithelial) barriers. The infection starts by adhesion and colonization and is followed by entering of the pathogen into the host through the mucosa or (injured) skin. (2) Next, infection arises if the pathogen multiplies and overgrows the normal microbial flora, either at the place of entrance or in deeper tissue layers or organs. (3) After the growth phase, the pathogen damages the host’s cells, tissues and organs by producing toxins or destructive enzymes. Thus, systems biology of microbial infection comprises all levels of the pathogen and the host’s immune system. The investigation may start with the pathogen, its adhesion and colonization at the host, its interaction with host cell types e.g. epithelia cells, dendritic cells, macrophages, neutrophils, natural killer cells, etc. Because infection diseases are mainly found in patients with a weakened immune system, e.g. reduced activities of immune effector cells or defects in the epithelial barriers, systems biology of infection can also start with modelling of the immune defence including innate and adaptive immunity. Systems biological studies comprise both experimental and theoretical approaches. The experimental studies may be dedicated to reveal the relevance of certain genes or proteins in the above mentioned processes on the side of the pathogen and/or the host by applying functional and biochemical analyses based on knock-out mutants and knock- down experiments. At the theoretical, i.e. mathematical and computational, side systems biology of microbial infection comprises: (1) modelling of molecular mechanisms of bacterial or fungal infections, (2) modelling of non-protective and protective immune defences against microbial pathogens to generate information for possible immune therapy approaches, (3) modelling of infection dynamics and identification of biomarkers for diagnosis and for individualized therapy, (4) identifying essential virulence determinants and thereby predicting potential drug targets.

Infection and Immunity

Infection and Immunity
  • Author : D H Davies,M A Halablab,T W K Young,F. E. G. Cox,J. Clarke
  • Publisher :Unknown
  • Release Date :2002-09-11
  • Total pages :237
  • ISBN : 9780203484388
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Summary : This concise text explores the interactions between pathogens and the immune system. Taking a disease-based approach, it explains how micro-organisms adapted to growth in human hosts can evade the immune system and cause disease. The opening chapter overviews the innate and adaptive immune responses to microbes. Subsequent chapters are specific to particular pathogens, beginning with their biology and leading on to illustrate mechanisms of adaptation and ensuing consequences. Each of these chapters ends with a summary, review questions and further reading lists. Summaries, review questions and further reading make this book suitable for self-directed study. Infection and Immunity is ideal for any undergraduates taking a course that explores the interaction between pathogens and the human immune system.

Parasitic Infections and the Immune System

Parasitic Infections and the Immune System
  • Author : Felipe Kierzenbaum
  • Publisher :Unknown
  • Release Date :2013-10-22
  • Total pages :254
  • ISBN : 9780080924052
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Summary : Featuring the work of several world authorities, this volume places primary emphasis on the mechanism of parasite produced changes in the immune response (i.e. immunosuppression). The text covers parasitic diseases on which the World Health Organization has aggressively promoted research through its Program on Research and Training In Tropical Diseases. Chapters cover parasitic diseases such as malaria, American trypanosomiasis (Chagas' disease), African trypanosomiasis (sleeping sickness), leishmaniasis, schistosomiasis and onchocerciasis. Also included are discussions of toxoplasmosis and amebiasis. The material is drawn from the body of literature that has been rapidly accumulating for the last 15 years. An important feature of this text is that the contributors first outline existing knowledge about the immunology of each infection, thereby enabling the reader to more easily appreciate why and how the immunological alterations that accompany a disease are important, and then, to review the postulated mechanisms for such alterations. Consequently, the impact that each parasitic infection has on the immune system is always described in the "heart" of each chapter rather than at the beginning.

Janeway's Immunobiology

Janeway's Immunobiology
  • Author : Murphy, Kenneth M.,Weaver, Casey
  • Publisher :Unknown
  • Release Date :2016-03-22
  • Total pages :904
  • ISBN : 9780815345510
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Summary : Explore the premier text for immunology at the advanced undergraduate, graduate, and medical school levels. Beginning students appreciate the bookÕs clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope and depth. This edition is thoroughly revised and up to date with significant developments in the field, especially on the topic of innate immunity.

