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The Neuroscience of Autism Spectrum Disorders

The Neuroscience of Autism Spectrum Disorders
  • Author : Joseph D. Buxbaum,Patrick R. Hof
  • Publisher :Unknown
  • Release Date :2013
  • Total pages :480
  • ISBN : 9780123919243
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Summary : Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available

The Neuroscience of Autism Spectrum Disorders

The Neuroscience of Autism Spectrum Disorders
  • Author : Joseph D. Buxbaum,Patrick R. Hof
  • Publisher :Unknown
  • Release Date :2012-12-31
  • Total pages :496
  • ISBN : 9780123919304
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Summary : Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Autism Spectrum Disorder

Autism Spectrum Disorder
  • Author : Martin J. Lubetsky MD,Benjamin L. Handen PhD,John J. McGonigle PhD
  • Publisher :Unknown
  • Release Date :2011-06-23
  • Total pages :360
  • ISBN : 9780199842513
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Summary : Autism Spectrum Disorder highlights current key topics for this complex and challenging developmental neurobiological disorder. In a very practical and concise manner, the reader will find a state-of-the-science review combining key factual knowledge with practical clinical considerations. Written in a user-friendly fashion, this text provides key fact boxes, summary questions, and references for further readings to enhance understanding. This invaluable book incorporates practical clinical knowledge within a didactic framework to provide a comprehensive overview of Autism Spectrum Disorder (ASD) across the lifespan.

The Neurobiology of Autism

The Neurobiology of Autism
  • Author : Margaret L. Bauman, M.D.,Thomas L. Kemper
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :404
  • ISBN : 0801880475
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Summary : For this long-anticipated new edition, neurologists Margaret L. Bauman and Thomas L. Kemper bring together leading researchers and clinicians to present the most current scientific knowledge and theories about autism. "Anyone doing research in autism or other developmental disorders will find this an invaluable book to read to make sure all areas are understood and to serve as a rich source of references." -- American Journal of Psychiatry

Biometals in Autism Spectrum Disorders

Biometals in Autism Spectrum Disorders
  • Author : Andreas Grabrucker
  • Publisher :Unknown
  • Release Date :2020-07-08
  • Total pages :222
  • ISBN : 9780128211335
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Summary : Biometals in Autism Spectrum Disorders will be the first to focus on trace metals and autism. Compared to other references examining ASDs or metallomics, a focused presentation of the findings of abnormal metal homeostasis in ASD has not yet come to be. This book provides for readers an overview of current findings on trace metal biology with respect to its role in ASD etiology and discusses how abnormal trace metal biology may be a common factor of several genetic and non-genetic causes of ASDs considered unrelated in the past. This will open new vistas for the development of new therapies based on targeted manipulation of trace metal homeostasis and generate awareness that trace metal levels during pregnancy must be tightly monitored. Reviews the role of trace metals in brain development Summarizes research linking trace metals and autism Explores heterogenous phenotypes as a factor of genetic and non-genetic factors Includes animal and human stem research Contains many diagrams, tables, and flow charts Proposes future therapies based on biometal homeostasis

Brain Connectivity in Autism

Brain Connectivity in Autism
  • Author : Rajesh K. Kana,Lucina Q. Uddin,Tal Kenet,Diane Chugani,Ralph-Axel Müller
  • Publisher :Unknown
  • Release Date :2014-09-23
  • Total pages :229
  • ISBN : 9782889192823
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Summary :

Autism Spectrum Disorder in the First Years of Life

Autism Spectrum Disorder in the First Years of Life
  • Author : Katarzyna Chawarska,Fred R. Volkmar
  • Publisher :Unknown
  • Release Date :2020-08-04
  • Total pages :397
  • ISBN : 9781462543250
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Summary : Synthesizing an explosion of recent research, this book presents dramatic advances in understanding and treating autism spectrum disorder (ASD) in very young children. Leading authorities describe the innovative tools and methods that are enabling clinicians to more effectively identify 0- to 5-year-olds with the disorder and those at risk for related problems. Chapters discuss the early core symptoms and co-occurring characteristics of ASD, the best diagnostic instruments, and lessons learned from large-scale screening and surveillance, including sibling studies. The book reviews evidence-based interventions and explores practical issues in treatment of young children and their families.

Autism Spectrum Disorder

Autism Spectrum Disorder
  • Author : Susan P. Sherkow,Alexandra M. Harrison , M.D.
  • Publisher :Unknown
  • Release Date :2013-11-14
  • Total pages :232
  • ISBN : 9780765708632
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Summary : Autism Spectrum Disorder: Perspectives from Psychoanalysis and Neuroscience, offers a guide to understanding and treating the ASD toddler from the dual perspectives of psychoanalysis and neurofunction through describing in great detail intensive treatments of four children who began therapy as toddlers. The authors hypothesize that dyadic therapy and Reflective Network Therapy can impact a child by modifying the biochemistry of the brain, resulting in alteration of emotion and cognition. Their chapter on neurobiological mechanisms of change describes these hypotheses in depth.

Neural and Synaptic Defects in Autism Spectrum Disorders

Neural and Synaptic Defects in Autism Spectrum Disorders
  • Author : Hansen Wang,Laurie C. Doering
  • Publisher :Unknown
  • Release Date :2015-07-07
  • Total pages :229
  • ISBN : 9782889196289
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Summary : Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of potential therapeutic targets for autism and other cognitive disorders. Our Research Topic which constitutes this e-book documents the recent development and ideas in the study of pathogenesis and treatment of ASDs, with an emphasis on syndromic disorders such as fragile X and Rett syndromes. In addition, model systems and methodological approaches with translational relevance to autism are covered herein. We hope that the Research Topic will enhance the global knowledge base in the autism research community and foster new research directions in autism related biology.

Autism Spectrum Disorder

Autism Spectrum Disorder
  • Author : Michael Fitzgerald
  • Publisher :Unknown
  • Release Date :2015-04-02
  • Total pages :378
  • ISBN : 9789535120377
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Summary : This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism cross culturally. It also examines the issue of hyperandrogenism and evidence-based treatments of autism. In terms of assessment, it focuses on psychological and biological assessment including neurotransmitters systems, structural and functional brain imaging, coping strategies of parents, examines the intertwining of language impairment, specific language impairment and ASD, as well as implicit and spontaneous Theory of Mind reading in ASD. In terms of aetiology, it focuses on genetic factors, epigenetics, synaptic vesicles, toxicity during neurodevelopment, immune system and sex differences. It also examines the link between social cognitive anatomical and neurophysiologic biomarkers and candidate genes. This book will be relevant to all mental health professionals because autism occurs in all the different areas of psychiatry and professionals who will find it helpful will be psychiatrists, psychologists, social workers, nurses, teachers and all those working with persons with Autism including parents who nowadays are interested in knowing more and more, at a detailed level about their children or adults with autism.

Autism Spectrum Disorders

Autism Spectrum Disorders
  • Author : David Amaral,Geraldine Dawson,Daniel Geschwind
  • Publisher :Unknown
  • Release Date :2011-06-17
  • Total pages :1416
  • ISBN : 9780195371826
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Summary : Written by the leading experts in autism research, this text provides a summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders.

Understanding Autism

Understanding Autism
  • Author : Steven O. Moldin,John L R Rubenstein
  • Publisher :Unknown
  • Release Date :2006-04-25
  • Total pages :552
  • ISBN : 9781420004205
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Summary : Taking an all-inclusive look at the subject, Understanding Autism: From Basic Neuroscience to Treatment reviews state-of-the-art research on the diagnosis, treatment, and prevention of autism. The book addresses potential mechanisms that may underlie the development of autism and the neural systems that are likely to be affected by these molecular, genetic, and infectious etiologies. It reviews key findings that inform diagnosis, epidemiology, clinical neuroscience, and treatment. The book concludes with a discussion of the economic cost of autism and provides a biomedical and public health perspective of the impact of this devastating disease. With chapters authored by clinical and basic researchers at the forefront of molecular and systems neuroscience, clinical neuroscience, and health economics, the book presents a powerful and comprehensive synthesis of current research on autism and its underlying neural substrates. The book's two editors are considered elite pioneers in this area of research. Dr. Rubenstein was recently elected to the highly prestigious Institute of the Medicine, an honor reserved for those most committed to professional achievement and public service.

Autism

Autism
  • Author : Elizabeth B. Torres,Caroline Whyatt
  • Publisher :Unknown
  • Release Date :2017-09-25
  • Total pages :386
  • ISBN : 9781315355245
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Summary : This is the first book to present the movement approach to autism in a comprehensive way, integrating scientific methods and results with the experience of affected people, ways to improve their experiences, and the societal integration of autism.

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability
  • Author : Carlo Sala,Chiara Verpelli
  • Publisher :Unknown
  • Release Date :2016-04-30
  • Total pages :394
  • ISBN : 9780128005330
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Summary : Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities Describes the genes implicated in autistic spectrum disorders and their function Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

Advanced Neuroimaging Methods for Studying Autism Disorder

Advanced Neuroimaging Methods for Studying Autism Disorder
  • Author : Alessandro Grecucci,Roma Siugzdaite,Remo Job
  • Publisher :Unknown
  • Release Date :2017-11-16
  • Total pages :229
  • ISBN : 9782889453160
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Summary : In the last twenty years, many attempts have been made to provide neurobiological models of autism. Functional, structural and connectivity analyses have highlighted reduced responses in key social areas, such as amygdala, medial prefrontal cortex, cingulate cortex, and superior temporal sulcus. However, these studies present discrepant results and some of them have been questioned for methodological limitations. The aim of this research topic is to present advanced neuroimaging methods able to capture the complexity of the neural deficits displayed in autism. This special issue presents new studies using structural and functional MRI, as well as magnetoencephalography, and novel protocols to analyze data (Analysis of Cluster Variability, Noise Reduction Strategies, Source-based Morphometry, Functional Connectivity Density, Restriction Spectrum Imaging and the others). We believe it is time to integrate data provided by different techniques and methodologies in order to have a better understanding of autism.

