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Molecular Neurology

Molecular Neurology
  • Author : Stephen Waxman
  • Publisher :Unknown
  • Release Date :2010-07-26
  • Total pages :600
  • ISBN : 0080546188
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Summary : Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. Describes the newest molecular aspects of neurological disorders Provides an introduction to neurological disorders for basic scientists Updates clinicians and clinical researchers on the most recent developments

Inflammatory Disorders of the Nervous System

Inflammatory Disorders of the Nervous System
  • Author : Alireza Minagar,J. Steven Alezander
  • Publisher :Unknown
  • Release Date :2007-10-28
  • Total pages :362
  • ISBN : 9781592599059
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Summary : A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.

Neuroimmunological Diseases

Neuroimmunological Diseases
  • Author : Susumu Kusunoki
  • Publisher :Unknown
  • Release Date :2016-06-24
  • Total pages :292
  • ISBN : 9784431555940
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Summary : This book offers a detailed review of the remarkable advances that have been made in research on the pathogenesis of a number of neuroimmunological diseases, as well as outlining novel treatments including the use of monoclonal antibodies. Written by renowned experts who have made major contributions in the field, such as identifying neuromyelitis optica as an immunopathological clinical condition, identifying the role of ganglioside and ganglioside-complex antibodies in Guillain-Barré syndrome, and developing a novel treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, the book summarizes recent advances in basic and clinical research. Neuroimmunological Diseases is a useful resource for not only researchers but also neurologists who are engaged in the management of neuroimmunological diseases.

Translational Neuroimmunology in Multiple Sclerosis

Translational Neuroimmunology in Multiple Sclerosis
  • Author : Ruth Arnon,Ariel Miller
  • Publisher :Unknown
  • Release Date :2016-05-10
  • Total pages :502
  • ISBN : 9780128020074
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Summary : Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon—such as neuroprotective strategies, stem cells, and repair promotion—are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development. Provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis and the translation of this research to immunotherapy treatment Edited by renowned leaders in the field of neuroimmunology and multiple sclerosis Contains the latest resource material for basic and clinical scientists and practitioners in neuroscience, neurology, immunology, and pharmacology

Neuro-Immune Interactions in Inflammation and Autoimmunity

Neuro-Immune Interactions in Inflammation and Autoimmunity
  • Author : Valentin A. Pavlov,Niccolo Terrando
  • Publisher :Unknown
  • Release Date :2018-07-24
  • Total pages :229
  • ISBN : 9782889455331
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Summary : The nervous system plays an important role in the regulation of immunity and inflammation. On the other hand unbalanced immune responses in inflammatory and autoimmune conditions may have a deleterious impact on neuronal integrity and brain function. Recent studies have characterized neural pathways communicating peripheral inflammatory signals to the CNS, and brain- and spinal cord-derived circuitries controlling various innate and adaptive immune responses and inflammation. A prototypical neural reflex circuit that regulates immunity and inflammation is the vagus nerve-based “inflammatory reflex”. Ongoing research has revealed cellular and molecular mechanisms underlying these neural circuits and indicated new therapeutic approaches in inflammatory and autoimmune disorders. Pharmacological and bioelectronic modulation of neural circuitry has been successfully explored in preclinical settings of sepsis, arthritis, inflammatory bowel disease, obesity-driven disorders, diabetes and other diseases. These studies paved the way to successful clinical trials with bioelectronic neuronal modulation in rheumatoid arthritis and inflammatory bowel disease. Dysregulated release of cytokines and other inflammatory molecules may have a severe impact on brain function. Brain inflammation (neuroinflammation), imbalances in brain neuronal integrity and neurotransmitter systems, and cognitive impairment are characteristic features of post-operative conditions, sepsis, liver diseases, diabetes and other disorders characterized by immune and metabolic dysregulation. Derangements in cytokine release also play a pivotal role in depression. Characteristic brain reactive antibodies in autoimmune conditions, including systemic lupus erythematosus and neuromyelitis optica, significantly contribute to brain pathology and cognitive impairment. These studies, and the simultaneous characterization of neuro-protective cytokines, identified new therapeutic approaches for treating neurological complications in inflammatory and autoimmune disorders. This Frontiers Research Topic is a forum for publishing research findings and methodological and conceptual advances at the intersection of immunology and neuroscience. We hope that presenting new insight into bi-directional neuro-immune communication in inflammation and autoimmunity will foster further collaborations and facilitate the development of new efficient therapeutic strategies.

Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis

Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis
  • Author : Karl Bechter,David Brown,Souhel Najjar
  • Publisher :Unknown
  • Release Date :2019-08-12
  • Total pages :229
  • ISBN : 9782889459506
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Summary : Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.

