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The Business of Precision Medicine

The Business of Precision Medicine
  • Author : Manuel Corpas, M.Sc, PhD.
  • Publisher :Unknown
  • Release Date :2019-07-15
  • Total pages :200
  • ISBN : 0128153245
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Summary : In a short period of time, precision medicine has grown from a new medical science to an implementable set of clinical methods and technologies whose concrete applications are revolutionizing the healthcare sector. With The Business of Precision Medicine, Dr. Manuel Corpas bridges knowledge gaps and brings true business advantage to those seeking to harness fresh opportunities in todays' global precision medicine landscape. Beginning with a basic overview of the precision medicine paradigm shift, this book provides in-depth case studies of companies, start-ups, and institutions of various kinds in the public and private sectors, demonstrating how they successfully adopted new genomic technologies and databases-including bioinformatics tools, genetic signatures, and gene panels-to build robust and scalable businesses. Dr. Corpas offers sound, evidence-driven approaches to incorporate genomic data discovery and access, DNA testing & diagnosis, direct to consumer genetic testing, genomics in individual health planning, biomarker development, companion diagnostics, and conducting clinical trials into your commercial strategy. With robust case studies and thoughtful business frameworks, The Business of Precision Medicine supports a diverse community of industry professionals, clinicians, and entrepreneurs driving the evolution of Precision Medicine. Those already working in and those who would like to enter precision medtech, biopharma, and healthcare, as well as life science industry representatives from pharmaceutical and diagnostic industries, will discover an invaluable guide in this practical text. Plan a business strategy that considers the impact of future research and clinical implementation of precision medicine Successfully navigate the regulatory environment that frames technology application in precision medicine Adopt fast-evolving 'data landscapes' and big data innovation frameworks in your business strategy Harness a variety of viable commercial models around bio banking, bioinformatics, and genomic analysis for stratified medicine

Personalizing Precision Medicine

Personalizing Precision Medicine
  • Author : Kristin Ciriello Pothier
  • Publisher :Unknown
  • Release Date :2017-10-02
  • Total pages :272
  • ISBN : 9781118792117
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Summary : The author uses decades of experience and interviews with experts in precision medicine to explain past, present, and future of precision medicine. She reviews the full continuum of personalizing precision medicine, including diagnostics, therapeutics, big data, supportive care, regulation, and reimbursement and innovation in precision medicine worldwide. • Combines a unique cross section of history, current technologies, and future directions for how precision medicine has and will affect people worldwide • Reviews precision medicine around the world, including the US, China, Japan, the Middle East, India, Europe, and Latin America • Discusses a number of diseases areas – cancer, cardiovascular, neurodegenerative, infectious disease, pain, immunology, rare diseases • Includes information and quotes from over 100 interviews with key industry experts in biotech, pharma, informatics, diagnostics, health providers, advocacy groups, and more. • Includes stories illustrating current issues and future promises in precision medicine for a human touch

Economic Dimensions of Personalized and Precision Medicine

Economic Dimensions of Personalized and Precision Medicine
  • Author : Ernst R. Berndt
  • Publisher :Unknown
  • Release Date :2019-04-22
  • Total pages :392
  • ISBN : 9780226611068
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Summary : Personalized and precision medicine (PPM)--the targeting of therapies according to an individual's genetic, environmental, or lifestyle characteristics--is becoming an increasingly important approach in health care treatment and prevention. The advancement of PPM is a challenge in traditional clinical, reimbursement, and regulatory landscapes because it is costly to develop and introduces a wide range of scientific, clinical, ethical, and socioeconomic issues. PPM raises a multitude of economic issues, including how information on accurate diagnosis and treatment success will be disseminated and who will bear the cost; changes to physician training to incorporate genetics, probability and statistics, and economic considerations; questions about whether the benefits of PPM will be confined to developed countries or will diffuse to emerging economies with less developed health care systems; the effects of patient heterogeneity on cost-effectiveness analysis; and opportunities for PPM's growth beyond treatment of acute illness, such as prevention and reversal of chronic conditions. This volume explores the intersection of the scientific, clinical, and economic factors affecting the development of PPM, including its effects on the drug pipeline, on reimbursement of PPM diagnostics and treatments, and on funding of the requisite underlying research; and it examines recent empirical applications of PPM.

