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Translational Immunotherapy of Brain Tumors

Translational Immunotherapy of Brain Tumors
  • Author : John H. Sampson
  • Publisher :Unknown
  • Release Date :2017-02-06
  • Total pages :404
  • ISBN : 9780128026250
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Summary : Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas Edited by a prominent neurosurgeon with contributions by leading researchers in the field Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors

Radioimmunotherapy – Translational Opportunities and Challenges

Radioimmunotherapy – Translational Opportunities and Challenges
  • Author : Udo S. Gaipl,Gabriele Multhoff,Alan Graham Pockley,Franz Rödel
  • Publisher :Unknown
  • Release Date :2020-03-13
  • Total pages :229
  • ISBN : 9782889636150
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Summary :

Immunotherapy in Translational Cancer Research

Immunotherapy in Translational Cancer Research
  • Author : Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran
  • Publisher :Unknown
  • Release Date :2018-02-08
  • Total pages :312
  • ISBN : 9781118684504
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Summary : A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Brain Tumor Immunotherapy

Brain Tumor Immunotherapy
  • Author : Linda M. Liau,Donald P. Becker,Timothy F. Cloughesy,Darell D. Bigner
  • Publisher :Unknown
  • Release Date :2000-11-10
  • Total pages :374
  • ISBN : 9781592590353
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Summary : An authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying brain tumor immunotherapy. Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.

Targeted Therapy in Translational Cancer Research

Targeted Therapy in Translational Cancer Research
  • Author : Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson,Maurie Markman
  • Publisher :Unknown
  • Release Date :2015-12-21
  • Total pages :400
  • ISBN : 9781118468579
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Summary : Translational medicine has opened the gateway to the era of personalized medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. Translational Oncology: Targeted Therapy in Translational Cancer Research provides a comprehensive overview of the pertinent molecular discoveries in the cancer field and explains the clinical ramifications and utility of these on targeted cancer therapies. Beginning with a chapter introducing the “Bench to Bedside and Back” paradigm, an overview is presented of the exponential growth in the field of translational medicine, including historical perspectives and recent progress. Following the introduction, subsequent chapters review the progress of targeted therapy within three major categories: hematological malignancies, solid tumors, and hereditary cancers. Each of these categories comprises a single a chapter with subsections that discuss specific cancer types. Following this is a chapter on targeted and functional imaging that reviews progress in the different modalities of anatomical and molecular imaging used to complement targeted therapy. The next chapter discusses the need to combine individual agents with existing therapies or in novel combinations in order to overcome drug resistance. Following this is a chapter presenting the challenges in drug development and the selection of targets for cancer therapeutics. The final chapter offers perspectives on personalized medicine and presents future challenges in the investigation of optimal combinations and the identification of biomarkers that can provide both predictive and prognostic information for tailoring targeted therapies to individual patients.

Immuno-Oncology

Immuno-Oncology
  • Author : O. Michielin,G. Coukos
  • Publisher :Unknown
  • Release Date :2015-09-09
  • Total pages :140
  • ISBN : 9783318055900
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Summary : Over the last decade, immuno-oncology has witnessed an astonishing pace of discovery and innovation translating into unprecedented successes in the clinical setting, arguably representing one of the most profound and transforming revolution in the history of cancer therapy. This book provides a concise and accurate outline of the main developments in major tumor types including melanoma, lung, breast, brain and renal cell cancers. In addition, transversal chapters that describe the commonalities of some of the therapeutic strategies are provided to cover topics like immune checkpoint biology, T cell engineering or rational combination therapies. Each chapter has been authored by senior key opinion leaders in their respective fields to provide the most up-to-date view on cancer immuno-oncology. To reflect on the key translational aspect of immuno-oncology, all chapters are making explicit connections between basic science discoveries and the resulting translational therapeutic strategies. Immuno-Oncology will be an invaluable source of information for scientists interested in the translation of basic immunology into the clinical practice, as well as for clinician interested in deepening their knowledge of current and upcoming immune strategies in the fight against cancers.

