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The Science, Etiology and Mechanobiology of Diabetes and its Complications

The Science, Etiology and Mechanobiology of Diabetes and its Complications
  • Author : Amit Gefen
  • Publisher :Unknown
  • Release Date :2021-05-03
  • Total pages :434
  • ISBN : 9780128210710
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Summary : The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective – addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia. Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here. Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry

The Science, Etiology and Mechanobiology of Diabetes and Its Complications

The Science, Etiology and Mechanobiology of Diabetes and Its Complications
  • Author : Amit Gefen
  • Publisher :Unknown
  • Release Date :2021-05-17
  • Total pages :434
  • ISBN : 9780128210703
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Summary : The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective - addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia. Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here. Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry

Principles of Regenerative Medicine

Principles of Regenerative Medicine
  • Author : Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
  • Publisher :Unknown
  • Release Date :2010-12-16
  • Total pages :1202
  • ISBN : 0123814235
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Summary : Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Biological, Physical and Technical Basics of Cell Engineering

Biological, Physical and Technical Basics of Cell Engineering
  • Author : Gerhard M. Artmann,Aysegül Artmann,Azhar A. Zhubanova,Ilya Digel
  • Publisher :Unknown
  • Release Date :2018-04-11
  • Total pages :481
  • ISBN : 9789811079047
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Summary : This book presents and discusses recent scientific progress on Cell and Stem Cell Engineering. It predominantly focuses on Biological, Physical and Technical Basics, and features new trends of research reaching far into the 21st century.

Pathobiology of Human Disease

Pathobiology of Human Disease
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2014-08-01
  • Total pages :5000
  • ISBN : 9780123864574
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Summary : Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human Organ Systems Molecular Pathology/Basic Mechanisms of Diseases Animal Models/Other Model Systems Experimental Pathology Clinical Pathology Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from research professionals to advanced undergraduate students. Reviews quantitative advances in the imaging and molecular analysis of human tissue, new microarray technologies for analysis of genetic and chromosomal alterations in normal and diseased cells and tissues, and new transgenic models of human disease using conditional, tissue-specific gene targeting Articles link through to relevant virtual microscopy slides, illustrating side-by-side presentation of "Normal" and "Disease" anatomy and histology images Fully-annotated with many supplementary full color images, graphs, tables, and video files linked to data sets and to live references, enabling researchers to delve deeper and visualize solutions

Innovations and Emerging Technologies in Wound Care

Innovations and Emerging Technologies in Wound Care
  • Author : Amit Gefen
  • Publisher :Unknown
  • Release Date :2019-10-20
  • Total pages :464
  • ISBN : 9780128150290
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Summary : Innovations and Emerging Technologies in Wound Care is a pivotal book on the prevention and management of chronic and non-healing wounds. The book clearly presents the research and evidence that should be considered when planning care interventions to improve health related outcomes for patients. New and emerging technologies are discussed and identified, along with tactics on how they can be integrated into clinical practice. This book offers readers a bridge between biomedical engineering and medicine, with an emphasis on technological innovations. It includes contributions from engineers, scientists, clinicians and industry professionals. Users will find this resource to be a complete picture of the latest knowledge on the tolerance of human tissues to sustained mechanical and thermal loads that also provides a deeper understanding of the risk for onset and development of chronic wounds. Describes the state-of-knowledge in wound research, including tissue damage cascades and healing processes Covers all state-of-the-art technology in wound prevention, diagnosis, prognosis and treatment Discusses emerging research directions and future technology trends in the field of wound prevention and care Offers a bench-to-bedside exploration of the key issues that affect the practice of prevention and management of non-healing wounds

Ethics and Intersex

Ethics and Intersex
  • Author : Sharon E. Sytsma
  • Publisher :Unknown
  • Release Date :2006-06-07
  • Total pages :328
  • ISBN : 9781402043147
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Summary : This collection of 21 articles is designed to serve as a state-of-the art reference book for intersexuals, their parents, health care professionals, ethics committee members, and anyone interested in problems associated with intersexuality. It fills an important need because of its uniqueness as an interdisciplinary effort, bringing together not just urologists and endocrinologists, but gynecologists, psychiatrists, psychologists, lawyers, theologians, gender theorists, medical historians, and philosophers. Most contributors are well-known experts on intersexuality in their respective fields. The book is also unique in that it is also an international effort, including authors from England, the Netherlands, Germany, Australia, India, Canada and the United States. The book begins with introductory chapters on the etiology of intersex conditions, conceptual clarification, legal issues, and reflections about the inherent characteristics of medical care that have led up to the issues we face today and explain the resistance to change in traditional practices. Researchers provide recent data on gender identity, surgical outcomes, and appropriate clinical care. Issues never having been addressed are introduced. The significance of intersexuality for Christianity and for philosophical concerns with authenticity add further depth to the collection. The final chapters deal with future possibilities in the treatment of intersex and for intersex advocacy.

