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Total Synthesis of Bioactive Natural Products

Total Synthesis of Bioactive Natural Products
  • Author : Goutam Brahmachari
  • Publisher :Unknown
  • Release Date :2019-04-27
  • Total pages :350
  • ISBN : 9780081028230
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Summary : Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules Outlines each step of the process in detail, with full experimental information supported by extensive schemes Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule

Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds

Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
  • Author : Shinsuke Inuki
  • Publisher :Unknown
  • Release Date :2011-11-23
  • Total pages :106
  • ISBN : 4431540431
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Summary : The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

Isolation, Structure Elucidation, and Total Synthesis of Bioactive Natural Products

Isolation, Structure Elucidation, and Total Synthesis of Bioactive Natural Products
  • Author : Roberto Forestieri
  • Publisher :Unknown
  • Release Date :2013
  • Total pages :229
  • ISBN : OCLC:1033169217
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Summary :

Bioactive Natural Products

Bioactive Natural Products
  • Author : Goutam Brahmachari
  • Publisher :Unknown
  • Release Date :2015-03-23
  • Total pages :544
  • ISBN : 9783527337941
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Summary : Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
  • Author : Atta-ur-Rahman
  • Publisher :Unknown
  • Release Date :2002-03-01
  • Total pages :1364
  • ISBN : 0080542069
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Summary : Bioactive Natural Products (Part G)

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
  • Author : Atta-ur- Rahman
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :401
  • ISBN : 9780444538369
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Summary : Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate, and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products. "There is a good mix of chemistry, structure elucidation, synthesis, and biology in the various chapters, thereby appealing to a diverse readership. The diagrams are clear and the writing excellent. In summary, this is another excellent volume in a very valuable series on natural products for which Professor Atta-ur-Rahman is to be congratulated...... an important and essential asset for those libraries supporting the efforts of natural product research groups." Geoffrey A. Cordell, University of Illinois, Chicago, USA, PHYTOCHEMISTRY, Vol.65, 2004 Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field A valuable source for researchers and engineers working in natural product and medicinal chemistry

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
  • Author : Atta-ur-Rahman
  • Publisher :Unknown
  • Release Date :2003-12-03
  • Total pages :916
  • ISBN : 0080542077
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Summary : Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the 29th volume in the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated. This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance. - Volume 29 is part of a great family of useful reference books - Illustrates the types of critical discoveries that emerge from the interface of chemistry and biology - Contributions are from well-respected authors

Synthetic Studies on Bioactive Natural Products

Synthetic Studies on Bioactive Natural Products
  • Author : Joji Hayashida
  • Publisher :Unknown
  • Release Date :2011-09
  • Total pages :396
  • ISBN : 1243616601
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Summary : The synthetic studies toward the total syntheses of recently isolated bioactive natural products, haouamine A, platensimycin and platencin were investigated. During the course study of a new alkaloid, haouamine A, we have developed a simple synthetic route of chiral 2-substituted-3-piperidinones by utilizing a sequential regioselective proline-mediated aldol condensation and rhodium-catalyzed asymmetric hydrogenation. The model studies on aza-[7]-paracyclophane moiety of haouamine A were also examined with the strategies involving in Diels-Alder reaction, Ramberg-Backlund Reaction, cyclotrimerization, and Danheiser Benzannulation. In the studies of platensimycin and platencin, we intended to apply the pseudo-biomimeric cyclization strategy for the introduction of their characteristic bicyclo[2.3.1]octane and bicyclo[2.2.2]octane bridgehead structures. As a result, we have accomplished the concise total synthesis of platencin from commercially available o-anisic acid in 14 steps with 3.5% overall yield. During the course of this investigation, we developed a convenient method to synthesize the two distinctive cis-decalines containing a chiral quaternary carbon center through Diels-Alder reaction by utilizing two different sizes of amino-siloxyl dienes. We also found the modification of nickel mediated conjugate addition, discovered an unprecedented chemical reactivity of vinylsilane under oxidation condition with iodosobenzene and hydrogen peroxide, and demonstrated the biomimeric protective group free coupling strategy.

Heterocycles in Natural Product Synthesis

Heterocycles in Natural Product Synthesis
  • Author : Krishna C. Majumdar,Shital K. Chattopadhyay
  • Publisher :Unknown
  • Release Date :2011-06-15
  • Total pages :658
  • ISBN : 9783527634897
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Summary : Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products. Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products ic covered in detail. Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.

