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The Preclinical and Clinical Effects of Cannabis and Cannabinoids on Cardiovascular Health

The Preclinical and Clinical Effects of Cannabis and Cannabinoids on Cardiovascular Health
  • Author : Rodney A. Samaan,Christopher Samaan
  • Publisher :Unknown
  • Release Date :2021-08-16
  • Total pages :308
  • ISBN : 0128174323
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Summary : The Preclinical and Clinical Effects of Cannabis and Cannabinoids on Cardiovascular Health is a comprehensive investigation into the cardiovascular health effects of marijuana use. As the prevalence of cannabis use increases both recreationally and clinically, a shroud of misinformation exists in academia, the public, and clinical realms. Further, since different studies show contradictory results it is hard to determine the exact benefits for cannabis use. This book will focus on a specific set of cardiovascular diseases plaguing the current population and the effects of cannabis will be addressed from numerous viewpoints including human physiological and clinical disease outcomes to issues in public health. By gathering this information in a way that addresses numerous viewpoints the book serves as a comprehensive reference and clinical guide Compiles the numerous contradictory reports about the effects of marijuana and cardiovascular disease for ease in comparison Examines the mechanisms that have shown how marijuana use might contribute to the development of chronic cardiovascular conditions and/or acutely trigger cardiovascular events Includes coverage of the drug's role in pharmacotherapy

The Health Effects of Cannabis and Cannabinoids

The Health Effects of Cannabis and Cannabinoids
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda
  • Publisher :Unknown
  • Release Date :2017-03-31
  • Total pages :486
  • ISBN : 9780309453073
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Summary : Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.

Marijuana and the Cannabinoids

Marijuana and the Cannabinoids
  • Author : Mahmoud A. ElSohly
  • Publisher :Unknown
  • Release Date :2007-11-15
  • Total pages :322
  • ISBN : 9781592599479
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Summary : Although primarily used today as one of the most prevalent illicit leisure drugs, the use of Cannabis sativa L., commonly referred to as marijuana, for medicinal purposes has been reported for more than 5000 years. Marijuana use has been shown to create numerous health problems, and, consequently, the expanding use beyond medical purposes into recreational use (abuse) resulted in control of the drug through international treaties. Much research has been carried out over the past few decades following the identification of the chemical structure of THC in 1964. The purpose of Marijuana and the Cannabinoids is to present in a single volume the comprehensive knowledge and experience of renowned researchers and scientists. Each chapter is written independently by an expert in his/her field of endeavor, ranging from the botany, the constituents, the chemistry and pharmacokinetics, the effects and consequences of illicit use on the human body, to the therapeutic potential of the cannabinoids.

The Health and Social Effects of Nonmedical Cannabis Use

The Health and Social Effects of Nonmedical Cannabis Use
  • Author : World Health Organization
  • Publisher :Unknown
  • Release Date :2016-02-15
  • Total pages :95
  • ISBN : 9789241510240
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Summary : Cannabis is globally the most commonly used psychoactive substance under international control. In 2013, an estimated 181.8 million people aged 15-64 years used cannabis for nonmedical purposes globally (UNODC, 2015). There is an increasing demand for treatment for cannabis-use disorders and associated health conditions in high- and middle-income countries. This report focuses on nonmedical use of cannabis, building on contributions from a broad range of experts and researchers from different parts of the world. It aims to present current knowledge on the impact of nonmedical cannabis use on health, from its impact on brain development to its role in respiratory diseases. The potential medical utility of cannabis -- including the pharmacology, toxicology and possible therapeutic applications of the cannabis plant -- is outside the scope of this report.