What Science Tells Us about Autism Spectrum Disorder

What Science Tells Us about Autism Spectrum Disorder
  • Author : Raphael A. Bernier,Geraldine Dawson,Joel T. Nigg
  • Publisher :Unknown
  • Release Date :2020-02-05
  • Total pages :328
  • ISBN : 9781462541379
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Summary : What have scientists learned about the causes of autism spectrum disorder? Why do different kids have such different symptoms, and what are the best ways to deal with them? Will there ever be a cure? From leading autism researchers, this accessible guide helps you put the latest advances to work for your unique child. Separating fact from fiction about causes, treatments, and prevention, the book guides you to make lifestyle choices that support the developing brain. From the impact of sleep, exercise, diet, and technology, to which type of professional help might be the right fit, the authors cover it all with expertise and compassion. Learn about the choices you face--and the steps you can take--to build a happier, healthier life for your child and family.

Autism and Joint Attention

Autism and Joint Attention
  • Author : Peter C. Mundy
  • Publisher :Unknown
  • Release Date :2016-03-01
  • Total pages :350
  • ISBN : 9781462525096
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Summary : From a preeminent researcher, this book looks at the key role of joint attention in both typical and atypical development. Peter C. Mundy shows that no other symptom dimension is more strongly linked to early identification and treatment of autism spectrum disorder (ASD). He synthesizes a wealth of knowledge on how joint attention develops, its neurocognitive underpinnings, and how it helps to explain the learning, language, and social-cognitive features of ASD across the lifespan. Clinical implications are explored, including reviews of cutting-edge diagnostic methods and targeted treatment approaches.

Autism

Autism
  • Author : Michael Fitzgerald,Jane Yip
  • Publisher :Unknown
  • Release Date :2017-04-12
  • Total pages :344
  • ISBN : 9789535130796
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Summary : This book opens with a discussion of neurodiversity and an elaboration of the diagnosis of autism. It then examines factors correlating with autism, including sex bias, month of birth, migration and impact of infant feeding. The next section is on the impact of autism. The neurobiology and genetic section deals with epigenetics and intracellular pathways associated with etiology. The development and behaviour section deals with proprioceptive profiles and joint attention in autism. The final section focuses on interventions including mindfulness, animal assisted activity, social/cultural perspective on autism intervention and physical activity. The book is relevant to all professionals and researchers working with persons with autism, including psychiatrists/psychologists, speech and language therapists, occupational therapists, teachers, nurses and care workers.

The Molecular Basis of Autism

The Molecular Basis of Autism
  • Author : S. Hossein Fatemi
  • Publisher :Unknown
  • Release Date :2015-03-20
  • Total pages :437
  • ISBN : 9781493921904
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Summary : This book is a comprehensive overview of the clinical and scientific aspects of Autism from the leading experts in the field. The clinical section covers everything from epidemiological features to epigenetic regulation to behavioral therapies and much in between. The basic science section presents the latest knowledge on the underlying causes of the disorder including the role of various neurotransmitters, neurexins and neuroligins, reelin, and other proteins. Chapters also explore the cognition and motor control in autism and the connection between oxidative stress and mitochondrial dysfunction and autism. The thorough description of these underlying causes may help researchers and clinicians find more effective treatments and therapies for the 1 in 68 American children who have been diagnosed with Autism.

Autism Spectrum Disorders

Autism Spectrum Disorders
  • Author : M. Créteil,P. Paris
  • Publisher :Unknown
  • Release Date :2015-02-11
  • Total pages :170
  • ISBN : 9783318026023
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Summary : Accurate and exhaustive, this book provides a wide overview of the current knowledge on phenotypes, mechanisms and treatment of autism spectrum disorders. It covers topics on diagnostic issues, comorbid conditions and therapeutic strategies along with a detailed discussion on the actual understanding of the pathophysiology of autism disorders. More specifically, this book reviews in detail the current knowledge on the comorbidity between mental and medical disorders, describes abnormal cognitive and social development and gives a thorough overview on genetic as well as brain imaging abnormalities observed in autism spectrum disorders. In addition, the current literature on environmental risk factors which may provide an explanation for the increased prevalence of autism is being described. The last chapter gives an extensive review of early detection and early therapeutic interventions encompassing psycho-social and pharmacological strategies. Each chapter is easy to read and gives the reader access to the most important information on each topic covered. This book provides innovative reading material for medical students, psychologists, researchers and clinicians who need accurate information on the best available diagnostic and therapeutic strategies as well as on up-to-date research data.

Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management

Personalized Food Intervention and Therapy for Autism Spectrum Disorder Management
  • Author : M. Mohamed Essa,M. Walid Qoronfleh
  • Publisher :Unknown
  • Release Date :2020-01-31
  • Total pages :693
  • ISBN : 9783030304027
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Summary : The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.