The Patient Equation

The Patient Equation
  • Author : Glen de Vries
  • Publisher :Unknown
  • Release Date :2020-09-16
  • Total pages :288
  • ISBN : 9781119622147
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Summary : How the data revolution is transforming biotech and health care, especially in the wake of COVID-19—and why you can’t afford to let it pass you by We are living through a time when the digitization of health and medicine is becoming a reality, with new abilities to improve outcomes for patients as well as the efficiency and success of the organizations that serve them. In The Patient Equation, Glen de Vries presents the history and current state of life sciences and health care as well as crucial insights and strategies to help scientists, physicians, executives, and patients survive and thrive, with an eye toward how COVID-19 has accelerated the need for change. One of the biggest challenges facing biotech, pharma, and medical device companies today is how to integrate new knowledge, new data, and new technologies to get the right treatments to the right patients at precisely the right times—made even more profound in the midst of a pandemic and in the years to come. Drawing on the fascinating stories of businesses and individuals that are already making inroads—from a fertility-tracking bracelet changing the game for couples looking to get pregnant, to an entrepreneur reinventing the treatment of diabetes, to Medidata's own work bringing clinical trials into the 21st century—de Vries shares the breakthroughs, approaches, and practical business techniques that will allow companies to stay ahead of the curve and deliver solutions faster, cheaper, and more successfully—while still upholding the principles of traditional therapeutic medicine and reflecting the current environment. How new approaches to cancer and rare diseases are leading the way toward precision medicine What data and digital technologies enable in the building of robust, effective disease management platforms Why value-based reimbursement is changing the business of life sciences How the right alignment of incentives will improve outcomes at every stage of the patient journey Whether you're a scientist, physician, or executive, you can't afford to let the moment pass: understand the landscape with this must-read roadmap for success—and see how you can change health care for the better.

Biomarkers, Diagnostics and Precision Medicine in the Drug Industry

Biomarkers, Diagnostics and Precision Medicine in the Drug Industry
  • Author : Abdel Halim
  • Publisher :Unknown
  • Release Date :2019-06-08
  • Total pages :294
  • ISBN : 9780128161227
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Summary : The high failure rate in the pharmaceutical industry has positioned biomarkers and personalized medicine in the frontline, as possible solutions. If executed right, biomarkers and companion diagnostics (CDx) can potentially help the drug industry enhance the probability of success, accelerate the time to market, and, more importantly, benefit patients by supporting accurate diagnosis and selection of the most effective and least toxic therapies. This book aims to examine the challenges and limitations in biomarkers and laboratory tests. It also offers advice on best practices to ensure proper application of biomarkers and bridges the gap between diagnostic business development claims and real-life deliverables. The book covers biomarkers for different purposes, provides examples from different technologies, which includes standard-of-care approved assays as well as for-investigational-use and for-research-use-only assays. It also includes new data for biomarkers in different therapeutic indications and offers case studies and practical examples. This book serves as a reference to drug developers, IVD providers, clinical labs, healthcare givers, academicians, and researchers for best practices to help increase the probability of success in drug development and improve patient management. Provides the unique insight of an expert with extensive experience in diagnostics and clinical laboratory on one side and drug discovery and development on the other side Addresses the challenges of drug development and precision medicine and suggests how to eliminate or mitigate these challenges through better utilization of biomarkers and diagnostics in drug development and patient management Features case studies and real-life examples from different classes of biomarkers on different platforms for different therapeutic areas and includes more than 200 illustrations

