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Systems Neuroscience in Depression

Systems Neuroscience in Depression
  • Author : Thomas Frodl
  • Publisher :Unknown
  • Release Date :2016-09-01
  • Total pages :420
  • ISBN : 9780128026281
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Summary : Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry. Knowledge covering the whole life span from early to later life Comprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscience Understanding the neurobiology of major depressive disorder Integrating stress and environmental factors with molecular underpinnings More than 25 illustrations and tables

Neurobiology of Depression

Neurobiology of Depression
  • Author : Francisco Lopez-Munoz,Cecilio Alamo
  • Publisher :Unknown
  • Release Date :2011-09-09
  • Total pages :522
  • ISBN : 9781439838495
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Summary : Major depressive disorders have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways hold promise as new therapeutics for depression. With the collaboration of the most prestigious international specialists in biochemistry, molecular biology, genomics, psychiatry, psychology, and pharmacology, Neurobiology of Depression discusses the nature of the central nervous system circuits responsible for the modifications of neuronal functioning that lead to depression. The book begins by discussing animal, neurophysiological, and neuropsychological models of depression as well as neural foundations. It explores genetic factors that contribute to depression and describes the effect of monoaminergic systems in the central nervous system. Next, the book profiles the rise of psychopharmacology in the treatment of depression and the research into serotonin and monoamine reuptake inhibitors. It examines the role of the glutamatergic, endocannabinoid, and opioid systems in the pathophysiology of mood disorders, as well as the effect of biological rhythms on the human body. Later chapters review the role of CRF-related ligands, CRF receptors, HPA axis activity, and glucocorticoid receptors in the regulation of the stress response and depression. They also describe cytokine modulation of molecular mechanisms. They examine the role of neuropeptide Y, nitric oxide, beta-arrestins, BDNF, and phosphodiesterases, and discuss the use of tachykinin antagonists in treatment. Finally, they analyze the neurobiological basis for the development of new antidepressant agents. Exploring myriad aspects of a disease that plagues a large percentage of the population worldwide, this volume captures the state of the science of this debilitating disorder, facilitating further research and discovery.

Neurobiology of Depression

Neurobiology of Depression
  • Author : Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate
  • Publisher :Unknown
  • Release Date :2019-01-03
  • Total pages :471
  • ISBN : 9780128133347
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Summary : Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

The Neuroscience of Depression

The Neuroscience of Depression
  • Author : Colin R. Martin,Lan-Anh Hunter,Vinood B. Patel,Victor R. Preedy,Rajkumar Rajendram
  • Publisher :Unknown
  • Release Date :2021-03-27
  • Total pages :1166
  • ISBN : 9780128180105
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Summary : The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression. The Neuroscience of Depression: Features, Diagnosis and Treatment Covers a pharmacological and behavioral treatment options Features sections on diagnosis and biomarkers of depression Discusses depression in children, teens and adults Contains information on comorbidity of physical and mental conditions Includes more than 250 illustrations and tables The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet Features a section on neurological and imaging, including SPECT Neuroimaging Analyzes how diet and nutrition effect depression Examines the molecular and cellular effects of depression Covers genetics of depression Includes more than 250 illustrations and tables

Vulnerability to Depression

Vulnerability to Depression
  • Author : Rick E. Ingram,Ruth Ann Atchley,Zindel V. Segal
  • Publisher :Unknown
  • Release Date :2011-07-07
  • Total pages :260
  • ISBN : 9781609182571
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Summary : Providing a cutting-edge examination of the mechanisms underlying depression, this volume integrates important areas of research that have largely remained separate. The authors explore both the cognitive and neurological processes that make some people more vulnerable than others to developing depression and experiencing recurrent episodes. They also probe how these processes interact—how negative life experiences, maladaptive belief systems, and patterns of thinking may actually affect neural circuitry, and vice versa. Explaining sophisticated theory and research in an accessible style, the book highlights the implications for improving clinical practices and patient outcomes.

The Neuroscience of Depression

The Neuroscience of Depression
  • Author : Colin R. Martin,Lan-Anh Hunter,Vinood B. Patel,Victor R. Preedy,Rajkumar Rajendram
  • Publisher :Unknown
  • Release Date :2021-05-08
  • Total pages :574
  • ISBN : 9780128179369
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Summary : The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression. Features a section on neurological and imaging, including SPECT Neuroimaging Analyzes how diet and nutrition effect depression Examines the molecular and cellular effects of depression Covers genetics of depression Includes more than 250 illustrations and tables

Ketamine for Treatment-Resistant Depression

Ketamine for Treatment-Resistant Depression
  • Author : Gustavo H. Vazquez,Carlos A. Zarate,Elisa Brietzke
  • Publisher :Unknown
  • Release Date :2020-10-01
  • Total pages :168
  • ISBN : 9780128210345
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Summary : Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. Provides efficacy research on ketamine as a treatment for depression Identifies best practices for clinical use, both long-term and acute Discusses the molecular mechanisms and neurobiology of action

