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Immunosensing for Detection of Protein Biomarkers

Immunosensing for Detection of Protein Biomarkers
  • Author : Huangxian Ju,Guosong Lai,Feng Yan
  • Publisher :Unknown
  • Release Date :2017-05-18
  • Total pages :304
  • ISBN : 9780081020005
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Summary : Immunosensing for Detection of Protein Biomarkers not only introduces the principles, methods, and classification of immunoassay, but also presents the latest achievements in areas such as electrochemical immunosensors, nanoprobe-based immunoassay, chemiluminescence immunoassay, electrochemiluminescent immunoassay, multianalyte immunoassay, optical imaging for immunoassay, signal amplification for immunoassay, and so on. In recent years, immunosensing and immunoassay methods have attracted considerable interest due to their applications in different fields, particularly clinical diagnosis. Although a large number of academic papers in immunosensing and immunoassay have been published in different journals recently, it is still a difficult and time-consuming task for researchers, especially those new to the area, to understand the principles, methods, and research progress of immunosensing. Based on the research experience of the authors and their research groups, this book offers readers with new research ideas to develop immunosensing methodology. As a monograph, it offers deeper and more complete coverage than review papers, which only report certain aspects of progress. Grounded in the research experience of Professor Ju’s research group, the book focuses on immunosensing for detection of protein biomarkers, summarizing understanding, research, and practice on immunosensing methodology in detection of protein biomarkers. Presents the latest research and thinking on immunosensing for detection of protein biomarkers Offers current techniques, and looks to the development of new methodologies Offers the latest developments in various aspects of immunosensing, including electrochemiluminescent immunoassay, multianalyte immunoassay, optical imaging immunoassay, and signal amplification immunoassay Offers readers new ideas to research and develop immunosensing methodologies for the future

Biomarkers and Biosensors

Biomarkers and Biosensors
  • Author : Ajit Sadana,Neeti Sadana
  • Publisher :Unknown
  • Release Date :2014-12-08
  • Total pages :702
  • ISBN : 9780444537959
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Summary : Biomarkers and Biosensors offers thorough coverage of biomarker/biosensor interaction, current research trends, and future developments in applications of drug discovery. This book is useful to researchers in this field as well as clinicians interested in new developments in early detection and diagnosis of disease or the mode of operation of biomarkers. Biomarkers and Biosensors also emphasizes kinetics, and clearly delineates how this influences the biomarker market. Offers thorough coverage of the kinetics of biomarker interaction with the biosensor surface Provides evidence-based approach to evaluate effectiveness Provides pharmaceutical chemists the possibilities and methodology in assessing the effectiveness of new drugs Provides the information needed for the selection of the best biomarker for a specific application

