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The Mechanics of Hydrogels

The Mechanics of Hydrogels
  • Author : Hua Li,Vadim V. Silberschmidt
  • Publisher :Unknown
  • Release Date :2020-10-01
  • Total pages :500
  • ISBN : 9780081028636
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Summary : The Mechanics of Hydrogels: Mechanical Properties, Testing, and Applications offers readers a systematic description of the mechanical properties and characterizations of hydrogels. Practical topics such as manufacturing hydrogels with controlled mechanical properties and the mechanical testing of hydrogels are covered at length, as are areas such as inelastic and nonlinear deformation, rheological characterization, fracture and indentation testing, mechanical properties of cellularly responsive hydrogels, and more. Proper instrumentation and modeling techniques for measuring the mechanical properties of hydrogels are also explored. Links the mechanical and biological behaviors and applications of hydrogels Looks at the manufacturing and mechanical testing of hydrogels Discusses the design and use of hydrogels in a wide array of applications

Mechanics of Microelectromechanical Systems

Mechanics of Microelectromechanical Systems
  • Author : Nicolae Lobontiu,Ephrahim Garcia
  • Publisher :Unknown
  • Release Date :2006-01-16
  • Total pages :405
  • ISBN : 9780387230375
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Summary : This book offers a comprehensive coverage to the mechanics of microelectromechanical systems (MEMS), which are analyzed from a mechanical engineer’s viewpoint as devices that transform an input form of energy, such as thermal, electrostatic, electromagnetic or optical, into output mechanical motion (in the case of actuation) or that can operate with the reversed functionality (as in sensors) and convert an external stimulus, such as mechanical motion, into (generally) electric energy. The impetus of this proposal stems from the perception that such an approach might contribute to a more solid understanding of the principles governing the mechanics of MEMS, and would hopefully enhance the efficiency of modeling and designing reliable and desirably-optimized microsystems. The work represents an attempt at both extending and deepening the mechanical-based approach to MEMS in the static domain by providing simple, yet reliable tools that are applicable to micromechanism design through current fabrication technologies. Lumped-parameter stiffness and compliance properties of flexible components are derived both analytically (as closed-form solutions) and as simplified (engineering) formulas. Also studied are the principal means of actuation/sensing and their integration into the overall microsystem. Various examples of MEMS are studied in order to better illustrate the presentation of the different modeling principles and algorithms. Through its objective, approach and scope, this book offers a novel and systematic insight into the MEMS domain and complements existing work in the literature addressing part of the material developed herein.

Biomaterials Surface Science

Biomaterials Surface Science
  • Author : Andreas Taubert,Joao F. Mano,Jos¿ Carlos Rodr¿guez-Cabello
  • Publisher :Unknown
  • Release Date :2013-07-12
  • Total pages :616
  • ISBN : 9783527649631
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Summary : At the interface of biology, chemistry, and materials science, this book provides an overview of this vibrant research field, treating the seemingly distinct disciplines in a unified way by adopting the common viewpoint of surface science. The editors, themselves prolific researchers, have assembled here a team of top-notch international scientists who read like a "who's who" of biomaterials science and engineering. They cover topics ranging from micro- and nanostructuring for imparting functionality in a top-down manner to the bottom-up fabrication of gradient surfaces by self-assembly, from interfaces between biomaterials and living matter to smart, stimuli-responsive surfaces, and from cell and surface mechanics to the elucidation of cell-chip interactions in biomedical devices. As a result, the book explains the complex interplay of cell behavior and the physics and materials science of artificial devices. Of equal interest to young, ambitious scientists as well as to experienced researchers.

Biophysics

Biophysics
  • Author : Mark C. Leake
  • Publisher :Unknown
  • Release Date :2016-09-15
  • Total pages :390
  • ISBN : 9781498702515
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Summary : An Up-to-Date Toolbox for Probing Biology Biophysics: Tools and Techniques covers the experimental and theoretical tools and techniques of biophysics. It addresses the purpose, science, and application of all physical science instrumentation and analysis methods used in current research labs. The book first presents the historical background, concepts, and motivation for using a physical science toolbox to understand biology. It then familiarizes students from the physical sciences with essential biological knowledge. The text subsequently focuses on experimental biophysical techniques that primarily detect biological components or measure/control biological forces. The author describes the science and application of key tools used in imaging, detection, general quantitation, and biomolecular interaction studies, which span multiple length and time scales of biological processes both in the test tube and in the living organism. Moving on to theoretical biophysics tools, the book presents computational and analytical mathematical methods for tackling challenging biological questions. It concludes with a discussion of the future of this exciting field. Future innovators will need to be trained in multidisciplinary science to be successful in industry, academia, and government support agencies. Addressing this challenge, this textbook educates future leaders on the development and application of novel physical science approaches to solve complex problems linked to biological questions.