Oncology in the Precision Medicine Era

Oncology in the Precision Medicine Era
  • Author : Ravi Salgia
  • Publisher :Unknown
  • Release Date :2019-12-17
  • Total pages :351
  • ISBN : 9783030314712
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Summary : This volume comprehensively reviews oncology in the precision medicine era of personalized care, latest developments in the field, and indications and clinical trials for the treatment of cancer with targeted therapies, immunotherapy, and epigenetic modulators. It thoroughly addresses concerns of various types of cancers including cancers of the head and neck, lung, colon, esophagus, bladder, pancreas, and breast; melanoma; multiple myeloma; hepatocellular carcinoma; renal cell carcinoma; and sarcomas. It is organized and written in a format that is easy to follow for both clinicians and non-clinical scientists interested in personalized medicine. Chapters cover the identification of the clinical problem and summary of recent findings, tumor biology and heterogeneity, genomics, examples of simple and complex cases, biological pathways, future clinical trials, and financial considerations. Oncology in the Precision Medicine Era: Value-Based Medicine will serve as a useful resource for medical oncologists and healthcare providers tailoring medicine to the needs of the individual patient, from prevention and diagnosis to treatment and follow up.

The Road from Nanomedicine to Precision Medicine

The Road from Nanomedicine to Precision Medicine
  • Author : Shaker A. Mousa,Raj Bawa,Gerald F. Audette
  • Publisher :Unknown
  • Release Date :2020-01-13
  • Total pages :1208
  • ISBN : 9781000021271
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Summary : The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.

Toward Precision Medicine

Toward Precision Medicine
  • Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
  • Publisher :Unknown
  • Release Date :2012-01-16
  • Total pages :142
  • ISBN : 9780309222228
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Summary : Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Precision Medicine: A Guide to Genomics in Clinical Practice

Precision Medicine: A Guide to Genomics in Clinical Practice
  • Author : Jeanette J. McCarthy,Bryce A. Mendelsohn
  • Publisher :Unknown
  • Release Date :2017-01-05
  • Total pages :304
  • ISBN : 9781259644146
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Summary : Incorporate genomics into every applicable area of your clinical practice with this complete how-to guide Precision Medicine: A Guide to Genomics in Clinical Practice is a comprehensive, yet succinct overview of the practice of genomic medicine. It is written for general healthcare practitioners, specialists, and trainees with the goal of providing detailed guidance on how to incorporate genomic medicine into daily practice. Features that make this book valuable to every practice: •Intentionally avoids excessive technical content and consistently emphasizes real-life patient care and decision support •Follows the course of a human life, beginning before conception through pregnancy, childhood, and adulthood, discussing the current and future applications of genomics and precision medicine at each stage •Organization allows healthcare providers to quickly and easily find the information relevant to their practice. •The authors highlight common pitfalls – technical and ethical – that might complicate the delivery of quality genomic healthcare •Enhanced by eleven valuable appendices that cover important topics ranging from the basics of genetics to ethical issues to regulation and reimbursement If you are searching for a clinically relevant, non-technical resource that will teach you how genomic medicine can and should be practiced in your specific field of interest, Precision Medicine: A Guide to Genomics in Clinical Practicebelongs on your desk.

Personalizing Precision Medicine

Personalizing Precision Medicine
  • Author : Kristin Ciriello Pothier
  • Publisher :Unknown
  • Release Date :2017-08-30
  • Total pages :272
  • ISBN : 9781118792124
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Summary : The author uses decades of experience and interviews with experts in precision medicine to explain past, present, and future of precision medicine. She reviews the full continuum of personalizing precision medicine, including diagnostics, therapeutics, big data, supportive care, regulation, and reimbursement and innovation in precision medicine worldwide. • Combines a unique cross section of history, current technologies, and future directions for how precision medicine has and will affect people worldwide • Reviews precision medicine around the world, including the US, China, Japan, the Middle East, India, Europe, and Latin America • Discusses a number of diseases areas – cancer, cardiovascular, neurodegenerative, infectious disease, pain, immunology, rare diseases • Includes information and quotes from over 100 interviews with key industry experts in biotech, pharma, informatics, diagnostics, health providers, advocacy groups, and more. • Includes stories illustrating current issues and future promises in precision medicine for a human touch

