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The Autoimmune Diseases

The Autoimmune Diseases
  • Author : Noel R. Rose,Ian R. Mackay
  • Publisher :Unknown
  • Release Date :1998
  • Total pages :895
  • ISBN : 0125969236
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Summary : Since the First Edition of The Autoimmune Diseases was published in 1985, interest as well as knowledge about autoimmune diseases has greatly increased. This edition incorporates new material and combines the basic aspects of autoimmunity with discussion of specific autoimmune diseases in humans. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels. In addition to a comprehensive discussion of various autoimmune diseases and organ systems, the editors also cover the role of autoimmunity in cancer, AIDS, and aging. Key Features * Provides comprehensive discussions of all autoimmune diseases and organ systems * Offers "bench to bedside" coverage of autoimmunity for both clinicians and research scientists * Discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels * Examines the environmental determinants of autoimmune disease * Examines the association between autoimmunity and aging, cancer, and AIDS

The Autoimmune Diseases

The Autoimmune Diseases
  • Author : Noel R. Rose,Ian R. Mackay
  • Publisher :Unknown
  • Release Date :2019-10-15
  • Total pages :1532
  • ISBN : 9780128122426
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Summary : The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy

Genetics of Rare Autoimmune Diseases

Genetics of Rare Autoimmune Diseases
  • Author : Javier Martín,Francisco David Carmona
  • Publisher :Unknown
  • Release Date :2019-07-31
  • Total pages :240
  • ISBN : 3030039331
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Summary : The main aim of this volume is to provide an updated overview of the genetic basis of a group of complex disorders that are considered rare individually, but show a relatively high prevalence on the whole in developed countries: the rare autoimmune diseases. These are chronic disorders that involve long and expensive treatments with considerable side effects that may dramatically reduce the quality of life of affected people. Therefore, shedding light into their pathologic mechanisms is a major concern given their growing social and economic awareness and impact. General sections include different chapters on single entities as systemic lupus and sclerosis, Behçet’s disease, Sjogren’s syndrome and polymiositis, and sections devoted to autoimmune vasculitis, hepatic autoimmune conditions, as well as those affecting the nervous system, and a concluding chapter in which the shared predisposition amongst all diseases is discussed. All the chapters are given a homogeneous scheme in which the authors explain the clinical singularities of every disease and report the recent breakthrough discoveries related to them, giving a critical interpretation and suggesting future perspectives. All contributors are renowned researchers with high expertise in each disease. Due to the exponential increase in our understanding of the genetic causes of these complex diseases, a major advance in biomedical discovery is taking place. However, most of the achievements in this field are very recent and there is a lack of bibliography gathering them together. This book is thus filling a gap and will prove a useful companion to clinicians in the first place (internists, rheumatologists, clinical immunologists, and hematologists) but also to basic and applied researchers.

Cytokines and Autoimmune Diseases

Cytokines and Autoimmune Diseases
  • Author : Vijay K. Kuchroo,Nora Sarvetnick,David A. Hafler,Lindsay B. Nicholson
  • Publisher :Unknown
  • Release Date :2001-11-09
  • Total pages :422
  • ISBN : 9781592591299
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Summary : Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.

The Molecular Biology of Autoimmune Disease

The Molecular Biology of Autoimmune Disease
  • Author : Andrew G. Demaine,J.-Paul Banga,Alan M. McGregor
  • Publisher :Unknown
  • Release Date :2013-06-29
  • Total pages :404
  • ISBN : 9783642751332
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Summary : Autoimmune diseases are common and often associated with considerable morbidity or - in diseases such as IDDM, myasthenia gravis and multiple sclerosis - mortality. In this volume, experts of international stature in basic science and clinical medicine with a common interest in understanding the normal and aberrant immune response present their experiences. It was their intention to fur- ther the understanding of potential clinical application of scientific observations and to help to comprehend the huge amount of results in autoimmunity research.

The Autoimmune Fix

The Autoimmune Fix
  • Author : Tom O'Bryan
  • Publisher :Unknown
  • Release Date :2016-09-20
  • Total pages :352
  • ISBN : 9781623367008
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Summary : Do you have crud in the blood? Millions of people suffer from autoimmunity whether they know it or not. The root cause of most weight gain, brain and mood problems, and fatigue, autoimmunity can take years--or even decades--for symptoms and a clear diagnosis to arise. Through years of research, Dr. Tom O’Bryan has discovered that autoimmunity is actually a spectrum, and many people experiencing general malaise are already on it. And while autoimmune diseases, such as Alzheimer’s, Multiple Sclerosis, osteoporosis, diabetes, and lupus, have become the third leading cause of death behind heart disease and cancer, many people affected are left in the dark. The good news is that many autoimmune conditions can be reversed through a targeted protocol designed to heal the autoimmune system, 70 percent of which is located in the gut. The Autoimmune Fix includes two comprehensive 3-week plans: In the first 3 weeks, you’ll follow a Paleo-inspired diet during which you cut out gluten, sweets, and dairy--the three primary culprits behind autoimmunity. Once the dietary changes have been addressed, The Autoimmune Fix focuses on the other causes of autoimmunity such as genetics, other dietary issues, and microbiome. The Autoimmune Fix provides a practical and much-needed guide to navigating these increasingly common conditions to help you feel better and develop a plan that works for you.