Mims' Medical Microbiology E-Book

Mims' Medical Microbiology E-Book
  • Author : Richard Goering,Hazel Dockrell,Mark Zuckerman,Peter L. Chiodini
  • Publisher :Unknown
  • Release Date :2018-07-25
  • Total pages :580
  • ISBN : 9780702072024
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Summary : Learn all the microbiology and basic immunology concepts you need to know for your courses and exams. Now fully revised and updated, Mims’ clinically relevant, systems-based approach and abundant colour illustrations make this complex subject easy to understand and remember. Learn about infections in the context of major body systems and understand why these are environments in which microbes can establish themselves, flourish, and give rise to pathologic changes. This systems-based approach to microbiology employs integrated and case-based teaching that places the ‘bug parade’ into a clinical context. Effectively review for problem-based courses with the help of chapter introductions and ‘Lessons in Microbiology’ text boxes that highlight the clinical relevance of the material, offer easy access to key concepts, and provide valuable review tools. Approach microbiology by body system or by pathogen through the accompanying electronic ‘Pathogen Parade’ – a quickly searchable, cross-referenced glossary of viruses, bacteria and fungi A new electronic ‘Vaccine Parade’ offers quick-reference coverage of the most commonly used vaccines in current clinical practice Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventative medicine. Grasp and retain vital concepts easily, with a user-friendly colour coded format, succinct text, key concept boxes, and dynamic illustrations. New and enhanced information reflects the growing importance of the human microbiota and latest molecular approaches Access the complete contents on the go via the accompanying interactive eBook, with a range of bonus materials to enhance learning and retention – includes self-assessment materials and clinical cases to check your understanding and aid exam preparation.

Elsevier's Integrated Review Immunology and Microbiology E-Book

Elsevier's Integrated Review Immunology and Microbiology E-Book
  • Author : Jeffrey K. Actor
  • Publisher :Unknown
  • Release Date :2011-09-28
  • Total pages :192
  • ISBN : 9781455727018
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Summary : Effectively merge basic science and clinical skills with Elsevier’s Integrated Review of Immunology and Microbiology, by Jeffrey K. Actor, PhD. This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in immunology and microbiology while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. . This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. Spend more time reviewing and less time searching thanks to an extremely focused, "high-yield" presentation. Gauge your mastery of the material and build confidence with case-based and USMLE-style questions that provide effective chapter review and quick practice for your exams. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. Grasp and retain vital concepts more easily thanks to a color-coded format, succinct text, key concept boxes, and dynamic illustrations that facilitate learning in a highly visual approach. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material.

Oral Microbiology and Immunology

Oral Microbiology and Immunology
  • Author : Richard J. Lamont,George N. Hajishengallis,Hyun (Michel) Koo,Howard F. Jenkinson
  • Publisher :Unknown
  • Release Date :2020-08-06
  • Total pages :565
  • ISBN : 9781555819996
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Summary : The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries. Against this backdrop, the third edition of Oral Microbiology and Immunology has been substantially expanded and rewritten by an international team of authors and editors. Featured in the current edition are: links between oral infections and systemic disease revised and updated overview of the role of the immune system in oral infections thorough discussions of biofilm development and control more extensive illustrations and Key Points for student understanding Graduate students, researchers, and clinicians as well as students will find this new edition valuable in study and practice. The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries. Against this backdrop, the third edition of Oral Microbiology and Immunology has been substantially expanded and rewritten by an international team of authors and editors. Featured in the current edition are: links between oral infections and systemic disease revised and updated overview of the role of the immune system in oral infections thorough discussions of biofilm development and control more extensive illustrations and Key Points for student understanding Graduate students, researchers, and clinicians as well as students will find this new edition valuable in study and practice.

Viral Pathogenesis

Viral Pathogenesis
  • Author : Michael G. Katze,Marcus J. Korth,G. Lynn Law,Neal Nathanson
  • Publisher :Unknown
  • Release Date :2015-12-30
  • Total pages :366
  • ISBN : 9780128011744
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Summary : Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field

Systems Biology

Systems Biology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2013
  • Total pages :263
  • ISBN : 1283945967
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Summary : First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies-oligonucleotide microarrays, mass spectrometry, and next-generation sequencing-and the analysis of this data through sophisticated mathematical algorithms.

The Microbiology of Respiratory System Infections

The Microbiology of Respiratory System Infections
  • Author : Kateryna Kon,Mahendra Rai
  • Publisher :Unknown
  • Release Date :2016-06-20
  • Total pages :312
  • ISBN : 9780128045763
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Summary : The Microbiology of Respiratory System Infections reviews modern approaches in the diagnosis, treatment, and prophylaxis of respiratory system infections. The book is very useful for researchers, scientists, academics, medical practitioners, graduate and postgraduate students, and specialists from pharmaceutical and laboratory diagnostic companies. The book has been divided into three sections according to the types of respiratory pathogens. The first section contains reviews on the most common and epidemiologically important respiratory viruses, such as influenza virus, severe acute respiratory system coronavirus, and recently discovered Middle East respiratory syndrome coronavirus. The second section is devoted to bacterial and fungal pathogens, which discusses etiology and pathogenesis including infections in patients with compromised immune system, and infections caused by fungal pathogens, such as Aspergillus and Pneumocystis. The third section incorporates treatment approaches against different types of bacterial infections of the lower respiratory tract. This section reviews classical antimicrobial and phytomedical approaches as well as the application of nanotechnology against respiratory pathogens. Offers the most up to date information on the microbiology of lower respiratory system infections Features contributors from across the world, presenting questions of interest to readers of both developed and developing countries Reviews the most common and epidemiologically important respiratory viruses Discusses the etiology and pathogenesis of bacterial and fungal pathogens including infections in patients with compromised immune system, and infections caused by fungal pathogens, such as Aspergillus and Pneumocystis

GI Microbiota and Regulation of the Immune System

GI Microbiota and Regulation of the Immune System
  • Author : Gary B. Huffnagle,Mairi Noverr
  • Publisher :Unknown
  • Release Date :2009-03-07
  • Total pages :149
  • ISBN : 9780387095509
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Summary : This book covers current trends in the investigation of GI microbiota. It examines the relationship between the microbiota and the immune system from a variety of angles.

