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The Value of BCG and TNF in Autoimmunity

The Value of BCG and TNF in Autoimmunity
  • Author : Denise Faustman
  • Publisher :Unknown
  • Release Date :2014-03-13
  • Total pages :164
  • ISBN : 9780128004616
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Summary : The Value of BCG and TNF in Autoimmunity provides an overview of current research and thinking related to tumor necrosis factor (TNF) induction and the use of the bacillus Calmette-Guérin (BCG) vaccine as potential treatment approaches to diverse forms of autoimmunity. BCG, commonly known as an anti-tuberculosis vaccine, is being explored in worldwide clinical trials as an approach to the treatment of certain forms of autoimmunity. The scope of research behind this therapeutic approach spans from the basic science of TNF signaling to research in diverse autoimmune disciplines, such as type 1 diabetes and multiple sclerosis. Overall, the book focuses on the lessons that can be learned from the researchers' individual experiences and data, and provides a rationale for bringing the inexpensive, generic BCG vaccine to the forefront of clinical trials in different forms of autoimmunity. Editor awarded 2005: Oprah Achievement Award," Top Health Breakthrough by a Female Scientist" Brings into one resource the international scientific literature on a unique way to treat autoimmunity Provides a different perspective on treatment approaches for certain autoimmune conditions Discusses TNF induction, rather than anti-TNF, as a therapeutic pathway for autoimmunity treatment

Idiotypes in Medicine: Autoimmunity, Infection and Cancer

Idiotypes in Medicine: Autoimmunity, Infection and Cancer
  • Author : R.C. Kennedy,S. Ferrone,Yehuda Shoenfeld
  • Publisher :Unknown
  • Release Date :1997-11-19
  • Total pages :540
  • ISBN : 0080534430
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Summary : This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

Novel Vaccination Strategies

Novel Vaccination Strategies
  • Author : Stefan H. E. Kaufmann
  • Publisher :Unknown
  • Release Date :2006-01-24
  • Total pages :670
  • ISBN : 9783527606092
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Summary : The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub-unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.

Guidelines on the Management of Latent Tuberculosis Infection

Guidelines on the Management of Latent Tuberculosis Infection
  • Author : WHO,World Health Organization
  • Publisher :Unknown
  • Release Date :2015-01-15
  • Total pages :34
  • ISBN : 9789241548908
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Summary : BACKGROUND: Latent tuberculosis infection (LTBI), defined as a state of persistent immune response to prior-acquired Mycobacterium tuberculosis antigens without evidence of clinically manifested active TB, affects about one-third of the world's population. Approximately 10% of people with LTBI will develop active TB disease in their lifetime, with the majority developing it within the first five years after initial infection. Currently available treatments have an efficacy ranging from 60% to 90%. Systematic testing and treatment of LTBI in at-risk populations is a critical component of WHO's eight-point framework adapted from the End TB Strategy to target pre-elimination and, ultimately, elimination in low incidence countries. OVERVIEW: Recognizing the importance of expanding the response to LTBI, in 2014 WHO developed Guidelines on the Management of Latent Tuberculosis Infection. The guidelines are primarily targeted at high-income or upper middle-income countries with an estimated TB incidence rate of less than 100 per 100 000 population, because they are most likely to benefit from it due to their current TB epidemiology and resource availability. The overall objective of the guidelines is to provide public health approach guidance on evidence-based practices for testing, treating and managing LTBI in individuals with the highest risk of progression to active disease. Specific objectives include identifying and prioritizing at-risk population groups for targeted intervention of LTBI testing and treatment, including defining an algorithm, and recommending specific treatment options. The guidelines are expected to provide the basis and rationale for the development of national guidelines for LTBI management based on available resources, epidemiology of TB including intensity of transmission, the health-care delivery system of the country, and other national and local determinants.

Vaccines and Autoimmunity

Vaccines and Autoimmunity
  • Author : Yehuda Shoenfeld,Nancy Agmon-Levin,Lucija Tomljenovic
  • Publisher :Unknown
  • Release Date :2015-07-07
  • Total pages :384
  • ISBN : 9781118663431
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Summary : In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others. Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.

