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Transformative Concepts for Drug Design: Target Wrapping

Transformative Concepts for Drug Design: Target Wrapping
  • Author : Ariel Fernandez
  • Publisher :Unknown
  • Release Date :2010-04-28
  • Total pages :230
  • ISBN : 3642117929
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Summary : In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful therapeutic agents are often recalled as unanticipated side effects are discovered. Exploiting the huge output of genomic studies to make safer drugs has proven to be much more difficult than anticipated. More than ever, the lead in the pharmaceutical industry depends on the ability to harness innovative research, and this type of innovation can only come from one source: fundamental knowledge. This book squarely addresses this crucial problem since it introduces fundamental discoveries in basic biomolecular research that hold potential to broaden the technological base of the pharmaceutical industry. The book takes a fresh and fundamental look at the problem of how to design an effective drug with controlled specificity. Since the novel transformative concepts are unfamiliar to most practitioners, the first part of this book explains matters very carefully starting from a fairly elementary physico-chemical level. The second part of the book is devoted to practical applications, aiming at nothing less than a paradigm shift in drug design. This book is addressed to scientists working at the cutting edge of research in the pharmaceutical industry, but the material is at the same time accessible to senior undergraduates or graduate students interested in drug discovery and molecular design.

Physics at the Biomolecular Interface

Physics at the Biomolecular Interface
  • Author : Ariel Fernández
  • Publisher :Unknown
  • Release Date :2016-05-11
  • Total pages :483
  • ISBN : 9783319308524
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Summary : This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics. The acknowledgment of how exquisitely the structure and dynamics of proteins and their aqueous environment are related attests to the overdue recognition that biomolecular phenomena cannot be effectively understood without dealing with interfacial behaviour. There is an urge to grasp how biologically relevant behaviour is shaped by the structuring of biomolecular interfaces and how interfacial tension affects the molecular events that take place in the cell. This book squarely addresses these needs from a physicist perspective. The book may serve as a monograph for practitioners and, alternatively, as an advanced textbook. Fruitful reading requires a background in physical chemistry and some basics in biophysics. The selected problems at the end of the chapters and the progression in conceptual difficulty make it a suitable textbook for a graduate level course or an elective course for seniors majoring in chemistry, physics, biomedical engineering or related disciplines.

Biomolecular Interfaces

Biomolecular Interfaces
  • Author : Ariel Fernández Stigliano
  • Publisher :Unknown
  • Release Date :2015-04-20
  • Total pages :372
  • ISBN : 9783319168500
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Summary : The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and bio molecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.

Computational and Visualization Techniques for Structural Bioinformatics Using Chimera

Computational and Visualization Techniques for Structural Bioinformatics Using Chimera
  • Author : Forbes J. Burkowski
  • Publisher :Unknown
  • Release Date :2014-07-29
  • Total pages :461
  • ISBN : 9781439836620
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Summary : A Step-by-Step Guide to Describing Biomolecular Structure Computational and Visualization Techniques for Structural Bioinformatics Using Chimera shows how to perform computations with Python scripts in the Chimera environment. It focuses on the three core areas needed to study structural bioinformatics: biochemistry, mathematics, and computation. Understand Important Concepts of Structural Bioinformatics The book covers topics that deal primarily with protein structure and includes many exercises that are grounded in biological problems at the molecular level. The text encourages mathematical analysis by providing a firm foundation for computations. It analyzes numerous Python scripts for the Chimera environment, with the scripts and other material available on a supplementary website. Build Python Scripts to Extend the Capabilities of Chimera Through more than 60 exercises that involve the development of Python scripts, the book gives you concrete guidance on using the scripting capabilities of Chimera. You’ll gain experience in solving real problems as well as understand the various applications of linear algebra. You can also use the scripts as starting points for the development of similar applications and use classes from the StructBio toolkit for computations, such as structure overlap, data plotting, scenographics, and display of residue networks.

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  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 9783642117930
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Summary :

Biopolymers for Medical Applications

Biopolymers for Medical Applications
  • Author : Juan M. Ruso,Paula V. Messina
  • Publisher :Unknown
  • Release Date :2017-02-17
  • Total pages :372
  • ISBN : 9781315351865
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Summary : This book presents an experimental and computational account of the applications of biopolymers in the field of medicine. Biopolymers are macromolecules produced by living systems, such as proteins, polypeptides, nucleic acids, and polysaccharides. Their advantages over polymers produced using synthetic chemistry include: diversity, abundance, relatively low cost, and sustainability. This book explains techniques for the production of different biodevices, such as scaffolds, hydrogels, functional nanoparticles, microcapsules, and nanocapsules. Furthermore, developments in nanodrug delivery, gene therapy, and tissue engineering are described.

