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The Guide to Investigation of Mouse Pregnancy

The Guide to Investigation of Mouse Pregnancy
  • Author : B. Anne Croy,Aureo T. Yamada,Francesco J. DeMayo,S. Lee Adamson
  • Publisher :Unknown
  • Release Date :2013-12-09
  • Total pages :832
  • ISBN : 9780123947949
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Summary : The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications Describes the angiogenic tree the mother’s uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success

Pathology of the Developing Mouse

Pathology of the Developing Mouse
  • Author : Brad Bolon
  • Publisher :Unknown
  • Release Date :2015-04-24
  • Total pages :446
  • ISBN : 9781420070095
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Summary : Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

Kaufman’s Atlas of Mouse Development Supplement

Kaufman’s Atlas of Mouse Development Supplement
  • Author : Richard Baldock,Jonathan Bard,Duncan Davidson,Gillian Morriss-Kay
  • Publisher :Unknown
  • Release Date :2015-09-23
  • Total pages :344
  • ISBN : 9780128009130
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Summary : Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. Provides high-resolution images for best visualization of key developmental processes and structures Offers in-depth anatomy and morphological views of organ systems Written descriptions convey developmental origins of the organ systems

Understanding the Materno-Fetal Interface During Microbial Infections

Understanding the Materno-Fetal Interface During Microbial Infections
  • Author : Demba Sarr,Ricardo E. Fretes,Ulrike Kemmerling,Sodiomon B. Sirima
  • Publisher :Unknown
  • Release Date :2020-12-11
  • Total pages :229
  • ISBN : 9782889662401
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Summary : Pregnancy is a physiologically and immunologically challenging health state. Immunological and physiological changes throughout the course of pregnancy make pregnant women usually susceptible to infection with microbial agents. Infections with pathogens during pregnancy can have devastating consequences to both the fetus and his/her mother. These infections are linked with adverse pregnancy outcomes. Infections with parasites, viruses, or bacteria can be associated with maternal anemia, abortion, intrauterine growth retardation, preterm delivery, fetal morbidity and high risk of mortality during the first years of life. Despite these significant consequences and complications associated with infections by microbial pathogens during the course of gestation, very little is known about the underlying mechanisms of the pathogenesis and immunopathology of infections during pregnancy. The Research Topic proposed here in, will focus on microbial infections during pregnancy. Studies and review papers addressing the pregnant host/fetus/pathogen interactions, the host/fetus immunological response against infections during gestation, trans-placental transfer of infections during pregnancy are welcome. Topics related to model systems used to mirror the biology in human, the pathogenesis and molecular pathways as well as the mechanisms of the disease at the maternofetal interface including the placenta, the amniotic fluid, and the fetal membranes will be considered making the scope and interest of the topic relatively broad. There is a growing number of pathogens associated with pregnancy. In most cases, women are more susceptible to infections with these pathogens when they become pregnant in comparison to their non-pregnant counterparts. Unfortunately, vertical transmission occurs in most cases but the underlying mechanisms are still unknown. The placenta has always been considered as a barrier against congenital infections but studies have indicated that microbial pathogens breach this barrier. The amniotic fluid, and the fetal membranes are also important components of vertical transmission because of their non-sterile state even in most healthy pregnancies. During pregnancy, infections by malaria or toxoplasmosis as well as other viral or bacterial pathogens lead to an uncontrolled inflammatory response recognized as a significant cause for preterm delivery and intra uterine growth retardation leading to low birth weight, a risk factor to infant morbidity and mortality. To successfully prevent, treat, eradicate or educate about microbial infections during pregnancy, we must understand the molecular mechanisms by which they cause poor birth outcomes including how vertical transmission occurs at the maternofetal interface.

Point Particles to Capture Polarized Embryonic Cells & Cold Pools in the Atmosphere

Point Particles to Capture Polarized Embryonic Cells & Cold Pools in the Atmosphere
  • Author : Silas Boye Nissen
  • Publisher :Unknown
  • Release Date :2020-08-31
  • Total pages :319
  • ISBN : 1230987654XX
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Summary : Part 1: How are the incredible diversity and robustness compatible with animal morphologies? Based on apical-basal and planar cell polarities’ ubiquity, I suggest a 3D mathematical model: Point particles represent cells having zero, one, or two unit-arrows representing polarities. I test the model abilities on preimplantation development, sea urchin gastrulation, mammalian neurulation, organoid folding, and tubulogenesis. I find that a minimal, versatile toolbox, including cellular polarities, captures the emergence of diverse and robust animal morphologies. Part 2: How are deep convective events spatially organized in the tropical atmosphere? Here, I test the importance of atmospheric cold pools for organizing convection. I suggest a 2D mathematical model: Points expand into circles representing cold pools. When circles meet, a convective event occurs, and a new circle forms. I find this model captures convective scale increase and initial stages of convective self-aggregation. The latter is crucial due to its link to tropical cyclogenesis.