Immunization Safety Review

Immunization Safety Review
  • Author : Institute of Medicine,Board on Health Promotion and Disease Prevention,Immunization Safety Review Committee
  • Publisher :Unknown
  • Release Date :2002-08-02
  • Total pages :152
  • ISBN : 9780309083287
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Summary : By two years of age, healthy infants in the United States can receive up to 20 vaccinations to protect against 11 diseases. Although most people know that vaccines effectively protect against serious infectious diseases, approximately one-quarter of parents in a recent survey believe that infants get more vaccines than are good for them, and that too many immunizations could overwhelm an infant's immune system. The Immunization Safety Review Committee reviewed the evidence regarding the hypothesis that multiple immunizations increase the risk for immune dysfunction. Specifically, the committee looked at evidence of potential biological mechanisms and at epidemiological evidence for or against causality related to risk for infections, the autoimmune disease type 1 diabetes, and allergic disorders.

Tuberculosis and the Tubercle Bacillus

Tuberculosis and the Tubercle Bacillus
  • Author : William R. Jacobs, Jr.,Helen McShane,Valerie Mizrahi,Ian M. Orme
  • Publisher :Unknown
  • Release Date :2020-07-15
  • Total pages :741
  • ISBN : 9781555819569
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Summary : Can today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.

Psoriasis

Psoriasis
  • Author : Anca Chiriac
  • Publisher :Unknown
  • Release Date :2017-07-05
  • Total pages :246
  • ISBN : 9789535132516
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Summary : In 2014, psoriasis was recognized as a serious noncommunicable disease in the World Health Assembly Resolution WHA67.9, with a great negative impact on patients' quality of life. Psoriasis is a worldwide chronic disease, affecting all ages and all races, and a serious global health problem. Psoriasis is a complex disease with still unknown etiology and no specific curative treatment. The chapters provide comprehensive and new description of some issues related to psoriasis research and for understanding of clinical correlations, genetic aspects, experimental research, and potential therapeutic interventions. The book could be a source of information for clinicians and researchers from different fields in raising awareness of the disease.

Management of Infections in the Immunocompromised Host

Management of Infections in the Immunocompromised Host
  • Author : Brahm H. Segal
  • Publisher :Unknown
  • Release Date :2018-06-18
  • Total pages :445
  • ISBN : 9783319776743
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Summary : This book provides a comprehensive, state-of-the-art review of the concepts vital to a modern treatment of common and opportunistic infections in the immunocompromised host. Chapters are written by experts in the field, and include their views on gaps in the field and future directions of research. This book begins with an overview of the normally functioning immune system followed by a detailed discussion of the major primary immunodeficiencies. Specific chapters are dedicated to providing practical knowledge in the prevention and treatment of infections in specific immunocompromised patients, including those with cancer, transplant recipients, HIV infection, and autoimmune disorders. Emphasis is placed on diagnostic evaluation, antimicrobial selection that includes consideration of the threat of antimicrobial-resistant pathogens, and immunotherapy tailored to specific patients. Finally, dedicated chapters on stem cell transplantation for patients with primary immunodeficiencies, adoptive cellular immunotherapy, and gene therapy will provide readers with insight into these rapidly evolving and cutting edge therapies.Management of Infections in the Immunocompromised Host is a valuable resource for infectious diseases specialists, immunologists, oncologists, hematologists, general physicians, students, researchers, and all other working with immunocompromised patients.

Principles of Cancer Biotherapy

Principles of Cancer Biotherapy
  • Author : Robert K. Oldham,Robert O. Dillman
  • Publisher :Unknown
  • Release Date :2009-08-29
  • Total pages :742
  • ISBN : 9048122899
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Summary : At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches. By 2003 and the fourth edition, it was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy has now truly matured into the fourth modality of cancer treatment. This fifth revised edition describes the tremendous progress that has been made in recent years using biologicals in cancer treatment. This book summarizes an evolving science and a rapidly changing medical practice in biotherapy. In this new millennium, it is now possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for a patient’s personalized cancer treatment. This was first envisioned in the 1987 initial edition of this textbook and is now a “new” and popular approach to cancer treatment. Some forms of cancer biotherapy use the strategy of tumor stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fifth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients for researchers and clinicians to explore and quickly apply these new opportunities in cancer biotherapy.