Handbook of Cannabis

Handbook of Cannabis
  • Author : Roger G. Pertwee
  • Publisher :Unknown
  • Release Date :2014
  • Total pages :747
  • ISBN : 9780199662685
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Summary : In addition it also examines the complex morphology, cultivation, harvesting, and processing of cannabis and the ways in which the plant's chemical composition can be controlled. As well as offering a raft of scientific information there is extensive coverage of cannabinoid-based medicines. Helping readers to identify and evaluate their benefits, chapters explore pharmacological actions and the effects that seem to underlie approved therapeutic uses, how they are currently used to treat certain disorders, and the ever-growing number of wide-ranging potential clinical applications. There is also coverage of both the legal and illegal sources of cannabis, including 'coffee shops' and 'cannabis dispensaries'. The complex issue of 'recreational cannabis' is also tackled.

Marijuana and Medicine

Marijuana and Medicine
  • Author : Institute of Medicine
  • Publisher :Unknown
  • Release Date :1999-07-10
  • Total pages :288
  • ISBN : 9780309071550
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Summary : The medical use of marijuana is surrounded by a cloud of social, political, and religious controversy, which obscures the facts that should be considered in the debate. This book summarizes what we know about marijuana from evidence-based medicine--the harm it may do and the relief it may bring to patients. The book helps the reader understand not only what science has to say about medical marijuana but also the logic behind the scientific conclusions. Marijuana and Medicine addresses the science base and the therapeutic effects of marijuana use for medical conditions such as glaucoma and multiple sclerosis. It covers marijuana's mechanism of action, acute and chronic effects on health and behavior, potential adverse effects, efficacy of different delivery systems, analysis of the data about marijuana as a gateway drug, and the prospects for developing cannabinoid drugs. The book evaluates how well marijuana meets accepted standards for medicine and considers the conclusions of other blue-ribbon panels. Full of useful facts, this volume will be important to anyone interested in informed debate about the medical use of marijuana: advocates and opponents as well as policymakers, regulators, and health care providers.

Handbook of Cannabis and Related Pathologies

Handbook of Cannabis and Related Pathologies
  • Author : Victor R. Preedy
  • Publisher :Unknown
  • Release Date :2016-12-31
  • Total pages :1170
  • ISBN : 9780128008270
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Summary : Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment is the first book to take an interdisciplinary approach to the understanding of cannabis use and misuse. Recent worldwide trends toward decriminalizing marijuana for medical use have increased legal use of the drug and recreational use remains high, making cannabis one of the most commonly used drugs. Cannabis has a wide range of adverse neurological effects, and use and abuse can lead to physical, social, and psychopathological issues that are multifarious and complex. Effective understanding and treatment requires knowledge of the drug’s effects from across scientific disciplines. This book provides an overview of the biological and pharmacological components of the cannabis plant, outlines its neurological, social, and psychopathological effects, assists in the diagnosis and screening for use and dependency, and aids researchers in developing effective treatments for cannabis-related issues and disorders. Fully illustrated, with contributions from internationally recognized experts, it is the go-to resource for neuroscientists, pharmacologists, pathologists, public-health workers, and any other researcher who needs an in-depth and cross-disciplinary understanding of cannabis and its effects. Comprehensive chapters include an abstract, key facts, mini dictionary of terms, and summary points Presents illustrations with at least six figures, tables, and diagrams per chapter Provides a one-stop-shopping synopsis of everything to do with cannabis and its related pathology, from chemicals and cells, individuals and communities, and diagnosis and treatment Offers an integrated and informed synopsis of the complex issues surrounding cannabis as a substance, its use, and its misuse

