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The Guide to Investigation of Mouse Pregnancy

The Guide to Investigation of Mouse Pregnancy
  • Author : B. Anne Croy,Aureo T. Yamada,Francesco J. DeMayo,S. Lee Adamson
  • Publisher :Unknown
  • Release Date :2013-12-09
  • Total pages :832
  • ISBN : 9780123947949
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Summary : The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications Describes the angiogenic tree the mother’s uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success

Pathology of the Developing Mouse

Pathology of the Developing Mouse
  • Author : Brad Bolon
  • Publisher :Unknown
  • Release Date :2015-04-24
  • Total pages :446
  • ISBN : 9781420070095
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Summary : Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

Kaufman’s Atlas of Mouse Development Supplement

Kaufman’s Atlas of Mouse Development Supplement
  • Author : Richard Baldock,Jonathan Bard,Duncan Davidson,Gillian Morriss-Kay
  • Publisher :Unknown
  • Release Date :2015-09-23
  • Total pages :344
  • ISBN : 9780128009130
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Summary : Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. Provides high-resolution images for best visualization of key developmental processes and structures Offers in-depth anatomy and morphological views of organ systems Written descriptions convey developmental origins of the organ systems

Understanding the Materno-Fetal Interface During Microbial Infections

Understanding the Materno-Fetal Interface During Microbial Infections
  • Author : Demba Sarr,Ricardo E. Fretes,Ulrike Kemmerling,Sodiomon B. Sirima
  • Publisher :Unknown
  • Release Date :2020-12-11
  • Total pages :229
  • ISBN : 9782889662401
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Summary : Pregnancy is a physiologically and immunologically challenging health state. Immunological and physiological changes throughout the course of pregnancy make pregnant women usually susceptible to infection with microbial agents. Infections with pathogens during pregnancy can have devastating consequences to both the fetus and his/her mother. These infections are linked with adverse pregnancy outcomes. Infections with parasites, viruses, or bacteria can be associated with maternal anemia, abortion, intrauterine growth retardation, preterm delivery, fetal morbidity and high risk of mortality during the first years of life. Despite these significant consequences and complications associated with infections by microbial pathogens during the course of gestation, very little is known about the underlying mechanisms of the pathogenesis and immunopathology of infections during pregnancy. The Research Topic proposed here in, will focus on microbial infections during pregnancy. Studies and review papers addressing the pregnant host/fetus/pathogen interactions, the host/fetus immunological response against infections during gestation, trans-placental transfer of infections during pregnancy are welcome. Topics related to model systems used to mirror the biology in human, the pathogenesis and molecular pathways as well as the mechanisms of the disease at the maternofetal interface including the placenta, the amniotic fluid, and the fetal membranes will be considered making the scope and interest of the topic relatively broad. There is a growing number of pathogens associated with pregnancy. In most cases, women are more susceptible to infections with these pathogens when they become pregnant in comparison to their non-pregnant counterparts. Unfortunately, vertical transmission occurs in most cases but the underlying mechanisms are still unknown. The placenta has always been considered as a barrier against congenital infections but studies have indicated that microbial pathogens breach this barrier. The amniotic fluid, and the fetal membranes are also important components of vertical transmission because of their non-sterile state even in most healthy pregnancies. During pregnancy, infections by malaria or toxoplasmosis as well as other viral or bacterial pathogens lead to an uncontrolled inflammatory response recognized as a significant cause for preterm delivery and intra uterine growth retardation leading to low birth weight, a risk factor to infant morbidity and mortality. To successfully prevent, treat, eradicate or educate about microbial infections during pregnancy, we must understand the molecular mechanisms by which they cause poor birth outcomes including how vertical transmission occurs at the maternofetal interface.

The Vertebrate Blood-Gas Barrier in Health and Disease

The Vertebrate Blood-Gas Barrier in Health and Disease
  • Author : Andrew N. Makanya
  • Publisher :Unknown
  • Release Date :2015-08-27
  • Total pages :243
  • ISBN : 9783319183923
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Summary : This comprehensive volume on the blood-gas barrier (BGB) among vertebrates covers its structure and composition along with aspects of evolution, bioengineering, and morphometry. The book also discusses the embryological development of the BGB, including chronology of events and molecular control in vertebrates; modulation of the barrier function, including cyclic stretch-induced increases in alveolar epithelial permeability; mechanisms of lung vascular/epithelial permeability; transport mechanisms of the BGB, including sodium transport channels; factors affecting trans-barrier traffic of fluids, such as chronic elevation of pulmonary microvascular pressure; stress failure; regulation and repair in acute lung injury; chronic lung disease; and lung transportation. Ten authoritative chapters approach the blood-gas barrier holistically, from basic structure and development to pathology and treatment. Properties of the BGB are discussed in the earlier chapters, followed by prenatal and post-natal development and mechanisms of the healthy BGB. The latter half of the book delves into the pathology of the BGB, analyzing common afflictions and exploring options for treatment, including its alterations during lung transplantation. Intuitively structured and comprehensive, The Vertebrate Blood-Gas Barrier in Health and Disease is ideal for researchers and clinicians interested in pneumology and angiology.