Multiscale Mechanobiology of Bone Remodeling and Adaptation

Multiscale Mechanobiology of Bone Remodeling and Adaptation
  • Author : Peter Pivonka
  • Publisher :Unknown
  • Release Date :2017-07-27
  • Total pages :324
  • ISBN : 9783319588452
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Summary : The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Osteoporosis

Osteoporosis
  • Author : Robert Marcus,David Feldman,Dorothy Nelson,Clifford Rosen
  • Publisher :Unknown
  • Release Date :2007-11-08
  • Total pages :2016
  • ISBN : 0080553478
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Summary : Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year. NEW TO THIS EDITION: *Recognizes the critical importance of the Wnt signaling pathway for bone health *Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone *Examines essential updates on estrogen prevention and treatment and the recent results from the WHI *Discusses the controversial topics of screening and clinical trial design for drug registration *Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone * Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease
  • Author : Stefaan Verbruggen
  • Publisher :Unknown
  • Release Date :2018-08-09
  • Total pages :527
  • ISBN : 9780128129531
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Summary : Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Computer Methods in Biomechanics and Biomedical Engineering

Computer Methods in Biomechanics and Biomedical Engineering
  • Author : Amit Gefen,Daphne Weihs
  • Publisher :Unknown
  • Release Date :2017-08-29
  • Total pages :263
  • ISBN : 9783319597645
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Summary : This edited volume collects the research results presented at the 14th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, Tel Aviv, Israel, 2016. The topical focus includes, but is not limited to, cardiovascular fluid dynamics, computer modeling of tissue engineering, skin and spine biomechanics, as well as biomedical image analysis and processing. The target audience primarily comprises research experts in the field of bioengineering, but the book may also be beneficial for graduate students alike.

Skeletal Tissue Mechanics

Skeletal Tissue Mechanics
  • Author : R. Bruce Martin,David B. Burr,Neil A. Sharkey,David P. Fyhrie
  • Publisher :Unknown
  • Release Date :2015-10-29
  • Total pages :501
  • ISBN : 9781493930029
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Summary : This textbook describes the biomechanics of bone, cartilage, tendons and ligaments. It is rigorous in its approach to the mechanical properties of the skeleton yet it does not neglect the biological properties of skeletal tissue or require mathematics beyond calculus. Time is taken to introduce basic mechanical and biological concepts, and the approaches used for some of the engineering analyses are purposefully limited. The book is an effective bridge between engineering, veterinary, biological and medical disciplines and will be welcomed by students and researchers in biomechanics, orthopedics, physical anthropology, zoology and veterinary science. This book also: Maximizes reader insights into the mechanical properties of bone, fatigue and fracture resistance of bone and mechanical adaptability of the skeleton Illustrates synovial joint mechanics and mechanical properties of ligaments and tendons in an easy-to-understand way Provides exercises at the end of each chapter

Congenital Anomalies of the Upper Extremity

Congenital Anomalies of the Upper Extremity
  • Author : Donald R. Laub Jr.
  • Publisher :Unknown
  • Release Date :2014-09-11
  • Total pages :356
  • ISBN : 9781489975041
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Summary : Written by leading experts in the fields of pediatrics, orthopedic surgery and plastic and reconstructive hand surgery, Congenital Anomalies of the Upper Extremity encompasses the current knowledge of genetic and molecular causes of and surgical and non-surgical treatment for, deformities of the hand. The book covers the many variations of congenital anomaly encountered in the clinical setting. Embryology, classification, incidence and anesthesia considerations are discussed first, followed by physical medicine, rehabilitation and therapy management, including psychological considerations, for children living with these conditions. Failures of formation and differentiation of the fingers and hand plate, duplication, and overgrowth, as well as other generalized anomalies, are then presented in detail, including symbrachydactyly, syndactyly, Apert syndrome, polydactyly, amniotic band syndrome and Madelung deformity, among others. Complete with plentiful photographs and illustrations to guide the clinician in preparing for and performing the necessary treatments, this is an essential book for hand surgeons, orthopedists and plastic surgeons.

