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Torsades de Pointes

Torsades de Pointes
  • Author : James E Tisdale
  • Publisher :Unknown
  • Release Date :2021-08-01
  • Total pages :310
  • ISBN : 9780128214619
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Summary : Over the past 25-30 years, deaths due to Torsades de Pointes (TdP) have resulted in numerous drugs being withdrawn from the market. However, nearly 200 drugs that may prolong the QT interval and cause TdP remain available. A number of drugs with the potential to cause TdP are among the top 200 most prescribed drugs in the US, whilst new information regarding TdP is emerging rapidly. The purpose of this book is to provide a comprehensive source of information on the topic of torsades de pointes (TdP), which is a life-threatening polymorphic ventricular tachyarrhythmia associated with QT interval prolongation on the electrocardiogram (ECG). Torsades de Pointes provides a detailed, up-to-date and emerging information related to the epidemiology, drug culprits, mechanisms, risk factors, and methods of prevention and management of the life-threatening polymorphic ventricular tachycardia, also known as torsades de pointes. The book contains current knowledge, incorporating recent and cutting-edge advances in understanding of topics including inherited channelopathies and congenital LQTS; drugs that cause QT interval prolongation and TdP; non-drug causes of acquired QT interval prolongation and TdP; epidemiology of inherited and acquired TdP; morbidity and mortality associated with TdP, particularly in association with specific antimicrobials, antidepressants and antipsychotics, and methadone; cellular and molecular mechanisms of TdP, traditional and emerging risk factors for TdP; methods of prevention and risk reduction for TdP; and clinical management of patients with TdP. This book is an essential reference for both clinicians and researchers – providing guidance for clinicians who care for patients receiving QT interval-prolonging drugs, as well as cutting edge information for scientists and investigators conducting research in the area. Up-to-date information on TdP associated with inherited channelopathies and the multiple forms of congenital LQTS Includes a wealth of new information emerging regarding TdP, including newly-described risk factors and cellular and molecular mechanisms, contributions of genetic polymorphisms to drug-induced TdP, methods of quantification of risk, and methods of risk reduction, including clinical decision support Contains information on nearly 200 commonly used drugs that have the potential to cause torsades de pointes, including antimicrobials, antipsychotics, antidepressants, antiarrhythmic agents, methadone, and many others An essential reference for clinicians and researchers – provides guidance for clinicians who care for patients receiving QT interval-prolonging drugs, as well as cutting edge information for scientists and investigators conducting research in the area

Acquired Long QT Syndrome

Acquired Long QT Syndrome
  • Author : A. John Camm,Marek Malik,Yee Guan Yap
  • Publisher :Unknown
  • Release Date :2008-04-15
  • Total pages :208
  • ISBN : 9781405146166
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Summary : In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes. Advances in ion channel cloning have greatly improved our understanding of the role of ionic channels in mediating cardiac repolarisation. Unfortunately, it is increasingly recognised that a number of drugs, both those associated with altering repolarisation, and others for non-cardiac conditions can increase the propensity for polymorphic ventricular tachycardia, syncope and even ventricular fibrillation and sudden death. In this volume, arrhythmia specialists from St. George’s Hospital Medical School, London discuss the mechanisms behind QT prolongation and torsades de pointes. They focus particularly on the risk of individual cardiac and non-cardiac drugs in provoking long QT syndrome, providing a comprehensive review which will be useful for all electrophysiologists treating polymorphic ventricular tachycardias, and will expose important regulatory issues for pharmaceutical authorities and for the wider medical community.

Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond

Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond
  • Author : Esther Pueyo,Blanca Rodriguez
  • Publisher :Unknown
  • Release Date :2018-08-16
  • Total pages :229
  • ISBN : 9782889455393
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Summary : Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs. This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.