Companion Diagnostics (CDx) in Precision Medicine

Companion Diagnostics (CDx) in Precision Medicine
  • Author : Il-Jin Kim
  • Publisher :Unknown
  • Release Date :2019-03-06
  • Total pages :256
  • ISBN : 9781000007213
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Summary : There is a new trend in anti-cancer therapeutics development: a targeted therapy and precision medicine that targets a subgroup of patients with specific biomarkers. An in vitro diagnostic (IVD) assay is required to identify a subgroup of cancer patients who would benefit from the targeted therapy, or not likely benefit, or have a high risk of side effects from the specific drug treatment. This IVD or medical device is called a companion diagnostic (CDx) assay. It is key to have a robust CDx assay or device for the success of targeted therapy and precision medicine. This book covers the technical, historical, clinical, and regulatory aspects of CDx in precision medicine. Clearly, more and more newly developed oncology drugs will require accompanying CDx assays, and this book, with chapters contributed by renowned oncologists, provides a comprehensive foundation for the knowledge and application of CDx for precision medicine.

Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine
  • Author : Claudio Carini,Mark Fidock,Alain van Gool
  • Publisher :Unknown
  • Release Date :2019-04-16
  • Total pages :631
  • ISBN : 9780429576737
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Summary : "The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Personalized and Precision Medicine Informatics

Personalized and Precision Medicine Informatics
  • Author : Terrence Adam,Constantin Aliferis
  • Publisher :Unknown
  • Release Date :2019-09-17
  • Total pages :349
  • ISBN : 9783030186265
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Summary : This book adopts an integrated and workflow-based treatment of the field of personalized and precision medicine (PPM). Outlined within are established, proven and mature workflows as well as emerging and highly-promising opportunities for development. Each workflow is reviewed in terms of its operation and how they are enabled by a multitude of informatics methods and infrastructures. The book goes on to describe which parts are crucial to discovery and which are essential to delivery and how each of these interface and feed into one-another. Personalized and Precision Medicine Informatics provides a comprehensive review of the integrative as well as interpretive nature of the topic and brings together a large body of literature to define the topic and ensure that this is the key reference for the topic. It is an unique contribution that is positioned to be an essential guide for both PPM experts and non-experts, and for both informatics and non-informatics professionals.

Artificial Intelligence for Drug Development, Precision Medicine, and Healthcare

Artificial Intelligence for Drug Development, Precision Medicine, and Healthcare
  • Author : Mark Chang
  • Publisher :Unknown
  • Release Date :2020-05-12
  • Total pages :352
  • ISBN : 9781000767308
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Summary : Artificial Intelligence for Drug Development, Precision Medicine, and Healthcare covers exciting developments at the intersection of computer science and statistics. While much of machine-learning is statistics-based, achievements in deep learning for image and language processing rely on computer science’s use of big data. Aimed at those with a statistical background who want to use their strengths in pursuing AI research, the book: · Covers broad AI topics in drug development, precision medicine, and healthcare. · Elaborates on supervised, unsupervised, reinforcement, and evolutionary learning methods. · Introduces the similarity principle and related AI methods for both big and small data problems. · Offers a balance of statistical and algorithm-based approaches to AI. · Provides examples and real-world applications with hands-on R code. · Suggests the path forward for AI in medicine and artificial general intelligence. As well as covering the history of AI and the innovative ideas, methodologies and software implementation of the field, the book offers a comprehensive review of AI applications in medical sciences. In addition, readers will benefit from hands on exercises, with included R code.

