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Turmeric and Curcumin for Neurodegenerative Diseases

Turmeric and Curcumin for Neurodegenerative Diseases
  • Author : Magisetty Obulesu
  • Publisher :Unknown
  • Release Date :2021-02-10
  • Total pages :186
  • ISBN : 9780128224496
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Summary : Turmeric and Curcumin for Neurodegenerative Diseases examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strategies to circumvent Alzheimer’s Disease, Parkinson’s, and liver diseases. With neurodegenerative and liver diseases posing a serious threat to health care systems worldwide, this book addresses how existing nanotechnology and therapeutic strategies have not been as successful in their treatment. In addition to discussing drawbacks, possible future perspectives to overcome these challenges are also examined. Chapters also focus on therapeutic efficacy and drug delivery systems, providing readers with a full summary of research in this field in one handy reference. Summarizes the therapeutic efficacy of turmeric and curcumin for neurodegenerative diseases Includes effects on Alzheimer’s, Parkinson’s and liver diseases Focuses on different types of drug delivery systems and their challenges Examines novel nanotechnological therapeutics and biomaterial design strategies

Curcumin for Neurological and Psychiatric Disorders

Curcumin for Neurological and Psychiatric Disorders
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher :Unknown
  • Release Date :2019-03-16
  • Total pages :544
  • ISBN : 9780128154625
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Summary : Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological Properties focuses on the different molecular mechanisms underlying curcumin-mediated beneficial effects in neurological diseases. The book's editors discuss the neurochemical and pharmacological properties of curcumin, followed by the effect of curcumin in neurotraumatic diseases, neurodegenerative diseases, and neuropsychiatric diseases. The book also offers a perspective on future studies on the treatment of neurological disorders. The beneficial effects of curcumin have been observed both in cultured cells and in animal models, thus paving the way for ongoing present and future human clinical trials. Curcumin produces antioxidant and anti-inflammatory effects not only by blocking oxidative stress and neuroinflammation in neurotraumatic and neurodegenerative diseases, but also by restoring cellular homeostasis and rebalancing redox equilibrium. Identifies molecular mechanisms of curcumin effects in neurological diseases Includes effects on neurotraumatic, neurodegenerative and psychiatric diseases Covers the antioxidant, anti-inflammatory and immunomodulatory effects of curcumin Examines curcumin’s potential in developing new therapeutic drugs

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
  • Author : Bharat B. Aggarwal,Young-Joon Surh,S. Shishodia
  • Publisher :Unknown
  • Release Date :2007-08-06
  • Total pages :490
  • ISBN : 9780387464015
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Summary : The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

The Benefits of Natural Products for Neurodegenerative Diseases

The Benefits of Natural Products for Neurodegenerative Diseases
  • Author : M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
  • Publisher :Unknown
  • Release Date :2016-09-20
  • Total pages :496
  • ISBN : 9783319283838
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Summary : Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Nanobiotechnology in Neurodegenerative Diseases

Nanobiotechnology in Neurodegenerative Diseases
  • Author : Mahendra Rai,Alka Yadav
  • Publisher :Unknown
  • Release Date :2021-01-01
  • Total pages :398
  • ISBN : 3030309320
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Summary : This book focuses on neurodegenerative diseases which have become a major threat to human health. Neurodegenerative diseases are age related disorders and have become increasingly prevalent in the elderly population in recent years. Hence, there is an urgent need to study and develop new strategies and alternative methods for the treatment of neurodegenerative diseases. This book showcases the promises that nanobiotechnology brings in research, diagnosis, and treatment of neurodegenerative diseases. It is very beneficial for varied group of readers including nanotechnologists, biotechnologists, pharmacists, medical professionals, bioengineers, biochemists and researchers working in this field. Nanobiotechnology in Neurodegenerative Diseases include various chapters including neurodegeneration and neurodegenerative diseases, nanotechnology for the rescue of neurodegenerative diseases, promising potential of nanomaterials for diagnosis and therapy of neurodegenerative diseases, nanotechnology mediated nose-to-brain drug delivery, and formulation and characterization of intranasal nanoparticles of antiretroviral drugs.

Oxidative Stress and Dietary Antioxidants in Neurological Diseases

Oxidative Stress and Dietary Antioxidants in Neurological Diseases
  • Author : Colin R. Martin,Victor R. Preedy
  • Publisher :Unknown
  • Release Date :2020-06-12
  • Total pages :444
  • ISBN : 9780128177815
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Summary : Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development. Offers an overview of oxidative stress from molecular biology to whole organs Discusses the potentially therapeutic usage of natural antioxidants in the patient diet Provides the framework for further in-depth analysis or studies of potential treatments

Curcumin in Health and Disease

Curcumin in Health and Disease
  • Author : Beatrice E. Bachmeier
  • Publisher :Unknown
  • Release Date :2019-10-11
  • Total pages :274
  • ISBN : 9783039214495
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Summary : The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.

