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The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols
  • Author : Warren H. Finlay
  • Publisher :Unknown
  • Release Date :2019-06-01
  • Total pages :302
  • ISBN : 9780081027868
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Summary : The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction, Second Edition provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols. This revised edition will allow researchers in the field to gain a thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. Chapters consider mechanics and deposition, specifically in the respiratory tract, while others discuss the mechanics associated with the three existing types of pharmaceutical inhalation devices. This text will be very useful for academics and for courses taught at both undergraduate and graduate levels. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise, but thorough exposition of fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering the area

Exam Prep for: The Mechanics of Inhaled Pharmaceutical Aerosols

Exam Prep for: The Mechanics of Inhaled Pharmaceutical Aerosols
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 1230987654XX
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Summary :

Pharmaceutical Inhalation Aerosol Technology, Second Edition

Pharmaceutical Inhalation Aerosol Technology, Second Edition
  • Author : Anthony J. Hickey
  • Publisher :Unknown
  • Release Date :2003-09-03
  • Total pages :288
  • ISBN : 0824756649
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Summary : This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.

Inhalation Aerosols

Inhalation Aerosols
  • Author : Anthony J. Hickey,Heidi M. Mansour
  • Publisher :Unknown
  • Release Date :2019-03-21
  • Total pages :417
  • ISBN : 9781351660518
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Summary : Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.

Pharmaceutical Inhalation Aerosol Technology, Third Edition

Pharmaceutical Inhalation Aerosol Technology, Third Edition
  • Author : Anthony J. Hickey,Sandro R. da Rocha
  • Publisher :Unknown
  • Release Date :2019-03-26
  • Total pages :730
  • ISBN : 9780429619564
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Summary : This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

Inhaled Medicines

Inhaled Medicines
  • Author : Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
  • Publisher :Unknown
  • Release Date :2021-02-05
  • Total pages :438
  • ISBN : 9780128149744
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Summary : Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ? Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ? Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ? Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ? Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

Aerosol Science

Aerosol Science
  • Author : Ian Colbeck,Mihalis Lazaridis
  • Publisher :Unknown
  • Release Date :2014-01-30
  • Total pages :496
  • ISBN : 9781118675359
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Summary : Aerosols influence many areas of our daily life. They are at the core of environmental problems such as global warming, photochemical smog and poor air quality. They can also have diverse effects on human health, where exposure occurs in both outdoor and indoor environments. However, aerosols can have beneficial effects too; the delivery of drugs to the lungs, the delivery of fuels for combustion and the production of nanomaterials all rely on aerosols. Advances in particle measurement technologies have made it possible to take advantage of rapid changes in both particle size and concentration. Likewise, aerosols can now be produced in a controlled fashion. Reviewing many technological applications together with the current scientific status of aerosol modelling and measurements, this book includes: • Satellite aerosol remote sensing • The effects of aerosols on climate change • Air pollution and health • Pharmaceutical aerosols and pulmonary drug delivery • Bioaerosols and hospital infections • Particle emissions from vehicles • The safety of emerging nanomaterials • Radioactive aerosols: tracers of atmospheric processes With the importance of this topic brought to the public’s attention after the eruption of the Icelandic volcano Eyjafjallajökull, this book provides a timely, concise and accessible overview of the many facets of aerosol science.

Aerosols Handbook

Aerosols Handbook
  • Author : Lev S. Ruzer,Naomi H. Harley
  • Publisher :Unknown
  • Release Date :2004-12-28
  • Total pages :728
  • ISBN : 0203493184
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Summary : As more attention is dedicated to understanding the occupational health risks associated with the industrial manufacture and use of nanotechnology, Aerosols Handbook: Measurement, Dosimetry, and Health Effects is a timely presentation of time-tested research in the field of aerosol science. The book covers a multitude of topics in indoor, outdoor,

Controlled Pulmonary Drug Delivery

Controlled Pulmonary Drug Delivery
  • Author : Hugh D.C. Smyth,Anthony J. Hickey
  • Publisher :Unknown
  • Release Date :2011-06-24
  • Total pages :558
  • ISBN : 1441997458
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Summary : The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release through sophisticated particle technologies. The large number of contributions to the scientific literature and variety of excellent texts published in recent years is evidence for the continued interest in pulmonary drug delivery research. This reference text endeavors to bring together the fundamental theory and practice of controlled drug delivery to the airways that is unavailable elsewhere. Collating and synthesizing the material in this rapidly evolving field presented a challenge and ultimately a sense of achievement that is hopefully reflected in the content of the volume.

Respiratory Drug Delivery (1989)

Respiratory Drug Delivery (1989)
  • Author : Peter R. Byron
  • Publisher :Unknown
  • Release Date :2018-04-20
  • Total pages :276
  • ISBN : 9781351358019
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Summary : The focus of this book is on subjects related to drug delivery to the lung. The text spans topics from aerosol deposition through pharmaceutical chemistry and formulation to the final clinical evaluation of pharmaceutical products. Utilizing a multi-disciplinary approach, the chapters consider toxicology from the point of view of drugs and pharmaceutical excipients used in aerosols.

Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products

Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products
  • Author : Terrence P. Tougas,Jolyon P. Mitchell,Svetlana A. Lyapustina
  • Publisher :Unknown
  • Release Date :2013-04-10
  • Total pages :442
  • ISBN : 9781461462965
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Summary : The purpose of this publication is to introduce a new, simpler and more effective way in which to interpret pharmaceutical aerosol particle size data from orally inhaled products (OIPs). Currently, the compendial and regulatory requirements dictate the need for measurements by full resolution multi-stage cascade impactor (CI), a process that is demanding for the operator, time consuming, prone to experimental error, and challenging for method transfers from one laboratory to another. Furthermore, we shall show that the current practice of reducing information from mass-weighted aerodynamic particle size distribution (APSD) measurements through the use of CI stage groupings is not the most effective decision-making tool for OIP quality control (QC) in comparison with newly introduced, mutually-independent efficient data analysis (EDA) metrics that can be derived either from full resolution or abbreviated impactor measurements (AIM).