Biomarkers in Cancer Screening and Early Detection

Biomarkers in Cancer Screening and Early Detection
  • Author : Sudhir Srivastava
  • Publisher :Unknown
  • Release Date :2017-08-28
  • Total pages :320
  • ISBN : 9781118468807
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Summary : Nuts and bolts of biomarker research / Sharmistha Ghosh and Sudhir Srivastava -- Cancer genome methylation : biology, biomarker and therapeutic opportunities / Shashwat Sharad, Taduru Sreenath, Shiv Srivastava, and Albert Dobi -- Microrna biomarkers for early detection of cancer / Wendy Wang, Matthew R. Young, and Sudhir Srivastava -- Inflammation and cancer / Pamela L. Beatty, Sandra Cascio, and Olivera J Finn -- Exosomes : a valuable biomedical tool in biomarker discovery and development / Jocelyn Lee, Sharmistha Ghosh, and Sudhir Srivastava -- Epithelial-to-mesenchymal transition (EMT) : clinical implications / Elisa CWoodhouse and Suresh Mohla -- Breast cancer / Benjamin A. Katchman, Christos Patriotis, and Karen S Anderson -- Ovarian cancer / Christos Patriotis, Archana Simmons, Karen H. Lu, Robert C. Bast, Jr, and Steven J. Skates -- Esophageal cancer biomarkers / Yanxin Luo, Kishore Guda, Sanford Markowitz, Amitabh Chak, Andrew M Kaz, and William M Grady -- Predictive biomarkers for therapy in adenocarcinoma of the upper digestive tract / Heath D Skinner, Qiongrong Chen, Elena Elimova, Roopma Wadhwa, Shumei Song, and Jaffer A Ajani -- Pancreatic cancer / Sam CWang and Peter J Allen -- Colon cancer / Paul DWagner -- Prognosis and predictive biomarkers for colorectal cancer / Upender Manne, Balananda-Dhurjati Kumar Putcha, Temesgen Samuel, and Sudhir Srivastava -- Early detection of lung cancer / Mohamed Hassanein, Melinda C. Aldrich, Stephen A. Deppen, Karl E. Krueger, Eric L. Grogan, and Pierre P. Massion -- Commonalities in lung cancer and COPD / Malgorzata Wojtowicz and Eva Szabo -- Prostate cancer / Jacob Kagan, Ian M. Thompson, and Daniel W. Chan -- Improving the clinical validity of biomarker research in cancer detection / David F. Ransohoff -- Cancer overdiagnosis, ramifications and research strategies / Barbara K. Dunn and Barnett S. Kramer -- Predictive markers and driver genes from treatment trials : potential utility for early diagnosis / Brian S. Sorg, Sarfraz Memon, Kelly Y. Kim, Aniruddha Ganguly, Tracy Lively, James Tricoli, Magdalena Thurin, Lokesh Agrawal, Tawnya C. McKee, Barbara A. Conley, and J. Milburn Jessup -- Statistical consideration in predictive and prognostic markers / Fei Ye and Yu Shyr -- Clinical validation of molecular biomarkers in translational medicine / Harry B. Burke and William E. Grizzle -- Cancer biomarker assays : performance standards / Anna K Fuzery and Daniel W. Chan -- Bioethics and cancer biomarker research / Nathan Nobis, William Grizzle, and Stephen Sodeke -- Colon cancer screening / Molly Perencevich, Jennifer Inra, and Sapna Syngal

Urine

Urine
  • Author : Youhe Gao
  • Publisher :Unknown
  • Release Date :2019-09-16
  • Total pages :244
  • ISBN : 9789811391095
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Summary : This book demonstrates the potential of urine as a biomarker resource for early disease detection, covering the related theory, strategies, tools and findings. Biomarkers are measurable changes associated with diseases. Blood, as a critical part of its internal environment, is closely monitored and controlled by the body to maintain homeostasis, especially in the early stages of diseases. In contrast, urine, as a form of waste excreted by the body, collects a variety of substance changes. Accordingly, urine can offer an ideal resource for early biomarker discovery. In addition, urine is more stable than blood in vitro, and is easy to store and analyze. The book discusses exciting preliminary applications of urine biomarkers for diseases affecting major biological systems. Its main goal is to make scientists, clinicians and medical companies aware of this important, exciting, undeveloped, and profitable field.

Nanobiosensors

Nanobiosensors
  • Author : Aiguo Wu,Waheed S. Khan
  • Publisher :Unknown
  • Release Date :2020-06-02
  • Total pages :416
  • ISBN : 9783527345106
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Summary : Containing cutting edge research on the hot topic of nanobiosensor, this book will become highly read Biosensor research has recently re-emerged as most vibrant area in recent years particularly after the advent of novel nanomaterials of multidimensional features and compositions. Nanomaterials of different types and striking properties have played a positive role in giving the boost and accelerated pace to biosensors development technology. Nanobiosensors - From Design to Applications covers several aspects of biosensors beginning from the basic concepts to advanced level research. It will help to bridge the gap between various aspects of biosensors development technology and applications. It covers biosensors related material in broad spectrum such as basic concepts, biosensors & their classification, biomarkers & their role in biosensors, nanostructures-based biosensors, applications of biosensors in human diseases, drug detection, toxins, and smart phone based biosensors. Nanobiosensors - From Design to Applications will prove a source of inspiration for research on biosensors, their local level development and consequently using for practical application in different industries such as food, biomedical diagnosis, pharmaceutics, agriculture, drug discovery, forensics, etc. * Discusses the latest technology and advances in the field of nanobiosensors and their applications in human diseases, drug detection, toxins * Offers a broad and comprehensive view of cutting-edge research on advanced materials such as carbon materials, nitride based nanomaterials, metal and metal oxide based nanomaterials for the fast-developing nanobiosensors research * Goes to a wide scientific and industry audience Nanobiosensors - From Design to Applications is a resource for polymer chemists, spectroscopists, materials scientists, physical chemists, surface chemists, and surface physicists.