Equine Dermatology - E-Book

Equine Dermatology - E-Book
  • Author : Danny W. Scott,William H. Miller
  • Publisher :Unknown
  • Release Date :2010-12-01
  • Total pages :552
  • ISBN : 9781437709216
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Summary : Diagnose, treat, and manage equine skin disorders with the most comprehensive reference available! With 900 full-color photos, Equine Dermatology covers skin diseases ranging from those that merely annoy the horse to others that interfere with the horse's ability to function in riding, working, or show. Thorough coverage includes essential basics and practical diagnostic methods, therapies, and specific abnormalities and defects. The book describes the structure and function of the skin, and discusses disorders including bacterial, fungal, parasitic, viral, protozoal, allergic, immune-mediated, endocrine, metabolic, and nutritional diseases. It also covers congenital and hereditary defects, pigmentation abnormalities, keratinization defects, environmental skin diseases, and skin tumors. Written by renowned equine dermatologists Danny Scott and Bill Miller, this all-inclusive resource covers the latest dermatologic topics and the newest therapies. Current, comprehensive coverage includes every known equine dermatosis. An emphasis on differential diagnosis includes key differentials and breed predilections for each disease, especially helpful when you have only a specimen and an incomplete history to work with. A consistent format makes it easy to locate information on each skin disorder, including a clinical description, its cause and pathogenesis, clinical features, clinical management, diagnosis, treatment, and any zoonotic aspects. Expert authors Danny W. Scott, DVM, and William H. Miller, Jr., VMD, offer years of knowledge, experience, and their vast image collections. Diagnostic tables in each chapter provide a quick reference for identifying lesions and disorders. An extensive list of references at the end of each chapter includes recommendations for further reading. New coverage of dermatologic conditions includes the latest topics and emerging disorders such as chronic progressive lymphedema, herpesvirus-2-associated dermatitis, salmonella-associated dermatoses, and nodular auricular chondropathy. Updated Diagnostic Methods chapter covers multiple methods of developing a differential diagnosis list based on breed, lesion type, patterns, and location. A focus on common clinical problems highlights the conditions most likely to be seen in practice. Almost 1,000 full-color photos of skin disorders make it easy to distinguish clinical characteristics and variations of normal and abnormal for accurate diagnosis and therapy.

Canadian Immunization Guide : User Survey : Final Report

Canadian Immunization Guide : User Survey : Final Report
  • Author : CRÉATEC + (Firm),Public Health Agency of Canada
  • Publisher :Unknown
  • Release Date :2005
  • Total pages :229
  • ISBN : OCLC:74028583
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Summary :

Autoantibodies

Autoantibodies
  • Author : Yehuda Shoenfeld,M. Eric Gershwin,M.E. Gershwin,Pier Luigi Meroni
  • Publisher :Unknown
  • Release Date :2011-10-13
  • Total pages :872
  • ISBN : 0080467237
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Summary : Autoantibodies was published and presented in November 2006 at the International Congress of Autoimmunity in Sorrento, a small town in Campania, Italy. The Congress also celebrated the 100th anniversary of the first routine test for autoantibodies. An autoantibody is a type of antibody that is produced by the immune system and that fights one or more of a person’s own proteins. These autoantibodies cause autoimmune diseases such as lupus erythematosus. The authors and editors of this book provide a critical review of autoantibodies and their primary functions. They cite a number of major developments in the field of autoantibodies, including the detection of autoantibodies in which a healthy person is a carrier; the discovery that autoantibodies can be both pathogenic and protective in some cases; and the development of a device that will help monitor and detect a specific autoantibody using a small amount of serum and proteomic arrays. Aside from the pathogenic and protective autoantibodies, the book also discusses irrelevant autoantibodies, as these may be relevant for future research. It also addresses the importance of the autoantibodies in a person’s body. Clinical physicians, as well as scientists interested in the significance of autoantibodies in the human body, will find this book relevant. It will also be of interest to those who suffer from an autoimmune disease. * Incudes and exhaustive list of autoantibodies not covered by other publications * Short reviews can easily be checked for quick reference information * Both basic and clinical aspects are covered

Immunotherapy of Cancer

Immunotherapy of Cancer
  • Author : Yoshiyuki Yamaguchi
  • Publisher :Unknown
  • Release Date :2016-02-22
  • Total pages :358
  • ISBN : 9784431550310
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Summary : This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.

Biology of Myelomonocytic Cells

Biology of Myelomonocytic Cells
  • Author : Anirban Ghosh
  • Publisher :Unknown
  • Release Date :2017-05-10
  • Total pages :172
  • ISBN : 9789535131236
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Summary : Myelomonocytes are the multipotent cells in the stage of blood cell differentiation, which mainly comprise blood monocytes, tissue macrophages and subset of dendritic cells. Actually, their position and ability of judgement of the health of tissue or organ environment are the key initiators of tissue-specific immune response in a local and global fashion. Interestingly, the morpho-functional aspects of this group of cells vary to a wide range with their positional diversity. Their ability to communicate or represent the tissue microenvironment to the peripheral immune system and efficiency to engage the system to effector activation hold the key for a successful immune endeavour. The present volume shows some glimpses of such an extensive area of current immunology research.