Reproduction in Mammals

Reproduction in Mammals
  • Author : Virginia Hayssen,Teri J. Orr
  • Publisher :Unknown
  • Release Date :2017-10-27
  • Total pages :368
  • ISBN : 9781421423166
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Summary : Readers will come away from this thought-provoking book with an understanding of not only how reproduction fits into the lives of female mammals but how biology has affected the enormously diverse reproductive patterns of the phenotypes we observe today.

The Vertebrate Blood-Gas Barrier in Health and Disease

The Vertebrate Blood-Gas Barrier in Health and Disease
  • Author : Andrew N. Makanya
  • Publisher :Unknown
  • Release Date :2015-08-27
  • Total pages :243
  • ISBN : 9783319183923
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Summary : This comprehensive volume on the blood-gas barrier (BGB) among vertebrates covers its structure and composition along with aspects of evolution, bioengineering, and morphometry. The book also discusses the embryological development of the BGB, including chronology of events and molecular control in vertebrates; modulation of the barrier function, including cyclic stretch-induced increases in alveolar epithelial permeability; mechanisms of lung vascular/epithelial permeability; transport mechanisms of the BGB, including sodium transport channels; factors affecting trans-barrier traffic of fluids, such as chronic elevation of pulmonary microvascular pressure; stress failure; regulation and repair in acute lung injury; chronic lung disease; and lung transportation. Ten authoritative chapters approach the blood-gas barrier holistically, from basic structure and development to pathology and treatment. Properties of the BGB are discussed in the earlier chapters, followed by prenatal and post-natal development and mechanisms of the healthy BGB. The latter half of the book delves into the pathology of the BGB, analyzing common afflictions and exploring options for treatment, including its alterations during lung transplantation. Intuitively structured and comprehensive, The Vertebrate Blood-Gas Barrier in Health and Disease is ideal for researchers and clinicians interested in pneumology and angiology.

Advances in Biomechanics and Tissue Regeneration

Advances in Biomechanics and Tissue Regeneration
  • Author : Mohamed Hamdy Doweidar
  • Publisher :Unknown
  • Release Date :2019-08-13
  • Total pages :430
  • ISBN : 9780128166109
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Summary : Advances in Biomechanics and Tissue Regeneration covers a wide range of recent development and advances in the fields of biomechanics and tissue regeneration. It includes computational simulation, soft tissues, microfluidics, the cardiovascular system, experimental methods in biomechanics, mechanobiology and tissue regeneration. The state-of-the-art, theories and application are presented, making this book ideal for anyone who is deciding which direction to take their future research in this field. In addition, it is ideal for everyone who is exploring new fields or currently working on an interdisciplinary project in tissue biomechanics. Combines new trends in biomechanical modelling and tissue regeneration Offers a broad scope, covering the entire field of tissue biomechanics Contains perspectives from engineering, medicine and biology, thus giving a holistic view of the field

Pericyte Biology in Different Organs

Pericyte Biology in Different Organs
  • Author : Alexander Birbrair
  • Publisher :Unknown
  • Release Date :2019-04-01
  • Total pages :277
  • ISBN : 9783030110932
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Summary : The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of thirteen detailed chapters on what we know so far about pericytes in distinct organs in physiological and pathological conditions. Further, it provides an update on the most novel functions attributed to these cells and will introduce a newer generation of researchers and scientists to the importance of these cells, ranging from their discovery in different organs through current state-of-the-science. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and vascular research. This volume explores pericytes' physiologic roles in different tissues, ranging from the pancreas, lungs and liver through skeletal muscle, gut, retina and more. Together with its companion volumes Pericyte Biology in Disease and Pericyte Biology – Novel Concepts, Pericyte Biology in Different Organs presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific organs.

Child Protective Services

Child Protective Services
  • Author : Diane Depanfilis
  • Publisher :Unknown
  • Release Date :1992-07-01
  • Total pages :98
  • ISBN : 0788119486
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Summary : Provides the foundation for casework practice in Child Protective Services (CPS). Describes the basic stages of the CPS process and the steps necessary to accomplish successfully each stage: intake, initial assessment/investigation, family assessment, case planning, service provision, and evaluation of family progress and case closure. Designed primarily for CPS caseworkers, supervisors, and administrators. Glossary. Bibiography.

