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Transgenic Animal Technology

Transgenic Animal Technology
  • Author : Carl A. Pinkert
  • Publisher :Unknown
  • Release Date :2014-06-13
  • Total pages :714
  • ISBN : 0124104908
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Summary : Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer - from molecular methods to whole animal considerations - for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols Fully revised with updates to reflect state-of-the-art technology and associated changes to date

Transgenic Animal Technology

Transgenic Animal Technology
  • Author : Carl A. Pinkert
  • Publisher :Unknown
  • Release Date :2012-12-02
  • Total pages :618
  • ISBN : 9780080574806
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Summary : A transgenic animal is one that is genetically modified to carry genes from another species. Transgenic species can be raised to carry potentially useful genes from a variety of species. While the topics of genetic engineering and cloning are controversial, the reality is that these technologies offer tremendous benefits to society - from offering a framework for developing and screening medical therapies, to enhancing the safety and nutrition of the food we eat. One potential application of research into transgenic animal technology is the creation of domestic animals genetically designed to express a certain human disease and therefore serve as models for the study and treatment of human illnesses. Although many mouse models of human diseases are available today, such models in large domestic animals physiologically more similar to humans are sparse and critically needed. Further research in this field will undoubtedly uncover many more direct and indirect benefits of this technology. Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer - from molecular methods to whole animal considerations - for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols New section on analysis

Transgenic Animal Technology

Transgenic Animal Technology
  • Author : Carl A. Pinkert
  • Publisher :Unknown
  • Release Date :2014-06-17
  • Total pages :714
  • ISBN : 9780124095366
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Summary : Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer — from molecular methods to whole animal considerations — for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols Fully revised with updates to reflect state-of-the-art technology and associated changes to date

Transgenic Animal Technology: A Laboratory Handbook

Transgenic Animal Technology: A Laboratory Handbook
  • Author : Carl A. Pinkert
  • Publisher :Unknown
  • Release Date :2017-11-13
  • Total pages :716
  • ISBN : 0128100893
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Summary : Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer - from molecular methods to whole animal considerations - for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems. Contains a comprehensive collection of transgenic animal and gene transfer methodsDiscusses background and introduction to techniques and animal systemsTeaches practical step-by-step protocolsFully revised with updates to reflect state-of-the-art technology and associated changes to date

Genetic Engineering in Livestock

Genetic Engineering in Livestock
  • Author : Margret Engelhard,Kristin Hagen,Matthias Boysen
  • Publisher :Unknown
  • Release Date :2008-10-20
  • Total pages :146
  • ISBN : 9783540858430
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Summary : Upcoming applications of genetic engineering in farm animals include higher yields, leaner meat, or disease resistance. The proceedings cover an analysis of the state of the art of the technology and its applications, an introduction to the specific application zoopharming (a method to produce biopharmaceuticals in transgenic livestock), including an analysis of the market for biopharmaceuticals. In addition an assessment of ethical aspects of livestock biotechnology and considerations regarding animal welfare implications are covered. The study is addressed to science, industry and politics.

Animal Biotechnology

Animal Biotechnology
  • Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Agriculture and Natural Resources,Committee on Agricultural Biotechnology, Health, and the Environment,Committee on Defining Science-Based Concerns Associated with Products of Animal Biotechnology
  • Publisher :Unknown
  • Release Date :2002-12-29
  • Total pages :200
  • ISBN : 9780309084390
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Summary : Genetic-based animal biotechnology has produced new food and pharmaceutical products and promises many more advances to benefit humankind. These exciting prospects are accompanied by considerable unease, however, about matters such as safety and ethics. This book identifies science-based and policy-related concerns about animal biotechnologyâ€"key issues that must be resolved before the new breakthroughs can reach their potential. The book includes a short history of the field and provides understandable definitions of terms like cloning. Looking at technologies on the near horizon, the authors discuss what we know and what we fear about their effectsâ€"the inadvertent release of dangerous microorganisms, the safety of products derived from biotechnology, the impact of genetically engineered animals on their environment. In addition to these concerns, the book explores animal welfare concerns, and our societal and institutional capacity to manage and regulate the technology and its products. This accessible volume will be important to everyone interested in the implications of the use of animal biotechnology.