Clinical Manual of Fever in Children

Clinical Manual of Fever in Children
  • Author : A. Sahib El-Radhi
  • Publisher :Unknown
  • Release Date :2018-12-07
  • Total pages :315
  • ISBN : 9783319923369
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Summary : This book discusses the latest scientific evidence related to fever and presents the principles of clinical practice, covering different types of fever and its possible complications. The book adopts a clearly defined, practical and effective approach to the management of fever, helping the clinician improve the care for the febrile child. The reader will learn about the guidelines on antipyretics and their side-effects and differential diagnoses, with problem-setting and solving as a case presentation.The second edition of this well-received book has been fully updated to include exciting new information of the pathogenesis of fever, including functions of interleukin and all the latest guidelines from NICE and Cochrane Library, as well as all the most up-to-date information and guidelines on febrile seizures. This reader-friendly reference on the disorders of body temperature in children covers the entire spectrum of subjects related to fever. It gives an overview of the best treatment options in order to achieve the best results. Containing a core message at the start of each chapter and with and a reader-friendly format this is an indispensable guide for paediatricians, family doctors and other professionals who are regularly consulted because of febrile children.

Tuberculosis

Tuberculosis
  • Author : Barry R. Bloom
  • Publisher :Unknown
  • Release Date :2014-06-24
  • Total pages :653
  • ISBN : 1555819109
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Summary : The authors discuss fundamental questions about the biology, genetics, mechanisms of pathogenicity, mechanisms of resistance, and drug development strategies that are likely to provide important new knowledge about TB and new interventions to prevent and treat this disease.

Pediatric Autoimmunity and Transplantation

Pediatric Autoimmunity and Transplantation
  • Author : Farzaneh Rahmani,Nima Rezaei
  • Publisher :Unknown
  • Release Date :2020-11-28
  • Total pages :496
  • ISBN : 3030262820
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Summary : This book is a collection of case-based questions, directed towards and meticulously selected to cover the most common and important aspects of pediatric autoimmune disorders. Autoimmune disorders of infancy and childhood, rheumatological disorders, dermatologic autoimmune disorders, autoinflammatory disorders, and clinical immunology in solid organ and hematopoietic stem cell transplantation are among the topics covered. Each chapter starts with a case description followed by a series of 5-6 multiple choice questions (MCQ), presenting the flow from diagnosis to treatment in a step-wise, logical manner. The text guides the reader through the stream of real clinical practice from initial presentation, differential diagnosis, next best step, lab data, and definitive diagnosis to management and adverse effects of therapy. This MCQ format along with precise, yet detailed answer ensure a quick, reality learning to the reader. The book provides a quick guide and hands-on learning experience for pediatricians, hematologists, immunologists, transplant specialists, pulmonologists, as well as PhD and post-graduate researchers around the world.

Anti-cancer Drugs

Anti-cancer Drugs
  • Author : Jasna Bankovic
  • Publisher :Unknown
  • Release Date :2016-12-07
  • Total pages :196
  • ISBN : 9789535128137
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Summary : We are in constant search for new therapeutic options to cure cancer. In this book, you can find out how scientists throughout the world deal with this problem. Readers will learn how to engage nature, chemical synthesis, and cell machinery to design new anticancer agents. Nature has already been very generous in providing us different compounds which are in widespread application. Starting from these resources, various synthetic processes are applied to create synthetic drugs which can be then obtained in large quantities. Also, the cell by itself provides different possibilities to meet the constantly increasing requirements for successful therapy. Explore the book and find out what are the new ways to fight cancer.

Essential Clinical Immunology

Essential Clinical Immunology
  • Author : John B. Zabriskie
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :362
  • ISBN : 9780521516815
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Summary : This book begins with basic concepts of immunology and then details the immunological aspects of various disease states involving major organs of the body. Designed as an introduction for practitioners and residents, this book explores how we can better understand disease and its treatment through clinical immunology.

Immunopathology and Immunomodulation

Immunopathology and Immunomodulation
  • Author : Krassimir Metodiev
  • Publisher :Unknown
  • Release Date :2015-11-18
  • Total pages :312
  • ISBN : 9789535122104
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Summary : This book is a continuation of the efforts of InTech to expand the scientific know-how in the field of immunopathology and bring valuable updated information to medical professionals and researchers. It consists of chapters related to various approaches to investigate the unique role of the immune system in response to different clinical disorders. The international team of authors is the bonus of the book, reflecting the rapid development of immunology and new achievements in medical science. We firmly hope that the book will be an excellent manual and guideline for people dealing with biology, microbiology, immunology, virology, pharmacology, general and dental medicine, and health care, from students and postdocs to high-level specialists and university professors.