Molecular Biology of the Cell

Molecular Biology of the Cell
  • Author : Bruce Alberts
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :229
  • ISBN : 0815332181
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Summary :

Mucosal Vaccines

Mucosal Vaccines
  • Author : David W. Pascual
  • Publisher :Unknown
  • Release Date :2019-10-19
  • Total pages :940
  • ISBN : 9780128119259
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Summary : Mucosal Vaccines: Innovation for Preventing Infectious Diseases discusses basic knowledge and discovery in the area of mucosal immunology and its related scientific fields. This completely updated, revised and authoritative treatise covers all aspects of mucosal vaccines, including their development, mechanisms of action, molecular/cellular aspects and practical applications. The book is organized in a unique format with basic, clinical and practical aspects described and discussed. The accumulated knowledge and new discoveries on the development of mucosal vaccines are logically introduced and discussed in an easy-to-understand format. Provides the latest views on mucosal vaccines Applies basic and current principles in the field of mucosal immunology and related scientific fields (e.g., microbiology, infectious diseases, systems biology, medicine, dentistry, veterinary medicine and translational research) to the development of new vaccines Links basic, clinical and practical aspects of mucosal vaccines to different infectious diseases Presents user-friendly organization using attractive illustrations

The Innate Immune Response to Infection

The Innate Immune Response to Infection
  • Author : Stefan H. E. Kaufmann,Ruslan Medzhitov,Siamon Gordon
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :465
  • ISBN : UOM:39015059146525
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Summary : Delivers a state-of-the-art review of the innate immune system, utilizing the most current concepts of cellular and molecular biology. The book focuses on evolutionary aspects, describing the major cells, humoral factors, receptors, and effector responses central to innate immunity and its important relation to acquired immunity. In-depth treatment is given to the performance of the innate immune system in various situations, including bacterial, viral, fungal, and parasitic infection.

Idiotypes in Medicine: Autoimmunity, Infection and Cancer

Idiotypes in Medicine: Autoimmunity, Infection and Cancer
  • Author : R.C. Kennedy,S. Ferrone,Yehuda Shoenfeld
  • Publisher :Unknown
  • Release Date :1997-11-19
  • Total pages :540
  • ISBN : 0080534430
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Summary : This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

Antibodies for Infectious Diseases

Antibodies for Infectious Diseases
  • Author : James E. Crowe, Jr.,Diana Boraschi,Rino Rappuoli
  • Publisher :Unknown
  • Release Date :2020-07-24
  • Total pages :457
  • ISBN : 9781555817411
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Summary : State-of-the-art reviews covering major aspects of antibodies and intervention against infectious diseases The connection between antibodies and infectious diseases has spawned entire related fields of study. Antibodies for Infectious Diseases presents perspectives from leading research scientists and summarizes the amazing progress in this area into a single definitive source. Providing a broad survey of the most important aspects of the field of antibodies for infectious diseases, this book presents general features pertaining to structure, function, isotype, and the role of complement in antibody function examines the role of antibodies in antimicrobial immunity with specific targets details new methods for expression of monoclonal antibodies, in plants or by transfer of antibody genes for in vivo expression in treated subjects Antibodies for Infectious Diseases is a comprehensive reference for researchers, pharmaceutical developers, and health care professionals on the status of the development of antibody-based therapies for treating infectious diseases. It is also useful as supplemental reading for upper level life sciences students.

Handbook of Systems Biology

Handbook of Systems Biology
  • Author : Marian Walhout,Marc Vidal,Job Dekker
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :552
  • ISBN : 9780123859457
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Summary : This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Chapters organized around broader themes of Organelles and Organisms, Systems Properties of Biological Processes, Cellular Networks, and Systems Biology and Disease discuss the development of concepts, the current applications, and the future prospects. Emphasis is placed on concepts and insights into the multi-disciplinary nature of the field as well as the importance of systems biology in human biological research. Technology, being an extremely important aspect of scientific progress overall, and in the creation of new fields in particular, is discussed in 'boxes' within each chapter to relate to appropriate topics. 2013 Honorable Mention for Single Volume Reference in Science from the Association of American Publishers' PROSE Awards Emphasizes the interdisciplinary nature of systems biology with contributions from leaders in a variety of disciplines Includes the latest research developments in human and animal models to assist with translational research Presents biological and computational aspects of the science side-by-side to facilitate collaboration between computational and biological researchers