Biomarkers in Toxicology

Biomarkers in Toxicology
  • Author : Ramesh C. Gupta
  • Publisher :Unknown
  • Release Date :2019-02-13
  • Total pages :1246
  • ISBN : 9780128146569
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Summary : Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more

Role of Biomarkers in Medicine

Role of Biomarkers in Medicine
  • Author : Mu Wang,Frank Witzmann
  • Publisher :Unknown
  • Release Date :2016-08-17
  • Total pages :260
  • ISBN : 9789535125051
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Summary : The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.

Cancer Biomarkers

Cancer Biomarkers
  • Author : Institute of Medicine,Committee on Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment
  • Publisher :Unknown
  • Release Date :2007-03-27
  • Total pages :250
  • ISBN : 0309133998
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Summary : Many cancer patients are diagnosed at a stage in which the cancer is too far advanced to be cured, and most cancer treatments are effective in only a minority of patients undergoing therapy. Thus, there is tremendous opportunity to improve the outcome for people with cancer by enhancing detection and treatment approaches. Biomarkers will be instrumental in making that transition. Advances in biotechnology and genomics have given scientists new hope that biomarkers can be used to improve cancer screening and detection, to improve the drug development process, and to enhance the effectiveness and safety of cancer care by allowing physicians to tailor treatment for individual patients—an approach known as personalized medicine. However, progress overall has been slow, despite considerable effort and investment, and there are still many challenges and obstacles to overcome before this paradigm shift in oncology can become a reality.

The Limits of Organic Life in Planetary Systems

The Limits of Organic Life in Planetary Systems
  • Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Division on Engineering and Physical Sciences,Space Studies Board,Committee on the Origins and Evolution of Life,Committee on the Limits of Organic Life in Planetary Systems
  • Publisher :Unknown
  • Release Date :2007-07-26
  • Total pages :116
  • ISBN : 9780309104845
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Summary : The search for life in the solar system and beyond has to date been governed by a model based on what we know about life on Earth (terran life). Most of NASA's mission planning is focused on locations where liquid water is possible and emphasizes searches for structures that resemble cells in terran organisms. It is possible, however, that life exists that is based on chemical reactions that do not involve carbon compounds, that occurs in solvents other than water, or that involves oxidation-reduction reactions without oxygen gas. To assist NASA incorporate this possibility in its efforts to search for life, the NRC was asked to carry out a study to evaluate whether nonstandard biochemistry might support life in solar system and conceivable extrasolar environments, and to define areas to guide research in this area. This book presents an exploration of a limited set of hypothetical chemistries of life, a review of current knowledge concerning key questions or hypotheses about nonterran life, and suggestions for future research.

Detection of Drug Misuse

Detection of Drug Misuse
  • Author : Kim Wolff
  • Publisher :Unknown
  • Release Date :2017-04-13
  • Total pages :396
  • ISBN : 9781782621577
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Summary : This book describes recent advances in biomarkers, instrumentation and analysis methodology for identifying drug misuse. It is aimed at healthcare professionals, academics and postgraduates.

Early Detection of Cancer

Early Detection of Cancer
  • Author : Sudhir Srivastava
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :98
  • ISBN : 1586035525
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Summary : Technological inventions allow us to identify molecular events that will effectively detect cancer earlier in biological specimens. This approach enables us to develop molecular biomarkers for detecting cancer early. It is believed that such a molecular marker approach enables the detection of the disease earlier.

Early Detection of Biomarkers for Disease

Early Detection of Biomarkers for Disease
  • Author : Richard Morgan,Nicholas Hoyle
  • Publisher :Unknown
  • Release Date :2014-03-01
  • Total pages :250
  • ISBN : 1849736138
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Summary : This volume presents the current knowledge on biomarkers for the early detection of disease, and the methodologies used for detecting these biomarkers, often present at very low concentrations in bodily fluids.

Biomarkers

Biomarkers
  • Author : Vishal S. Vaidya,Joseph V. Bonventre
  • Publisher :Unknown
  • Release Date :2010-10-28
  • Total pages :632
  • ISBN : 0470918551
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Summary : This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.