Introduction to Pharmaceutical Biotechnology

Introduction to Pharmaceutical Biotechnology
  • Author : Saurabh Bhatia,Divakar Goli
  • Publisher :Unknown
  • Release Date :2017-12
  • Total pages :589
  • ISBN : 0750313005
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Summary : Animal biotechnology is a broad field including polarities of fundamental and applied research, as well as DNA science, covering key topics of DNA studies and its recent applications. In Introduction to Pharmaceutical Biotechnology, DNA isolation procedures followed by molecular markers and screening methods of the genomic library are explained in detail. Interesting areas such as isolation, sequencing and synthesis of genes, with broader coverage of the latter, are also described. The book begins with an introduction to biotechnology and its main branches, explaining both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It then moves on to the historical development and scope of biotechnology with an overall review of early applications that scientists employed long before the field was defined. Additionally, this book offers first-hand accounts of the use of biotechnology tools in the area of genetic engineering and provides comprehensive information related to current developments in the following parameters: plasmids, basic techniques used in gene transfer, and basic principles used in transgenesis. The text also provides the fundamental understanding of stem cell and gene therapy, and offers a short description of current information on these topics as well as their clinical associations and related therapeutic options.

Sustainable Food Production

Sustainable Food Production
  • Author : Paul Christou,Roxana Savin,Barry Costa-Pierce,Ignacy Misztal,Bruce Whitelaw
  • Publisher :Unknown
  • Release Date :2013-02-13
  • Total pages :1869
  • ISBN : 1461458498
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Summary : Gathering some 90 entries from the Encyclopedia of Sustainability Science and Technology, this book covers animal breeding and genetics for food, crop science and technology, ocean farming and sustainable aquaculture, transgenic livestock for food and more.

Gene Transfer to Animal Cells

Gene Transfer to Animal Cells
  • Author : Richard Twyman
  • Publisher :Unknown
  • Release Date :2004-12-01
  • Total pages :256
  • ISBN : 9781135322786
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Summary : Gene transfer to animal cells was first achieved more than thirty years ago. Since then, transformation technology has developed rapidly, resulting in a multitude of techniques for cell transformation and the creation of transgenic animals. As with any expanding technology, it becomes difficult to keep track of all the developments and to find a concise and comprehensive source of information that explains all the underlying principles. Gene Transfer to Animals Cells addresses this problem by describing the principles behind gene transfer technologies, how gene expression is controlled in animal cells and how advanced strategies can be used to add, exchange or delete sequences from animal genomes in a conditional manner. A final chapter provides an overview of all the applications of animal cell transformation in farming, medicine and research.

Applications of Gene-Based Technologies for Improving Animal Production and Health in Developing Countries

Applications of Gene-Based Technologies for Improving Animal Production and Health in Developing Countries
  • Author : Harinder P.S. Makkar,Gerrit J. Viljoen
  • Publisher :Unknown
  • Release Date :2005-08-12
  • Total pages :793
  • ISBN : 9781402033117
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Summary : Modern Biotechnology has potential for solving many problems associated with animal productivity and health and offers exciting opportunities for enhancing agricultural productivity. At present the focus is, however, on the issues and problems of significance for livestock producers in the developed world. In order to fully realize the benefits of this technology in developing countries, there is a need to identify, characterize and apply appropriate gene-based technologies for these regions. These proceedings present peer reviewed state-of-the-art papers describing the achievements in the areas of animal breeding and genetics, animal nutrition, animal health, and environment, ethics, safety, and regulatory aspects of gene-based technologies; achievements which could be realized using these modern scientific tools to maximise the benefits from the 'livestock revolution' that is taking place; and the constraints in the use of gene-based technologies and their specific research needs. This book will help in bridging the wide gap between developed and developing countries, in the development and use of gene-based technologies, and to elucidate the current and future roles of such technologies in the developing world. It is a good reference source for researchers, students and policy-makers alike.

Insights from Animal Reproduction

Insights from Animal Reproduction
  • Author : Rita Payan-Carreira
  • Publisher :Unknown
  • Release Date :2016-03-23
  • Total pages :252
  • ISBN : 9789535122685
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Summary : The chapters in this volume of "Insights from Animal Reproduction" address several, particular hot topics in the field of reproduction. The book begins with a comprehensive overview of the cryopreservation of sheep-produced embryos. The following chapter revises the assisted reproductive techniques available for South American wild mammals. Chapter 3 presents the technical procedures necessary to produce transgenic goats. Chapter 4 provides a comprehensive revision of the major molecular determinants of litter size in prolific species. Chapter 5 examines the germ cell determinant transmission, segregation, and function using the zebrafish as a model for germ cell specification in the embryo. Chapter 6 summarizes the current understanding of the molecular and cellular mechanisms regulating the early stages of folliculogenesis. Chapter 7 examines the sperm motility regulatory proteins as a tool to enhance sperm quality in cryopreservation processes. Chapter 8 discusses contemporary knowledge on the effects of extremely low frequency magnetic fields (ELF-MF) on male reproductive function in rodents. Chapter 9 highlights the importance of the cytogenetic evaluation in searching for causes of infertility of phenotypically normal animals, as well as individuals with an abnormal sex development. The last chapter provides evidence that other uterine diseases may be hidden behind the clinical diagnosis of pyometra that in some case may have a poor outcome.