The Autoimmune Diseases II

The Autoimmune Diseases II
  • Author : Ian R. Mackay,Noel R Rose
  • Publisher :Unknown
  • Release Date :2012-12-02
  • Total pages :444
  • ISBN : 9780323140331
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Summary : This book deals with autoimmune disease in humans (as opposed to autoimmunity itself). It discusses the biological basis of disease at the molecular, genetic, cellular, and epidemiologic levels. It also describes the clinical problems of diagnosis, prognosis, and treatment. The intended audience includes physicians of all specialties in practice, physicians in training such as house staff and fellows, and medical students. It will also be valuable for basic scientists and graduate students interested in the solution of important clinical problems. The book concentrates on topics that have grown or changed dramatically since publication of The Autoimmune Diseases.

Janeway's Immunobiology

Janeway's Immunobiology
  • Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
  • Publisher :Unknown
  • Release Date :2010-06-22
  • Total pages :229
  • ISBN : 0815344570
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Summary : The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Autoimmune Diseases

Autoimmune Diseases
  • Author : Munther A Khamashta,Manuel Ramos-Casals
  • Publisher :Unknown
  • Release Date :2011-05-26
  • Total pages :416
  • ISBN : 0857293583
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Summary : Autoimmune Diseases: Acute and Complex Situations provides a detailed overview of conditions associated with autoimmune diseases that are considered either life-threatening or requiring complex management. These include abdominal pain, arthritis, cutaneous ulcers, gastrointestinal hemorrhage, epilepsy, pancreatitis, stroke and white-matter CNS lesions. Autoimmune Diseases: Acute and Complex Situations addresses the latest clinical and immunological prognostic factors that may help to identify patients at higher risk of developing potentially life-threatening involvement. This book comprehensively helps the reader to diagnose these patients, in whom an early therapeutic approach is essential. Autoimmune Diseases: Acute and Complex Situations is a valuable reference tool for rheumatologists, internists, immunologists, and all the specialists involved in the multidisciplinary care of patient with rheumatic and systemic autoimmune diseases.

Idiotypes in Medicine: Autoimmunity, Infection and Cancer

Idiotypes in Medicine: Autoimmunity, Infection and Cancer
  • Author : R.C. Kennedy,S. Ferrone,Yehuda Shoenfeld
  • Publisher :Unknown
  • Release Date :1997-11-19
  • Total pages :540
  • ISBN : 0080534430
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Summary : This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

Diagnostic Criteria in Autoimmune Diseases

Diagnostic Criteria in Autoimmune Diseases
  • Author : Yehuda Shoenfeld,Ricard Cervera,M. Eric Gershwin
  • Publisher :Unknown
  • Release Date :2010-06-08
  • Total pages :593
  • ISBN : 1603272852
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Summary : According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.

The Molecular Pathology of Autoimmune Diseases

The Molecular Pathology of Autoimmune Diseases
  • Author : Argyrios N Theofilopoulos,Constantin A. Bona
  • Publisher :Unknown
  • Release Date :2002-12-06
  • Total pages :1200
  • ISBN : 9057026457
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Summary : Remarkable advances have been made in the pathogenesis of autoimmunity, such as with bone marrow transplantation, which is becoming a powerful strategy in treating certain life-threatening diseases. The Molecular Pathology of Autoimmune Diseases is a concise and centralized resource for information on the topic, with a special focus on the molecular and genetic basis of these disorders. Dozens of international experts devote themselves to illuminating the reader in this volume, with discussions on the basic aspects of autoimmune processes to systemic and organ-specific diseases. This volume is an invaluable reference to students and professionals in immunology and related fields.

Autoimmune Diseases in Pediatric Gastroenterology

Autoimmune Diseases in Pediatric Gastroenterology
  • Author : Faruk Hadziselimovic
  • Publisher :Unknown
  • Release Date :2002-09-30
  • Total pages :262
  • ISBN : 0792387783
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Summary : This book is the proceedings of the Falk Symposium No. 127 on `Autoimmune Diseases in Paediatric Gastroenterology' (IV International Falk Symposium on Paediatric Gastroenterology), held in Basel, Switzerland, on November 8-9, 2001. The symposium focused on the role of the immune system, both the acquired and the innate systems, in inflammatory bowel disease (IBD) in children and adolescents. The innate system has an important fundamental role in host defence by initiating immune responses against potentially deleterious matter. However, a mutation within the innate system may elicit an immune response against the host: hence, an autoimmune response. Chronic autoimmune hepatitis occurs predominantly in young people, and especially in women. Immunological changes are conspicuous. Tissue antibodies are found in a large number of patients. This is a disease of disordered immunoregulation marked by a deficit in suppressor T cells causing the production of autoantibodies against specific hepatocyte surface antigen. Liver membrane protein is found in the sera of patients with autoimmune chronic acute hepatitis and with primary biliary cirrhosis (PBC). The latter condition of progressive granulomatous destruction of intrahepatic bile ducts is, in many respects, analogous to the graft-versus-host syndrome where the immune system has become sensitized to foreign HLA-molecules. Primary sclerosing cholangitis (PSC) is another condition of unknown origin. All parts of the biliary tree can be involved in a chronic, fibrosing, inflammatory process that results in obliteration of the biliary tree and ultimately in biliary cirrhosis. About half of the patients also suffer from ulcerative colitis and rarely from Crohn's disease. Circulating antibodies to some antigens are found in obstructed portal tracts, as well as increased concentrations of biliary immune complexes in patients with PBC. In all three previous Falk symposia on paediatric gastroenterology, attention was focused on the role of the innate immune system in the aetiology of IBD. It has become increasingly clear in recent years that the innate system has a much more important and fundamental role in host defence. The decision to initiate an immune response is one of the major roles of the innate system. Mutations within this system could transform it into becoming constitutively active, resulting in an inflammatory reaction and thus eliciting an autoimmune response. Following an introduction to the basic phenomena of autoimmunity, the proceedings discuss clinical aspects of autoimmune diseases. In particular, current knowledge and the state of the art about the diagnosis and treatment of the autoimmune diseases of the gastrointestinal tract are described by world-renowned experts. The book also contains the short presentations on selected topics, as well as abstracts of the mini-posters read by title, which were included in the symposium.

The Neurologic Involvement in Systemic Autoimmune Diseases

The Neurologic Involvement in Systemic Autoimmune Diseases
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2004-11-05
  • Total pages :296
  • ISBN : 0080479685
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Summary : Systemic autoimmune diseases can affect both the central and peripheral nervous systems in a myriad of ways and through a heterogeneous number of mechanisms leading to many different clinical manifestations. As a result, neurological complications of these disorders can result in significant morbidity and mortality. Advances in the diagnosis, laboratory investigations, and management of these conditions has placed an increasing burden on the practicing clinician to correctly assess and treat these patients. This volume of the Handbook of the Systemic Autoimmune Diseases will help the clinician and researcher better understand the current concepts of nervous system involvement from systemic autoimmune disorders, recognize current approaches to diagnosis and treatment, current controversies, and areas that need significant research efforts. It is believed that providing this approach in a single volume will facilitate its use as a frequent resource for all those caring for or investigating these patients and their diseases. Each chapter follows a consistent outline to provide the reader with important and useful information in an easy-to-navigate manner and is also liberally referenced to provide more primary source material for further consideration. The standardized approach to each chapter will allow the reader to be able to compare and contrast more efficiently the neurological complications of the autoimmune diseases discussed.

Cancer and Autoimmunity

Cancer and Autoimmunity
  • Author : M.E. Gershwin,Yehuda Shoenfeld
  • Publisher :Unknown
  • Release Date :2000-03-27
  • Total pages :468
  • ISBN : 0080528457
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Summary : Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike. The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival. This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art. This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.

Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume 16

Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume 16
  • Author : James Galloway
  • Publisher :Unknown
  • Release Date :2020-03-16
  • Total pages :226
  • ISBN : 9780444642172
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Summary : Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume Sixteen describes the state-of-the-art of the risk factors and management treating the most common systemic autoimmune diseases (SADS). This updated volume consists of an introductory chapter that provides a brief overview of what different types of infectious diseases exist, followed by eight chapters detailing risk factors, guidelines and recommendations per different disease and bacterial infections. International in scope, the list of more than 20 contributors from Europa and America reads like a who's who of clinical researchers in the field.

