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Translating MicroRNAs to the Clinic

Translating MicroRNAs to the Clinic
  • Author : Jeffrey Laurence
  • Publisher :Unknown
  • Release Date :2016-09-17
  • Total pages :392
  • ISBN : 9780128005545
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Summary : Translating microRNA to the Clinic reviews the possibilities of current methodological tools and experimental approaches used by leading translational researchers. The book features the uses of micro ribonucleic acid as deployed in cancer targeting in biomarkers, diabetes, cardiovascular disease, and neurodegeneration, among many others. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field, promoting a cross-disciplinary communication between the sub-specialities of medicine, but in common with other books on the topic. In addition, the book emphasizes recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Encompasses the latest innovations and tools being used to apply microRNA from lab to clinic“/li> Extensive pedagogical updates aiming to improve the education of translational researchers in this field Transdisciplinary approach aims to support cross-fertilization between different sub-specialties of medicine

Translating Regenerative Medicine to the Clinic

Translating Regenerative Medicine to the Clinic
  • Author : Jeffrey Laurence,Pedro Baptista,Anthony Atala
  • Publisher :Unknown
  • Release Date :2015-11-18
  • Total pages :354
  • ISBN : 9780128005521
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Summary : Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin. Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic. Encompasses the latest innovations and tools being used to develop regenerative medicine in the lab and clinic Covers the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field Contains extensive pedagogical updates aiming to improve the education of translational researchers in this field Provides a transdisciplinary approach that supports cross-fertilization between different sub-specialties of medicine

Translating Epigenetics to the Clinic

Translating Epigenetics to the Clinic
  • Author : Jeffrey Laurence
  • Publisher :Unknown
  • Release Date :2016-12-30
  • Total pages :324
  • ISBN : 9780128006122
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Summary : Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole. Encompasses the latest innovations and tools being used to apply epigenetics in the lab and clinic Features extensive pedagogical updates aiming to improve the education of translational researchers in this field Offers a transdisciplinary approach to support cross-fertilization between different sub-specialties of medicine

Molecular Biology of Cancer: Translation to the Clinic

Molecular Biology of Cancer: Translation to the Clinic
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2010-12-16
  • Total pages :400
  • ISBN : 012385072X
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Summary : Advances in molecular biology over the last several decades are being steadily applied to our understanding of the molecular biology of cancer, and these advances in knowledge are being translated into the clinical practice of oncology. This volume explores some of the most exciting recent advances in basic research on the molecular biology of cancer and how this knowledge is leading to advances in the diagnosis, treatment, and prevention of cancer. * This series provides a forum for discussion of new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Translating Gene Therapy to the Clinic

Translating Gene Therapy to the Clinic
  • Author : Jeffrey Laurence,Michael Franklin
  • Publisher :Unknown
  • Release Date :2014-11-14
  • Total pages :346
  • ISBN : 9780128005644
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Summary : Translating Gene Therapy to the Clinic, edited by Dr. Jeffrey Laurence and Michael Franklin, follows the recent, much-lauded special issue of Translational Research in emphasizing clinical milestones and critical barriers to further progress in the clinic. This comprehensive text provides a background for understanding the techniques involved in human gene therapy trials, and expands upon the disease-specific situations in which these new approaches currently have the greatest therapeutic application or potential, and those areas most in need of future research. It emphasizes methods, tools, and experimental approaches used by leaders in the field of translational gene therapy. The book promotes cross-disciplinary communication between the sub-specialties of medicine, and remains unified in theme. Presents impactful and widely supported research across the spectrum of science, method, implementation and clinical application Offers disease-based coverage from expert clinician-scientists, covering everything from arthritis to congestive heart failure, as it details specific progress and barriers for current translational use Provides key background information from immune response through genome engineering and gene transfer, relevant information for practicing clinicians contemplating enrolling patients in gene therapy trials