Principles of Regenerative Medicine

Principles of Regenerative Medicine
  • Author : Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
  • Publisher :Unknown
  • Release Date :2010-12-16
  • Total pages :1202
  • ISBN : 0123814235
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Summary : Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Synthesis of Novel Hydrogels with Unique Mechanical Properties

Synthesis of Novel Hydrogels with Unique Mechanical Properties
  • Author : Yi Cao,Kerstin G. Blank,Fei Sun
  • Publisher :Unknown
  • Release Date :2020-12-23
  • Total pages :229
  • ISBN : 9782889662593
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Summary :

Quantitative Systems Pharmacology

Quantitative Systems Pharmacology
  • Author : Davide Manca
  • Publisher :Unknown
  • Release Date :2018-07-18
  • Total pages :418
  • ISBN : 9780444639677
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Summary : Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource. Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy Discusses how drugs are driven to specific targets using nanoparticles Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation

Biologically-responsive Hybrid Biomaterials

Biologically-responsive Hybrid Biomaterials
  • Author : Esmaiel Jabbari,Ali Khademhosseini
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :423
  • ISBN : 9789814295680
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Summary : Conjugation of synthetic materials with cell-responsive biologically-active molecules, in addition to providing structural support and release of biomolecules in the regenerating region, can provide the signaling factors required to initiate the cascade of cell migration, adhesion, differentiation, maturation, growth factor modulation, maintenance of matrix integrity, and tissue morphogenesis. Nanoparticles conjugated with ligands that preferentially interact with cell surface receptors in the tumor environment have the potential to drastically improve bioavailability, selectivity and residence time of the chemotherapeutic agent in the tumor microenvironment, while limiting their peripheral toxicity. Multivalent presentation of tumor-associated antigens on a targeted delivery system containing T and B cell epitopes can result in strong, long-lasting, self-adjuvant immunity against cancer and other diseases in vaccination. These examples demonstrate that cell-responsive conjugate biomaterials have profoundly impacted the medical field. This book is divided into three sections. In the first section, synthesis and characterization, conformation, structure-activity, self-assembly, and host response of conjugate hybrid biomaterials are covered. The second section is dedicated to the applications of conjugate biomaterials in drug delivery and vaccination while the last section is devoted to tissue engineering applications including cell adhesion, control of the stem cell niche, cartilage regeneration, neural and vascular tissue engineering, and dynamic cell culture systems for functionalized biomaterials. There is no doubt that biologically-responsive conjugate biomaterials play a key role in the design of biologics and medical devices, and this pioneering reference book provides a comprehensive review on synthesis, characterization, structure-activity, 3D assembly/fabrication, host response and the emerging applications of conjugate hybrid biomaterials.

Biophysical Regulation of Vascular Differentiation and Assembly

Biophysical Regulation of Vascular Differentiation and Assembly
  • Author : Sharon Gerecht
  • Publisher :Unknown
  • Release Date :2018-11-07
  • Total pages :195
  • ISBN : 9783319993195
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Summary : This book updates and expands on various aspects of the vasculature’s microenvironment and how these regulate differentiation and assembly. Discussed in this new edition are efforts to capitalize on combing engineering techniques, to study and manipulate various biophysical cues, including: endothelial cell- pericyte interactions (Davis), mechanical forces to regulate vascularization in three-dimensional constructs (Levenberg), how matrix properties and oxygen tension regulate vascular fate and assembly (Gerecht), biophysical cues in relation to vascular aging (Ferreira), 3D printing of complex vascularized tissue (Hibino), the harnessing of biophysical cues for therapeutic vasculature interfacing with the damaged brain (Segura) and finally, the infarcted heart (Grayson). This second edition of Biophysical Regulation of Vascular Differentiation and Assembly provides an interdisciplinary view of vasculature regulation thru various biophysical cues and presents recent advances in measuring and controlling such parameters. This book will be of interest to biologists, biophysicists and engineers who work with vascular differentiation and assembly.