Mosaic of Autoimmunity

Mosaic of Autoimmunity
  • Author : Carlo Perricone,Yehuda Shoenfeld
  • Publisher :Unknown
  • Release Date :2019-02-15
  • Total pages :1136
  • ISBN : 9780128143070
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Summary : The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications

The Autoimmune Solution Cookbook

The Autoimmune Solution Cookbook
  • Author : Amy Myers, M.D.
  • Publisher :Unknown
  • Release Date :2018-05-08
  • Total pages :336
  • ISBN : 9780062853554
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Summary : The companion cookbook to the revolutionary New York Times bestseller The Autoimmune Solution, filled with more than 150 nutritious, easy-to-prepare, every day recipes to heal symptoms of inflammation and autoimmune disorders, including Graves’ Disease, Psoriasis, Fibromyalgia, Lupus, Celiac disease, Hashimoto’s thyroiditis, and Multiple sclerosis. Nine in ten Americans suffer from inflammation or an autoimmune disorder—conditions for which conventional medicine has no cure. Minor irritations like rashes and runny noses are ignored, while chronic and debilitating diseases like Crohn’s and rheumatoid arthritis are handled with a cocktail of toxic treatments that fail to address their root cause. But as Dr. Amy Myers revealed in The Autoimmune Solution, there are solutions. In this invaluable cookbook, she now shows you how to repair your body and reverse your symptoms by eating your way to good health. The Autoimmune Solution Cookbook delivers more than 150 grain-free recipes designed to prevent and reverse the full spectrum of autoimmune diseases, including allergies, obesity, asthma, cardiovascular disease, fibromyalgia, lupus, IBS, chronic headaches, fatigue, multiple sclerosis, colitis, Graves’ disease, and Hashimoto’s thyroiditis. As our food and environment becomes more toxic, the health of millions of us have been impaired. Thanks to Dr. Myers, you no longer need to rely on prescriptions—with troubling, sometimes dangerous side effects—to counteract your body’s over-reactive immune system. The Autoimmune Solution Cookbook is the healthy alternative to cope with and conquer inflammatory-related symptoms and diseases.

Immunopathogenesis and Immune-based Therapy for Selected Autoimmune Disorders

Immunopathogenesis and Immune-based Therapy for Selected Autoimmune Disorders
  • Author : Mourad Aribi
  • Publisher :Unknown
  • Release Date :2017-03-22
  • Total pages :182
  • ISBN : 9789535130215
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Summary : The book Immunopathogenesis and Immune-Based Therapy for Selected Autoimmune Disorders is a synthesis work that discusses two main aspects of autoimmunity: Immunopathogenesis and therapeutic approaches essentially based on the immunotherapies. This book deals with different topics on a number of autoimmune disorders, including type 1 diabetes, autoimmune cardiomyopathy, autoimmunity of gastrointestinal tract, systemic sclerosis, and myasthenia gravis. This book will be useful to clinicians, biologists, researchers, teachers, and students who are interested in immunology and immunopathology.

The Autoimmune Connection

The Autoimmune Connection
  • Author : Rita Baron-Faust,Jill P. Buyon
  • Publisher :Unknown
  • Release Date :2003-04-22
  • Total pages :304
  • ISBN : 9780071425513
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Summary : Empowers women to make informed decisions about autoimmune disorders More than 50 million Americans, most of them women, suffer from a constellation of mysterious, often misdiagnosed diseases that can result in disability, disfigurement, and death. Called "autoimmune diseases," they arise when the immune system attacks healthy tissues in almost any area of the body, and include lupus rheumatoid arthritis, Crohn's disease, scleroderma, and Graves' disease. Now Jill Buyon, a doctor working on the cutting edge of research into these diseases, and Rita Baron-Faust, an award-winning medical journalist, arm women with the knowledge they need to obtain accurate diagnoses and the best possible treatments. In The Autoimmune Connection readers learn about the recent groundbreaking discovery of the links between the different autoimmune diseases and why women are more likely to develop them. The authors offer the most up-to-date information on diagnosis, treatments, and risks for women with one or more autoimmune disease.

Biologic Markers in Immunotoxicology

Biologic Markers in Immunotoxicology
  • Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Immunotoxicology
  • Publisher :Unknown
  • Release Date :1992-02-01
  • Total pages :224
  • ISBN : 9780309043892
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Summary : Are environmental pollutants threatening the human immune system? Researchers are rapidly approaching definitive answers to this question, with the aid of biologic markers--sophisticated assessment tools that could revolutionize detection and prevention of certain diseases. This volume, third in a series on biologic markers, focuses on the human immune system and its response to environmental toxicants. The authoring committee provides direction for continuing development of biologic markers, with strategies for applying markers to immunotoxicology in humans and recommended outlines for clinical and field studies. This comprehensive, up-to-date volume will be invaluable to specialists in toxicology and immunology and to biologists and investigators involved in the development of biologic markers.