Presenilins and Alzheimer’s Disease

Presenilins and Alzheimer’s Disease
  • Author : Steven G. Younkin,Rudolph E. Tanzi
  • Publisher :Unknown
  • Release Date :2012-12-06
  • Total pages :100
  • ISBN : 9783642721038
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Summary : The role of the familial Alzheimer's Disease genes called "presenilins" in causing neuronal cell death and Alzheimer-related pathology.

Neuroprotection in Alzheimer's Disease

Neuroprotection in Alzheimer's Disease
  • Author : Illana Gozes
  • Publisher :Unknown
  • Release Date :2016-12-30
  • Total pages :342
  • ISBN : 9780128037126
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Summary : Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Update on Dementia

Update on Dementia
  • Author : Davide Moretti
  • Publisher :Unknown
  • Release Date :2016-09-28
  • Total pages :558
  • ISBN : 9789535126546
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Summary : The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Therapeutic Potentials of Curcumin for Alzheimer Disease

Therapeutic Potentials of Curcumin for Alzheimer Disease
  • Author : Akhlaq A Farooqui
  • Publisher :Unknown
  • Release Date :2016-03-05
  • Total pages :402
  • ISBN : 9783319158891
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Summary : This is the first book on the market that explores the importance of curcumin for the treatment of neurological disorders. It has been estimated that 35.6 million people globally had dementia in 2010 and the prevalence of dementia has been predicted to double every 20 years. Thus, 115.4 million people may be living with dementia in 2050. Alzheimer’s disease (AD) is the leading cause of dementia and is present in 60%–70% of people with dementia. Unless new discoveries are made in the prevention or treatment of AD, the number of cases in the US alone is estimated to increase threefold, to 13.2 million by the year 2050. Thus, it is important to focus on delaying and treating the onset of AD by curcumin may be an important step for controlling AD. Regular consumption of healthy diet containing curcumin enriched foods, moderate exercise, and regular sleep may produce beneficial effects not only on motor and cognitive functions, but also on memory deficits that occur to some extent during normal aging and to a large extent in AD. Delaying the onset and progression of AD and improving its symptoms by few years with regular consumption of curcumin may relieve some of the burden on health care systems. In service of this goal, this volume gives readers a comprehensive and cutting edge description of the importance of curcumin for the treatment of AD in cell culture and animal models in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. It can be used as supplement text for a range of neuroscience and nutrition courses. Clinicians, neuroscientists, neurologists and pharmacologists will find this book useful for understanding molecular aspects of AD treatment by curcumin.

Polyphenols in Human Health and Disease

Polyphenols in Human Health and Disease
  • Author : Ronald Ross Watson,Victor R. Preedy,Sherma Zibadi
  • Publisher :Unknown
  • Release Date :2013-10-26
  • Total pages :1488
  • ISBN : 9780123984678
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Summary : Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more. Explores neuronal protection by polyphenol metabolites and their application to medical care Defines modulation of enzyme actions to help researchers see and study polyphenols’ mechanisms of action, leading to clinical applications Includes insights on polyphenols in brain and neurological functions to apply them to the wide range of aging diseases

Challenges in Parkinson's Disease

Challenges in Parkinson's Disease
  • Author : Jolanta Dorszewska,Wojciech Kozubski
  • Publisher :Unknown
  • Release Date :2016-08-24
  • Total pages :400
  • ISBN : 9789535124634
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Summary :

Experimental Therapeutics

Experimental Therapeutics
  • Author : Martin Wilkins
  • Publisher :Unknown
  • Release Date :2004-11-23
  • Total pages :248
  • ISBN : 1135411646
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Summary : As a general rule, for every 10,000 molecules screened in a given program in the laboratory, only one will survive to launch. To minimize costs, companies need to catch potential failures, due either to lack of clinical effect or toxicity, in the early discovery phase, long before they reach patients. Experimental Therapeutics introduces the dynamic and competitive discipline of experimental medicine. Informative, concise, and easy-to-read, the book emphasizes what scientists involved in drug discovery need to know about the rapid advances made in molecular biology, genetics, and technology. Each chapter starts with a summary box, has several high yield boxes, tables, and figures and ends with a reference section that has key URLs and carefully selected references to scientific papers. The book is a useful primer for anyone working to advance the pharmacological management of disease.