Transformative Assessment

Transformative Assessment
  • Author : W. James Popham
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :150
  • ISBN : 9781416606673
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Summary : Testing expert W. James Popham cuts through the jargon and the hype to provide the definitive nuts-and-bolts introduction to formative assessment, a process with the power to completely transform teaching and learning. In his inimitable style, Popham explains the research supporting formative assessment's effectiveness and why familiarity with this research is the key to preserving both teacher sanity and district funds. You'll find step-by-step guidance on how to build frameworks for formative assessment and how to carry out each of the process's four levels: teachers' instructional adjustments, students' learning tactic adjustments, a classroom climate shift, and schoolwide implementation. This book is the place to start for educators considering formative assessment, curious about why their school system is embracing formative assessment, or wondering why the "formative assessments" they're using now aren't producing the desired results. Here, you'll learn what formative assessment is and isn't, what it can do and what it can't, and the practical way to reap its very real rewards: better teaching and better learning.

Pusher Myths

Pusher Myths
  • Author : Ross Coomber
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :207
  • ISBN : UOM:39015064735981
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Summary : Drug dealers are commonly presented as 'dealing in death', preying on the young and innocent and spreading addiction with little care or regard for those they entangle. Drug markets are commonly depicted as being hierarchically organized and riddled with unscrupulous practices and chaotic violence. While a strong case has been made in recent years that the powers of particular drugs have often led to an unreasonable demonization of drug users, there has been little by way of understanding drug dealers as part of that same process. Who is a drug dealer? How does the dealer operate in the drug market? What if many common perceptions, both about dealers themselves and drug markets more generally, are either incorrect or unreasonably distorted? Reviewing recent research into the minutiae of drug dealing and drug market operations, Pusher Myths suggests that these overly simplistic characterizations of who the drug dealer is, what drug dealers do, and the context within which they operate serve to perpetuate unhelpful ideas of what the drug problem is and, thus ultimately, how it should be resolved. Focusing on issues such as dangerous drug adulteration, the pushing of street drugs onto the young and innocent, the provision of free drugs to hook new clients, and the legend of the Blue Star LSD Tattoo, this book goes in the direction of recasting our understanding of the drug dealer as one that has been unreasonably demonized and de-humanized. This book also provides a contemporary analysis of how the various myths (untruths) surrounding drug dealers may be understood within the broader conceptual analysis of the place of myth in modern society.

Textbook of Drug Design and Discovery, Third Edition

Textbook of Drug Design and Discovery, Third Edition
  • Author : Tommy Liljefors,Povl Krogsgaard-Larsen,Ulf Madsen
  • Publisher :Unknown
  • Release Date :2002-07-25
  • Total pages :592
  • ISBN : 0415282888
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Summary : Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

The Drug Development Paradigm in Oncology

The Drug Development Paradigm in Oncology
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum
  • Publisher :Unknown
  • Release Date :2018-03-12
  • Total pages :144
  • ISBN : 9780309457941
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Summary : Advances in cancer research have led to an improved understanding of the molecular mechanisms underpinning the development of cancer and how the immune system responds to cancer. This influx of research has led to an increasing number and variety of therapies in the drug development pipeline, including targeted therapies and associated biomarker tests that can select which patients are most likely to respond, and immunotherapies that harness the body's immune system to destroy cancer cells. Compared with standard chemotherapies, these new cancer therapies may demonstrate evidence of benefit and clearer distinctions between efficacy and toxicity at an earlier stage of development. However, there is a concern that the traditional processes for cancer drug development, evaluation, and regulatory approval could impede or delay the use of these promising cancer treatments in clinical practice. This has led to a number of effortsâ€"by patient advocates, the pharmaceutical industry, and the Food and Drug Administration (FDA)â€"to accelerate the review of promising new cancer therapies, especially for cancers that currently lack effective treatments. However, generating the necessary data to confirm safety and efficacy during expedited drug development programs can present a unique set of challenges and opportunities. To explore this new landscape in cancer drug development, the National Academies of Sciences, Engineering, and Medicine developed a workshop held in December 2016. This workshop convened cancer researchers, patient advocates, and representatives from industry, academia, and government to discuss challenges with traditional approaches to drug development, opportunities to improve the efficiency of drug development, and strategies to enhance the information available about a cancer therapy throughout its life cycle in order to improve its use in clinical practice. This publication summarizes the presentations and discussions from the workshop.