Drugs in Pregnancy and Lactation

Drugs in Pregnancy and Lactation
  • Author : Gerald G. Briggs,Roger K. Freeman,Sumner J. Yaffe
  • Publisher :Unknown
  • Release Date :2012-03-28
  • Total pages :1728
  • ISBN : 9781451153590
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Summary : An A-Z listing of drugs by generic name. Each monograph summarizes the known and/or possible effects of the drug on the fetus. It also summarizes the known/possible passage of the drug into the human breast milk. A careful and exhaustive summarization of the world literature as it relates to drugs in pregnancy and lacation. Each monograph contains six parts: generic US name, Pharmacologic class, Risk factor, Fetal risk summary, Breast feeding summary, References

Exercise and Sporting Activity During Pregnancy

Exercise and Sporting Activity During Pregnancy
  • Author : Rita Santos-Rocha
  • Publisher :Unknown
  • Release Date :2018-12-13
  • Total pages :345
  • ISBN : 9783319910321
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Summary : This clinically and practice oriented, multidisciplinary book is intended to fill the gap between evidence-based knowledge on the benefits of physical activity and exercise during pregnancy and the implementation of exercise programmes and related health promotion measures in pregnant women. It will provide medical, sports, and fitness professionals both with the knowledge needed to allay undue fears regarding the consequences of exercising during pregnancy and with the practical expertise to offer optimal guidance on exercising to pregnant exercisers and athletes. Readers will find up-to-date evidence on the psychological, social, physiological, body composition, musculoskeletal, and biomechanical changes that occur during pregnancy and their implications for physical activity and exercise. Detailed descriptions are provided of the components of exercise testing and prescription for pregnant women, the current evidence-based and practice-oriented guidelines, and exercise selection and adaptation during pregnancy. Exercises specifically targeting musculoskeletal health are discussed separately, and a concluding chapter explains the nutritional requirements in pregnant women who exercise.

Musculoskeletal Health in Pregnancy and Postpartum

Musculoskeletal Health in Pregnancy and Postpartum
  • Author : Colleen Fitzgerald,Neil Segal
  • Publisher :Unknown
  • Release Date :2015-04-04
  • Total pages :284
  • ISBN : 9783319143194
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Summary : Providing clinicians with a comprehensive, evidence-based summary of musculoskeletal health in pregnancy and postpartum, this is the first book of its kind to describe the physiologic changes, prevalence, etiology, diagnostic strategies, and effective treatments for the most common musculoskeletal clinical conditions encountered during this phase of life. Lumbopelvic pain, upper and lower extremity diagnoses, labor and delivery considerations, including the impact on the pelvic floor, and medical therapeutics will be discussed. Additionally, the importance and influence of exercise in pregnancy, the long-term implications of musculoskeletal health in pregnancy and current and future directions for research will be addressed. The childbearing period is a time of remarkable reproductive and musculoskeletal change, predisposing women to potential injury, pain, and resultant disability. Musculoskeletal Health in Pregnancy and Postpartum offers musculoskeletal medicine specialists, obstetricians and any clinicians involved in the care of pregnant or postpartum women the tools necessary to prepare for, treat and prevent these concurrent injuries during an already challenging time.

A Practical Manual of Diabetes in Pregnancy

A Practical Manual of Diabetes in Pregnancy
  • Author : David McCance,Michael Maresh,David A. Sacks
  • Publisher :Unknown
  • Release Date :2017-09-20
  • Total pages :448
  • ISBN : 9781119043775
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Summary : The revised and updated second edition of a multidisciplinary, evidence-based clinical guide for the care of pregnant women with diabetes The second edition of A Practical Manual of Diabetes in Pregnancy offers a wealth of new evidence, new material, new technologies, and the most current approaches to care. With contributions from a team of international experts, the manual is highly accessible and comprehensive in scope. It covers topics ranging from preconception to postnatal care, details the risks associated with diabetic pregnancy, and the long-term implications for the mother and baby. The text also explores recent controversies and examines thorny political pressures. The manual’s treatment recommendations are based on the latest research to ensure pregnant women with diabetes receive the best possible care. The text takes a multi-disciplinary approach that reflects best practice in the treatment of diabetes in pregnancy. The revised second edition includes: New chapters on the very latest topics of interest Contributions from an international team of noted experts Practical, state-of-the-art text that has been fully revised with the latest in clinical guidance Easy-to-read, accessible format in two-color text design Illustrative case histories, practice points, and summary boxes, future directions, as well as pitfalls and what to avoid boxes Multiple choice questions with answers in each chapter Comprehensive and practical, the text is ideal for use in clinical settings for reference by all members of the multi-disciplinary team who care for pregnant women with diabetes. The manual is also designed for learning and review purposes by trainees in endocrinology, diabetes, and obstetrics.