Designer Animals

Designer Animals
  • Author : Conrad Grebel Brunk
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :273
  • ISBN : 9781442639973
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Summary : "Designer Animals is an in-depth study of the debates surrounding the development of animal biotechnology, which is quickly emerging out of the laboratory and into the commercial marketplace. This book innovatively combines expert analysis on the technology's economic, professional, ethical, and religious implications while remaining firmly grounded in the 'real world' political environment in which the issue is played out. Designer Animals uses non-technical language to explore the science behind animalbiotechnology and the ethical frameworks at play in its surrounding debates. By investigating the interests of major stakeholders--including researchers on the cutting edge of science, mainstream and 'alternative' agriculture organizations, the animal welfare movement, and health care providers, patients, and researchers--the contributors illuminate the most important points of agreement and disagreement on this hotly contested topic."--Dust jacket.

Animal Cell Technology: Basic & Applied Aspects

Animal Cell Technology: Basic & Applied Aspects
  • Author : T. Kobayashi,Y. Kitagawa,K. Okumura
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :615
  • ISBN : 9789401108485
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Summary : Animal cell technology is a growing discipline of cell biology which aims to understand the structure, function and behaviour of differentiated animal cells, and especially the development of such abilities as are useful for industrial purposes. These developments range from clonal expansion of differentiated cells with useful abilities, to optimization of cell culture on industrial scale and modulation of the cells' abilities to produce drugs and monoclonal antibodies. The sixth volume in this series gives a complete review of today's state of the art in Japan, a country where this field is especially well advanced. It will be of interest to cell biologists, biochemists, molecular biologists, immunologists and other disciplines related to animal cell culture, working in the academic environment as well as in (biotechnology or pharmaceutical) industry.

Animal Transgenesis and Cloning

Animal Transgenesis and Cloning
  • Author : Louis-Marie Houdebine
  • Publisher :Unknown
  • Release Date :2003-04-02
  • Total pages :220
  • ISBN : STANFORD:36105111818394
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Summary : Designed to be a concise, balanced introduction to this dynamic subject, covering key issues and current techniques currently used in animal transgenesis and cloning. Provides the essentials of the subject, from the molecular basis of gene structure and function to therapeutic gene cloning in humans. Social and ethical implications of this important area of research are also considered.

Transgenic Animals as Model Systems for Human Diseases

Transgenic Animals as Model Systems for Human Diseases
  • Author : Erwin F. Wagner,F. Theuring
  • Publisher :Unknown
  • Release Date :2013-04-17
  • Total pages :151
  • ISBN : 9783662029251
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Summary : Some of the current concepts used in transgenic research, an increasingly important tool to study the regulation and function of genes, are illustrated in this book. With these techniques, animal models can be used to study human diseases; this opens up new possibilities in both applied and basic research. Specifically, the ability to introduce genes into the germline of mice and the successful expression of the inserted gene within an organism provide new insights and opportunities for biomedical research. The discussion here shows how a detailed analysis of the underlying molecular mechanisms will provide new insights into the genetic origin of certain diseases and will lead to a better understanding of normal and abnormal physiological processes.

Transgenic Insects

Transgenic Insects
  • Author : Mark Q. Benedict
  • Publisher :Unknown
  • Release Date :2014-10-29
  • Total pages :399
  • ISBN : 9781780644516
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Summary : Insect transgenesis promises improvements in agriculture, pharmaceuticals and public health. Many important insects can now be routinely transformed with effectors that have useful applications. Agriculture presents the largest market for transgenic insects and has a foundational history of success with sterile insect technique for control of pests including Mediterranean fruit flies and screwworms. Biotechnology will contribute superior markers, suppressible sterility and sex-conversion. Public health is also seeing transgenic mosquitoes developed which suppress natural populations and are incapable of transmitting disease. Experts in the field will contribute their insights into the latest technology and its applications. Authors will also consider the larger risks, social and economic aspects of transgenic insects whose value must be proven in political, regulatory and public acceptance arenas.