Clinical Arrhythmology and Electrophysiology E-Book

Clinical Arrhythmology and Electrophysiology E-Book
  • Author : Ziad Issa,John M. Miller,Douglas P. Zipes
  • Publisher :Unknown
  • Release Date :2018-08-07
  • Total pages :752
  • ISBN : 9780323568821
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Summary : Part of the highly regarded Braunwald’s family of cardiology references, Clinical Arrhythmology and Electrophysiology, 3rd Edition, offers complete coverage of the latest diagnosis and management options for patients with arrhythmias. Expanded clinical content and clear illustrations keep you fully abreast of current technologies, new syndromes and diagnostic procedures, new information on molecular genetics, advances in ablation, and much more.

Cardiac Repolarization

Cardiac Repolarization
  • Author : Nabil El-Sherif
  • Publisher :Unknown
  • Release Date :2019-10-24
  • Total pages :354
  • ISBN : 9783030226725
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Summary : This book provides a comprehensive, up-to-date overview of clinical and research aspects of cardiac repolarization geared toward practicing cardiologists and physicians. It analyzes elements of pathophysiology and molecular biology as they relate to the clinical aspects of cardiac repolarization, long QT syndromes, early repolarization syndromes, and special cardiac repolarization syndromes. Each chapter examines different aspects of the field with basic and clinical overviews and highlights the impact on medical management. The book covers a variety of repolarization topics including the influence of the autonomic system, racial and gender differences in patients, the future role of stem cells, inflammation and autoimmunity, and cardiovascular risk. Cardiac Repolarization: Basic Science and Clinical Management is an essential resource for physicians and related professionals, residents, fellows, and graduate students in cardiology, clinical cardiac electrophysiology, internal medicine, and cardiovascular biology.

Sex and Cardiac Electrophysiology

Sex and Cardiac Electrophysiology
  • Author : Marek Malik
  • Publisher :Unknown
  • Release Date :2020-07-11
  • Total pages :1032
  • ISBN : 9780128177297
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Summary : Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women is a comprehensive investigation into all aspects of sex differences in cardiac electrophysiology. As there are substantial differences between female and male patients in physiology, pathology triggering factors, disease progression, clinical approaches and treatment outcome, this book provides a comprehensive examination. In cardiology, the differences between women and men are more recognized, hence this title summarizes these important differences, providing the essential information needed for clinical specialists and researchers involved in the design and implementation of clinical studies. Explores topics ranging from the physiologic differences between women and men to the differences in clinical handling of arrhythmic disorders between female and male patients Provides sex differences in cardiac electrophysiology in separate chapters Covers the sex differences of cardiac electrical disorders, providing insights beyond cardiac metabolic syndrome, hypertension, atherogenesis and heart failure

The Prevention of Sudden Cardiac Death

The Prevention of Sudden Cardiac Death
  • Author : John B. Kostis,Michael Sanders
  • Publisher :Unknown
  • Release Date :1990-03-19
  • Total pages :305
  • ISBN : UOM:39015017753420
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Summary : Presenting the latest diagnostic and therapeutic developments in a multifaceted field, this book addresses the problems involved in preventing sudden cardiac death (SCD), focusing on risk stratification techniques designed to direct the selection and application of appropriate treatment modalities. Material reflects recent discoveries concerning the epidemiology and SCD pathophysiology, offering guidelines for more rational treatment approaches, both pharmacologic and interventional. The text reviews the vast epidemiologic data from the Framingham Study, with special emphasis on identifying clinical risk factors and the relation of coronary heart disease to SCD. It also details the background for risk stratification based on well-established exercise testing and ambulatory electrocardiography techniques, as well as newer methods of electrophysiologic testing and signal average electrocardiography. Current prevention strategies--lifestyle alteration, prospective drug trials, surgical and implantable devices--are also discussed.