CMBEBIH 2019

CMBEBIH 2019
  • Author : Almir Badnjevic,Ranko Škrbić,Lejla Gurbeta Pokvić
  • Publisher :Unknown
  • Release Date :2019-05-10
  • Total pages :782
  • ISBN : 9783030179717
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Summary : This volume gathers the proceedings of the International Conference on Medical and Biological Engineering, which was held from 16 to 18 May 2019 in Banja Luka, Bosnia and Herzegovina. Focusing on the goal to ‘Share the Vision’, it highlights the latest findings, innovative solutions and emerging challenges in the field of Biomedical Engineering. The book covers a wide range of topics, including: biomedical signal processing, medical physics, biomedical imaging and radiation protection, biosensors and bioinstrumentation, bio-micro/nano technologies, biomaterials, biomechanics, robotics and minimally invasive surgery, and cardiovascular, respiratory and endocrine systems engineering. Further topics include bioinformatics and computational biology, clinical engineering and health technology assessment, health informatics, e-health and telemedicine, artificial intelligence and machine learning in healthcare, as well as pharmaceutical and genetic engineering. Given its scope, the book provides academic researchers, clinical researchers and professionals alike with a timely reference guide to measures for improving the quality of life and healthcare.

Textbook on Scar Management

Textbook on Scar Management
  • Author : Luc Téot,Thomas A. Mustoe,Esther Middelkoop,Gerd G. Gauglitz
  • Publisher :Unknown
  • Release Date :2021-01-08
  • Total pages :553
  • ISBN : 9783030447663
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Summary : This text book is open access under a CC BY 4.0 license. Written by a group of international experts in the field and the result of over ten years of collaboration, it allows students and readers to gain to gain a detailed understanding of scar and wound treatment – a topic still dispersed among various disciplines. The content is divided into three parts for easy reference. The first part focuses on the fundamentals of scar management, including assessment and evaluation procedures, classification, tools for accurate measurement of all scar-related elements (volume density, color, vascularization), descriptions of the different evaluation scales. It also features chapters on the best practices in electronic-file storage for clinical reevaluation and telemedicine procedures for safe remote evaluation. The second section offers a comprehensive review of treatment and evidence-based technologies, presenting a consensus of the various available guidelines (silicone, surgery, chemical injections, mechanical tools for scar stabilization, lasers). The third part evaluates the full range of emerging technologies offered to physicians as alternative or complementary solutions for wound healing (mechanical, chemical, anti-proliferation). Textbook on Scar Management will appeal to trainees, fellows, residents and physicians dealing with scar management in plastic surgery, dermatology, surgery and oncology, as well as to nurses and general practitioners

Dupuytren Disease and Related Diseases - The Cutting Edge

Dupuytren Disease and Related Diseases - The Cutting Edge
  • Author : Paul M. N. Werker,Joseph Dias,Charles Eaton,Bert Reichert,Wolfgang Wach
  • Publisher :Unknown
  • Release Date :2016-09-07
  • Total pages :450
  • ISBN : 9783319321998
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Summary : In this book, leading international experts showcase the latest advances in research into Dupuytren disease and its clinical management. The coverage spans all relevant specialties, including cell biology, biomechanics, genomics, surgery, pharmacotherapy, and radiotherapy. The opening sections address epidemiology, cellular and extracellular events, and genetics. Treatment by means of collagenase injection, percutaneous needle fasciotomy, and other surgical and minimally invasive approaches is then extensively discussed. Comparative studies of different approaches are reviewed, and aspects of patient assessment, examined. The prevention and treatment of disease recurrences are also addressed. Further sections consider related conditions, other treatment options, and future pathways for research. This book should be read by all who treat or conduct research into Dupuytren disease. It is based on presentations delivered at the 2015 International Conference on Dupuytren Disease, held in Groningen, the Netherlands, which was designed to promote a coordinated global response to the disease involving patients, scientists, and clinicians.

Biology of Orthodontic Tooth Movement

Biology of Orthodontic Tooth Movement
  • Author : Bhavna Shroff
  • Publisher :Unknown
  • Release Date :2016-05-30
  • Total pages :164
  • ISBN : 9783319266091
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Summary : ​This book presents the current knowledge and understanding of the biological processes involved in the orthodontic movement of teeth and discusses recent progress in the field. It links research advances to their immediate clinical applications and offers researchers and clinicians a state of the art reference on topical issues relating to orthodontic tooth movement. Biological events play a central role in the movement of teeth during orthodontic therapy. The basis for understanding the sequence of cellular events that leads to orthodontic movement has been well established in the literature through the use of animal models. In recent years, researchers and clinicians have focused their efforts on developing treatment modalities to increase the speed of orthodontic treatment and provide better anchorage options for noncompliant patients. This book will be an invaluable aid in understanding the biology of tooth movement and the relevance of the latest concepts to clinical practice.