Bioactive Natural Products

Bioactive Natural Products
  • Author : Goutam Brahmachari
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :670
  • ISBN : 9789814335379
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Summary : Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Bioactive Marine Natural Products

Bioactive Marine Natural Products
  • Author : Dewan S. Bhakuni,D.S. Rawat
  • Publisher :Unknown
  • Release Date :2006-06-30
  • Total pages :382
  • ISBN : 9781402034848
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Summary : Bioactive Marine Natural Products is the first book available that covers all aspects of bioactive marine natural products. It fills the void in the literature for bioactive marine natural products. The book covers various aspects of marine natural products and it is hoped that all the major classes of bioactive compounds are included. Different classes of marine organisms and the separation and isolation techniques are discussed. The chemistry and biology of marine toxins, peptides, alkaloids, nucleosides and prostanoids are discussed in detail. Biological, toxicological and clinical evaluations are also dealt with to ensure that the book may be adopted at any stage by any practicing organic chemist or biologist, working in academia or in R and D divisions of pharmaceutical companies. Each chapter in the book includes an abstract to highlight the major points discussed in the text and concluding remarks are given. References to books, monographs, review articles and original papers are provided at the end of each chapter.

Medicinal Chemistry of Bioactive Natural Products

Medicinal Chemistry of Bioactive Natural Products
  • Author : Xiao-Tian Liang,Wei-Shuo Fang
  • Publisher :Unknown
  • Release Date :2006-03-17
  • Total pages :336
  • ISBN : 9780471739333
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Summary : Current discoveries and research into bioactive naturalproducts Medicinal Chemistry of Bioactive Natural Products provides amuch-needed survey of bioactive natural products and theirapplications in medicinal chemistry. This comprehensive referencefeatures articles by some of the world's leading scientists in thefield on discovery, structure elucidation, and elegant syntheticstrategies--developed for natural products--with an emphasis on thestructure activity relationship of bioactive natural products. Thetopics have been carefully chosen on the basis of relevance tocurrent research and to importance as clinicially usefulagents. Rather than attempting to be a comprehensive encyclopedia ofbioactive natural products, Medicinal Chemistry of BioactiveNatural Products guides the reader to the key developments in thefield. By providing not only practical detail but a historicalperspective on the chemistry and biology of the compounds underconsideration, the book serves as a handy resource for researchersin their own work developing pharmaceuticals, and as an inspiringintroduction for young scientists to the dynamic field of bioactivenatural products research. Enhanced by examples with updated research results, the discussioncovers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and itsanalogs * The antimalarial properties of the traditional Chinese medicine,Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer'sdisease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIVagents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and theirstructurally modified mimics

Bioactive Natural Products

Bioactive Natural Products
  • Author : Atta-ur- Rahman
  • Publisher :Unknown
  • Release Date :1988
  • Total pages :1347
  • ISBN : CHI:60669616
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Summary : Cover -- Contents -- Foreword -- Preface -- Contributors -- Chapter 1. Acid-catalysed epimerization of bioactive indole alkaloids and their derivatives -- Chapter 2. Antitumor-promoting and anti-inflammatory activities of triterpenoids and sterols fiom plants and fungi -- Chapter 3. Bioactive oleanene glucuronides obtained from fabaceous plants -- Chapter 4. Biotransformation of terpenoids by microorganisms -- Chapter 5. Cycloartane and oleanane saponins from Astragalus sp. -- Chapter 6. Labdane-type diterpenes: Chemistry and biological activity -- Chapter 7. Metabolism of the tomato saponin a-tomatine by phytopathogenic fungi -- Chapter 8. Heme aggregation inhibitors: Antimalarial drugs targeting an essential biomineralization process -- Chapter 9. Bioactive peptides as signal molecules in plant defense, growth and development -- Chapter 10. Enzymes involved in the biosynthesis of brassinosteroids -- Chapter 11. Immunopotentiating effects of a glycoprotein from Chlorella vulgaris stra ...

Metathesis in Natural Product Synthesis

Metathesis in Natural Product Synthesis
  • Author : Janine Cossy,Stellios Arseniyadis,Christophe Meyer
  • Publisher :Unknown
  • Release Date :2011-09-22
  • Total pages :412
  • ISBN : 9783527642083
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Summary : Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this is a comprehensive view of a hot topic. Written by top international authors, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications. A real must-have for anyone working in natural product synthesis.

Biomedical Index to PHS-supported Research

Biomedical Index to PHS-supported Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1991
  • Total pages :229
  • ISBN : IND:30000090515432
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Summary :

Chemical Biology of Natural Products

Chemical Biology of Natural Products
  • Author : David J. Newman,Gordon M. Cragg,Paul Grothaus
  • Publisher :Unknown
  • Release Date :2017-09-22
  • Total pages :622
  • ISBN : 9781351643283
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Summary : Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.

The Claisen Rearrangement

The Claisen Rearrangement
  • Author : Martin Hiersemann,Udo Nubbemeyer
  • Publisher :Unknown
  • Release Date :2007-02-27
  • Total pages :591
  • ISBN : 9783527610556
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Summary : The first comprehensive coverage of all facets of the Claisen rearrangement and its variants. As such, this book helps synthetic chemists to exploit the vast potential of this elegant C-C linking reaction, discusses a wealth of catalytic options, and gives those more theory-minded chemists a detailed insight into the mechanistic aspects of the Claisen rearrangement. An invaluable source of information and a ready reference for all organic and catalytic chemists, as well as those working with/on organometallics, and in industry.

Bioactive Natural Products (Part E)

Bioactive Natural Products (Part E)
  • Author : Atta-ur-Rahman
  • Publisher :Unknown
  • Release Date :2000-12-22
  • Total pages :1170
  • ISBN : 008054200X
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Summary : Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. The significance, therefore, of the Studies in Natural Product Chemistry series, edited by Professor Atta-ur-Rahman, cannot be overestimated. This volume, in accordance with previous volumes, presents us with cutting-edge contributions of great importance.

Synthesis of Medicinal Agents from Plants

Synthesis of Medicinal Agents from Plants
  • Author : Ashish Tewari,Supriya Tiwari
  • Publisher :Unknown
  • Release Date :2018-04-17
  • Total pages :368
  • ISBN : 9780081022740
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Summary : Synthesis of Medicinal Agents from Plants highlights the importance of synthesizing medicinal agents from plants and outlines methods for performing it effectively. Beginning with an introduction to the significance of medicinal plants, the book goes on to provide a historical overview of drug synthesis before exploring how this can be used to successfully replicate and adapt the active agents from natural sources. Chapters then explore the medicinal properties of a number of important plants, before concluding with a discussion of the future of drugs from medicinal plants. Illustrated with real-world examples, it is a practical resource for researchers in this field. In an age of rapid environmental destruction, hundreds of medicinal plants are at risk of extinction from overexploitation and deforestation, limiting the natural resources available for active agent extraction, thereby threatening the discovery of future cures for diseases. Simultaneously, with the increasing population and advances in medical sciences, the demand for drugs is continuously increasing and cannot be met with just plants. The ability to synthetically replicate the active compounds from these plants is essential in creating an ecologically-aware, sustainable future for drug design Includes detailed coverage of therapeutic compound synthesis Uses multiple real-world examples to support content Lays out a sustainable template for the future of developing active agents from natural products

Recent Progress in the Chemical Synthesis of Antibiotics

Recent Progress in the Chemical Synthesis of Antibiotics
  • Author : Gabor Lukacs,Masaji Ohno
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :803
  • ISBN : 9783642756177
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Summary : The use of antibiotics in the treatment by antibacterial and antifungal chemo therapy, has become standard practice since the end of World War Two and has had an enormous impact on healthcare throughout the world. Compounds belonging to this class have also reached an important place in the medical treatment of human cancer. Although, the discovery of most of these agents came from more or less sophisticated screening programs of soil microrganisms, many of the important antibiotics used today in clinical practice are derived from the original biosynthetic products by the application of often novel and generally elaborated chemical synthetic methodologies. In fact the antibiotics have represented (and still represent) for a generation of organic chemists an endless source of molecular structures whose varied assemblage of carbon atom backbones and chemical functions was beyond any possibility of imagination. Perhaps a similar repertoire of chemotypes was formerly offered by the natural products, namely the alkaloids, the terpenes, the vitamins and hormones as well as the pigments of the animal and plant kingdoms, albeit the chemical arrange ments of the antibiotic molecules appeared much more surprising and diverse to the admiring eyes of cultivated organic chemists. The idea of this book, certainly a landmark in the field, came during the Symposium of EUCHEM on Chemical Synthesis of Antibiotics, that was held at Aussois in Savoy, France (May 2-6, 1988), the initiative being taken by Gabor Lukacs to whom Masaji Ohno readily associated as a co-editor.

Classics in Total Synthesis

Classics in Total Synthesis
  • Author : K. C. Nicolaou,E. J. Sorensen
  • Publisher :Unknown
  • Release Date :1996-04-11
  • Total pages :821
  • ISBN : 9783527292318
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Summary : K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.