Challenging Cases and Complication Management in Pain Medicine

Challenging Cases and Complication Management in Pain Medicine
  • Author : Magdalena Anitescu,Honorio T. Benzon,Mark S. Wallace
  • Publisher :Unknown
  • Release Date :2017-11-17
  • Total pages :346
  • ISBN : 9783319600727
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Summary : This comprehensive book provides reviews of pain management complications that arise in clinical practice. Organized into sections focused on types of pain therapy and procedures, each chapter is based on actual complications; starting with a case description that delineates the context with a short past medical and surgical history, pain management technique and outcome it is followed by a comprehensive review of the topic described in the first section. Authors emphasize the elements of differential diagnosis that pointed towards establishing of the complication and describe the best way to treat the identified complication. Physicians treating pain patients will be presented the necessary tools in identifying and treating unanticipated complications following pain interventions, thus providing safer care for their patients.

Cardiac Mapping

Cardiac Mapping
  • Author : Mohammad Shenasa,Gerhard Hindricks,David J. Callans,John M. Miller,Mark E. Josephson
  • Publisher :Unknown
  • Release Date :2019-04-04
  • Total pages :1304
  • ISBN : 9781119152620
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Summary : The expanded guide to cardiac mapping The effective diagnosis and treatment of heart disease may vitally depend upon accurate and detailed cardiac mapping. However, in an era of rapid technological advancement, medical professionals can encounter difficulties maintaining an up-to-date knowledge of current methods. This fifth edition of the much-admired Cardiac Mapping is, therefore, essential, offering a level of cutting-edge insight that is unmatched in its scope and depth. Featuring contributions from a global team of electrophysiologists, the book builds upon previous editions' comprehensive explanations of the mapping, imaging, and ablation of the heart. Nearly 100 chapters provide fascinating accounts of topics ranging from the mapping of supraventricular and ventriculararrhythmias, to compelling extrapolations of how the field might develop in the years to come. In this text, readers will find: Full coverage of all aspects of cardiac mapping, and imaging Explorations of mapping in experimental models of arrhythmias Examples of new catheter-based techniques Access to a companion website featuring additional content and illustrative video clips Cardiac Mapping is an indispensable resource for scientists, clinical electrophysiologists, cardiologists, and all physicians who care for patients with cardiac arrhythmias.

Field Guide to the Arrhythmias

Field Guide to the Arrhythmias
  • Author : Ellis Lader
  • Publisher :Unknown
  • Release Date :2013-05-06
  • Total pages :174
  • ISBN : 9781118386095
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Summary : …The cardiac unit is a jungle, inhabited by fierce nurses, killer intensivists, marauding attendings, various flesh-eating specialists, sick patients, and lots of arrhythmias. –from the Preface Can you recognize the call of the normal sinus rhythm? Name the natural habitat of Multifocal Atrial Tachycardia or Ventricular Fibrillation? Are you well-versed in the proper care and feeding of Asystole and Atrial Flutter? If you answered “no” to any of these questions, then you need this trusty guide to help you identify and respond to arrhythmias in the veritable wilderness of the busy hospital ward. Created by a seasoned physician educator at a major urban medical center and inspired by the “field guides” used by birders, botanists and the like to identify flora or fauna in the wild, this new book offers a unique – and uniquely humorous -- approach to mastering the ever-vexing challenge of arrhythmia identification. Each arrhythmia is covered beginning with a sample ECG strip, followed by brief text describing its significant characteristics; where and when it is likely to be encountered (its “Habitat”); comments, questions and queries likely to be heard from physicians and other colleagues on the ward (the “Call”); and finally what steps the reader needs to take upon identifying the arrhythmia in a patient (“Care and Feeding”). Dr. Lader’s approach brings the sights and sounds of a modern hospital to life, enabling you to understand arrhythmia diagnosis and clinical response in context, and his offbeat, sometimes irreverent humor makes each detail memorable. Fifty self-assessment questions are included to help you master arrhythmia essentials and test your knowledge.

Ventricular Arrhythmias

Ventricular Arrhythmias
  • Author : John M. Miller
  • Publisher :Unknown
  • Release Date :2008-07-01
  • Total pages :184
  • ISBN : 1416062750
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Summary : Ventricular arrhythmias cause most cases of sudden cardiac death, which is the leading cause of death in the US. This issue reviews the causes of arrhythmias and the promising new drugs and devices to treat arrhythmias.

