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• Author : Drozdstoy Stoyanov,Paolo Brambilla
• Publisher :Unknown
• Release Date :2020-08-21
• Total pages :229
• ISBN : 9782889639540

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• Author : Robert A. McArthur
• Publisher :Unknown
• Release Date :2012
• Total pages :421
• ISBN : 9780123869456

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Summary : With a unique collaborative approach of author teams from industry and academia, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment provides an integrated perspective of small animal and human brain imaging in the development of translational models and biomarkers to understand human neuropsychiatric disorders and to accelerate the development of novel drugs for their treatment. The book provides chapters on methodical issues in human and animal neuroimaging translational research, allowing a beginning researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in studies. Additional chapters cover selected neuropsychiatric disorders, examining the role of neuroimaging in translational model development from the preclinical, animal model perspective as well as from the human experimental medicine perspective. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to researchers working in and studying CNS drug treatment research across industry and academia. Provides a background of translational research and the use of imaging in studies Dicusses the application of imaging in specific disease states Features an accompanying website with additional images and text

• Author : Trevor W. Robbins,Barbara J. Sahakian
• Publisher :Unknown
• Release Date :2016-09-22
• Total pages :498
• ISBN : 9783319339139

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Summary : This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.

• Author : James E. Barrett,Joseph T. Coyle,Michael Williams
• Publisher :Unknown
• Release Date :2012-06-28
• Total pages :366
• ISBN : 9780521519762

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Summary : Translational neuroscience is at the heart of clinical advancement in the fields of psychiatry, neurology and neurodevelopmental disorders. Written and edited by leading scientists and clinicians, this is a comprehensive and authoritative analysis of this emerging strategy for developing more effective treatments for brain disorders. Introductory chapters bring together perspectives from both academia and industry, while subsequent sections focus on disease groups, including bipolar disorder and depression, attention deficit hyperactivity disorder, substance abuse, autism, Alzheimer's disease, pain, epilepsy, Parkinson's disease and multiple sclerosis. Each section includes topical introductory and summary chapters, providing an overview and synthesis of the field. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders is an important text for clinicians, scientists and students in academic settings, government agencies and industry, as well as those working in the fields of public health and the behavioural sciences.

• Author : Daniel Laskowitz,Gerald Grant
• Publisher :Unknown
• Release Date :2016-04-21
• Total pages :412
• ISBN : 9781466584921

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Summary : Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

• Author : Anonim
• Publisher :Unknown
• Release Date :2012-12-26
• Total pages :32
• ISBN : 9781481625531

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Summary : Psychotherapeutic Agents—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Psychotherapeutic Agents in a compact format. The editors have built Psychotherapeutic Agents—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Psychotherapeutic Agents in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Psychotherapeutic Agents—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

• Author : Anonim
• Publisher :Unknown
• Release Date :2013-06-21
• Total pages :71
• ISBN : 9781481687324

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Summary : Dopamine Receptors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Dopamine D1 Receptors in a concise format. The editors have built Dopamine Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Dopamine D1 Receptors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Dopamine Receptors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

• Author : David Borsook,Lino R. Beccera,Edward Bullmore,Richard J. Hargreaves
• Publisher :Unknown
• Release Date :2010-03-10
• Total pages :396
• ISBN : 1441901345

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Summary : Drug development today needs to balance agility, speed, and risk in defining probability of success for molecules, mechanisms, and therapeutic concepts. New techniques such as fMRI promise to be part of a sequence that could transform drug development. Although numerous review articles exist that discuss the use of imaging in drug development, no one source is available that combines the various techniques and includes a discussion of disease mapping. Imaging in CNS Drug Discovery and Development, Implications for Disease and Therapy will serve to distill the most salient developments in the use of imaging in drug development and disease mapping. It will launch evolving concepts that integrate new imaging technologies and paradigms with molecular medicine and molecular profiling ("monics") as well as consider the ethical issues that arise as a result of disease or state diagnosis and the use of imaging in the public eye.