Precision Medicine and the Reinvention of Human Disease

Precision Medicine and the Reinvention of Human Disease
  • Author : Jules J. Berman
  • Publisher :Unknown
  • Release Date :2018-01-26
  • Total pages :398
  • ISBN : 9780128143940
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Summary : Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Precision Medicine in Cancers and Non-Communicable Diseases

Precision Medicine in Cancers and Non-Communicable Diseases
  • Author : Debmalya Barh
  • Publisher :Unknown
  • Release Date :2018-09-03
  • Total pages :326
  • ISBN : 9781351650786
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Summary : The availability of human genome, large amount of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the era of clinical practice of "Precision Medicine". This book aims to provide a readily available resource on all the important developments achieved so far in the field of oncology. All recent developments have been explained along with epidemiology, technologies and approaches to manage the included diseases. Therefore, readers will get the up to date information on the next-generation approach in tackling all kinds of cancer. Key Features • Presents the latest trend of cancer management based on precision/predictive medicine approach • Reviews the latest and up to date literature in the field of Precision Medicine • Highlights the next generation approach in tackling malignant diseases • Discusses how a life-threatening disease like cancer can be managed with the help of Precision Medicine • Encapsulates a global prospective

Unlocking Precision Medicine

Unlocking Precision Medicine
  • Author : Paul Howard,Peter Huber
  • Publisher :Unknown
  • Release Date :2016-10-18
  • Total pages :48
  • ISBN : 9781594039188
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Summary : New medicines in the pipeline can extend lives, save money, and even help prevent disease before symptoms appear – if we don’t discourage their innovators and investors by trying to lower drug prices artificially. Unlocking Precision Medicine explores the environment necessary for creation of these health care game-changers, and explains how the marketplace can effectively make them more affordable to all without killing the golden goose.

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine
  • Author : Nosheen Masood,Saima Shakil Malik
  • Publisher :Unknown
  • Release Date :2020-03-20
  • Total pages :499
  • ISBN : 9789811510670
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Summary : This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Oxytocin's routes in social behavior: into the 21st century. “Precision Medicine” approach for Oxytocin

Oxytocin's routes in social behavior: into the 21st century. “Precision Medicine” approach for Oxytocin
  • Author : Alaine Keebaugh,Elissar Andari,Lisa A. Parr
  • Publisher :Unknown
  • Release Date :2015-12-21
  • Total pages :132
  • ISBN : 9782889196968
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Summary : Our brain is endowed with an incredible capacity to be social, to trust, to cooperate, to be altruistic, to feel empathy and love. Nevertheless, the biological underpinnings of such behaviors remain partially hardwired. Seminal research in rodents has provided important insights on the identification of specific genes in modulating social behaviors, in particular, the arginine vasopressin receptor and the oxytocin receptor genes. These genes are involved in regulating a wide range of social behaviors, mother-infant interactions, social recognition, aggression and socio-sexual behavior. Remarkably, we now know that these genes contribute to social behavior in a broad range of species from voles to humans. Indeed, advances in human non-invasive neuroimaging techniques and genetics have enabled scientists to begin to elucidate the neurobiological basis of the complexity of human social behaviors using "pharmacological fMRI" and "imaging genetics". Over the past few years, there has been a strong interest focused on the role of oxytocin in modulating human social behaviors with translational relevance for understanding neuropsychiatric disorders, such as autism, schizophrenia and depression, in which deficits in social perception and social recognition are key phenotypes. The convergence of this interdisciplinary research is beginning to reveal the complex nature of oxytocin’s actions. For instance, the way that oxytocin does influence social functioning is highly related to individual differences in social experiences, but also to the inter-individual variability in the receptor distribution of this molecule in the brain. Remarkably, despite the increasing evidence that oxytocin has a key role in regulating human social behavior, we still lack of knowledge on the core mechanisms of action of this molecule. Understanding its fundamental actions is a crucial need in order to target optimal therapeutic strategies for human social disorders. The originality of this Research Topic stands on its translational focus on bridging the gap between fundamental knowledge acquired from oxytocin research in voles and monkeys and recent clinical investigations in humans. For instance, what are the key animal findings that can import further knowledge on the mechanisms of actions of this molecule in humans? What are the key experiences that can be performed in the animal model in order to answer significant science gaps in the treatment of neuropsychiatric disorders? Hence, within this Research Topic, we will review the current state of the field, identify where the gaps in knowledge are, and propose directions for future research. This issue will begin with a comparative review that examines the role of this peptide in diverse animal models, which highlights the adaptive value of oxytocin’s function across multiple species. Then, a series of reviews will examine the role of oxytocin in voles, primates, and humans with an eye toward revealing commonalities in the underlying brain circuits mediating oxytocin’s effects on social behavior. Next, there will be a translational review highlighting the evidence for oxytocin’s role in clinical applications in psychopathology. Hence, via the continuum of basic to translational research areas, we will try to address the important gaps in our understanding of the neurobiological routes of social cognition and the mechanisms of action of the neuropeptides that guide our behaviors and decisions.