Intelligent Hydrogels

Intelligent Hydrogels
  • Author : Gabriele Sadowski,Walter Richtering
  • Publisher :Unknown
  • Release Date :2014-01-28
  • Total pages :279
  • ISBN : 9783319016832
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Summary : This volume of Progress in Colloid and Polymer Science assembles original contributions and invited reviews from the priority research program "Intelligent Hydrogels", funded by the German Science Foundation DFG since 2006, with about 25 contributing research groups. In the center of interest of this program and the present book are responsive hydrogels, i.e. hydrophilic polymer or polyelectrolyte networks that are able to respond to environmental stimuli such as changes in temperature, pH, additive concentration or electrical field. The activities focus on different aspects: on hydrogel synthesis, on the modeling and simulation of thermophysical hydrogel properties, as well as on innovative new hydrogel applications as smart materials. The present book summarizes the highlights in the results of the priority program in original contributions and invited reviews.

Smart Drug Delivery System

Smart Drug Delivery System
  • Author : Ali Demir Sezer
  • Publisher :Unknown
  • Release Date :2016-02-10
  • Total pages :398
  • ISBN : 9789535122470
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Summary : This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Viscosupplementation Agents—Advances in Research and Application: 2012 Edition

Viscosupplementation Agents—Advances in Research and Application: 2012 Edition
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2012-12-26
  • Total pages :98
  • ISBN : 9781481606011
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Summary : Viscosupplementation Agents—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Viscosupplementation Agents. The editors have built Viscosupplementation Agents—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Viscosupplementation Agents in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Viscosupplementation Agents—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Advances in Heterogeneous Material Mechanics 2008

Advances in Heterogeneous Material Mechanics 2008
  • Author : Jinghong Fan,Haibo Chen
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :1714
  • ISBN : 9781932078800
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Summary : This book offers over 400 never before published and rigorously refereed papers demonstrating the connections between nanoscale phenomena and the critical properties of dozens of engineered and natural materials—from polymer composites to human bone. Information is presented on new techniques for studying and quantifying the behavior of materials at nanoscale levels and linking this data to macroscale properties such as strength, fatigue, and failure points. The techniques include novel experiments and uses of instrumentation, as well as modeling and numerical methods. Virtually all the analyses in this book are offered here for the first time. They include information of value for materials investigators in defense, civil engineering, biomaterials, and transportation

Mechanics of Biological Systems and Materials & Micro-and Nanomechanics, Volume 4

Mechanics of Biological Systems and Materials & Micro-and Nanomechanics, Volume 4
  • Author : Martha E. Grady
  • Publisher :Unknown
  • Release Date :2019-11-09
  • Total pages :92
  • ISBN : 9783030300135
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Summary : Mechanics of Biological Systems and Materials & Micro-and Nanomechanics, Volume 4 of the Proceedings of the 2019 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the fourth volume of six from the Conference, brings together contributions to important areas of research and engineering. The collection presents early findings and case studies on a wide range of topics, including: Extreme NanomechanicsIn-Situ NanomechanicsExpanding Boundaries in MetrologyMicro and Nanoscale DeformationMEMS for Actuation, Sensing and Characterization1D & 2D MaterialsCardiac MechanicsCell Mechanics Biofilms and Microbe MechanicsTraumatic Brain InjuryOrthopedic BiomechanicsLigaments and Soft Materials

Handbook of Physics in Medicine and Biology

Handbook of Physics in Medicine and Biology
  • Author : Robert Splinter
  • Publisher :Unknown
  • Release Date :2010-04-05
  • Total pages :548
  • ISBN : 9781420075250
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Summary : In considering ways that physics has helped advance biology and medicine, what typically comes to mind are the various tools used by researchers and clinicians. We think of the optics put to work in microscopes, endoscopes, and lasers; the advanced diagnostics permitted through magnetic, x-ray, and ultrasound imaging; and even the nanotools, that allow us to tinker with molecules. We build these instruments in accordance with the closest thing to absolute truths we know, the laws of physics, but seldom do we apply those same constants of physics to the study of our own carbon-based beings, such as fluidics applied to the flow of blood, or the laws of motion and energy applied to working muscle. Instead of considering one aspect or the other, Handbook of Physics in Medicine and Biology explores the full gamut of physics’ relationship to biology and medicine in more than 40 chapters, written by experts from the lab to the clinic. The book begins with a basic description of specific biological features and delves into the physics of explicit anatomical structures starting with the cell. Later chapters look at the body's senses, organs, and systems, continuing to explain biological functions in the language of physics. The text then details various analytical modalities such as imaging and diagnostic methods. A final section turns to future perspectives related to tissue engineering, including the biophysics of prostheses and regenerative medicine. The editor’s approach throughout is to address the major healthcare challenges, including tissue engineering and reproductive medicine, as well as development of artificial organs and prosthetic devices. The contents are organized by organ type and biological function, which is given a clear description in terms of electric, mechanical, thermodynamic, and hydrodynamic properties. In addition to the physical descriptions, each chapter discusses principles of related clinical diagnostic methods and technological aspects of therapeutic applications. The final section on regenerative engineering, emphasizes biochemical and physiochemical factors that are important to improving or replacing biological functions. Chapters cover materials used for a broad range of applications associated with the replacement or repair of tissues or entire tissue structures.