Invasive Bladder Cancer

Invasive Bladder Cancer
  • Author : PierFrancesco Bassi,Francesco Pagano
  • Publisher :Unknown
  • Release Date :2007-07-29
  • Total pages :303
  • ISBN : 9781846283772
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Summary : Invasive bladder tumors affect the muscle wall, and have a propensity to metastasize and spread to other areas of the body, and are more likely to be fatal. This book presents state-of-the-art diagnoses and treatments available for bladder cancer that has metastasised into the body. A thorough review of current practice is presented in a full color volume with more than 40 tables and 50 illustrations. The book offers a comprehensive review of the subject, covering epidemiology, screening, diagnostic factors, surgery, chemotherapy and post-operative monitoring. Most chapters are jointly written by a basic researcher and a clinician.

Cancer Biomarkers

Cancer Biomarkers
  • Author : Debmalya Barh,Angelo Carpi,Mukesh Verma,Mehmet Gunduz
  • Publisher :Unknown
  • Release Date :2014-01-30
  • Total pages :951
  • ISBN : 9781466584280
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Summary : Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer markers that are under development or currently in use. It deals with a majority of commonly prevalent cancers and can help anyone working in the health-care industry to recommend or develop early diagnostics, at-risk tests, and prognostic biomarkers for various cancers. It explores the practice of determining biomarkers by their characteristics and relative methodologies, and presents the most recent data as well as a number of current and upcoming early diagnostic noninvasive molecular markers for many common cancers. It also considers the sensitivity and specificity of markers, biomarker market, test providers, and patent information. Approximately 30-35 Cancer Specific Noninvasive Molecular Diagnostic Markers in a Single Volume The book details the general and technical aspects of noninvasive cancer markers. It covers imaging, cutting-edge molecular technologies for biomarker development, and noninvasive or minimally invasive sources of molecular markers, as well as quality control and ethical issues in cancer biomarker discovery. It also provides a detailed account of brain, head and neck, and oral cancer markers, and provides information on a number of gastrointestinal cancers, lung cancer, and mesothelioma markers. Emphasizes the Importance of Volatile Markers in Early Cancer Diagnosis Presents noninvasive early molecular markers in urological cancers Describes gynecological and endocrine cancer markers Details noninvasive markers of breast, ovarian, cervical, and thyroid cancers Addresses hematological malignancies Contains information on noninvasive molecular markers in myelodysplastic syndromes, acute myeloid leukemia, Hodgkin’s lymphoma, and multiple myeloma Provides comprehensive information on diagnostic and prognostic biomarkers in cutaneous melanoma This text considers molecular technologies for biomarker development, noninvasive or minimally invasive sources of molecular markers, and quality control and ethical issues in cancer biomarker discovery.

Cancer Biomarkers

Cancer Biomarkers
  • Author : Alexandros G Georgakilas
  • Publisher :Unknown
  • Release Date :2012-11-19
  • Total pages :382
  • ISBN : 9781466565531
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Summary : This unique synthesis of chapters from top experts in their fields targets the essential area of cancer biomarkers and the need for better and more rigorous design and clinical trials. The contributors cover several aspects of cancer molecular markers from innovation and screening to their controversies and future directions. The book is an ideal r

Predictive Biomarkers in Oncology

Predictive Biomarkers in Oncology
  • Author : Sunil Badve,George Louis Kumar
  • Publisher :Unknown
  • Release Date :2018-12-06
  • Total pages :642
  • ISBN : 9783319952284
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Summary : “Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed “predictive biomarker”. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner. This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized. Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how “predictive biomarkers” are used in precision cancer therapy.

Ovarian Cancer

Ovarian Cancer
  • Author : Omer Devaja,Andreas Papadopoulos
  • Publisher :Unknown
  • Release Date :2018-10-24
  • Total pages :364
  • ISBN : 9781789843330
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Summary : Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

Detection Methods in Precision Medicine

Detection Methods in Precision Medicine
  • Author : Mengsu Yang,Michael Thompson
  • Publisher :Unknown
  • Release Date :2020-12-14
  • Total pages :370
  • ISBN : 9781788017619
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Summary : This book will be among the first to cover the detection methods for precision medicine that are set to transform health care in the future.

Evolution of Translational Omics

Evolution of Translational Omics
  • Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
  • Publisher :Unknown
  • Release Date :2012-09-13
  • Total pages :354
  • ISBN : 9780309224185
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Summary : Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Imaging Biomarkers

Imaging Biomarkers
  • Author : Luis Martí-Bonmatí,Angel Alberich-Bayarri
  • Publisher :Unknown
  • Release Date :2016-11-03
  • Total pages :316
  • ISBN : 9783319435046
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Summary : This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.