Genetic Patterns in Neuroimaging, An Issue of Neuroimaging Clinics,

Genetic Patterns in Neuroimaging, An Issue of Neuroimaging Clinics,
  • Author : Luis Celso Hygino de Cruz
  • Publisher :Unknown
  • Release Date :2014-12-27
  • Total pages :268
  • ISBN : 9780323354639
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Summary : Genetic Patterns in Neuroimaging is explored in this important Neuroimaging Clinics issue. Articles include: Brain imaging and genetic risk of congenital malformations; Understanding genetics in neuroimaging; Influence of genetics in neuropathology; Building a bridge between genomics and neuroradiology; Systems genetics approaches to neuroimaging phenotypes; Imaging genetic predictions at an individual level; Brain imaging and genetic risk in the pediatric population; Imaging phenotypes in cognitive diseases; Molecular imaging in genetics; Imaging phenotypes in psychiatric disease; Genomics of brain tumor imaging; Neuroimaging and genetic influence in post-treatment brain neoplasms; Imaging phenotypes in multiple sclerosis; Genetic markers and influences in cerebrovascular malformations, and more.

Molecular Pathology, An Issue of Clinics in Laboratory Medicine,

Molecular Pathology, An Issue of Clinics in Laboratory Medicine,
  • Author : Martin H. Bluth
  • Publisher :Unknown
  • Release Date :2013-11-30
  • Total pages :209
  • ISBN : 9780323261050
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Summary : Molecular pathology has significantly matured over the past decade to establish itself as a discipline in its own right. Patient diagnosis, prognosis, management and care have been influenced by molecular pathology testing algorithms on a global scale. Whether it pertains to carrier status of deleterious genes, diagnosis by molecular techniques, assessment of appropriate remission post treatment, parentage or forensics testing – molecular pathology continues to increase its presence and influence in the diagnostic laboratory armamentarium. Furthermore, intellectualization and proprietization of molecular pathology with respect to the discovery of new genes and or new techniques continues to pose new challenges of test ownership, legalities, liabilities, widespread acceptance and utility. This issue of Laboratory Clinics seeks to provide selective state of the art understanding of molecular pathology with respect to its relationship to key pathology disciplines as well as the current challenges and promise for the future.

The Lymphatic System in Thoracic Oncology, An Issue of Thoracic Surgery Clinics - E-Book

The Lymphatic System in Thoracic Oncology, An Issue of Thoracic Surgery Clinics - E-Book
  • Author : Federico Venuta,Erino A. Rendina
  • Publisher :Unknown
  • Release Date :2012-05-28
  • Total pages :128
  • ISBN : 9781455744428
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Summary : The aim of this issue is to provide the thoracic surgeon with information about the staging and treatment of cancer to the mediastinal lymph nodes. The issue includes articles on the anatomy and physiology of the lymph nodes, imaging of the lymph nodes, and various techniques for diagnosing and dissecting the lymph nodes, including video-assisted mediastinoscopic lymphadenectomy and transcervical extended mediastinal lymphadenectomy.

MicroRNA in Regenerative Medicine

MicroRNA in Regenerative Medicine
  • Author : Chandan K. Sen
  • Publisher :Unknown
  • Release Date :2014-11-26
  • Total pages :1288
  • ISBN : 9780124058583
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Summary : This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering. Regulating virtually all biological processes, the genome’s 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering Multi-colour text layout with 150 colour figures to illustrate important findings Take home messages encapsulate key lessons throughout text Short chapters offer focused discussion and clear ‘voice’

Eosinophilic Esophagitis, An issue of Gastroenterology Clinics of North America, E-Book

Eosinophilic Esophagitis, An issue of Gastroenterology Clinics of North America, E-Book
  • Author : Ikuo Hirano
  • Publisher :Unknown
  • Release Date :2014-06-16
  • Total pages :238
  • ISBN : 9780323299398
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Summary : Ikuo Hirano, an international leader and pioneer in EoE, has assembled well-recognized experts in the field to provide a state-of-the-art, practical understanding of EoE for both children and adults in 2014. Topics you will find in this issue of Gastroenterology Clinics of North America include the epidemiology, clinical presentation, diagnosis, and management of EoE as well as a glimpse into what the future holds. In addition, articles dedicated to mechanisms of disease pathogenesis and complications complete this comprehensive assessment of the field at present.The Editors believe that this issue will enhance your understanding of EoE.

AGO-Driven Non-Coding RNAs

AGO-Driven Non-Coding RNAs
  • Author : Bibekanand Mallick
  • Publisher :Unknown
  • Release Date :2019-01-20
  • Total pages :387
  • ISBN : 9780128156704
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Summary : The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy

MicroRNAs in Cancer

MicroRNAs in Cancer
  • Author : César López-Camarillo,Laurence A. Marchat
  • Publisher :Unknown
  • Release Date :2013-02-22
  • Total pages :426
  • ISBN : 9781466576773
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Summary : MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and therapeutic targets as well as the potential use in translational medicine. Chapters present comprehensive and expert perspectives on the roles of miRNAs in most common cancers from bench to bedside applications and are written by an international team of renowned experts in the field.

Exercise and Rehabilitation in Heart Failure, An Issue of Heart Failure Clinics,

Exercise and Rehabilitation in Heart Failure, An Issue of Heart Failure Clinics,
  • Author : Ross Arena
  • Publisher :Unknown
  • Release Date :2014-12-26
  • Total pages :201
  • ISBN : 9780323341936
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Summary : This multidisciplinary issue of Heart Failure Clinics examines a critical element in the management and treatment of heart failure (HF)—exercise and rehabilitation. Topics include the reversal of HF-associated pathophysiology with exercise; quantifying function; prognosis; rehabilitation practice patterns in the United States, Canada, South America, Asia, and Europe; special considerations such as obesity, high-intensity interval training, inspiratory muscle training, and technology to promote and increase physical activity.

Tumor Liquid Biopsies

Tumor Liquid Biopsies
  • Author : Florence Schaffner,Jean-Louis Merlin,Nikolas von Bubnoff
  • Publisher :Unknown
  • Release Date :2019-10-11
  • Total pages :368
  • ISBN : 9783030264390
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Summary : This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

MicroRNAs in Medicine

MicroRNAs in Medicine
  • Author : Charles H. Lawrie
  • Publisher :Unknown
  • Release Date :2013-10-30
  • Total pages :720
  • ISBN : 9781118300343
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Summary : MicroRNAs in Medicine provides an access point intothe current literature on microRNA for both scientists andclinicians, with an up-to-date look at what is happening in theemerging field of microRNAs and their relevance to medicine. Eachchapter is a comprehensive review, with descriptions of the latestmicroRNA research written by international leaders in their field.Opening with an introduction to what microRNAs are and how theyfunction, the book goes on to explore the role of microRNAs innormal physiological functions, infectious diseases, non-infectiousdiseases, cancer, circulating microRNAs as non-invasive biomarkers,and finally their potential as novel therapeutics. Including background information on the field as well as reviewsof the latest research breakthroughs, MicroRNAs inMedicine is a one-stop source of information to satisfythe specialists and non-specialists alike, appealing to students,researchers, and clinicians interested in understanding thepotential of microRNAs in medicine and research.

A Concise Review of Molecular Pathology of Breast Cancer

A Concise Review of Molecular Pathology of Breast Cancer
  • Author : Mehmet Gunduz
  • Publisher :Unknown
  • Release Date :2015-03-25
  • Total pages :234
  • ISBN : 9789535120308
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Summary : Cancer is one of the leading causes of death in most countries and its consequences result in huge economic, social and psychological burden. Breast cancer is the most frequently diagnosed cancer type and the leading cause of cancer death among females. In this book, we discussed gene expression and DNA abnormalities including methylation in breast cancer. A recent important topic, roles of miRNAs and their potential use in cancer therapy have been discussed in this cancer type as well. Bioinformatics is very important part of recent human genome developments and data mining and thus this topic has also been added for the readers. It is hoped that this book will contribute to development of novel diagnostic as well as therapeutic approaches, which lead to cure of breast cancer.

Cardiac Markers, An Issue of Clinics in Laboratory Medicine, E-Book

Cardiac Markers, An Issue of Clinics in Laboratory Medicine, E-Book
  • Author : Kent Balanis Lewandrowski
  • Publisher :Unknown
  • Release Date :2014-02-15
  • Total pages :209
  • ISBN : 9780323287111
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Summary : Topics in this clinically focused publication devoted to Cardiac Markers include: Overview of cardiac markers in heart disease; Methodologies for measurement of cardiac markers; Natriuretic peptides in HF and ACS; Tropoinins and high sensitivity troponins; Point-of-care testing for cardiac markers; ST-2 and galectin 3 in patients with heart failure; Cardiac markers following heart surgery and percutaneous coronary intervention; Cholesterol, lipoproteins, high sensitivity CRP and other risk factors for atherosclerosis; Myocarditis and cardiac transplant and rejection; New molecular genetic tests in the diagnosis of heart disease; Biomarkers for cholesterol balance.

Molecular Pathology of Pituitary Adenomas

Molecular Pathology of Pituitary Adenomas
  • Author : Cristiana Tanase,Irina Ogrezeanu,Corin Badiu
  • Publisher :Unknown
  • Release Date :2011-10-31
  • Total pages :130
  • ISBN : 9780124158528
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Summary : The pituitary gland is an important one since it controls several of the other hormone glands, such as the thyroid and adrenals. A pituitary adenoma is an abnormal growth or tumor in this gland, and they are the subject of very active clinical and pathological research. This book examines the latest developments in this field and discusses the most important molecules implicated in apoptosis, angiogenesis and signal transduction. A good understanding of these processes is needed to identify the best therapies. Facilitates the understanding of the processes involved and how they are translated into therapy Illustrations are used to explain the complex mechanisms involved

Update on Amyotrophic Lateral Sclerosis

Update on Amyotrophic Lateral Sclerosis
  • Author : Humberto Foyaca Sibat,Lourdes de Fátima Ibañez-Valdés
  • Publisher :Unknown
  • Release Date :2016-09-14
  • Total pages :280
  • ISBN : 9789535126003
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Summary : This book contains selected peer-reviewed chapters which cover updated information on ALS written by international researchers. Update on Amyotrophic Lateral Sclerosis is comprised of 13 chapters from some of the world's top central nervous system researchers and neurologists to provide a timely review of the most recent developments in ALS, covering historic aspects, experimental animal models, genetics, pathogenesis, clinical aspects and imagenology among others. Contributors from Belgium, France, Japan, India, Italy, Mexico, Russia, South Africa, and Switzerland have collaborated enthusiastically and efficiently, dedicating their time to create this reader-friendly yet comprehensive work which includes many explanatory figures, tables and photos to enhance legibility and make the book clinically useful. We are looking forward with confidence and pride in the remarkable role that this book will play for a new vision and mission.

Acute Respiratory Distress Syndrome, An Issue of Clinics in Chest Medicine,

Acute Respiratory Distress Syndrome, An Issue of Clinics in Chest Medicine,
  • Author : Lorraine B. Ware
  • Publisher :Unknown
  • Release Date :2014-11-20
  • Total pages :249
  • ISBN : 9780323326438
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Summary : This issue of Clinics in Chest Medicine focuses on Acute Respiratory Distress Syndrome and covers topics such as: Epidemiology and Definitions of ARDS and Early Acute Lung Injury, Environmental Risk Factors for ARDS, Clinical and Biological Heterogeneity in ARDS: Direct vs. Indirect Lung Injury,Obesity and Nutrition, Important Immunomodulators in ARDS?, Beyond SNPs—Genetics, Genomics and Other Omic Approaches to ARDS, Clinical Approach to the Patient with ARDS, The Immunocompromised Patient with ARDS: Role of Invasive Diagnostic Strategies, Clinical Trial Design in Prevention and Treatment of ARDS, Beyond Low Tidal Volume—Ventilating the Patient with ARDS, Prone Positioning in ARDS, and more!

Cystic Fibrosis in the Light of New Research

Cystic Fibrosis in the Light of New Research
  • Author : Dennis Wat
  • Publisher :Unknown
  • Release Date :2015-08-24
  • Total pages :392
  • ISBN : 9789535121527
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Summary : Cystic Fibrosis in the Light of New Research provides the latest research and clinical evidence that will be useful for clinicians, scientists and researchers to further their knowledge around this fascinating condition. The authors have brought along their expertise and wealth of knowledge to produce this book, including the basic science that underlies the disease, the burden of bacterial and viral infections, immunologic aspects of CF, a variety of clinical measurements to predict prognosis and novel therapies including gene therapy. This book will be invaluable and entertaining for anyone who is involved in the care of patients with cystic fibrosis.