Leonardo’s Choice

Leonardo’s Choice
  • Author : Carol Gigliotti
  • Publisher :Unknown
  • Release Date :2009-09-18
  • Total pages :256
  • ISBN : 9048124794
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Summary : Leonardo’s Choice: Genetic Technologies and Animals is an edited collection of twelve essays and one dialogue focusing on the profound affect the use of animals in biotechnology is having on both humans and other species. Communicating crucial understandings of the integrated nature of the human and non-human world, these essays, unlike the majority of discussions of biotechnology, take seriously the impact of these technologies on animals themselves. This collection’s central questions revolve around the disassociation Western ideas of creative freedom have from the impacts those ideas and practices have on the non-human world. This transdisciplinary collection includes perspectives from the disciplines of philosophy, cultural theory, art and literary theory, history and theory of science, environmental studies, law, landscape architecture, history, and geography. Included authors span three continents and four countries. Included essays contribute significantly to a growing scholarship surrounding “the question of the animal” emanating from philosophical, cultural and activist discourses. Its authors are at the forefront of the growing number of theorists and practitioners across the disciplines concerned with the impact of new technologies on the more-than-human world.

Position Paper on the Necessity of Patents for Transgenic Animal Technology for Human Health Purposes

Position Paper on the Necessity of Patents for Transgenic Animal Technology for Human Health Purposes
  • Author : Gene Pharming Europe,Pharmaceutical Proteins (Firm),Imutran (Firm)
  • Publisher :Unknown
  • Release Date :1994
  • Total pages :13
  • ISBN : OCLC:800668070
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Summary :

Meat Quality

Meat Quality
  • Author : Wieslaw Przybylski, PhD,David Hopkins, PhD
  • Publisher :Unknown
  • Release Date :2015-10-15
  • Total pages :472
  • ISBN : 9781482220322
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Summary : One of the biggest challenges faced by meat producers today is the requirement to improve the quality of meat while maintaining focus on efficiency and higher yields. Numerous studies have shown that consumers are willing to pay premiums for meat products with guaranteed eating quality. This book examines the complicated multistep process of producing high-quality meat, from the growth of the animals to the final product. It discusses specific aspects of meat quality for beef, pork, and sheep. Meat Quality: Genetic and Environmental Factors covers key topics such as animal welfare, nutrition, pre-slaughter handling, slaughter technology, breeding strategies, and the influence of common genetic factors on meat quality. It also discusses the latest meat production systems designed to ensure high-quality meat and the role of transgenic animal technology in meat quality. The book devotes separate chapters to beef, pork, and sheep quality, looking at the effects of breed, genetic type, gender, and age on meat quality. The chapters are written by contributors from universities, research institutes, and breeding companies from different countries and continents. The chapters are based on the research and teaching experience of the contributors as well as on a critical evaluation of the current literature. No other book available today covers the key issues regarding meat quality in such a comprehensive way. This book should be of keen interest to students of food technology, nutrition, commodities sciences, and animal sciences, as well as to food scientists and engineers who want to update their knowledge about the determinants of meat quality.

Frankenstein's Cat

Frankenstein's Cat
  • Author : Emily Anthes
  • Publisher :Unknown
  • Release Date :2013-03-12
  • Total pages :256
  • ISBN : 9781429949521
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Summary : Winner of 2014 AAAS/Subaru SB&F Prize for Best Young Adult Science Book Longlisted for the PEN/E.O. Wilson Literary Science Writing Award One of Nature's Summer Book Picks One of Publishers Weekly's Top Ten Spring 2013 Science Books For centuries, we've toyed with our creature companions, breeding dogs that herd and hunt, housecats that look like tigers, and teacup pigs that fit snugly in our handbags. But what happens when we take animal alteration a step further, engineering a cat that glows green under ultraviolet light or cloning the beloved family Labrador? Science has given us a whole new toolbox for tinkering with life. How are we using it? In Frankenstein's Cat, the journalist Emily Anthes takes us from petri dish to pet store as she explores how biotechnology is shaping the future of our furry and feathered friends. As she ventures from bucolic barnyards to a "frozen zoo" where scientists are storing DNA from the planet's most exotic creatures, she discovers how we can use cloning to protect endangered species, craft prosthetics to save injured animals, and employ genetic engineering to supply farms with disease-resistant livestock. Along the way, we meet some of the animals that are ushering in this astonishing age of enhancement, including sensor-wearing seals, cyborg beetles, a bionic bulldog, and the world's first cloned cat. Through her encounters with scientists, conservationists, ethicists, and entrepreneurs, Anthes reveals that while some of our interventions may be trivial (behold: the GloFish), others could improve the lives of many species-including our own. So what does biotechnology really mean for the world's wild things? And what do our brave new beasts tell us about ourselves? With keen insight and her trademark spunk, Anthes highlights both the peril and the promise of our scientific superpowers, taking us on an adventure into a world where our grandest science fiction fantasies are fast becoming reality.

Molecular Biology and Genetic Engineering

Molecular Biology and Genetic Engineering
  • Author : P. K. Gupta
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :613
  • ISBN : 8171337198
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Summary : PART I Molecular Biology 1. Molecular Biology and Genetic Engineering Definition, History and Scope 2. Chemistry of the Cell: 1. Micromolecules (Sugars, Fatty Acids, Amino Acids, Nucleotides and Lipids) Sugars (Carbohydrates) 3. Chemistry of the Cell . 2. Macromolecules (Nucleic Acids; Proteins and Polysaccharides) Covalent and Weak Non-covalent Bonds 4. Chemistry of the Gene: Synthesis, Modification and Repair of DNA DNA Replication: General Features 5. Organisation of Genetic Material 1. Packaging of DNA as Nucleosomes in Eukaryotes Techniques Leading to Nucleosome Discovery 6. Organization of Genetic Material 2. Repetitive and Unique DNA Sequences 7. Organization of Genetic Material: 3. Split Genes, Overlapping Genes, Pseudogenes and Cryptic Genes Split Genes or .Interrupted Genes 8. Multigene Families in Eukaryotes 9. Organization of Mitochondrial and Chloroplast Genomes 10. The Genetic Code 11. Protein Synthesis Apparatus Ribosome, Transfer RNA and Aminoacyl-tRNA Synthetases Ribosome 12. Expression of Gene . Protein Synthesis 1. Transcription in Prokaryotes and Eukaryotes 13. Expression of Gene: Protein Synthesis: 2. RNA Processing (RNA Splicing, RNA Editing and Ribozymes) Polyadenylation of mRNA in Prokaryotes Addition of Cap (m7G) and Tail (Poly A) for mRNA in Eukaryotes 14. Expression of Gene: Protein Synthesis: 3. Synthesis and Transport of Proteins (Prokaryotes and Eukaryotes) Formation of Aminoacyl tRNA 15. Regulation of Gene Expression: 1. Operon Circuits in Bacteria and Other Prokaryotes 16. Regulation of Gene Expression . 2. Circuits for Lytic Cycle and Lysogeny in Bacteriophages 17. Regulation of Gene Expression 3. A Variety of Mechanisms in Eukaryotes (Including Cell Receptors and Cell Signalling) PART II Genetic Engineering 18. Recombinant DNA and Gene Cloning 1. Cloning and Expression Vectors 19. Recombinant DNA and Gene Cloning 2. Chimeric DNA, Molecular Probes and Gene Libraries 20. Polymerase Chain Reaction (PCR) and Gene Amplification 21. Isolation, Sequencing and Synthesis of Genes 22. Proteins: Separation, Purification and Identification 23. Immunotechnology 1. B-Cells, Antibodies, Interferons and Vaccines 24. Immunotechnology 2. T-Cell Receptors and MHC Restriction 25. Immunotechnology 3. Hybridoma and Monoclonal Antibodies (mAbs) Hybridoma Technology and the Production of Monoclonal Antibodies 26. Transfection Methods and Transgenic Animals 27. Animal and Human Genomics: Molecular Maps and Genome Sequences Molecular Markers 28. Biotechnology in Medicine: l.Vaccines, Diagnostics and Forensics Animal and Human Health Care 29. Biotechnology in Medicine 2. Gene Therapy Human Diseases Targeted for Gene Therapy Vectors and Other Delivery Systems for Gene Therapy 30. Biotechnology in Medicine: 3. Pharmacogenetics / Pharmacogenomics and Personalized Medicine Phannacogenetics and Personalized 31. Plant Cell and Tissue Culture' Production and Uses of Haploids 32. Gene Transfer Methods in Plants 33. Transgenic Plants . Genetically Modified (GM) Crops and Floricultural Plants 34. Plant Genomics: 35. Genetically Engineered Microbes (GEMs) and Microbial Genomics References