Regulation of Implantation and Establishment of Pregnancy in Mammals

Regulation of Implantation and Establishment of Pregnancy in Mammals
  • Author : Rodney D. Geisert,Fuller W. Bazer
  • Publisher :Unknown
  • Release Date :2015-10-08
  • Total pages :270
  • ISBN : 9783319158563
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Summary : Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics along with the ability to selectively knockout genes of interest has greatly advanced our understanding of maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides a foundation from which to build research endeavors to help resolve infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. The present volume on “Regulation of Implantation and Establishment of Pregnancy in Mammals” brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. Reviews will provide current knowledge on the role of endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved with regulation of conceptus development.

Child Protective Services

Child Protective Services
  • Author : Diane Depanfilis
  • Publisher :Unknown
  • Release Date :1992-07-01
  • Total pages :98
  • ISBN : 0788119486
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Summary : Provides the foundation for casework practice in Child Protective Services (CPS). Describes the basic stages of the CPS process and the steps necessary to accomplish successfully each stage: intake, initial assessment/investigation, family assessment, case planning, service provision, and evaluation of family progress and case closure. Designed primarily for CPS caseworkers, supervisors, and administrators. Glossary. Bibiography.

Reproductive and Developmental Toxicology

Reproductive and Developmental Toxicology
  • Author : Ramesh C. Gupta
  • Publisher :Unknown
  • Release Date :2017-03-24
  • Total pages :1460
  • ISBN : 9780128042403
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Summary : Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife. Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis

Maternal-Fetal Nutrition During Pregnancy and Lactation

Maternal-Fetal Nutrition During Pregnancy and Lactation
  • Author : Michael E. Symonds,Margaret M. Ramsay
  • Publisher :Unknown
  • Release Date :2010-01-28
  • Total pages :208
  • ISBN : 9780521887090
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Summary : With the aim to improve clinicians' understanding of the important effects nutrition can have on maternal health and fetal and neonatal development, Maternal-Fetal Nutrition During Pregnancy and Lactation defines the nutritional requirements with regard to the stage of development and growth, placing scientific developments into clinical context.

Guide for the Care and Use of Laboratory Animals

Guide for the Care and Use of Laboratory Animals
  • Author : Institute for Laboratory Animal Research,Commission on Life Sciences,Division on Earth and Life Studies,National Research Council
  • Publisher :Unknown
  • Release Date :1996-08-06
  • Total pages :118
  • ISBN : 9780309588690
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Summary : A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been revised by a committee of experts, based on input from scientists and the public. The Guide incorporates recent research on commonly used species, including farm animals, and includes extensive references. It is organized around major components of animal use: Institutional policies and responsibilities. The committee discusses areas that require policy attention: the role and function of the Institutional Animal Care and Use Committee, protocols for animal care and use, occupational health and safety, personnel qualifications, and other areas. Animal environment, husbandry, and management. The committee offers guidelines on how to design and run a management program, addressing environment, nutrition, sanitation, behavioral and social issues, genetics, nomenclature, and more. Veterinary care. The committee discusses animal procurement and transportation, disease and preventive medicine, and surgery. The Guide addresses pain recognition and relief and issues surrounding euthanasia. Physical plant. The committee identifies design and construction issues, providing guidelines for animal-room doors, drainage, noise control, surgery, and other areas. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities--a resource of proven value, now updated and expanded. This revision will be important to researchers, animal care technicians, facilities managers, administrators at research institutions, policymakers involved in research issues, and animal welfare advocates.

Manipulating the Mouse Embryo

Manipulating the Mouse Embryo
  • Author : Andras Nagy,Marina Gertsenstein,Richard R. Behringer,Kristina Vintersten
  • Publisher :Unknown
  • Release Date :2003
  • Total pages :764
  • ISBN : 0879695749
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Summary : Provides information and guidelines for developing a mouse colony and conducting experiments, including proper protocols, step-by-step procedures, and analysis strategies.