Rheumatic Disease in Geriatrics

Rheumatic Disease in Geriatrics
  • Author : Gleb Slobodin,Yehuda Shoenfeld
  • Publisher :Unknown
  • Release Date :2020-05-25
  • Total pages :404
  • ISBN : 9783030442347
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Summary : This book provides a practical guide to the diagnosis and management of rheumatic disease in geriatric patients. It details information on the effect of ageing on musculoskeletal and immune systems and specifies impact of a variety of inflammatory and degenerative rheumatic disorders on the elderly. The clinical diagnostic approach to an older individual with musculoskeletal complaints is a cornerstone of this book, which includes also insights into the most important comorbidities for this age and discusses in depth available treatments and rehabilitation tools. The symptoms, imaging features and recommendations on the interpretation of specific laboratory tests for rheumatic diseases in geriatrics are also covered. This book encompasses traditionally associated with older age conditions including temporal arteritis, polymyalgia rheumatica, osteoarthritis, as well as common systemic autoimmune diseases that can produce atypical manifestations in the elderly. It will enable the readers to develop a thorough understanding of how to deal with these patients in their clinical practice. Rheumatic Disease in Geriatrics: Diagnosis and Management systematically describes how to diagnose and treat geriatric patients with a variety of rheumatic conditions and is a valuable resource for all medical professionals involved.

The Shoulder Made Easy

The Shoulder Made Easy
  • Author : Charalambos Panayiotou Charalambous
  • Publisher :Unknown
  • Release Date :2019-02-27
  • Total pages :557
  • ISBN : 9783319989082
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Summary : This book provides a concise and up-to-date resource on common shoulder disorders. The reader will learn about various shoulder conditions, their presentation, evaluation and management. Anatomy, biomechanics, function, clinical history taking and examination, radiological imaging and other investigations, as well as principles of non-surgical and surgical management of the troublesome shoulder are presented first. The Shoulder Made Easy conveys clear, easily understood information to help practitioners in day-to-day clinical practice as well as in preparation for undergraduate or postgraduate exams. The book focuses on: Commonly encountered clinical symptoms of the shoulder: patients don't present with a clinical diagnosis but with symptoms such as pain, stiffness, weakness or instability and a thorough consideration of what could be accounting for such symptoms and how such symptoms may be dealt with is presented. Commonly encountered clinical disorders of the shoulder: each clinical disorder is concisely presented with the background, clinical symptoms, investigations, differential diagnosis, treatment and a further reading section. This book attempts to present information in an easily read, succinct way. In particular, this book tries to unpick and explain those concepts of shoulder disorders that may be difficult to understand. An attempt is made to pass on knowledge but more importantly also stimulate lateral thinking. Key diagrams, clinical photographs and radiographs are used as necessary to highlight important points; references to relevant landmark articles are also provided in each chapter. The book will be of great interest to medical students, junior orthopaedic doctors, GP’s and physiotherapists.

Acute Heart Failure

Acute Heart Failure
  • Author : Wolfgang Krüger,Andrew Ludman
  • Publisher :Unknown
  • Release Date :2009-05-31
  • Total pages :178
  • ISBN : 9783034600224
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Summary : Acute heart failure is a potentially life threatening situation where correct, rapid therapy can have a life saving impact. In this rapidly changing area of medicine this text aims to bring the latest understanding of the pathophysiology together with a practical guide to diagnosis and management using a thoroughly evidence based approach. This will appeal to a wide audience of health care professionals who will treat patients with acute heart failure, including doctors, medical students, nurses, and other professionals in the Emergency Department, General Internal Medicine, Anaesthetics, Cardiology (Medicine and Surgery) and Critical Care settings. It may be used as an evidence based guide for the junior practitioner or as an aide-memoire for the more senior. Always keeping the underlying pathophysiology at the forefront of the discussion, the reader is encouraged to understand the aetiology of the acute situation and how to direct management in order to correct the abnormal physiology. Each chapter is heavily referenced allowing the reader to easily refer to the original experimental studies and pursue topics in more detail if required. This text is a valuable addition to any practitioner who treats patients with acute heart failure and wants a deeper understanding of the condition.

Epigenetic Contributions in Autoimmune Disease

Epigenetic Contributions in Autoimmune Disease
  • Author : Esteban Ballestar
  • Publisher :Unknown
  • Release Date :2011-02-16
  • Total pages :182
  • ISBN : 9781441982162
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Summary : This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease.