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Therapeutic Drug Monitoring Data

Therapeutic Drug Monitoring Data
  • Author : Catherine A. Hammett-Stabler,Amitava Dasgupta
  • Publisher :Unknown
  • Release Date :2007-01-01
  • Total pages :241
  • ISBN : 1594250758
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Therapeutic Drug Monitoring Data

Therapeutic Drug Monitoring Data
  • Author : Amitava Dasgupta,Matthew Krasowski
  • Publisher :Unknown
  • Release Date :2019-09-14
  • Total pages :382
  • ISBN : 9780128158500
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Summary : Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Population Pharmacokinetic Analysis of Therapeutic Drug Monitoring Data in Optimizing Pharmacotherapy of Antiepileptic Drugs

Population Pharmacokinetic Analysis of Therapeutic Drug Monitoring Data in Optimizing Pharmacotherapy of Antiepileptic Drugs
  • Author : Katarina Vučićević
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :229
  • ISBN : OCLC:1154198210
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Summary : Population Pharmacokinetic Analysis of Therapeutic Drug Monitoring Data in Optimizing Pharmacotherapy of Antiepileptic Drugs.

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics
  • Author : Georg Hempel
  • Publisher :Unknown
  • Release Date :2019-10-17
  • Total pages :380
  • ISBN : 9780444640673
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Summary : Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Clinical Challenges in Therapeutic Drug Monitoring

Clinical Challenges in Therapeutic Drug Monitoring
  • Author : William Clarke,Amitava Dasgupta
  • Publisher :Unknown
  • Release Date :2016-07-21
  • Total pages :376
  • ISBN : 9780128020524
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Summary : Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Drug Monitoring Data Pocket Guide II

Drug Monitoring Data Pocket Guide II
  • Author : Therapeutic Drug Monitoring and Toxicology Laboratory Improvement Program Committee,American Association for Clinical Chemistry
  • Publisher :Unknown
  • Release Date :1994-01-01
  • Total pages :143
  • ISBN : 0915274701
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Summary : The AACC DRUG MONITORING DATA POCKET GUIDE is an up-to-date, easy-to-use source of information on the most commonly measured therapeutic drugs in today's clinical laboratory. It provides a quick reference to drug pharmacokinetics, analysis & sample handling. References are provided for those needing more detail. The guide will be very useful for clinical scientists involved in therapeutic drug monitoring & as an education aid. 1994, 4 1/2 x 6 Softcover, ISBN 0-915274-70-1, $15, Order #625.

Handbook of Drug Monitoring Methods

Handbook of Drug Monitoring Methods
  • Author : Amitava Dasgupta
  • Publisher :Unknown
  • Release Date :2007-10-23
  • Total pages :445
  • ISBN : 9781588297808
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Summary : In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

Interpretation of Equine Laboratory Diagnostics

Interpretation of Equine Laboratory Diagnostics
  • Author : Nicola Pusterla,Jill Higgins
  • Publisher :Unknown
  • Release Date :2017-12-18
  • Total pages :448
  • ISBN : 9781118739792
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Summary : Interpretation of Equine Laboratory Diagnostics offers a comprehensive approach to equine laboratory diagnostics, including hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics. Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to establish and new diagnostic procedures Offers a practical resource for the accurate interpretation of laboratory results, with examples showing real-world applications Covers hematology, clinical chemistry, serology, body fluid analysis, microbiology, clinical parasitology, endocrinology, immunology, and molecular diagnostics Introduces the underlying principles of laboratory diagnostics Provides clinically oriented guidance on performing and interpreting laboratory tests Presents a complete reference to established and new diagnostic procedures

Applied Pharmacokinetics & Pharmacodynamics

Applied Pharmacokinetics & Pharmacodynamics
  • Author : Michael E. Burton
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :867
  • ISBN : 0781744318
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Summary : The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.

Neuropsychiatric Disorders

Neuropsychiatric Disorders
  • Author : Manfred Gerlach,Jürgen Deckert,Kay Double,Eleni Koutsilieri
  • Publisher :Unknown
  • Release Date :2007-12-28
  • Total pages :341
  • ISBN : 3211735747
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Summary : This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.

Novel Treatment of Epilepsy

Novel Treatment of Epilepsy
  • Author : Humberto Foyaca Sibat
  • Publisher :Unknown
  • Release Date :2011-09-22
  • Total pages :342
  • ISBN : 9533076674
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Summary : Epilepsy continues to be a major health problem throughout the planet, affecting millions of people, mainly in developing countries where parasitic zoonoses are more common and cysticercosis, as a leading cause, is endemic. There is epidemiological evidence for an increasing prevalence of epilepsy throughout the world, and evidence of increasing morbidity and mortality in many countries as a consequence of higher incidence of infectious diseases, head injury and stroke. We decided to edit this book because we identified another way to approach this problem, covering aspects of the treatment of epilepsy based on the most recent technological results "in vitro" from developed countries, and the basic treatment of epilepsy at the primary care level in rural areas of South Africa. Therefore, apart from the classic issues that cannot be missing in any book about epilepsy, we introduced novel aspects related with epilepsy and neurocysticercosis, as a leading cause of epilepsy in developing countries. Many experts from the field of epilepsy worked hard on this publication to provide valuable updated information about the treatment of epilepsy and other related problems.

Population kinetics of antidepressant and neuroleptic drugs : studies of therapeutic drug monitoring data to evaluate kinetic variability, drug interactions, nonlinear kinetics and the influence of genetic factors

Population kinetics of antidepressant and neuroleptic drugs : studies of therapeutic drug monitoring data to evaluate kinetic variability, drug interactions, nonlinear kinetics and the influence of genetic factors
  • Author : Markus Jerling
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :41
  • ISBN : 9162814834
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Summary :

Individualized Drug Therapy for Patients

Individualized Drug Therapy for Patients
  • Author : Roger W Jelliffe,Michael Neely
  • Publisher :Unknown
  • Release Date :2016-11-15
  • Total pages :434
  • ISBN : 9780128033494
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Summary : Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient. Uses pharmacokinetic approaches as the tools with which therapy is individualized Provides examples using specific software that illustrate how best to apply these approaches and to make sense of the more sophisticated mathematical foundations upon which this book is based Incorporates clinical cases throughout to illustrate the real-world benefits of using these approaches Focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal

Drug Monitoring and Clinical Chemistry

Drug Monitoring and Clinical Chemistry
  • Author : Georg Hempel
  • Publisher :Unknown
  • Release Date :2004-05-15
  • Total pages :378
  • ISBN : 9780080530543
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Summary : Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered. The book contains important information for analyst working on drug analysis in clinical chemistry, hospital pharmacists involved in therapeutic drug monitoring, other pharmacists, chemists or physicians working on pharmacokinetic studies in industry or academia. In contrast to other books in this field, this book provides up-to-date information regarding both methodology and clinical applications. For the applications, only fields are described where therapeutic drug monitoring is used in clinical routine and provides benefit to the patients. Overview of all important field where therapeutic drug monitoring is applied All relevant analytical and computational methods are discussed Written by experts with a lot of practical experience in the field

Applied Pharmacokinetics

Applied Pharmacokinetics
  • Author : William E. Evans,Jerome J. Schentag,William J. Jusko
  • Publisher :Unknown
  • Release Date :1992
  • Total pages :1202
  • ISBN : UOM:39015013811040
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Summary : The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers and practitioners, this book is the most advanced kinetics reference available. All chapters have been extensively updated or completely rewritten for this edition, and six new chapters have been added on pharmacodynamics, pharmacogenetics, pharmacokinetic considerations in the obese, dietary influences on drug disposition, zidovudine, and corticosteroids. Each chapter is tightly focused on the most important concepts and issues. Chapters on specific drugs are organized in a consistent format for quick, easy information retrieval. Major subheadings include Clinical Pharmacokinetics, Pharmacodynamics, Clinical Application of Pharmacokinetic Data, Analytical Methods, and Prospectus.

Personalized Immunosuppression in Transplantation

Personalized Immunosuppression in Transplantation
  • Author : Michael Oellerich,Amitava Dasgupta
  • Publisher :Unknown
  • Release Date :2015-08-08
  • Total pages :316
  • ISBN : 9780128011331
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Summary : Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. Focuses on the personalized management of immunosuppression therapy in individual transplant patients Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy

Analytical Methods for Therapeutic Drug Monitoring and Toxicology

Analytical Methods for Therapeutic Drug Monitoring and Toxicology
  • Author : Q. Alan Xu,Timothy L. Madden
  • Publisher :Unknown
  • Release Date :2011-04-12
  • Total pages :520
  • ISBN : 0470922796
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Summary : This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.

Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill

Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill
  • Author : Andrew A. Udy,Jason A. Roberts,Jeffrey Lipman
  • Publisher :Unknown
  • Release Date :2017-09-18
  • Total pages :275
  • ISBN : 9789811053368
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Summary : This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.

Introduction to Epilepsy

Introduction to Epilepsy
  • Author : Gonzalo Alarcón,Antonio Valentín
  • Publisher :Unknown
  • Release Date :2012-04-26
  • Total pages :624
  • ISBN : 9780521691581
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Summary : Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.

Therapeutic Drug Monitoring

Therapeutic Drug Monitoring
  • Author : Gerald E. Schumacher
  • Publisher :Unknown
  • Release Date :1995
  • Total pages :684
  • ISBN : UOM:39015033266571
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Summary :

Treatment of Tuberculosis

Treatment of Tuberculosis
  • Author : World Health Organization
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :43
  • ISBN : UIUC:30112118366886
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Summary :