Cannabis and Cannabinoids

Cannabis and Cannabinoids
  • Author : Ethan B Russo
  • Publisher :Unknown
  • Release Date :2013-09-05
  • Total pages :478
  • ISBN : 9781136614934
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Summary : Study the latest research findings by international experts! This comprehensive volume presents state-of-the-art scientific research on the therapeutic uses of cannabis and its derivatives. All too often, discussions of the potential medical uses of this substance are distorted by political considerations that have no place in a medical debate. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential features fair, equitable discussion of this emerging and controversial medical topic by the world’s foremost researchers. Cannabis and Cannabinoids examines the benefits, drawbacks, and side effects of medical marijuana as a treatment for various conditions and diseases. This book discusses the scientific basis for marijuana’s use in cases of pain, nausea, anorexia, and cachexia. It also explores its possible benefits in glaucoma, ischemia, spastic disorders, and migraine. Cannabis and Cannabinoids examines all facets of the medical use of marijuana, including: botany history biochemistry pharmacology clinical use toxicology side effects Cannabis and Cannabinoids is a reference work that will become indispensable to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public. No other book available offers this comprehensive, even-handed look at a deeply divisive subject.

Cannabinoids in Health and Disease

Cannabinoids in Health and Disease
  • Author : Rosaria Meccariello,Rosanna Chianese
  • Publisher :Unknown
  • Release Date :2016-06-15
  • Total pages :258
  • ISBN : 9789535124290
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Summary : This book provides a comprehensive overview of current knowledge of cannabinoid activity in human physiology and points out the importance of endocannabinoid system for the maintenance of human health and treatment of diseases. Each chapter has been organized with the aim to cover basic concepts in the modulation of endocannabinoid system in both physiological and pathological conditions, thanks to the integration of data from experimental animal models and clinical observations. A special focus has been put on the medical use of cannabinoids and on the targeting of endocannabinoid system as new therapeutic strategy for the prevention and treatment of human diseases. Taken together, this book targets a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding in the field of cannabinoids.

Handbook of Cannabis for Clinicians: Principles and Practice

Handbook of Cannabis for Clinicians: Principles and Practice
  • Author : Dustin Sulak DO
  • Publisher :Unknown
  • Release Date :2021-06-29
  • Total pages :384
  • ISBN : 9780393714197
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Summary : The first foundational text on the clinical use of cannabis and cannabinoid therapies. Despite thousands of years of medical use and an impressive record of safety, versatility, and efficacy, Cannabis sativa has existed outside the modern pharmacopeia since the 1940s. Primarily driven by popular demand, this botanical has returned to health care, but most clinicians lack the knowledge essential for identifying candidates for treatment, guiding patients, maximizing benefit, and minimizing harm. Dustin Sulak provides health care professionals—including physicians, psychologists, pharmacists, and nurses—with an accessible and evidence-based reference that empowers them to intelligently discuss cannabis with their patients and implement cannabis and cannabinoid therapies with confidence. Based on over a decade of clinical experience and an extensive review of the literature, this detailed and scientifically accurate guide includes the history of cannabis in medicine, the foundations of endocannabinoid physiology, the pharmacological effects of cannabis’ myriad active constituents, the clinical utility of its various preparations, and specific strategies and cautions for treating the most common conditions presenting to a cannabis clinician. This guide is an essential resource for practitioners of any specialty field or experience level who wish to improve their patients’ outcomes, harness the healing potential of the endocannabinoid system, and wield a powerful solution to many of healthcare’s challenges.

Therapeutic Uses of Cannabis

Therapeutic Uses of Cannabis
  • Author : British Medical Association
  • Publisher :Unknown
  • Release Date :2020-08-12
  • Total pages :160
  • ISBN : 9781000159653
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Summary : At the last Annual Representative Meeting of the British Medical Association a motion was passed that `certain additional cannabinoids should be legalized for wider medicinal use.'' This report supports this landmark statement by reviewing the scientific evidence for the therapeutic use of cannabinoids and sets the agenda for change. It will be welcomed by those who believe that cannabinoids can be used in medical treatment. The report discusses in a clear and readable form the use and adverse effects of the drug for nausea, multiple sclerosis, pain, epilepsy, glaucoma, and asthma.