Causes and Consequences of Intrauterine Growth Restriction

Causes and Consequences of Intrauterine Growth Restriction
  • Author : Elke Winterhager,Ivo Bendix,Suzanne Lee Miller
  • Publisher :Unknown
  • Release Date :2020-06-04
  • Total pages :229
  • ISBN : 9782889637683
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Summary :

Management of Animal Care and Use Programs in Research, Education, and Testing

Management of Animal Care and Use Programs in Research, Education, and Testing
  • Author : Robert H. Weichbrod,Gail A. (Heidbrink) Thompson,John N. Norton
  • Publisher :Unknown
  • Release Date :2017-09-07
  • Total pages :872
  • ISBN : 9781498748452
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Summary : AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work with a multi-generational, multi-cultural workforce. This book is the ideal resource for these professionals. It also serves as an indispensable resource text for certification exams and credentialing boards for a multitude of professional societies Co-publishers on the second edition are: ACLAM (American College of Laboratory Animal Medicine); ECLAM (European College of Laboratory Animal Medicine); IACLAM (International Colleges of Laboratory Animal Medicine); JCLAM (Japanese College of Laboratory Animal Medicine); KCLAM (Korean College of Laboratory Animal Medicine); CALAS (Canadian Association of Laboratory Animal Medicine); LAMA (Laboratory Animal Management Association); and IAT (Institute of Animal Technology).

Immunization in Practice

Immunization in Practice
  • Author : World Health Organization
  • Publisher :Unknown
  • Release Date :2015
  • Total pages :279
  • ISBN : 9789241549097
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Summary : This practical guide contains seven modules targeted at district and health facility staff. It intends to meet the demands to improve immunization services so as to reach more infants in a sustainable way, building upon the experiences of polio eradication. It includes materials adapted from polio on planning, monitoring and use of data to improve the service, that can be used at any level. Revising the manual has been a team exercise. There are contributions from a large number of experts, organizations and institutions. This new edition has seven modules. Several new vaccines that have become more readily available and used in recent years have been added. Also the section on integration with other health interventions has been expanded as exciting opportunities and experiences have become evident in the years following the previous edition. Module 1: Target diseases and vaccines Module 2: The vaccine cold chain Module 3: Ensuring safe injections Module 4: Microplanning for reaching every community Module 5: Managing an immunization session Module 6: Monitoring and surveillance Module 7: Partnering with communities.

WHO Guidelines on Drawing Blood

WHO Guidelines on Drawing Blood
  • Author : Neelam Dhingra
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :109
  • ISBN : 9241599227
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Summary : Phlebotomy uses large, hollow needles to remove blood specimens for lab testing or blood donation. Each step in the process carries risks - both for patients and health workers. Patients may be bruised. Health workers may receive needle-stick injuries. Both can become infected with bloodborne organisms such as hepatitis B, HIV, syphilis or malaria. Moreover, each step affects the quality of the specimen and the diagnosis. A contaminated specimen will produce a misdiagnosis. Clerical errors can prove fatal. The new WHO guidelines provide recommended steps for safe phlebotomy and reiterate accepted principles for drawing, collecting blood and transporting blood to laboratories/blood banks.

The Psychosocial Implications of Disney Movies

The Psychosocial Implications of Disney Movies
  • Author : Lauren Dundes
  • Publisher :Unknown
  • Release Date :2019-07-11
  • Total pages :246
  • ISBN : 9783038978480
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Summary : In this volume of 15 articles, contributors from a wide range of disciplines present their analyses of Disney movies and Disney music, which are mainstays of popular culture. The power of the Disney brand has heightened the need for academics to question whether Disney’s films and music function as a tool of the Western elite that shapes the views of those less empowered. Given its global reach, how the Walt Disney Company handles the role of race, gender, and sexuality in social structural inequality merits serious reflection according to a number of the articles in the volume. On the other hand, other authors argue that Disney productions can help individuals cope with difficult situations or embrace progressive thinking. The different approaches to the assessment of Disney films as cultural artifacts also vary according to the theoretical perspectives guiding the interpretation of both overt and latent symbolic meaning in the movies. The authors of the 15 articles encourage readers to engage with the material, showcasing a variety of views about the good, the bad, and the best way forward.