A Mathematical Approach to Protein Biophysics

A Mathematical Approach to Protein Biophysics
  • Author : L. Ridgway Scott,Ariel Fernández
  • Publisher :Unknown
  • Release Date :2017-12-04
  • Total pages :290
  • ISBN : 9783319660325
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Summary : This book explores quantitative aspects of protein biophysics and attempts to delineate certain rules of molecular behavior that make atomic scale objects behave in a digital way. This book will help readers to understand how certain biological systems involving proteins function as digital information systems despite the fact that underlying processes are analog in nature. The in-depth explanation of proteins from a quantitative point of view and the variety of level of exercises (including physical experiments) at the end of each chapter will appeal to graduate and senior undergraduate students in mathematics, computer science, mechanical engineering, and physics, wanting to learn about the biophysics of proteins. L. Ridgway Scott has been Professor of Computer Science and of Mathematics at the University of Chicago since 1998, and the Louis Block Professor since 2001. He obtained a B.S. degree (Magna Cum Laude) from Tulane University in 1969 and a PhD degree in Mathematics from the Massachusetts Institute of Technology in 1973. Professor Scott has published over 130 papers and three books, extending over biophysics, parallel computing and fundamental computing aspects of structural mechanics, fluid dynamics, nuclear engineering, and computational chemistry. Ariel Fernández (born Ariel Fernández Stigliano) is an Argentinian-American physical chemist and mathematician. He obtained his Ph. D. degree in Chemical Physics from Yale University and held the Karl F. Hasselmann Endowed Chair Professorship in Bioengineering at Rice University. He is currently involved in research and entrepreneurial activities at various consultancy firms. Ariel Fernández authored three books on translational medicine and biophysics, and published 360 papers in professional journals. He holds two patents in the field of biotechnology.

The Body Keeps the Score

The Body Keeps the Score
  • Author : Bessel A. Van der Kolk
  • Publisher :Unknown
  • Release Date :2015-09-08
  • Total pages :443
  • ISBN : 9780143127741
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Summary : Originally published by Viking Penguin, 2014.

Male Roles, Masculinities and Violence

Male Roles, Masculinities and Violence
  • Author : Expert Group Meeting on Male Roles and M
  • Publisher :Unknown
  • Release Date :2000
  • Total pages :288
  • ISBN : STANFORD:36105110666471
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Summary : This book is based on an expert group meeting entitled 'Male Roles and Masculinities in the Perspective of a Culture of Peace', which was organised by UNESCO in Oslo, Norway in 1997, the first international discussion of the connections between men and masculinity and peace and war. The group consisted of researchers, activists, policy makers and administrators and the aim of the meeting was to formulate practical suggestions for change. Chapters in the book consist of both regional case studies and social science research on the connections of traditional masculinity and patriarchy to violence and peace building. The Culture of Peace initiatives in this book show how violence is ineffective, and the book contests the views in the socialisation of boy-children that aggressiveness, violence and force are an acceptable means of expression.

Cooking for Geeks

Cooking for Geeks
  • Author : Jeff Potter
  • Publisher :Unknown
  • Release Date :2010-07-20
  • Total pages :432
  • ISBN : 9781449396039
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Summary : Presents recipes ranging in difficulty with the science and technology-minded cook in mind, providing the science behind cooking, the physiology of taste, and the techniques of molecular gastronomy.

The United Nations world water development report, 2017

The United Nations world water development report, 2017
  • Author : WWAP,UNESCO
  • Publisher :Unknown
  • Release Date :2017-03-15
  • Total pages :180
  • ISBN : 9789231002014
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Summary :

A Century of Innovation

A Century of Innovation
  • Author : 3M Company
  • Publisher :Unknown
  • Release Date :2002
  • Total pages :236
  • ISBN : 0972230211
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Summary : A compilation of 3M voices, memories, facts and experiences from the company's first 100 years.