Biological and Biomimetic Adhesives

Biological and Biomimetic Adhesives
  • Author : Romana Santos,Nick Aldred,Stanislav Gorb,Patrick Flammang
  • Publisher :Unknown
  • Release Date :2013-05-31
  • Total pages :208
  • ISBN : 9781849737135
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Summary : Due to their impressive performance biological adhesives have inspired the development of superior industrial adhesives. Biological adhesives often provide elegant solutions to engineering and biomedical requirements and are expected to inspire future technological innovations for adhesives for use in hostile conditions. Containing a selection of papers presented at the 1st International Conference on Biological and Biomimetic Adhesives, this book will showcase the latest advances in the chemical and structural characterisation of adhesives, the mechanical testing of adhesives and theory, fabrication and applications of biomimetic adhesives. Following the work of COST Action TD0909, the aim is to gain greater understanding of the mode of action of biological adhesives to allow successful development of improved synthetic counterparts. Appealing to a wide range of researchers in biology, chemistry, physics and engineering, the title provides the background and drive to improve scientific and technological progress in this important area.

Mechanics of Time-Dependent Materials and Processes in Conventional and Multifunctional Materials, Volume 3

Mechanics of Time-Dependent Materials and Processes in Conventional and Multifunctional Materials, Volume 3
  • Author : Tom Proulx
  • Publisher :Unknown
  • Release Date :2011-05-21
  • Total pages :301
  • ISBN : 9781461402138
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Summary : Mechanics of Time-Dependent Materials and Processes in Conventional and Multifunctional Materials represents one of eight volumes of technical papers presented at the Society for Experimental Mechanics Annual Conference on Experimental and Applied Mechanics, held at Uncasville, Connecticut, June 13-16, 2011. The full set of proceedings also includes volumes on Dynamic Behavior of Materials, Mechanics of Biological Systems and Materials; MEMS and Nanotechnology; Optical Measurements, Modeling and, Metrology; Experimental and Applied Mechanics, Thermomechanics and Infra-Red Imaging, and Engineering Applications of Residual Stress.

Comprehensive Medicinal Chemistry III

Comprehensive Medicinal Chemistry III
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2017-06-03
  • Total pages :4536
  • ISBN : 9780128032015
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Summary : Comprehensive Medicinal Chemistry III provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Hydrogels

Hydrogels
  • Author : Thakur Raghu Raj Singh,Garry Laverty,Ryan Donnelly
  • Publisher :Unknown
  • Release Date :2018-02-28
  • Total pages :344
  • ISBN : 9781498748629
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Summary : Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This book elucidates the underlying concepts and emerging applications of hydrogels and will provide key case studies and critical analysis of the existing research.

Cellular and Biomolecular Mechanics and Mechanobiology

Cellular and Biomolecular Mechanics and Mechanobiology
  • Author : Amit Gefen
  • Publisher :Unknown
  • Release Date :2010-12-02
  • Total pages :562
  • ISBN : 3642142184
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Summary : This book describes these exciting new developments, and presents experimental and computational findings that altogether describe the frontier of knowledge in cellular and biomolecular mechanics, and the biological implications, in health and disease. The book is written for bioengineers with interest in cellular mechanics, for biophysicists, biochemists, medical researchers and all other professionals with interest in how cells produce and respond to mechanical loads.

Hydrogels

Hydrogels
  • Author : Sajjad Haider,Adnan Haider
  • Publisher :Unknown
  • Release Date :2018-08-01
  • Total pages :210
  • ISBN : 9781789233681
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Summary : This new important book is a collection of research and review articles from different parts of the world discussing the dynamic and vibrant field of hydrogels. The articles are linking new findings and critically reviewing the fundamental concepts and principles that are making the base for innovation. Each chapter discusses the potential of hydrogels in diverse areas. These areas include tissue engineering, implants, controlled drug release, and oil reserve treatment. The book is offering an up-to-date knowledge of hydrogels to experienced as well as new researchers.