Inflammation and Immunity in Depression

Inflammation and Immunity in Depression
  • Author : Bernhard Baune
  • Publisher :Unknown
  • Release Date :2018-05-23
  • Total pages :636
  • ISBN : 9780128110744
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Summary : Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system Explores translational potential of targeting immune dysfunction for clinical interventions

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide
  • Author : Yogesh Dwivedi
  • Publisher :Unknown
  • Release Date :2012-06-25
  • Total pages :482
  • ISBN : 9781439838815
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Summary : With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Handbook of the Behavioral Neurobiology of Serotonin

Handbook of the Behavioral Neurobiology of Serotonin
  • Author : Christian P. Muller,Barry Jacobs
  • Publisher :Unknown
  • Release Date :2009-12-30
  • Total pages :836
  • ISBN : 0080878172
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Summary : Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft. The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour. This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise. The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders. The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community Of great value not only for researchers and experts, but also for students and clinicians as a background reference

The Upward Spiral

The Upward Spiral
  • Author : Alex Korb
  • Publisher :Unknown
  • Release Date :2015-03-01
  • Total pages :232
  • ISBN : 9781626251229
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Summary : Depression can feel like a downward spiral, pulling you into a vortex of sadness, fatigue, and apathy. In The Upward Spiral, neuroscientist Alex Korb demystifies the intricate brain processes that cause depression and offers a practical and effective approach to getting better. Based on the latest research in neuroscience, this book provides dozens of straightforward tips you can do every day to rewire your brain and create an upward spiral towards a happier, healthier life. Whether you suffer from depression or just want a better understanding of the brain, this book offers an engaging and informative look at the neuroscience behind our emotions, thoughts, and actions. The truth is that there isn’t one big solution to depression, but there are numerous simple steps you can take to alter brain activity and chemistry. Some are as easy as relaxing certain muscles to reduce anxiety, or getting more sunlight to improve your mood. Small steps in the right direction can have profound effects—giving you the power to become your best self as you literally reshape your brain, one small change at a time.

The Inflamed Mind

The Inflamed Mind
  • Author : Edward Bullmore
  • Publisher :Unknown
  • Release Date :2018-12-31
  • Total pages :256
  • ISBN : 9781250318152
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Summary : As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression. A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge profressor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future.

Major Depressive Disorder

Major Depressive Disorder
  • Author : Yong-Ku Kim
  • Publisher :Unknown
  • Release Date :2015-06-11
  • Total pages :156
  • ISBN : 9789535121299
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Summary : Major depressive disorder (MDD) is a complex and heterogeneous disorder, phenotypically and biologically. MDD may be caused by complex interaction between genes and environment in susceptible individuals. Thus, a combination of certain genetic polymorphism, environmental stress, and personal susceptibility ultimately may induce MDD. Gene-environment interactions in the pathophysiology of MDD lead to advancement in personalized medicine by means of genotyping for inter-individual variability in drug action and metabolism. Gene-environment interactions may explain why some subjects become depressed while others remain unaffected. The aim of this book is to describe current knowledge of MDD from the point of view of neurobiology, molecular genetics and cognition. The authors address a deep understanding of cognitive and neurobiological mechanisms involved in MDD.

Cognitive-Affective Neuroscience of Depression and Anxiety Disorders

Cognitive-Affective Neuroscience of Depression and Anxiety Disorders
  • Author : Dan J. Stein
  • Publisher :Unknown
  • Release Date :2002-11-14
  • Total pages :152
  • ISBN : 1841841005
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Summary : Data on depression and anxiety disorders now spans a range of fields from molecular neuroscience, through cognitive and affective science, and on to evolutionary psychology. The author here integrates this work into one volume, providing the clinician with a theoretical synthesis as well as a useful practical framework. Cognitive-Affective Neuroscience of Depression and Anxiety Disorders helps professionals in these various fields to manage patients with major depression, generalized anxiety disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder and social anxiety disorder. Neuroscientists, neurologists, pharmacologists, psychiatrists and mental health practitioners will benefit from this text.

Neurobiology of Mental Illness

Neurobiology of Mental Illness
  • Author : Dennis S. Charney,Eric J. Nestler,Pamela Sklar,Joseph D. Buxbaum
  • Publisher :Unknown
  • Release Date :2013-07-04
  • Total pages :1222
  • ISBN : 9780199934959
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Summary : Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Neurobiology of Brain Disorders

Neurobiology of Brain Disorders
  • Author : Michael J. Zigmond,Joseph T. Coyle,Lewis P. Rowland
  • Publisher :Unknown
  • Release Date :2014-12-03
  • Total pages :824
  • ISBN : 9780123982803
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Summary : Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material

Magnesium in the Central Nervous System

Magnesium in the Central Nervous System
  • Author : Robert Vink,Mihai Nechifor
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :342
  • ISBN : 9780987073051
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Summary : The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Menopause