Immunological Aspects of Neurological Diseases

Immunological Aspects of Neurological Diseases
  • Author : J. A. Aarli,Olav Tönder
  • Publisher :Unknown
  • Release Date :1980
  • Total pages :189
  • ISBN : UOM:39015006719275
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Summary :

Clinical Neuroimmunology

Clinical Neuroimmunology
  • Author : Jack P. Antel
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :452
  • ISBN : 9780198510680
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Summary : Provides broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches to disease and injury of the nervous system that are currently only marginally amenable to therapy. Neuroimmunology is a well-recognised and growing specialty world wide, both at the basic science and clinical level. Chapters are dedicated to the role of the immune system in disorders affecting both the central and peripheral nervous systems, including important neurodegenerative diseases (such as multiple sclerosis and HIV-related neural degeneration) which cause life-long disability. Extensive coverage is given to a whole array of immune-directed therapies.

Immunological and Inflammatory Disorders of the Central Nervous System

Immunological and Inflammatory Disorders of the Central Nervous System
  • Author : Neil Scolding
  • Publisher :Unknown
  • Release Date :1999
  • Total pages :264
  • ISBN : UOM:39015042796824
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Summary : A variety of diseases which are driven by immunological and inflammatory disturbances can affect the central nervous system; some are primary neurological conditions, e.g. multiple sclerosis, whilst other CNS diseases reflect an inflammatory disorder, e.g. vasculitis. The clinical features, immunological background and treatment of these primary and secondary disorders of the CNS are the subject of this book.

Neuroimmunology in Clinical Practice

Neuroimmunology in Clinical Practice
  • Author : Bernadette Kalman,Thomas H. Brannagan, III
  • Publisher :Unknown
  • Release Date :2008-04-15
  • Total pages :280
  • ISBN : 9780470766187
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Summary : Written by field experts, Neuroimmunology in Clinical Practice fills a void in traditional neuroimmunology literature, which tends to cover the discipline’s scientific aspects with little emphasis on clinical applications. This unique book is essential reading in clinical neuroimmunology. Written by field experts this book provides a comprehensive description of immune mediated neurological disorders complemented with the most pertinent and up to date scientific data Covers inflammatory demyelination in the central nervous system, autoimmune diseases of the peripheral nervous system and the muscle, and disorders of the central and peripheral nervous systems Fills a gap in existing neuroimmunology literature by focusing on clinical applications

Neurorheumatology

Neurorheumatology
  • Author : Tracey A. Cho,Shamik Bhattacharyya,Simon Helfgott
  • Publisher :Unknown
  • Release Date :2019-06-29
  • Total pages :293
  • ISBN : 9783030169282
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Summary : This detailed, practical textbook focuses on immune mediated disorders of the nervous system with particular focus on systemic autoimmune disorders. Divided into three sections, the first discusses the neuroanatomical and pathophysiologic basis of immune mediated disorders of the nervous system. Following this are 25 chapters devoted to individual clinical conditions. To conclude, the final section explains what is known about the mechanisms of immunomodulatory treatments and practical points about monitoring patients on these treatments. Neurorheumatology: A Comprehensive Guide to Immune Mediated Disorders of the Nervous System bridges the gaps among different branches of medicine and is an indispensable resource for rheumatologists and neurologists looking to develop a firm understanding of these dynamic disorders

Neuroinflammation

Neuroinflammation
  • Author : Alireza Minagar
  • Publisher :Unknown
  • Release Date :2010-12-17
  • Total pages :540
  • ISBN : 0123849144
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Summary : Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities

Immunology, Its Role in Disease and Health

Immunology, Its Role in Disease and Health
  • Author : United States. Task Force on Immunology and Disease,National Institute of Allergy and Infectious Diseases (U.S.)
  • Publisher :Unknown
  • Release Date :1976
  • Total pages :157
  • ISBN : PURD:32754081178133
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Summary :

The Utility of Therapeutic Plasmapheresis for Neurological Disorders

The Utility of Therapeutic Plasmapheresis for Neurological Disorders
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1986
  • Total pages :7
  • ISBN : MINN:31951D01951429H
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Summary :

Neuro-Immuno-Gastroenterology

Neuro-Immuno-Gastroenterology
  • Author : Cris S. Constantinescu,Rāzvan I. Arsenescu,Violeta Arsenescu
  • Publisher :Unknown
  • Release Date :2016-05-24
  • Total pages :337
  • ISBN : 9783319286099
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Summary : This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.

Neurological Disorders

Neurological Disorders
  • Author : World Health Organization
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :218
  • ISBN : 9789241563369
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Summary : Although there are several gaps in understanding the many issues related to neurological disorders, we know enough to be able to shape effective policy responses to some of the most common. This book describes and discusses the increasing public health impact of common neurological disorders such as dementia, epilepsy, headache disorders, multiple sclerosis, neuroinfections, neurological disorders associated with malnutrition, pain associated with neurological disorders, Parkinson's disease, stroke and traumatic brain injuries. It provides information and advice on public health interventions that may reduce their occurrence and consequences, and offers health professionals and planners the opportunity to assess the burden caused by these disorders. The clear message that emerges is that unless immediate action is taken globally, the neurological burden is likely to become an increasingly serious and unmanageable.