• Author : Carl Faingold,Hal Blumenfeld
• Publisher :Unknown
• Release Date :2013-12-26
• Total pages :512
• ISBN : 9780124158641

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Summary : Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

• Author : Nancy Adler,Judith Stewart
• Publisher :Unknown
• Release Date :2010-03-22
• Total pages :352
• ISBN : STANFORD:36105213135309

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Summary : How does socioeconomic status "get into the body" to affect health? A decade ago, when the MacArthur Foundation Research Network on Socioeconomic Status and Health began to answer this question, few studies directly tested the pathways and mechanisms that contribute to the gradient relationship between socioeconomic status and health. The scientific research presented in this volume captures where the field stands after 10 years of intense research by the MacArthur Network and others into the mechanisms of health disparities. In addition, it illustrates the power of a multidisciplinary approach to complex social issues. Finally, it presents potential applications of the accumulated knowledge for social interventions and raises pragmatic issues that are important to consider when science is translated into policy and intervention. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

• Author : Georgios P. D. Argyropoulos
• Publisher :Unknown
• Release Date :2020-02-27
• Total pages :290
• ISBN : 9783030356873

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Summary : This book provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative brain abnormalities on speech and language. To this end, this edited volume brings together contributions from several leading experts in a markedly broad range of disciplines, comprising Neurology, Neurosurgery, Genetics, Engineering, Neuroimaging and Neurostimulation, Neuropsychology, and Speech and Language Therapy.

• Author : National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on State of the Science of Nuclear Medicine
• Publisher :Unknown
• Release Date :2007-09-11
• Total pages :173
• ISBN : 0309134153

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Summary : Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.

• Author : Jean Decety,Yves Christen
• Publisher :Unknown
• Release Date :2013-12-11
• Total pages :219
• ISBN : 9783319029047

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Summary : Traditionally, neuroscience has considered the nervous system as an isolated entity and largely ignored influences of the social environments in which humans and many animal species live. However, there is mounting evidence that the social environment affects behavior across species, from microbes to humans. This volume brings together scholars who work with animal and human models of social behavior to discuss the challenges and opportunities in this interdisciplinary academic field.

• Author : Luca Saba
• Publisher :Unknown
• Release Date :2015-01-08
• Total pages :640
• ISBN : 9780191651403

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Summary : Diagnosing neurodegenerative diseases can prove particularly intimidating to clinicians, because many times the diagnosis cannot be critically "confirmed" by a simple test. New imaging modalities have advanced to the point of high resolution, morphological, metabolic and functional analysis. Computed tomography, magnetic resonance, nuclear medicine and molecular imaging have recently emerged as outstanding non-invasive techniques for the study of the neurodegenerative disorders. Imaging in Neurodegenerative Disorders covers all the imaging techniques and new exciting methods like new tracers, biomarker, metabolomic and gene-array profiling, potential for applying such techniques clinically, and offers present and future applications as applied to the neurodegenerative disorders with the most world renowned scientists in these fields. This book is an invaluable resource for researchers, clinicians, and trainees in neuroscience, neurology, psychiatry, and radiology.

• Author : Ronald J. Bradley,R. Adron Harris,Peter Jenner
• Publisher :Unknown
• Release Date :2006-06-07
• Total pages :312
• ISBN : 9780080463520

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Summary : Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering recent advances in the field of neurobiology. Topics covered include chromosome 22 deletion syndrome and schizophrenia; characterization of proteome of human cerebrospinal fluid; hormonal pathways regulating intermale and interfemale aggression; neuronal gap junctions; effects of genes and stress on the neurobiology of depression; quantitative imaging with teh MicroPET small-animal PET tomograph; understanding myelination through studying its evolution.

• Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
• Publisher :Unknown
• Release Date :2011-01-07
• Total pages :36
• ISBN : 0309186889

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Summary : Nearly 5.3 million Americans are living with Alzheimer's disease, and 26.6 million people are affected worldwide. The Alzheimer's Disease Neuroimaging Initiative (ADNI), a public-private partnership, provides a publicly available, international database of clinical and imaging data to foster research and collaboration on Alzheimer's research worldwide. The Institute of Medicine held a workshop on July 12, 2010, to explore opportunities to use information from and partnerships formed because of ADNI to continue to improve the understanding and treatment of Alzheimer's disease.

• Author : Professor of Translational Neuroscience David Linden
• Publisher :Unknown
• Release Date :2016-05-24
• Total pages :192
• ISBN : 9780198739609

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Summary : An introduction to Neuroimaging and Neurophysiology in Psychiatry, this book explains the basic physics and physiology behind the main techniques of neuroimaging, including MRI and PET, and non-invasive neurophysiology. This title covers all the clinically relevant aspects of neuroimaging and neurophysiology methods. It includes individual chapters on techniques, diagnostic disease markers, and neurophysiological treatments to ensure psychiatrists are familiar with the clinical relevance of reported abnormalities. With the latest research, Neuroimaging and Neurophysiology in Psychiatry is an invaluable and easy-to-read reference that will help practising psychiatrists in the evaluation of the use of neuroimaging methods in clinical, research, and forensic settings.

• Author : Lawrence Kruger,Alan R Light
• Publisher :Unknown
• Release Date :2009-11-24
• Total pages :432
• ISBN : 9781439812105

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Summary : One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

• Author : Allan James MacKenzie-Graham
• Publisher :Unknown
• Release Date :2006
• Total pages :258
• ISBN : UCLA:L0096925276

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• Author : Jay J. Pillai
• Publisher :Unknown
• Release Date :2014-11-13
• Total pages :193
• ISBN : 9780323323840

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Summary : Editor Jay J. Pillai and authors review important areas in Clinical Applications of Functional MRI. Articles will include: Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging for Presurgical Planning; Visual Mapping Using Blood Oxygen Level Dependent Functional MRI; Applications of BOLD fMRI and DTI in Epilepsy; Pretherapeutic fMRI in Children; BOLD fMRI for Presurgical Planning; Brain Tensor Imaging for Brain Malformations: Does it Help?; Technical Considerations for fMRI Analysis; Special Considerations/Technical Limitations of BOLD fMRI; The Economics of Functional MRI: Clinical and Research; Memory Assessment in the Clinical Context Using fMRI: A Critical Look at the State of the Field; Resting State BOLD fMRI for Pre-surgical Planning, and more!

• Author : Alison D. Murray
• Publisher :Unknown
• Release Date :2012
• Total pages :121
• ISBN : 9781455742073

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Summary : Dementia is a massive and increasing global problem, with the current prevalence anticipated to double every 20 years as people live longer. Neuroimaging in dementia is recommended by most clinical guidelines and its role has traditionally been to exclude a mass lesion, rather than to support a specific diagnosis. All radiologists will be aware of a steady rise in the number of requests for brain imaging in old people, but what can imaging reliably tell us and what kind of imaging should we use? In affluent societies we now have a range of structural and molecular brain imaging techniques at our disposal, with specific ligands and sophisticated image analysis techniques now available for clinical use. However, we have difficulty justifying which patients to scan, using which modality and when. We know that Alzheimer's disease is the most common neuropathology contributing to a diagnosis of Alzheimer's disease but we also know from large post-mortem studies that most brain pathology in those who have died with a diagnosis of dementia is mixed. Thus understanding different diseases that can cause dementia, how these co-exist or interact and appreciating that not all dementia is Alzheimer's disease is important. Equally important is awareness of individual differences in response to a neuropathological burden and what factors provide resilience against dementia that might be maximized to reduce or postpone its impact. This issue draws together contributions from experts in their fields to provide clarity to the topic in a comprehensive collection of articles.