Menopause
  • Author : Juan Francisco Rodríguez-Landa,Jonathan Cueto-Escobedo
  • Publisher :Unknown
  • Release Date :2017-08-16
  • Total pages :136
  • ISBN : 9789535134053
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Summary : Menopause is a natural state of development in women, but it is also a period of vulnerability to the development of several disorders, such as vasomotor symptoms, hot flashes, vaginal dryness, osteoporosis, cognitive deterioration, depression, and anxiety. Factors as diverse as culture, diet, exercise, maternity, age, and genetics can influence the severity of symptoms that are experienced during menopause and can modify the response to diverse therapies. Studying menopause from a multidisciplinary perspective will help elucidate the different factors that affect health during this specific stage of a woman's life. This book presents several aspects of menopause, including its evolutionary origins, novel nonhormonal therapies, and the neurobiology of related disorders.

Fundamental Neuroscience

Fundamental Neuroscience
  • Author : Larry Squire,Darwin Berg,Floyd E. Bloom,Sascha du Lac,Anirvan Ghosh,Larry R. Squire,Nicholas C. Spitzer,Susan K. McConnell,James L. Roberts,Michael J. Zigmond
  • Publisher :Unknown
  • Release Date :2002-11-19
  • Total pages :1426
  • ISBN : 9780080521800
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Summary : With over 300 training programs in neuroscience currently in existence, demand is great for a comprehensive textbook that both introduces graduate students to the full range of neuroscience, from molecular biology to clinical science, but also assists instructors in offering an in-depth course in neuroscience to advanced undergraduates. The second edition of Fundamental Neuroscience accomplishes all this and more. The thoroughly revised text features over 25% new material including completely new chapters, illustrations, and a CD-ROM containing all the figures from the text. More concise and manageable than the previous edition, this book has been retooled to better serve its audience in the neuroscience and medical communities. Key Features * Logically organized into 7 sections, with uniform editing of the content for a "one-voice" feel throughout all 54 chapters * Includes numerous text boxes with concise, detailed descriptions of specific experiments, disorders, methodological approaches, and concepts * Well-illustrated with over 850 full color figures, also included on the accompanying CD-ROM

The Immune System and Mental Health

The Immune System and Mental Health
  • Author : Hymie Anisman,Shawn Hayley,Alexander Kusnecov
  • Publisher :Unknown
  • Release Date :2018-07-19
  • Total pages :700
  • ISBN : 9780128113523
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Summary : The Immune System and Mental Health fully investigates how immune-related cellular, molecular and anatomical changes impact mental functioning. The book combines human and animal studies to reveal immunological changes related to mental-health problems. In addition, users will find comprehensive information on new research related to the microbial composition of the gut, aka, the microbiome, and how it influences brain function and mental health. Common comorbidities with mental illness and their inherent immunological or inflammatory components are also covered. Written by leaders in the field, the book synthesizes basic and clinical research to provide a thorough understanding on the role of immunity in neuropsychiatry. Sociology, psychology, psychiatry, neuroscience and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. This book covers devastating mental-health conditions, such as depression, anxiety, schizophrenia, and autism-like spectrum disorders. In addition, degenerative disorders of the brain, such as Parkinson’s and Alzheimer’s-like dementia are explored. Considers both basic human and animal studies that address immunological changes relating to mental health problems across the lifespan Incorporates techniques, concepts and ideas from a variety of social, behavioral and life sciences Explores the relatively new area of the microbiome and how the microbial composition of the gut influences brain function and mental health

Self-System Therapy for Depression

Self-System Therapy for Depression
  • Author : Kari M. Eddington,Timothy J. Strauman,Angela Z. Vieth,Gregory G. Kolden
  • Publisher :Unknown
  • Release Date :2017-11-01
  • Total pages :128
  • ISBN : 9780190669720
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Summary : Depression is one of the most common forms of psychological distress and can have devastating consequences for individuals and their loved ones. Decades of research have shown that there are many possible causes of depression, and one of those causes involves problems with self-regulation. Self-regulation involves setting and pursuing important personal goals - put simply, the process of trying to be the kind of person you want to be. Self-System Therapy for Depression: Therapist Guide provides a thorough description of Self-System Therapy (SST)-a motivational approach to treating depression that helps decrease feelings of disappointment and failure and increase feelings of pride and accomplishment, by improving the process of self-regulation. Clinical studies have shown that SST is effective in reducing depression and anxiety. The treatment program is structured within a 16-session plan, and strategies and techniques for each phase of treatment are presented in detail, along with case vignettes and examples. The core strategies of SST focus on identifying appropriate and reasonable personal goals and standards (including coping with perfectionistic standards), evaluating and improving the effectiveness of goal pursuit strategies, and adjusting goals in order to improve opportunities for positive emotions. The accompanying Client Workbook explains the basics of self-regulation in simple terms and provides worksheets to help illustrate and implement these strategies.