Cannabis in Medical Practice

Cannabis in Medical Practice
  • Author : Mary Lynn Mathre, R.N.
  • Publisher :Unknown
  • Release Date :2012-11-12
  • Total pages :247
  • ISBN : 9780786483907
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Summary : Because marijuana is a Schedule I drug under the Controlled Substances Act, the therapeutic benefits of cannabis are no longer mentioned in the formal education of health care professionals. Doctors who do learn of the drug’s therapeutic value are often intimidated by its illegal status. Thus millions of patients afflicted with such illnesses as glaucoma, AIDS, cancer, multiple sclerosis, spinal cord injuries, seizure disorders and chronic pain are denied access to information about the drug’s benefits and, in many cases, suffer needlessly. Straightforward and nonpoliticized information on the therapeutic uses of cannabis is provided here by medical, legal and scientific professionals. Legal issues, a worldwide history of therapeutic cannabis and a discussion of its pharmacology are covered. Specific medical uses are then examined, including its application for sufferers of cancer, AIDS, glaucoma, and seizure disorders, and its potential use in psychiatry. Dosages and administration of cannabis are explored, along with considerations on the use of the drug during pregnancy and the risks of addiction and dependency.

Cannabinoids in Neurologic and Mental Disease

Cannabinoids in Neurologic and Mental Disease
  • Author : Liana Fattore
  • Publisher :Unknown
  • Release Date :2015-01-23
  • Total pages :496
  • ISBN : 9780124171244
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Summary : The application of cannabis sativa for the treatment of neurologic and mental disease is expanding. Cannabinoids in Neurologic and Mental Disease collects and presents for the first time recent research involving the use of pharmacological cannabinoids for the treatment of neurodegenerative and neuroinflammatory disease. The neurologic application of cannabinoid therapy builds upon psychiatric and psychological use for the treatment of a variety of core mental disorders. This comprehensive reference on the known uses of cannabinoids will be useful for clinical neurologists, neuroscience and clinical neuroscience researchers, clinical psychologists and psychiatrists and the general medical community. A comprehensive reference on the clinical uses of cannabinoids for treating major neurologic and mental diseases Detailed coverage of cannabinoid use for neuroinflammatory and neurodegenerative disease including Multiple Sclerosis, Epilepsy, Huntington's disease, Parkinson's disease, and Alzheimer's disease Detailed coverage of cannabinoid use for major psychiatric and psychological diseases and disorders including schizophrenia, bipolar disorders, Tourette's syndrome, and post-traumatic stress disorder (PTSD)

Cannabis Healing

Cannabis Healing
  • Author : Franjo Grotenhermen
  • Publisher :Unknown
  • Release Date :2020-09-22
  • Total pages :240
  • ISBN : 9781620558324
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Summary : Everything you need to know to use cannabinoids safely and effectively for better health and healing of a wide range of conditions • Explains the biochemistry of cannabinoids and shows how they interact with the human body • Offers a complete discussion of safe use, possible side effects, contraindications, and precautions, including during pregnancy and chemotherapy • Explores the use of CBD to treat seizures, anxiety, muscular disorders, and psychotic states and the use of THC to treat schizophrenia, Alzheimer’s, ADHD, Tourette’s, Parkinson’s, depression, COPD, and chronic pain, among many other physical, neurological, and emotional conditions In this authoritative yet practical guide to the healing properties of cannabis and cannabinoids such as THC and CBD, Franjo Grotenhermen, M.D., explores how to use these substances to treat a wide range of physical and emotional conditions. Dr. Grotenhermen first examines the history of marijuana as medicine, including its important role in U.S. medical practice during the 19th century. He explains the biochemistry of cannabinoids and shows how they interact with the human body, including a look at cannabinoid receptors and how cannabinoids occur naturally in the body. The author then draws on his years of experience legally treating patients in Germany as well as numerous research studies and tests to provide an in-depth guide to the many healing applications for cannabis and its derivatives. The therapeutic applications covered include the use of CBD to treat seizures, epilepsy, anxiety, several forms of cancer, muscular disorders, and psychotic states and the use of THC to treat schizophrenia, Alzheimer’s, ADHD, Tourette’s, Parkinson’s, impotence, depression, lupus, COPD, and chronic pain, among many other physical, neurological, and emotional conditions. The author examines the various cannabis-derived medications available, such as Cannabinol, Dronabinol, and Marinol, and the main methods of administering cannabis. He offers a complete discussion of safe use, possible side effects, contraindications, and precautions (including during pregnancy and chemotherapy), alongside research data that confirms cannabis as one of the least toxic substances in existence. Written by a practicing physician, this guide provides everything you need to know to use cannabinoids safely and effectively for health and healing.