PISA Take the Test Sample Questions from OECD's PISA Assessments

PISA Take the Test Sample Questions from OECD's PISA Assessments
  • Author : OECD
  • Publisher :Unknown
  • Release Date :2009-02-02
  • Total pages :318
  • ISBN : 9789264050815
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Summary : This book presents all the publicly available questions from the PISA surveys. Some of these questions were used in the PISA 2000, 2003 and 2006 surveys and others were used in developing and trying out the assessment.

Granulated Metrial Gland Cells

Granulated Metrial Gland Cells
  • Author : Sandra Peel
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :112
  • ISBN : 9783642741708
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Summary : 1. 1 Historical Aspects and Terminology Granulated metrial gland (GMG) cells are readily identified by their cytoplasmic granules and were observed a number of years before the term "metrial gland" was introduced. A series of papers by Duval in 1891 provided a comprehensive description and a critical review of earlier studies of the placenta of rodents, but it was not until 1902 that the first convincing illustrations of GMG cells appeared in the literature (Jenkinson 1902). Jenkinson described "maternal glycogen cells" in the pregnant mouse uterus and noted that they contained cytoplasmic granules which stained with a variety of dyes. From his detailed description of the appearance and distribution of these maternal glycogen cells it is clear that he had observed what are now called granulated metrial gland cells. In 1911 Ancel and Bouin used the phrase une glande myometriale endocrine to describe a structure appearing between the muscle layers of the uterus at the insertion site of the placenta in rabbits. They described one of the cell types present in the glande myometriale as having the characteristics of glandular cells and noted their content of safraninophilic cytoplasmic granules. A glande myometriale endo crine was also described in the pregnant rat uterus by Weill (1919). He reported that the cellules granuleuses contained acidophilic inclusions and despite the absence of any illustrations in his paper it is apparent that he also had observed GMG cells.

Communicating Risks and Benefits

Communicating Risks and Benefits
  • Author : Baruch Fischhoff
  • Publisher :Unknown
  • Release Date :2012-03-08
  • Total pages :240
  • ISBN : 0160901790
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Summary : Effective risk communication is essential to the well-being of any organization and those people who depend on it. Ineffective communication can cost lives, money and reputations. Communicating Risks and Benefits: An Evidence-Based User’s Guide provides the scientific foundations for effective communications. The book authoritatively summarizes the relevant research, draws out its implications for communication design, and provides practical ways to evaluate and improve communications for any decision involving risks and benefits. Topics include the communication of quantitative information and warnings, the roles of emotion and the news media, the effects of age and literacy, and tests of how well communications meet the organization’s goals. The guide will help users in any organization, with any budget, to make the science of their communications as sound as the science that they are communicating.

Manipulating the Mouse Embryo

Manipulating the Mouse Embryo
  • Author : Andras Nagy,Marina Gertsenstein,Richard R. Behringer,Kristina Vintersten
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :764
  • ISBN : 0879695749
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Summary : Provides information and guidelines for developing a mouse colony and conducting experiments, including proper protocols, step-by-step procedures, and analysis strategies.

Guidance for the Description of Animal Research in Scientific Publications

Guidance for the Description of Animal Research in Scientific Publications
  • Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research
  • Publisher :Unknown
  • Release Date :2011-09-16
  • Total pages :42
  • ISBN : 9780309219549
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Summary : The publication of research articles involving animal studies is central to many disciplines in science and biomedicine. Effective descriptions in such publications enable researchers to interpret the data, evaluate and replicate findings, and move the science forward. Analyses of published studies with research animals have demonstrated numerous deficiencies in the reporting of details in research methods for animal studies. Considerable variation in the amount of information required by scientific publications and reported by authors undermines this basic scientific principle and results in the unnecessary use of animals and other resources in failed efforts to reproduce study results. Guidance for the Description of Animal Research in Scientific Publications outlines the information that should be included in scientific papers regarding the animal studies to ensure that the study can be replicated. The report urges journal editors to actively promote effective and ethical research by encouraging the provision of sufficient information. Examples of this information include: conditions of housing and husbandry, genetic nomenclature, microbial status, detailed experimental manipulations, and handling and use of pharmaceuticals. Inclusion of this information will enable assessment and interpretation of research findings and advancement of knowledge based on reproducible results.

Nutrient Requirements of Laboratory Animals,

Nutrient Requirements of Laboratory Animals,
  • Author : National Research Council,Board on Agriculture,Committee on Animal Nutrition,Subcommittee on Laboratory Animal Nutrition
  • Publisher :Unknown
  • Release Date :1995-02-01
  • Total pages :192
  • ISBN : 9780309051262
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Summary : In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparation--including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.