Electrocardiogram in Clinical Medicine

Electrocardiogram in Clinical Medicine
  • Author : Michael J. Lipinski,Andrew E. Darby,Michael C. Bond,Nathan P. Charlton,Korin Hudson,Kelly Williamson
  • Publisher :Unknown
  • Release Date :2020-11-09
  • Total pages :512
  • ISBN : 9781118754559
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Summary : Offers a guide for a complete understanding of the disease and conditions most frequently revealed in ECGs recorded in the acute, critical, and emergency care settings Electrocardiogram in Clinical Medicine offers an authoritative guide to ECG interpretation that contains a focus and perspective from each of the three primary areas of medical care: acute care, critical care and emergency care. It can be used as a companion with the book ECGs for the Emergency Physician I & II (by Mattu and Brady) or as a stand-alone text. These three books can be described as a cumulative EGG reference for the medical provider who uses the electrocardiogram on a regular basis. Electrocardiogram in Clinical Medicine includes sections on all primary areas of ECG interpretation and application as well as sections that highlight use, devices and strategies. The medical content covers acute coronary syndromes and all related issues, other diseases of the myocardium, morphologic syndromes, toxicology and paediatrics; dysrhythmias will also be covered in detail. This important resource: • Goes beyond pattern recognition in ECGs to offer a real understanding of the clinical syndromes evidenced in ECGs and implications for treatment • Covers the indications, advantages and pitfalls of the use of ECGs for diagnosis in all acute care settings, from EMS to ED to Critical Care • Examines the ECG in toxic, metabolic and environmental presentations; critical information for acute care clinicians who need to be able to differentiate ODs, poisoning and other environmental causes from MI or other cardiac events • Facilitates clinical decision-making Written for practicing ER, general medicine, family practice, hospitalist and ICU physicians and medical students, Electrocardiogram in Clinical Medicine is an important book for the accurate interpretation of EGG results.

ECG Masters’ Collection, Volume 2

ECG Masters’ Collection, Volume 2
  • Author : Mohammad Shenasa, MD,Mark E. Josephson, MD,N. A. Mark Estes III, MD,Ezra A. Amsterdam, MD,Melvin Scheinman, MD
  • Publisher :Unknown
  • Release Date :2018-02-15
  • Total pages :216
  • ISBN : 9781942909217
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Summary : Over 75 exceptional electrocardiogram case studies curated from the libraries of 60 internationally recognized master teachers of ECG interpretation are brought together in this one-of-a-kind resource for student and teacher alike. Organized by disease type, ECG case studies are presented in a clinical context followed by questions and discussion. Medical students, residents, fellows, physicians — anyone who is involved in caring for patients with various cardiovascular diseases and other systemic pathologies — will find this unique collection with a global perspective useful and practical in developing the skills necessary to reading ECGs.

Diagnostic Molecular Pathology

Diagnostic Molecular Pathology
  • Author : William B. Coleman,Gregory J. Tsongalis
  • Publisher :Unknown
  • Release Date :2016-10-05
  • Total pages :582
  • ISBN : 9780128011577
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Summary : Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing is organized around disease types (genetic disease, infectious disease, neoplastic disease, among others). In each section, the authors provide background on disease mechanisms and describe how laboratory testing is built on knowledge of these mechanisms. Sections are dedicated to general methodologies employed in testing (to convey the concepts reflected in the methods), and specific description of how these methods can be applied and are applied to specific diseases are described. The book does not present molecular methods in isolation, but considers how other evidence (symptoms, radiology or other imaging, or other clinical tests) is used to guide the selection of molecular tests or how these other data are used in conjunction with molecular tests to make diagnoses (or otherwise contribute to clinical workup). In addition, final chapters look to the future (new technologies, new approaches) of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests. Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing contains exercises to test readers on their understanding of how molecular diagnostic tests are utilized and the value of the information that can be obtained in the context of the patient workup. Readers are directed to an ancillary website that contains supplementary materials in the form of exercises where decision trees can be employed to simulate actual clinical decisions. Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis, and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for prognostication of disease Features an ancillary website with self-testing exercises where decision trees can be employed to simulate actual clinical decisions Highlights new technologies and approaches of applied molecular pathology and how discovery-based research will yield new and useful biomarkers and tests

The Esc Textbook of Cardiovascular Medicine

The Esc Textbook of Cardiovascular Medicine
  • Author : A. John Camm,Professor of Clinical Cardiology A John Camm,Director of Research Education & Development and Consultant of Cardiology Thomas F Luscher,Thomas F. Luscher,Gerald Maurer,Professor of Cardiology Patrick W Serruys, MD, PhD
  • Publisher :Unknown
  • Release Date :2018-11-25
  • Total pages :2384
  • ISBN : 0198784902
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Summary : This new third edition of The ESC Textbook of Cardiovascular Medicine is a ground breaking initiative from the European Society of Cardiology that is transforming reference publishing in cardiovascular medicine in order to better serve the changing needs of the global cardiology community. Providing the evidence-base behind clinical practice guidelines, with in-depth peer-reviewed articles and broad coverage of this fast-moving field, both the print and digital publication are invaluable resources for cardiologists across the world. Overseen by Professors A. John Camm, Thomas F. Lüscher, Patrick W. Serruys, and Gerald Maurer, supported by an editorial board of subject experts, and more than 900 of the world's leading specialists from research and the clinic contributing, this dynamic encyclopaedic resource covers more than 63 disciplines within cardiology. Split into six key parts; Introduction to the cardiovascular system; Investigations; Heart diseases; Vascular disease; Special populations, and Other aspects of cardiology, providing readers with a trustworthy insight into all aspects of cardiovascular medicine. To respond nimbly to the rapid evolution of the field the digital publication, ESC CardioMed, is continuously updated by the author teams. With expert editors and authors, and stringent peer-review, the publication combines the discoverability of digital with the highest standards of academic publishing. Highly illustrated with embedded multi-media features, along with cross-referenced links to ESC Clinical Practice Guidelines, related content and primary research data in European Heart Journal, as well as all other major journals in the field, ESC CardioMed provides users with the most dynamic and forward thinking digital resource at the heart of cardiology. As a consistently evolving knowledge base, the ESC Textbook of Cardiovascular Medicine 3e together with the online counterpart ESC CardioMed, equips all those, from trainees and consultants, to device specialists and allied healthcare professionals with a powerful, multifaceted resource covering all aspects of cardiovascular medicine.

Electrocardiography (ECG)

Electrocardiography (ECG)
  • Author : Jean-Jacques Goy,Jean-Christophe Stauffer,Jürg Schlaepfer,Pierre Christeler
  • Publisher :Unknown
  • Release Date :2013-06-27
  • Total pages :159
  • ISBN : 9781608054794
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Summary : This e-book starts with a comprehensive overview of the basic principles in Electrocardiography (ECG) with just enough depth to lift the reader above the crowd when it comes to understanding the physics behind ECG. Subsequent chapters provide an approach to the analysis of the ECG, followed by sections with insight into conduction abnormalities, arrhythmia, and myocardial ischemia. The e-book has a straightforward layout, a very clear format, and abundant ECG tracings for interested readers. The diagnostic algorithms provided in the volume prove to be very useful in daily medical practice. Overall, the e-book will help novice physicians, students and fellows to improve their knowledge in ECG interpretation. Electrocardiography (ECG) is, therefore, a very attractive book for all levels of physicians and health-care professionals interested in ECG and it is a welcome addition to the medical literature.