How Learning Works

How Learning Works
  • Author : Susan A. Ambrose,Michael W. Bridges,Michele DiPietro,Marsha C. Lovett,Marie K. Norman
  • Publisher :Unknown
  • Release Date :2010-04-16
  • Total pages :336
  • ISBN : 0470617608
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Summary : Praise for How Learning Works "How Learning Works is the perfect title for this excellent book. Drawing upon new research in psychology, education, and cognitive science, the authors have demystified a complex topic into clear explanations of seven powerful learning principles. Full of great ideas and practical suggestions, all based on solid research evidence, this book is essential reading for instructors at all levels who wish to improve their students' learning." —Barbara Gross Davis, assistant vice chancellor for educational development, University of California, Berkeley, and author, Tools for Teaching "This book is a must-read for every instructor, new or experienced. Although I have been teaching for almost thirty years, as I read this book I found myself resonating with many of its ideas, and I discovered new ways of thinking about teaching." —Eugenia T. Paulus, professor of chemistry, North Hennepin Community College, and 2008 U.S. Community Colleges Professor of the Year from The Carnegie Foundation for the Advancement of Teaching and the Council for Advancement and Support of Education "Thank you Carnegie Mellon for making accessible what has previously been inaccessible to those of us who are not learning scientists. Your focus on the essence of learning combined with concrete examples of the daily challenges of teaching and clear tactical strategies for faculty to consider is a welcome work. I will recommend this book to all my colleagues." —Catherine M. Casserly, senior partner, The Carnegie Foundation for the Advancement of Teaching "As you read about each of the seven basic learning principles in this book, you will find advice that is grounded in learning theory, based on research evidence, relevant to college teaching, and easy to understand. The authors have extensive knowledge and experience in applying the science of learning to college teaching, and they graciously share it with you in this organized and readable book." —From the Foreword by Richard E. Mayer, professor of psychology, University of California, Santa Barbara; coauthor, e-Learning and the Science of Instruction; and author, Multimedia Learning

Sharing Clinical Trial Data

Sharing Clinical Trial Data
  • Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Strategies for Responsible Sharing of Clinical Trial Data
  • Publisher :Unknown
  • Release Date :2015-04-20
  • Total pages :304
  • ISBN : 9780309316323
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Summary : Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research--from funders, to researchers, to journals, to physicians, and ultimately, to patients.

Using ICTs and blended learning in transforming technical and vocational education and training

Using ICTs and blended learning in transforming technical and vocational education and training
  • Author : Latchem, Colin,Commonwealth of Learning
  • Publisher :Unknown
  • Release Date :2017-04-17
  • Total pages :232
  • ISBN : 9789231002120
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Summary :

Global Age-friendly Cities

Global Age-friendly Cities
  • Author : World Health Organization
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :76
  • ISBN : 9789241547307
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Summary : The guide is aimed primarily at urban planners, but older citizens can use it to monitor progress towards more age-friendly cities. At its heart is a checklist of age-friendly features. For example, an age-friendly city has sufficient public benches that are well-situated, well-maintained and safe, as well as sufficient public toilets that are clean, secure, accessible by people with disabilities and well-indicated. Other key features of an age-friendly city include: well-maintained and well-lit sidewalks; public buildings that are fully accessible to people with disabilities; city bus drivers who wait until older people are seated before starting off and priority seating on buses; enough reserved parking spots for people with disabilities; housing integrated in the community that accommodates changing needs and abilities as people grow older; friendly, personalized service and information instead of automated answering services; easy-to-read written information in plain language; public and commercial services and stores in neighbourhoods close to where people live, rather than concentrated outside the city; and a civic culture that respects and includes older persons.

Managing Data in Motion

Managing Data in Motion
  • Author : April Reeve
  • Publisher :Unknown
  • Release Date :2013-02-26
  • Total pages :204
  • ISBN : 9780123977915
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Summary : Managing Data in Motion describes techniques that have been developed for significantly reducing the complexity of managing system interfaces and enabling scalable architectures. Author April Reeve brings over two decades of experience to present a vendor-neutral approach to moving data between computing environments and systems. Readers will learn the techniques, technologies, and best practices for managing the passage of data between computer systems and integrating disparate data together in an enterprise environment. The average enterprise's computing environment is comprised of hundreds to thousands computer systems that have been built, purchased, and acquired over time. The data from these various systems needs to be integrated for reporting and analysis, shared for business transaction processing, and converted from one format to another when old systems are replaced and new systems are acquired. The management of the "data in motion" in organizations is rapidly becoming one of the biggest concerns for business and IT management. Data warehousing and conversion, real-time data integration, and cloud and "big data" applications are just a few of the challenges facing organizations and businesses today. Managing Data in Motion tackles these and other topics in a style easily understood by business and IT managers as well as programmers and architects. Presents a vendor-neutral overview of the different technologies and techniques for moving data between computer systems including the emerging solutions for unstructured as well as structured data types Explains, in non-technical terms, the architecture and components required to perform data integration Describes how to reduce the complexity of managing system interfaces and enable a scalable data architecture that can handle the dimensions of "Big Data"