Cannabis Use Disorders

Cannabis Use Disorders
  • Author : Ivan D. Montoya,Susan R. B. Weiss
  • Publisher :Unknown
  • Release Date :2018-11-24
  • Total pages :271
  • ISBN : 9783319903651
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Summary : This book is an unbiased scientific compendium documenting the state-of-the-art in the etiology, diagnosis and treatment of Cannabis Use Disorders (CUD). Unlike any other current medical text, this volume focuses on the scientific aspects of CUDs and provides a resource for researchers, physicians and other health care providers who treat patients suffering from the disorder or its consequences. It begins by establishing the landscape of the disorder, including its prevalence, association with disabilities and comorbidities, and frequency of patients seeking treatment. The text delves into the complexity of the disorder in today’s environment by including the discoveries on the nature and extent of the endocannabinoid system as well as potential breakthroughs in safe and effective pharmacological and nonpharmacological treatments. Experts in the field contribute discussions on the most cutting-edge diagnostic and biological topics, including genetics, medical consequences, and clinical manifestations. The text also covers the challenges and risks presented by external factors, including social repercussions, protective factors, psychiatric comorbidities, withdrawal, and treatment services. Cannabis Use Disorders is a vital resource for researchers, psychiatrists, psychologists, addiction medicine specialists, toxicologists, hospital administrators, nurses, social workers, and all health care professionals working with patients who misuse cannabis.

Marijuana and Madness

Marijuana and Madness
  • Author : David Castle,Robin M. Murray,Deepak Cyril D'Souza
  • Publisher :Unknown
  • Release Date :2011-10-27
  • Total pages :229
  • ISBN : 9781139502672
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Summary : The second edition of this critically acclaimed and award-winning text provides a comprehensive overview of the psychiatry and neuroscience of Cannabis sativa (marijuana). It outlines the very latest developments in our understanding of the human cannabinoid system, and links this knowledge to clinical and epidemiological facts about the impact of cannabis on mental health. Clinically focused chapters review not only the direct psychomimetic properties of cannabis, but also the impact consumption has on the courses of evolving or established mental illnesses such as schizophrenia. Effects of cannabis on mood are reviewed, as are its effects on cognition. This new edition has been extensively updated and expanded with 10 new chapters to incorporate major new research findings. This book will be of interest to all members of the mental health team, as well as to neuroscientists, epidemiologists, public health specialists and those involved in drug and alcohol research.

The Medicinal Uses of Cannabis and Cannabinoids

The Medicinal Uses of Cannabis and Cannabinoids
  • Author : Geoffrey William Guy,Brian Anthony Whittle,Philip Robson
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :488
  • ISBN : UOM:39015061855352
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Summary : Describes current research findings relating to the medicinal use of cannabis and cannabinoids. Topics covered include the pharmacology, formulation, safety and efficacy of cannabis as a therapeutic agent; growth and breeding of cannabis as a medicine; cannabis in neuropathic-pain treatment and multiple sclerosis; clinical studies and the development of cannabis-based medicine; and forensic and international control of cannabis.