Clin-Alert 2001

Clin-Alert 2001
  • Author : Joyce Generali
  • Publisher :Unknown
  • Release Date :2001-02-05
  • Total pages :270
  • ISBN : 1587160781
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Summary : Now the adverse drug reaction events reported in the newsletter Clin-Alert during Y2000 have been compiled, organized, re-formatted, indexed, and published in a convenient one-volume reference book, Clin-Alert 2001. The new book contains the full texts of all 311 reports from Clin-Alert newsletter 2000 issues. The reports have been grouped by fourteen major drug categories and indexed in six different ways for quick look-up. The reports were originally prepared for the Clin-Alert newsletter based on an ongoing search of more than 100 major medical journals, and summarization of key information included in journal articles on adverse drug reaction events. The summary reports were prepared by drug information specialists, and include the following information: o generic name of the drug or other substance involved o a brief characterization of the adverse reaction o a one paragraph summary of the event and related patient information o the author's conclusions or warnings o original source information Established in 1962, the Clin-Alert newsletter is a semi-monthly drug information service widely used by healthcare professionals involved in drug therapy and administration. It is independent, accepts no advertising, and is published for professional use. Now published, Clin-Alert 2001 provides an easy-to-use, quick and reliable reference that will be useful to healthcare professionals working with drugs.

Electrical Diseases of the Heart

Electrical Diseases of the Heart
  • Author : Ihor Gussak,Charles Antzelevitch
  • Publisher :Unknown
  • Release Date :2008-09-08
  • Total pages :600
  • ISBN : 9781846288548
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Summary : This book provides a unique contemporary and succinct distillation of the current status of recently delineated electrical diseases of the heart, emphasizing their common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science. The book is divided into seven major parts. Each part consists of chapters (total of 64) dealing with related topics.

Myocardial Repolarization: From Gene to Bedside

Myocardial Repolarization: From Gene to Bedside
  • Author : Ali Oto,Gunter Breithardt
  • Publisher :Unknown
  • Release Date :2001-12-10
  • Total pages :402
  • ISBN : 0879934778
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Summary : A convenient guide of easily accessible information on the mechanisms of myocardial repolarization and related clinical issues. This book provides a unique collection of contributions by prominent cardiologists on the current knowledge of the mechanisms of arrhythmias, the molecular and genetic bases of noninvasive electrocardiologic diagnosis, and other related clinical issues. In addition to mechanistic aspects, recent developments in the diagnosis of arrhythmias using newly recognized markers (QT dispersion, T-wave alternans, etc.) and their clinical importance are addressed in an easily accessible manner by world-renowned authors. The book is a quick-reference for practicing cardiologists and electrophysiologists, those in training, and others who work in the field of arrhythmology.

Chou's Electrocardiography in Clinical Practice E-Book

Chou's Electrocardiography in Clinical Practice E-Book
  • Author : Borys Surawicz,Timothy Knilans
  • Publisher :Unknown
  • Release Date :2008-04-22
  • Total pages :752
  • ISBN : 9781437711028
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Summary : Widely considered the optimal electrocardiography reference for practicing physicians, and consistently rated as the best choice on the subject for board preparation, this is an ideal source for mastering the fundamental principles and clinical applications of ECG. The 6th edition captures all of the latest knowledge in the field, including expanded and updated discussions of pediatric rhythm problems, pacemakers, stress testing, implantable cardiodefibrillator devices, and much more. It's the perfect book to turn to for clear and clinically relevant guidance on all of today’s ECG applications. Comprehensively and expertly describes how to capture and interpret all normal and abnormal ECG findings in adults and children. Features the expertise of internationally recognized authorities on electrocardiography, for advanced assistance in mastering the subtle but critical nuances of this complex diagnostic modality. Features new chapters on pediatric electrocardiography that explore rhythm problems associated with pediatric obesity, heart failure, and athletic activity. Presents a new chapter on recording and interpreting heart rhythms in patients with pacemakers. Includes new material on interpreting ECG findings associated with implantable cardioverter-defibrillators. Provides fully updated coverage on the increased importance of ECGs in stress testing.

Pluripotent Stem Cells

Pluripotent Stem Cells
  • Author : Deepa Bhartiya,Nibedita Lenka
  • Publisher :Unknown
  • Release Date :2013-08-28
  • Total pages :640
  • ISBN : 9789535111924
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Summary : Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.