The Duke Glioma Handbook

The Duke Glioma Handbook
  • Author : Darell D. Bigner,Allan H. Friedman,Henry S. Friedman,Roger McLendon
  • Publisher :Unknown
  • Release Date :2016-03-31
  • Total pages :229
  • ISBN : 9781316665169
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Summary : The management of patients with a glioma is challenging and best achieved by a team approach encompassing a combination of chemotherapy, radiotherapy, immunotherapy, and surgical excision in a specialist Cancer Center - the balance of treatment depending on the site and grade of tumor. Survival rates are improving and care of patients with or recovering from gliomas is increasingly handled in the community under the care of local physicians. This book provides an authoritative, multi-disciplinary summary of glioma biology, genetics, management and social issues, based on the world-leading program at the Duke University Preston Robert Tisch Brain Tumor Center, one of the world's largest and most successful Centers to offer brain cancer treatment and translational research. The text is written by specialists from this Center, giving it a consistent approach and style. This is an important educational resource for neurologists, neurosurgeons, oncologists, psychiatrists, neurohospitalists and ancillary members of neuro-oncology teams.

Cancer Immunotherapy Principles and Practice

Cancer Immunotherapy Principles and Practice
  • Author : Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
  • Publisher :Unknown
  • Release Date :2017-06-28
  • Total pages :920
  • ISBN : 9781617052736
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Summary : Cancer Immunotherapy Principles and Practice, from the Society of Immunotherapy of Cancer (SITC), is the authoritative reference on cancer immunobiology and the immunotherapy treatments that harness the immune system to combat malignant disease. Featuring five sections and over 50 chapters covering the Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy, this book covers all major topics that have shaped the development of immunotherapy and propelled it to its current place at the forefront of cancer treatment innovation. This volume is a comprehensive resource for oncologists and fellows, immunologists, cancer researchers, and related practitioners seeking understanding of the basic science and clinical applications of cancer immunotherapy. As well as presenting the evidence for immune-based cancer treatment, it positions immunotherapy in the context of other available cancer treatments and provides data on response rates, risks, and toxicities across a variety of diseases. Filled with detailed tables, and instructive illustrations, as well as key points for quick reference, Cancer Immunotherapy Principles and Practice simplifies a challenging and dynamic subject. Key Features: Clearly summarizes the basic principles and research supporting cancer immunotherapy clinical translation Contains expert guidance and treatment strategies for all immunotherapy classes and agents, including cell-based therapies, monoclonal antibodies, cytokine therapies, checkpoint inhibitors, oncolytic viruses, adjuvant approaches, and treatment combinations Includes expert perspectives from leading authorities in the field Provides information on all FDA-approved immunotherapies, including clinical management and outcome data Discusses clinical aspects of immunotherapy for individual cancer types, including melanoma and other skin cancers, lung cancers, gynecologic cancers, gastrointestinal cancers, hematologic cancers, genitourinary cancers, head and neck cancers, sarcomas, brain and other CNS cancers, breast cancer, and pediatric malignancies. Explains regulatory aspects behind the development and approval of immunotherapy drugs Includes Online Access to the Digital Book

Brain Tumors

Brain Tumors
  • Author : Amit Agrawal,Luis Rafael Moscote-Salazar
  • Publisher :Unknown
  • Release Date :2018-08-22
  • Total pages :248
  • ISBN : 9781789235562
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Summary : We all know that the field of neuro-oncology is heterogeneous and under continuous development with the addition of new knowledge and information on a regular basis. The present book "Brain Tumor - An Update" is an attempt to share the personal experiences of experts who are involved in neuro-oncology-related research. Through this book, the authors share their experiences and provide details about the pathophysiology, neuroimaging approaches, and management options, and how to go about decision-making in patients with brain tumors. We hope that the valuable contributions from the authors shall facilitate understanding about brain tumors. I am grateful to all the authors who have contributed their tremendous expertise, and I would like to acknowledge the outstanding support of Ms. Danijela Sakic, Author Service Manager, IntechOpen Science, who collaborated tirelessly in crafting this book.