The Psychosocial Implications of Disney Movies

The Psychosocial Implications of Disney Movies
  • Author : Lauren Dundes
  • Publisher :Unknown
  • Release Date :2019-07-11
  • Total pages :246
  • ISBN : 9783038978480
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Summary : In this volume of 15 articles, contributors from a wide range of disciplines present their analyses of Disney movies and Disney music, which are mainstays of popular culture. The power of the Disney brand has heightened the need for academics to question whether Disney’s films and music function as a tool of the Western elite that shapes the views of those less empowered. Given its global reach, how the Walt Disney Company handles the role of race, gender, and sexuality in social structural inequality merits serious reflection according to a number of the articles in the volume. On the other hand, other authors argue that Disney productions can help individuals cope with difficult situations or embrace progressive thinking. The different approaches to the assessment of Disney films as cultural artifacts also vary according to the theoretical perspectives guiding the interpretation of both overt and latent symbolic meaning in the movies. The authors of the 15 articles encourage readers to engage with the material, showcasing a variety of views about the good, the bad, and the best way forward.

Cystic Fibrosis in the Light of New Research

Cystic Fibrosis in the Light of New Research
  • Author : Dennis Wat
  • Publisher :Unknown
  • Release Date :2015-08-24
  • Total pages :392
  • ISBN : 9789535121527
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Summary : Cystic Fibrosis in the Light of New Research provides the latest research and clinical evidence that will be useful for clinicians, scientists and researchers to further their knowledge around this fascinating condition. The authors have brought along their expertise and wealth of knowledge to produce this book, including the basic science that underlies the disease, the burden of bacterial and viral infections, immunologic aspects of CF, a variety of clinical measurements to predict prognosis and novel therapies including gene therapy. This book will be invaluable and entertaining for anyone who is involved in the care of patients with cystic fibrosis.

First-Trimester Ultrasound

First-Trimester Ultrasound
  • Author : Jacques S. Abramowicz
  • Publisher :Unknown
  • Release Date :2015-08-24
  • Total pages :408
  • ISBN : 9783319202037
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Summary : This book offers a unique and focused study of the use of ultrasound during the first trimester, a critical time in a fetus’ development. It includes basic examination guidelines as well as cutting-edge ultrasound modalities, including Doppler and three-dimensional ultrasound, for the period immediately preceding conception through early embryology. Beginning with a discussion of the safety and efficacy of diagnostic ultrasound and the use of this modality for the evaluation and treatment of infertility, recognized experts in the field explore conditions that may interfere with normal conception or development, including maternal diseases that would benefit from early scanning, elements of teratology, multiple gestations, ectopic pregnancy, gestational trophoblastic disease, fetal anomalies and invasive procedures in the first trimester. Numerous illustrations and figures are provided to serve as aids for understanding key concepts. First-Trimester Ultrasound is a valuable resource for many, in or after training, in obstetrics and gynecology, radiology, emergency medicine, family medicine and genetics.

PISA Take the Test Sample Questions from OECD's PISA Assessments

PISA Take the Test Sample Questions from OECD's PISA Assessments
  • Author : OECD
  • Publisher :Unknown
  • Release Date :2009-02-02
  • Total pages :318
  • ISBN : 9789264050815
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Summary : This book presents all the publicly available questions from the PISA surveys. Some of these questions were used in the PISA 2000, 2003 and 2006 surveys and others were used in developing and trying out the assessment.

The Role of Pregnancy Nutrition in Maternal and Offspring Health

The Role of Pregnancy Nutrition in Maternal and Offspring Health
  • Author : Ekaterina Maslova
  • Publisher :Unknown
  • Release Date :2019-12-03
  • Total pages :320
  • ISBN : 9783039219964
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Summary : In pregnancy, maternal nutrition sustains and nourishes the developing child. Imbalances in either the direction of nutritional excess or deficiency can have adverse consequences for child health. In addition, more research now suggests that good pregnancy nutrition influences child health beyond pregnancy and delivery. This includes modifying the risk of child health outcomes as they enter childhood and adulthood through influences on placental development, hormonal pathways, and organ structure and function. Poor pregnancy nutrition may also compromise maternal health during pregnancy, which may have long-term consequences for women’s health. Understanding the biological and social mechanisms operating during pregnancy can help in the design of better clinical and public health interventions. This Special Issue on “The Role of Pregnancy Nutrition in Maternal and Offspring Health” includes etiological and mechanistic studies of pregnancy nutrition with short- and long-term maternal and child health outcomes, including original research, narrative reviews, and systematic reviews and meta-analyses. Together, this body of work provides important insights into the influence of dietary patterns, food groups, and nutrients on pregnancy outcomes, and long-term neurodevelopmental, respiratory, and metabolic health in the children. It also highlights nutritional consequences for specific groups of women, including those with pregnancy complications and eating disorders.

A Practical Guide to the Histology of the Mouse

A Practical Guide to the Histology of the Mouse
  • Author : Cheryl L. C. Scudamore
  • Publisher :Unknown
  • Release Date :2014-02-10
  • Total pages :248
  • ISBN : 9781119941200
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Summary : A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. Written by experienced pathologists and specifically tailored to the needs of scientists and histologists Full colour throughout Provides advice on sampling tissues, necropsy and recording data Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation