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Translational Advances in Gynecologic Cancers

Translational Advances in Gynecologic Cancers
  • Author : Michael Birrer,Lorenzo Ceppi
  • Publisher :Unknown
  • Release Date :2017-01-25
  • Total pages :354
  • ISBN : 9780128037980
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Summary : Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included. Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus. Provides a comprehensive description of all evolving translational gynecologic cancer research for clinicians Identifies knowledge gaps to inform the next research direction Ties together clinical research and patient needs to help both the researcher and clinician Addresses genomics, new target therapies, novel tools, and more for ovarian, endometrial, and cervical cancer

Ovarian Cancers

Ovarian Cancers
  • Author : Eric Pujade-Lauraine,Isabelle Ray-Coquard,Fabrice Lécuru
  • Publisher :Unknown
  • Release Date :2016-10-17
  • Total pages :286
  • ISBN : 9783319321103
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Summary : This book provides an overview of the latest developments in the concepts and management of ovarian cancer. The new data presented throughout opens the way to radically different therapeutic approaches. Surgery remains the core of ovarian cancer treatment, but its ultimate goal and the standard surgical procedure have evolved, giving rise to the question of how to label expert centers for debulking surgery. Neo-adjuvant chemotherapy is becoming more popular and is also a new field for testing novel drug combinations. Over recent years, ovarian cancer management has embraced molecular biology. It is now more correct to talk about cancers of the ovary rather than ovarian cancer, since it is not a unique disease but several entities with different molecular drivers. The significant advances in drugs targeting the microenvironment or the tumor cell DNA repair mechanisms are presented in detail together with exciting future perspectives. All these advances would not have been possible without collaborative groups such as the GINECO group in France and their integration in wider clinical research networks at the European (ENGOT) and international (GCIG) level.

Noninvasive Molecular Markers in Gynecologic Cancers

Noninvasive Molecular Markers in Gynecologic Cancers
  • Author : Debmalya Barh,Mehmet Gunduz
  • Publisher :Unknown
  • Release Date :2015-01-22
  • Total pages :516
  • ISBN : 9781466569393
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Summary : Early detection is critical for any given cancer. With the advent of the latest omics technologies, molecular markers in combination with conventional diagnostic and screening methods are emerging as next-generation early diagnostic and prognostic strategies that can allow early-stage diagnosis, resulting in more effective treatment and patient car

Applications of NMR Spectroscopy: Volume 8

Applications of NMR Spectroscopy: Volume 8
  • Author : Atta-ur-Rahman,M. Iqbal Choudhary
  • Publisher :Unknown
  • Release Date :2020-10-02
  • Total pages :159
  • ISBN : 9789811433832
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Summary : Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture. The eighth volume of the series features six reviews focusing on NMR spectroscopic techniques in food science, molecular biology and medical diagnosis. The reviews in this volume are: - qNMR as a Tool for Determination of Six Common Sugars in Foods - Correlation of VIP Scores and 1H NMR to Extract Information of Psychological Attention Tests Applied Before and After Coffee Intake - NMR Spectroscopy for Probing the Structural Determinants of Aptamer Optimization and Riboswitch Engineering - Applications of NMR Spectroscopy in Medical Diagnosis - Applications of NMR Spectroscopy in Cancer Diagnosis - NMR as a Tool for Exploring Protein Interactions and Dynamics

Gynecologic Cancers

Gynecologic Cancers
  • Author : Kunle Odunsi, MD,Tanja Pejovic, MD
  • Publisher :Unknown
  • Release Date :2013-10-09
  • Total pages :192
  • ISBN : 9781617051517
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Summary : Over the course of the last decade, the treatment of gynecologic cancer has evolved quite rapidly. New scientific and clinical advances have modified the standard of care and led to improved patient outcomes. At the same time, the treatment of gynecologic cancer has become increasingly complex, requiring the comprehensive review and assessment of multiple issues including genetics, radiology, surgery, molecular diagnostics, chemotherapy, and more. As a result, the harmony and open communication between these specialties facilitated by a multidisciplinary team approach are crucial in providing the best care to patients and ensuring successful treatment. Gynecologic Cancers: A Multidisciplinary Approach to Diagnosis and Management, written by a multidisciplinary team of authors representing a range of disciplines, is a valuable resource for physicians, fellows, nurses, physician assistants, physical therapists, and all health care providers involved in the treatment of gynecologic cancer. Gynecologic Cancers: A Multidisciplinary Approach to Diagnosis and Management summarizes the state-of-the-art issues related to the treatment of gynecologic cancer and describes an approach for optimal multidisciplinary care for women who have been diagnosed with or who are at higher risk to develop gynecologic cancer. About the Series: The Current Multidisciplinary Oncology series, edited by Charles R. Thomas, consolidates and integrates the varied aspects of multidisciplinary care for major topics in oncology, including breast, lung, prostrate, head and neck and more. The volumes in the Current Multidisciplinary Oncology series represent all related topic areas, including oncology, radiation oncology, pain, pathology, imaging, psychological support and the primary disease. In addition, each volume includes a chapter focusing on special populations and the disease's impact / difference on them, and discussion of future directions and quality of life issues. In addition each volume has a chapter written by a private practice oncologist. All Current Multidisciplinary Oncology titles provide: Consolidation and integration of the varied aspects of multidisciplinary care for major topics in oncology Coverage of all related topic areas, including medical and surgical oncology, radiation oncology, pain, pathology, imaging, psychological support, and the primary disease A chapter focusing on special populations and the disease's differing impact on them Discussion of quality-of-life issues

Ovarian Cancer

Ovarian Cancer
  • Author : Ivan Diaz-Padilla
  • Publisher :Unknown
  • Release Date :2013-02-27
  • Total pages :384
  • ISBN : 9789535110309
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Summary : "Ovarian Cancer: A Clinical and Translational Update" embraces the most recent advances in diagnosis and treatment of ovarian cancer. With the valuable collaboration of international experts in the field, this book is intended to provide the readership with a comprehensive update in the subject of epithelial ovarian cancer.

Molecular Oncology: Underlying Mechanisms and Translational Advancements

Molecular Oncology: Underlying Mechanisms and Translational Advancements
  • Author : Ammad Ahmad Farooqi,Muhammad Ismail
  • Publisher :Unknown
  • Release Date :2017-03-29
  • Total pages :302
  • ISBN : 9783319530826
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Summary : Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

Recent Advances in Prostate Cancer

Recent Advances in Prostate Cancer
  • Author : Donald J. Tindall,Peter T. Scardino
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :671
  • ISBN : 9789814329453
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Summary : The easy way to boost employee engagement Today more than ever, companies and leaders need a road map to help them boost employee engagement levels. Employee Engagement For Dummies helps employers implement the necessary plans to create and sustain an engaging culture, allowing them to attract and retain the best people while boosting their productivity and creativity. Employee Engagement For Dummies helps you foster employee engagement, a concept that furthers an organization′s interests through ensuring that employees remain involved in, committed to, and fulfilled by their work. It covers: practical steps to boost employee engagement with your company or team; how to engage different generations of employees; the keys to reduce voluntary employee turnover; practical tools to help retain and engage your employees; processes that will boost employee retention and productivity; hiring the best fits from the start; and much more. Helps you recognize and understand the impact of positive employee engagement Helps you attract and retain the best employees Employee Engagement For Dummies is for business leaders at all levels who are looking to better engage their employees and increase morale and productivity.

European Journal of Gynaecological Oncology

European Journal of Gynaecological Oncology
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2007
  • Total pages :229
  • ISBN : UCLA:L0099040461
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Summary :

Gynecologic Cancer

Gynecologic Cancer
  • Author : William P. McGuire,Martin Gore,Michael A. Quinn,Gillian Thomas
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :1001
  • ISBN : UOM:39015061741503
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Summary : This brand-new reference provides multidisciplinary guidance on the biology, diagnosis, treatment, and supportive care of patients with cancers of the female reproductive tract. An international group of experts present sections on management controversies, complications of cancer treatment, surgical techniques, symptom management, and more.

Ovarian Cancer

Ovarian Cancer
  • Author : Omer Devaja,Andreas Papadopoulos
  • Publisher :Unknown
  • Release Date :2018-10-24
  • Total pages :364
  • ISBN : 9781789843330
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Summary : Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

Anticancer Research

Anticancer Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2008
  • Total pages :229
  • ISBN : UCLA:L0098923741
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Summary :

Controversies in the Management of Gynecological Cancers

Controversies in the Management of Gynecological Cancers
  • Author : Jonathan A. Ledermann,Carien L. Creutzberg,Michael A. Quinn
  • Publisher :Unknown
  • Release Date :2013-12-13
  • Total pages :349
  • ISBN : 9780857299109
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Summary : This is a novel text that highlights the controversial areas in the management of gynecological cancers. None of the topics in this book have definitive answers; they represent the everyday decision-making facing gynecologists, oncologists, radiologists, pathologists and other health professionals treating women with these conditions. This book is not to be used as a traditional textbook; it is a text that specialists and trainees will use to help them weigh up the arguments that exist in a variety of areas in the treatment of gynecological cancers. Each chapter will have two or more authors, selected either for their opposing views or for their ability to provide an opposite view or opinion to the other. The content will be evidence-based, illustrating contrasting evidence and scientific opinion in the literature. Each chapter will close on a summary indicating the direction of research needed to address the issues being discussed.

Departments of Labor, Health and Human Services, and Education, and related agencies appropriations bill, 2007

Departments of Labor, Health and Human Services, and Education, and related agencies appropriations bill, 2007
  • Author : United States. Congress. House. Committee on Appropriations
  • Publisher :Unknown
  • Release Date :2006
  • Total pages :383
  • ISBN : PURD:32754078109133
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Summary :

Uncommon Gynecologic Cancers

Uncommon Gynecologic Cancers
  • Author : Marcela del Carmen,John O. Schorge,Robert H. Young
  • Publisher :Unknown
  • Release Date :2014-11-11
  • Total pages :280
  • ISBN : 9781118655313
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Summary : Rare gynecological cancers kill all too commonly Gynecological cancer is a frightening prospect for women. It isterrifying also for physicians who need, but often can’tfind, guidance on how to investigate and appropriately treat thetumors. Rare cancers provide greater challenges as information canbe harder to find and more difficult to verify. Rare Gynecologic Cancers: Diagnosis and Management bringstogether all you need to know on these life-threatening diseases.Straightforward summaries of pathophysiologic processes lead to theinvestigations that will improve your diagnostic accuracy. Thisprovides the basis for you to identify effective treatmentstrategies for your patients. Written by a world-leading team ofEditors and Authors and covering cancers of the • Ovaries • Uterus • Vulva • Vagina • Cervix Rare Gynecologic Cancers: Diagnosis and Management willguide you to the best life-saving treatment for your patients.

Immunotherapy

Immunotherapy
  • Author : Aung Naing,Joud Hajjar
  • Publisher :Unknown
  • Release Date :2020-04-16
  • Total pages :339
  • ISBN : 9783030410087
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Summary : Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. The third edition of Immunotherapy is an updated overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. It explores the breath of immunotherapeutic strategies available to treat a wide range of cancers, from melanoma and non-small cell lung cancer to gastrointestinal, genitourinary, gynecologic and nervous system malignancies. With increasing use of checkpoint inhibitors as standard of care and in clinical trials, the challenges associated with their use undoubtedly increase. As objective response is limited to a subset of patients and is often associated with distinct immune related side effects that are potentially life threatening, it is essential to identify patients who are likely to respond to immunotherapy and those who are at a risk for developing treatment-related side effects. In the absence of a validated predictive biomarker, innovative technologies and assays are being used to identify critical biomarkers that drive the immune response. Hence, a chapter to provide a basic understanding of the diagnostic procedures has been included besides the chapter on the cellular components of the human immune system. This new edition will also inform readers on use of novel microbiome and imaging approaches. Finally, the book includes a chapter on patient-reported outcomes in patients treated with immunotherapies as the authors recognize the importance of including missing patient voice in clinical trials and longitudinal assessment of symptom reports. In short, the third edition of this book provides a comprehensive overview of the latest developments in the field of immune-oncology that will help health care professionals make informed treatment decisions. The book’s chapters are written by a diverse cast of experts conducting cutting-edge research, providing the reader with the most up-to-date science.

Ovarian Cancer

Ovarian Cancer
  • Author : M. Sharon Stack,David A. Fishman
  • Publisher :Unknown
  • Release Date :2009-09-18
  • Total pages :408
  • ISBN : 0387980946
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Summary : Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effective tumor-specific therapeutics. Ovarian carcinogenesis, invasion, and metastatic dissemination require a complex cascade of interrelated genetic, molecular, and biochemical events that regulate the neoplastic transition of normal ovarian surface epithelium. This updated second edition includes exciting new advances in ovarian cancer detection and treatment and provides an analysis of current research into aspects of malignant transformation, growth control, and metastasis. A more detailed understanding of these processes may ultimately translate into the development of novel approaches for the detection and control of ovarian cancer.

Molecular Diagnosis and Targeting for Gynecologic Malignancy

Molecular Diagnosis and Targeting for Gynecologic Malignancy
  • Author : Seiji Isonishi,Yoshihiro Kikuchi
  • Publisher :Unknown
  • Release Date :2021-05-13
  • Total pages :110
  • ISBN : 9813360127
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Summary : This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.

Precision Medicine Oncology

Precision Medicine Oncology
  • Author : Lorna Rodriguez-Rodriguez
  • Publisher :Unknown
  • Release Date :2019-09-13
  • Total pages :122
  • ISBN : 9780813575889
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Summary : Precision medicine is rapidly becoming the standard-of-care for the treatment of cancer patients. This is made possible, in part, by the ready availability and reasonable costs of comprehensive DNA and RNA sequencing assays. However, precision medicine is complex and incorporates entirely new types of data and treatment paradigms that are outside of the training of most oncologists in practice today. Precision Medicine Oncology: A Primer is a concise review of the fundamental principles and applications of precision medicine, intended for clinicians, particularly those working in oncology. It provides an accessible introduction to the technological advances in DNA and RNA sequencing, gives a detailed overview of approaches to the interpretation of molecular test results and their point-of-care implementation for individual patients, and describes innovative clinical trial designs in oncology as well as characteristics of the computational infrastructures through which massive quantities of data are collected, stored, and used in precision medicine oncology.

Endometrial Cancer: From Biological to Clinical Approaches

Endometrial Cancer: From Biological to Clinical Approaches
  • Author : Massimo Nabissi,Frederic Amant,Paola Gehrig
  • Publisher :Unknown
  • Release Date :2019-09-26
  • Total pages :157
  • ISBN : 9782889630493
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Summary : In developed countries, cancer of the endometrium (EC) is the most common cancer of the female reproductive organs, affecting mainly postmenopausal women. The highest incidence of EC is in Northern America and Europe, but its incidence is growing around the world. Several factors influence the risk of developing EC, including: impaired hormone levels, obesity, physical activity, family history, and having been diagnosed with breast or ovarian cancer in the past. For EC, a standard screening test does not exist. It is often diagnosed at stage I/II due to frequent vaginal bleeding, while invasive EC (stage III/IV) is mainly diagnosed in its advanced stage. Despite the different clinical improvements when EC is progressed to the advanced/metastatic stage, the patients still have poor prognoses and unsatisfactory outcomes with conventional chemotherapy. The need for precision drugs is underscored by the limited number of options these patients have. So, the introduction of new techniques and the discovery of new biological characteristics, such as identification of transcriptome, proteome and metabolomics profiles, and new potential diagnostic/prognostic biomarkers are fundamental to improve our knowledges on EC. The scope of this Research Topic is to welcome articles and reviews from clinicians and scientists around the world in order to give an updated vision of the recent clinical insights, technical advances, and cellular and molecular targets related to endometrial cancer. Dedicated to Mr. Dario Conti, which supported endometrial cancer research.

Molecular Genetics of Endometrial Carcinoma

Molecular Genetics of Endometrial Carcinoma
  • Author : Lora Hedrick Ellenson
  • Publisher :Unknown
  • Release Date :2016-12-01
  • Total pages :281
  • ISBN : 9783319431390
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Summary : This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.