Molecular Markers of Brain Tumor Cells

Molecular Markers of Brain Tumor Cells
  • Author : Bela Bodey,Stuart E. Siegel,Hans E. Kaiser
  • Publisher :Unknown
  • Release Date :2004-09-14
  • Total pages :362
  • ISBN : 1402027818
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Summary : I. MOLECULAR BIOLOGY OF TUMORS. 1. Brain Tumors 2. Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors II. ANTI-NEOPLASTIC BIOLOGICAL THERAPIES 3. Experimental Therapies in Brain Tumors 4. Biologic Anti-Neoplastic Therapies 5. The lymphokine activated killer (LAK) cell phenomenon 6. Angiogenesis Inhibition in Anti-Neoplastic Therapy 7. Antigen Presentation by Dendritic Cells and Their Significance in Anti-Neoplastic Immunotherapy 8. Genetically Engineered Antibodies for Direct Anti-Neoplastic Treatment and Systematic Delivery of Various Therapeutic Agents to Cancer Cells 9. Cancer-Testis Antigens: Promising Targets for Antigen Directed Anti-neoplastic Immunotherapy III. APPENDIX 10. Materials and Methods

Advances in Veterinary Neurology, An Issue of Veterinary Clinics of North America: Small Animal Practice,

Advances in Veterinary Neurology, An Issue of Veterinary Clinics of North America: Small Animal Practice,
  • Author : Natasha J. Olby
  • Publisher :Unknown
  • Release Date :2014-11-12
  • Total pages :273
  • ISBN : 9780323326919
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Summary : This issue highlights the advances in neurological treatments for dogs and cats. Articles include: New Treatment Modalities for Brain Tumors in Dogs and Cats, Altered Mental Status in Dogs and Cats: Stupor and Coma, Steroid Use in Veterinary Neurology, Hereditary Ataxia and Paroxysmal Movement Disorders in Dogs and Cats, Paroxysmal Movement Disorders in Dogs and Cats, Cluster Seizures and Status Epilepticus, Aging in the canine and feline brain, Acute Spinal Cord Injury: Tetraparesis and Paraparesis, Meningoencephalitis of Unknown Etiology, and more!

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy
  • Author : Herbert B. Newton
  • Publisher :Unknown
  • Release Date :2018-03-28
  • Total pages :848
  • ISBN : 9780128121016
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Summary : Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Science

Science
  • Author : John Michels
  • Publisher :Unknown
  • Release Date :2001-03
  • Total pages :229
  • ISBN : UIUC:30112037729776
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Summary :

Brain Tumor Therapy

Brain Tumor Therapy
  • Author : Mark L. Rosenblum,Charles B. Wilson
  • Publisher :Unknown
  • Release Date :1984
  • Total pages :288
  • ISBN : 3805536992
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Summary :

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor
  • Author : Terry Lichtor
  • Publisher :Unknown
  • Release Date :2015-03-25
  • Total pages :434
  • ISBN : 9789535120315
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Summary : A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular, recent new avenues regarding the role of microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to radiation therapy have been developed. A discussion of certain surgical management issues including improvements in imaging along with issues concerning tumor induced epilepsy is included. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book, a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.

Immunotherapy, An Issue of Neurosurgery Clinics - E-Book

Immunotherapy, An Issue of Neurosurgery Clinics - E-Book
  • Author : Isaac Yang,Michael J Lim
  • Publisher :Unknown
  • Release Date :2010-01-05
  • Total pages :229
  • ISBN : 9781455700455
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Summary : For this issue, Dr. Michael Lim of Johns Hopkins and Dr. Isaac Yang of UCSF team up to deliver a packed issue on the latest developments in Immunotherapy. The issue covers hot topics such as immunostimulants, Passive Antibody Mediated Immunotherapy, Clinical Applications of A Peptide Based Vaccine, Challenges for Clinical Design of Immunotherapy Trials, The EGFRv3 Peptide Vaccine, Stem Cell Therapy and Dendritic Cell Vaccines, Dendritic Glioma Fusion Vaccine, Adoptive Cellular Immunotherapy, Virus Mediated Immunotherapy, and so much more.