Precision Medicine in Cancer Therapy

Precision Medicine in Cancer Therapy
  • Author : Daniel D. Von Hoff,Haiyong Han
  • Publisher :Unknown
  • Release Date :2019-06-17
  • Total pages :283
  • ISBN : 9783030163914
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Summary : This book presents the latest advances in precision medicine in some of the most common cancer types, including hematological, lung and breast malignancies. It also discusses emerging technologies that are making a significant impact on precision medicine in cancer therapy. In addition to describing specific approaches that have already entered clinical practice, the book explores new concepts and tools that are being developed. Precision medicine aims to deliver personalized healthcare tailored to a patient’s genetics, lifestyle and environment, and cancer therapy is one of the areas in which it has flourished in recent years. Documenting the latest advances, this book is of interest to physicians and clinical fellows in the front line of the war on cancer, as well as to basic scientists working in the fields of cancer biology, drug development, biomarker discovery, and biomedical engineering. The contributing authors include translational physicians with first-hand experience in precision patient care.

Precision Medicine

Precision Medicine
  • Author : Gerard Blokdijk
  • Publisher :Unknown
  • Release Date :2017-10-29
  • Total pages :102
  • ISBN : 1979241384
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Summary : How do you use Precision Medicine data and information to support organizational decision making and innovation? Does the Precision Medicine performance meet the customer's requirements? What tools and technologies are needed for a custom Precision Medicine project? What potential environmental factors impact the Precision Medicine effort? Think about the people you identified for your Precision Medicine project and the project responsibilities you would assign to them. what kind of training do you think they would need to perform these responsibilities effectively? Defining, designing, creating, and implementing a process to solve a business challenge or meet a business objective is the most valuable role... In EVERY company, organization and department. Unless you are talking a one-time, single-use project within a business, there should be a process. Whether that process is managed and implemented by humans, AI, or a combination of the two, it needs to be designed by someone with a complex enough perspective to ask the right questions. Someone capable of asking the right questions and step back and say, 'What are we really trying to accomplish here? And is there a different way to look at it?' For more than twenty years, The Art of Service's Self-Assessments empower people who can do just that - whether their title is marketer, entrepreneur, manager, salesperson, consultant, business process manager, executive assistant, IT Manager, CxO etc... - they are the people who rule the future. They are people who watch the process as it happens, and ask the right questions to make the process work better. This book is for managers, advisors, consultants, specialists, professionals and anyone interested in Precision Medicine assessment. All the tools you need to an in-depth Precision Medicine Self-Assessment. Featuring 487 new and updated case-based questions, organized into seven core areas of process design, this Self-Assessment will help you identify areas in which Precision Medicine improvements can be made. In using the questions you will be better able to: - diagnose Precision Medicine projects, initiatives, organizations, businesses and processes using accepted diagnostic standards and practices - implement evidence-based best practice strategies aligned with overall goals - integrate recent advances in Precision Medicine and process design strategies into practice according to best practice guidelines Using a Self-Assessment tool known as the Precision Medicine Scorecard, you will develop a clear picture of which Precision Medicine areas need attention. Included with your purchase of the book is the Precision Medicine Self-Assessment downloadable resource, which contains all questions and Self-Assessment areas of this book in a ready to use Excel dashboard, including the self-assessment, graphic insights, and project planning automation - all with examples to get you started with the assessment right away. Access instructions can be found in the book. You are free to use the Self-Assessment contents in your presentations and materials for customers without asking us - we are here to help.