Nutrition and Lifestyle in Neurological Autoimmune Diseases

Nutrition and Lifestyle in Neurological Autoimmune Diseases
  • Author : Ronald Ross Watson,William D. S. Killgore
  • Publisher :Unknown
  • Release Date :2016-12-23
  • Total pages :302
  • ISBN : 9780128054444
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Summary : Nutrition and Lifestyle in Neurological Autoimmune Diseases: Multiple Sclerosis discusses important discoveries relating to the types of, and efficacy of, nutritional and lifestyle responses to symptoms and reoccurrence of MS. Each chapter defines a new approach to use in foods, dietary supplements, exercise, behavior, and/or lifestyle in health promotion and symptoms management for MS. This book presents the role of non-pharmaceutical approaches and is essential reading for neurologists, physicians, nurses, nutritionists, dietitians, healthcare professionals, research scientists, biochemists, and general practitioners. Presents a comprehensive overview that details the role of nutrition and exercise in Multiple Sclerosis Written for researchers and clinicians in neurology, neuroscience, and exercise and nutrition Defines a new approach that focuses on foods, dietary supplements, exercise, behavior, and lifestyle in health promotion and symptoms management for MS

Neuroinfectious Diseases

Neuroinfectious Diseases
  • Author : Barry Bradford
  • Publisher :Unknown
  • Release Date :2021-06-15
  • Total pages :275
  • ISBN : 0128191112
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Summary : Neuroinfectious Diseases brings to light the latest information in a field that is rapidly expanding as a result of the re-emergence of unvaccinated populations. Newly emerging infections may rapidly grow to epidemic proportions and spread over large geographical areas. Infectious diseases of the nervous system, for example, can be caused by a diverse range of infectious agents as well as post-infectious neurological syndromes. In this book, renowned experts review the most recent advances to provide a timely and up-to-date overview of the field. Covers emerging diseases like Ebola, Chikungunya, West Nile and Zika Examines the role of the systemic immune system and neuroimmune interaction Discusses animal models, in vitro drug discovery, and human studies Addresses the dearth of clinical trials and how research can proceed Looks ahead to future potential epidemics like tick-borne illnesses

Clinical Immunology of the Dog and Cat, Second Edition

Clinical Immunology of the Dog and Cat, Second Edition
  • Author : Michael J Day
  • Publisher :Unknown
  • Release Date :2011-11-28
  • Total pages :464
  • ISBN : 9781840766318
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Summary : This second edition of a bestseller details the manifestations, diagnosis and treatment of immune-related disease in the dog and cat. It is illustrated throughout in full color, to show and explain to the reader as clearly as possible the complicated principles of disease and immunodiagnostic tests, supported by clinical cases, gross and histopathology, cytology, hematology, immunohistochemistry and other immunological tests.

Allergy and Clinical Immunology

Allergy and Clinical Immunology
  • Author : Richard F. Lockey
  • Publisher :Unknown
  • Release Date :1979
  • Total pages :1193
  • ISBN : UOM:39015002440223
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Summary : "An examination of the future role of the South China sea in international relations and a tour of the the nations surrounding the South China Sea and their interests in the region. In exploring each of these countries individually, Kaplan clearly shows where the conflicts may arise and why they will be challenging for the international community"--

Neuroimmunology

Neuroimmunology
  • Author : Bibiana Bielekova,Robert P. Lisak
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :328
  • ISBN : 9780190050801
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Summary : Neuroimmunology, the latest volume in the Contemporary Neurology Series, provides a practical, clinical, and scientific background on a diverse group of neurological disorders in this rapidly expanding field. The book includes chapters on multiple sclerosis and related disorders in adults and children, neuromyelitis optica spectrum disorder, Guillain-Barre Syndrome, chronic inflammatory demyelinating polyradiculoneuropathy and variants, immune-mediated disorders of the neuromuscular junction, inflammatory myopathies, paraneoplastic disorders and autoimmune encephalitities, and neurologic manifestations of systemic immune-mediated diseases. Unique to the work, the authors have included an introductory chapter on the basics of immunology and another on mechanisms of action of therapies used in neuroimmunologic disorders. The clinical chapters cover epidemiology, pathology, pathogenesis, and pathophysiology of the different diseases along with clinical presentation, diagnostic testing, differential diagnosis, and treatment. All are presented in an accessible, practical format, making this volume a valuable resource for physicians and other healthcare providers that will care for persons with neuroimmunologic diseases.