Marijuana and Mental Health

Marijuana and Mental Health
  • Author : Michael T. Compton, M.D., M.P.H.
  • Publisher :Unknown
  • Release Date :2016-03-18
  • Total pages :272
  • ISBN : 9781615370085
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Summary : With relatable clinical vignettes that illustrate the applicability of each chapter’s content, as well as key chapter points that summarize major themes, Marijuana and Mental Health is the definitive, single source of comprehensive information on marijuana and mental health in modern American society. Balanced, focused, and highly readable, chapters address topics such as the effects of marijuana on the brain and mind, marijuana-related policy and legislation, the complex link between marijuana use and psychotic disorders, synthetic cannabinoids, and the treatment and prevention of marijuana misuse. Beyond offering clinical and research psychiatrists, psychiatric residents and fellows, clinical psychologists, and psychiatric nurses a comprehensive but concise compilation of research in this area, this reference informs clinical mental health practice as well as policy decisions by articulating the connection between marijuana and mental health, particularly in the United States.

Cannabinoids As Therapeutic Agents

Cannabinoids As Therapeutic Agents
  • Author : Raphael Mechoulam
  • Publisher :Unknown
  • Release Date :2019-06-13
  • Total pages :186
  • ISBN : 9780429536267
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Summary : Published in 1986: The plant Cannabis sativa L. and its numerous preparations have been used as therapeutic agents for millenia. In the present book, the editor has tried to summarize the use in the past, to present an overview of modern research and applications to predict future developments.

Natural Products and Cancer Drug Discovery

Natural Products and Cancer Drug Discovery
  • Author : Farid A. Badria
  • Publisher :Unknown
  • Release Date :2017-07-05
  • Total pages :316
  • ISBN : 9789535133131
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Summary : This book, Natural Products and Cancer Drug Discovery, is written by leading experts in natural products in cancer therapy. The first two sections describe new applications of common herbs and foods for treatment of cancer. Section 3 deals with the development of new chemotherapeutics from Cannabis and endophytic fungi. Section 4 presented formulations of natural products for treatment of malignant melanoma. Made-to-order anticancer therapy from natural products using computational and tissue engineering approaches is addressed in the fifth section. It is our hope that this book may motivate readers to approach the evidence of anticancer natural products with an open mind and thereby spark an interest in making further contributions to the cancer treatment efforts.

Cannabis for Seniors

Cannabis for Seniors
  • Author : Beverly A. Potter, PhD
  • Publisher :Unknown
  • Release Date :2017-03-20
  • Total pages :200
  • ISBN : 9781579512439
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Summary : CANNABIS FOR SENIORS is written for independent seniors - as well as for family members and caretakers seeking ways to manage their everyday health concerns without resorting to powerful, habit-forming, potentially dangerous medications. CANNABIS FOR SENIORS reviews the latest scientific research regarding the health effects of marijuana and the effectiveness of various cannabis strains for managing specific health conditions. It also presents anecdotal reports on cannabis use by seniors – so readers can learn about people “just like them” who have tried medical marijuana and had good results. It addresses the myths and worries that many seniors have about marijuana use showing which concerns are founded in fact and which are simply based on inadequate or partial information. CANNABIS FOR SENIORS discusses various methods of administering medical marijuana, explaining which conditions are best handled by smoking, eating, or using skin patches containing active medicinal cannabis components. It deals in detail with the major conditions that cannabis can help: • Sleep issues • Depression • Alzheimer’s disease • Chronic pain • Anxiety • Digestive disorders • Cancer • Glaucoma • Multiple sclerosis • Parkinson’s disease • Concussions • Stroke • …….and many more For each condition, CANNABIS FOR SENIORS explains the scientific research and personal anecdotes supporting use of medical marijuana; helping seniors decide for themselves, or with the help of a caregiver, how best to cope with their personal health situations. CANNABIS FOR SENIORS also discusses social elements of life that are facilitated by marijuana. Research shows that seniors who remain connected to friends, family members and community live longer, happier and healthier lives. The book shows how medical marijuana can help with these important social connections.