Gene Therapy of Cancer

Gene Therapy of Cancer
  • Author : Stanton L. Gerson,Edmund C. Lattime
  • Publisher :Unknown
  • Release Date :2002-04-04
  • Total pages :534
  • ISBN : 0080491367
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Summary : The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Key Features * Provides in-depth description of targeted systems and treatment strategies * Explains the underlying cancer biology necessary for understanding a given therapeutic approach * Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses * Presents translational focus with emphasis on requirements for clinical implementation * Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

Practical Surgical Neuropathology

Practical Surgical Neuropathology
  • Author : Arie Perry,Daniel J. Brat
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :620
  • ISBN : 9780443069826
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Summary : Practical Surgical Neuropathy-a volume in the new Pattern Recognition series- offers you a practical guide to solving the problems you encounter in the surgical reporting room. Drs. Arie Perry and Daniel J. Brat present diagnoses according to a pattern-based organization that guides you from a histological pattern, through the appropriate work-up, around the pitfalls, and to the best diagnosis. Lavish illustrations capture key neuropathological patterns for a full range of common and rare conditions, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. No other single source delivers the practical, hands-on information you need to solve even the toughest diagnostic challenges in neuropathology. Includes fully searchable access to the text online at expertconsult.com, along with an image bank of over 1430 downloadable images and tables. Provides all the information essential for completing a sign-out report: clinical findings, pathologic findings, diagnosis, treatment, and prognosis. Illustrates key pathologic and clinical aspects of disease entities through over 1430 superb, high-quality full-color images that help you evaluate and interpret biopsy samples. Presents a team of internationally recognized experts for authoritative and up-to-date information from leading diagnosticians in neuropathology. Features a user-friendly design with patterns color-coded to specific entities in the table of context and text and key points summarized in tables, charts, and graphs so you can quickly and easily find what you are looking for. Directs you to the chapter and specific page number of the in-depth diagnostic guidance you need through a unique, pattern-based visual index at the beginning of the book. Details key diagnostic features associated with rare and esoteric conditions in a visual encyclopedia with distinctive findings and artifacts for unusual patterns at the end of the book. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Molecular Oncology: Underlying Mechanisms and Translational Advancements

Molecular Oncology: Underlying Mechanisms and Translational Advancements
  • Author : Ammad Ahmad Farooqi,Muhammad Ismail
  • Publisher :Unknown
  • Release Date :2017-03-29
  • Total pages :302
  • ISBN : 9783319530826
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Summary : Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.

Oligodendroglioma

Oligodendroglioma
  • Author : Nina A. Paleologos,Herbert B. Newton
  • Publisher :Unknown
  • Release Date :2019-06-18
  • Total pages :422
  • ISBN : 9780128131596
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Summary : Oligodendroglioma: Clinical Presentation, Pathology, Molecular Biology, Imaging, and Treatment features the latest "cutting-edge" molecular biology, molecular therapeutics, imaging, immunotherapy, and research methods on the topic of oligodendrogliomas. The most detailed and comprehensive resource on the subject, it provides up-to-date information on clinical presentation, pathology, molecular biology, and treatment methods, including immunotherapy. This book is a critical for students, physicians and researchers in the fields of neuroscience, neuro-oncology, neurosurgery, radiation oncology, medical oncology, and others working in research or with patients. Provides the most up-to-date information regarding the clinical presentation, pathology, molecular biology, and methods for the treatment of oligodendroglioma brain tumors, including surgical therapy, radiotherapy, molecular therapeutics, chemotherapy, and immunotherapy Broadly appeals to anyone interested in the field of neuro-oncology and the treatment of patients with oligodendrogliomas Useful to clinicians interested in a thorough overview of the basic science and treatment of oligodendrogliomas Includes a section on immunotherapy, with updates on the use of vaccines and immune-based treatment approaches applied to oligodendrogliomas

Summers And Winters At Balmwhapple: By The North Sea

Summers And Winters At Balmwhapple: By The North Sea
  • Author : Sir John Skelton
  • Publisher :Unknown
  • Release Date :2019-03-27
  • Total pages :272
  • ISBN : 1011581078
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Summary : This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.