Inhalation Aerosols

Inhalation Aerosols
  • Author : Anthony J. Hickey
  • Publisher :Unknown
  • Release Date :1996-06-07
  • Total pages :536
  • ISBN : 1420002252
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Summary : This unique reference integrates the theory and practical use of aerosols in inhalation therapy into a single resource-presenting the physical chemistry of formulation, the physics of aerosol generation, aerodynamic behavior, and therapeutic implications. Offers up-to-date techniques for droplet and particle generation, including air-blast and ultrasonic nebulizers, propellant-driven metered-dose inhalers, dry-powder inhalers, and elecctrospray systems!

Aerosol Measurement

Aerosol Measurement
  • Author : Pramod Kulkarni,Paul A. Baron,Klaus Willeke
  • Publisher :Unknown
  • Release Date :2011-09-09
  • Total pages :900
  • ISBN : 1118001672
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Summary : Aerosol Measurement: Principles, Techniques, and Applications Third Edition is the most detailed treatment available of the latest aerosol measurement methods. Drawing on the know-how of numerous expert contributors; it provides a solid grasp of measurement fundamentals and practices a wide variety of aerosol applications. This new edition is updated to address new and developing applications of aerosol measurement, including applications in environmental health, atmospheric science, climate change, air pollution, public health, nanotechnology, particle and powder technology, pharmaceutical research and development, clean room technology (integrated circuit manufacture), and nuclear waste management.

The Journal of the Royal Astronomical Society of Canada

The Journal of the Royal Astronomical Society of Canada
  • Author : Royal Astronomical Society of Canada
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :229
  • ISBN : UCSD:31822036002368
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Summary : "Library catalogue in 1911" (31 p.) appended to v. 4.

Atomization and Sprays

Atomization and Sprays
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :229
  • ISBN : UCSD:31822036045565
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Summary :

Drug Delivery to the Respiratory Tract

Drug Delivery to the Respiratory Tract
  • Author : David Ganderton,T. C. Jones,Trevor M. Jones
  • Publisher :Unknown
  • Release Date :1987
  • Total pages :141
  • ISBN : UOM:39015012587559
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Summary : In treating diseases of the respiratory tract, the direct administration of drugs has great advantages in terms of clinical efficiency. This book reviews the most important recent developments in drug delivery systems to the respiratory tract. Starting with a detailed description of lung strucure and function, successive chapters investigate the usefulness of the pulmonary presention of beta-agonists, steroids and chromoglycate, and explain metabolic function and susceptibility to chemical damage from the environment, showing that the lung is far from being a passive organ. Further contributions demonstrate the importance of mucus in humidification, particle capture and particle removal before attention is given to the practical problems of drug delivery and the commercially viable devices available to the pharmaceutical technologist: the metered dose inhaler, the powder inhaler, and the jet nebuliser. The final chapter examines the future role of intranasal delivery systems, based upon the principles described.

Concise Catalog of Deep-sky Objects

Concise Catalog of Deep-sky Objects
  • Author : W.H. Finlay
  • Publisher :Unknown
  • Release Date :2006-04-18
  • Total pages :252
  • ISBN : 9781852338510
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Summary : Here is a unique and fascinating reference book for every serious deep-sky observer! Entries for each of more than 500 deep-sky objects provide far more than the usual astronomical data – they also detail, in every case, the most interesting facts. Physical factors, astrophysical information, evolution, unusual features, the list is endless. The objects are all listed in NGC order. Astronomers can now get an insight into exactly what they are looking at, to add a new level of insight and enjoyment to deep-sky observing.

Aerosols

Aerosols
  • Author : Konstantin Volkov
  • Publisher :Unknown
  • Release Date :2016-12-28
  • Total pages :206
  • ISBN : 9789535128434
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Summary : Aerosols have a significant impact on technological processes and human activities. In many cases, aerosols are at the core of human health, environmental and technological problems (climate change and air quality). However, aerosols can be successfully used in industry and technology (new materials, fire suppression and fuel delivery). The current scientific status of aerosol modelling and simulation and measurements and some advances in computational techniques, particle measurement technologies and practical applications of aerosols are reviewed and considered in this book. This book also includes a number of case studies focused on analysis of optical thickness and air quality in various regions.

International Research Centers Directory

International Research Centers Directory
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :229
  • ISBN : IND:30000126795594
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Summary : "A world guide to government, university, independent nonprofit, and commercial research and development centers, institutes, laboratories, bureaus, test facilities, experiment stations, and data collection and analysis centers, as well as foundations, councils and other organizations which support research," [1992/93-].

Research Centers Directory

Research Centers Directory
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :229
  • ISBN : STANFORD:36105211718148
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Summary : Research institutes, foundations, centers, bureaus, laboratories, experiment stations, and other similar nonprofit facilities, organizations, and activities in the United States and Canada. Entry gives identifying and descriptive information of staff and work. Institutional, research centers, and subject indexes. 5th ed., 5491 entries; 6th ed., 6268 entries.

Drug Delivery to the Lung

Drug Delivery to the Lung
  • Author : Hans Bisgaard,Chris O'Callaghan,Gerald C. Smaldone
  • Publisher :Unknown
  • Release Date :2001-10-02
  • Total pages :536
  • ISBN : 0824741978
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Summary : This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice. Examines the behavior of inspired spherical particles in the respiratory tract! Featuring over 1300 references, drawings, tables, photographs,