Natural Products for Cancer Chemoprevention

Natural Products for Cancer Chemoprevention
  • Author : John M. Pezzuto
  • Publisher :Unknown
  • Release Date :2021
  • Total pages :229
  • ISBN : 9783030398552
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Summary :

Anti-inflammatory Nutraceuticals and Chronic Diseases

Anti-inflammatory Nutraceuticals and Chronic Diseases
  • Author : Subash Chandra Gupta,Sahdeo Prasad,Bharat B. Aggarwal
  • Publisher :Unknown
  • Release Date :2016-09-26
  • Total pages :482
  • ISBN : 9783319413341
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Summary : This comprehensive volume focuses on anti-inflammatory nutraceuticals and their role in various chronic diseases. Food and Drug Administration (FDA) approved drugs such as steroids, non-steroidal anti-inflammatory drugs (NSAIDS), statins and metformin have been shown to modulate inflammatory pathways, but their long-term intake has been associated with numerous side effects. This means that there is enormous potential for dietary agents that can modulate inflammatory pathways in humans. Leading experts describe the latest research on the role of anti-inflammatory nutraceuticals in preventing and treating chronic diseases.

Anti-Inflammation Diet For Dummies

Anti-Inflammation Diet For Dummies
  • Author : Morris,Molly Rossiter
  • Publisher :Unknown
  • Release Date :2011-08-10
  • Total pages :384
  • ISBN : 9781118145425
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Summary : Trusted information and healthy, delicious recipes to fight inflammation Low-grade inflammation is a condition inside the body, directly related to diet, that slowly wears on the body, facilitating chronic diseases like arthritis, diabetes, obesity, and heart disease. Also, the latest research has detected a correlation between inflammation and conditions like severe allergies, asthma, and even cancer. Anti-Inflammation Diet For Dummies takes a preventative dietary approach to fighting inflammation by stimulating natural healing with anti-inflammatory foods and supplements. It reveals the causes of inflammation and provides a how-to prescription for eliminating it through diet changes, stress reduction, and healthy weight loss. Defines what inflammation is, how it develops, and its associated risks Outlines foods and supplements rich in natural inflammation-fighting agents 100 healthy and delicious recipes loaded with anti-inflammatory agents Anti-Inflammation For Dummies is an invaluable resource to help you make smart diet choices by avoiding problematic foods that instigate the inflammatory process, and arms you with knowledge and delicious recipes to get on the road to a healthier you.

Neuroprotective Effects of Phytochemicals in Neurological Disorders

Neuroprotective Effects of Phytochemicals in Neurological Disorders
  • Author : Tahira Farooqui,Akhlaq A. Farooqui
  • Publisher :Unknown
  • Release Date :2017-03-20
  • Total pages :648
  • ISBN : 9781119155140
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Summary : Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.

Nutraceuticals in Veterinary Medicine

Nutraceuticals in Veterinary Medicine
  • Author : Ramesh C. Gupta,Ajay Srivastava,Rajiv Lall
  • Publisher :Unknown
  • Release Date :2019-05-21
  • Total pages :877
  • ISBN : 9783030046248
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Summary : This unique work compiles the latest knowledge around veterinary nutraceuticals, commonly referred to as dietary supplements, from ingredients to final products in a single source. More than sixty chapters organized in seven sections collate all related aspects of nutraceutical research in animal health and disease, among them many novel topics: common nutraceutical ingredients (Section-I), prebiotics, probiotics, synbiotics, enzymes and antibacterial alternatives (Section-II), applications of nutraceuticals in prevention and treatment of various diseases such as arthritis, periodontitis, diabetes, cognitive dysfunctions, mastitis, wounds, immune disorders, and cancer (Section-III), utilization of nutraceuticals in specific animal species (Section-IV), safety and toxicity evaluation of nutraceuticals and functional foods (Section-V), recent trends in nutraceutical research and product development (Section-VI), as well as regulatory aspects for nutraceuticals (Section-VII). The future of nutraceuticals and functional foods in veterinary medicine seems bright, as novel nutraceuticals will emerge and new uses of old agents will be discovered. International contributors to this book cover a variety of specialties in veterinary medicine, pharmacology, pharmacognosy, toxicology, chemistry, medicinal chemistry, biochemistry, physiology, nutrition, drug development, regulatory frameworks, and the nutraceutical industry. This is a highly informative and carefully presented book, providing scientific insight for academia, veterinarians, governmental and regulatory agencies with an interest in animal nutrition, complementary veterinary medicine, nutraceutical product development and research.

The Wahls Protocol

The Wahls Protocol
  • Author : Terry Wahls M.D.,Eve Adamson
  • Publisher :Unknown
  • Release Date :2014-03-13
  • Total pages :432
  • ISBN : 9781101605684
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Summary : Fully expanded with new information and updated research, a clear prescriptive guide about how to beat autoimmune conditions using functional medicine and nutrient-rich foods, from a doctor, researcher, and sufferer of progressive multiple sclerosis. The Wahls Protocol has become a sensation, transforming the lives of people with autoimmune diseases. Now in this fully revised edition, Dr. Terry Wahls outlines the latest research that validates the program and offers new, powerful tools to arm readers and help them achieve total health. The Wahls Protocol comes out of Dr. Wahls' own quest to treat the debilitating symptoms she experiences as a sufferer of progressive MS. Informed by science, she began using Paleo principles as guidelines for her unique, nutrient-rich plan. This book shares Dr. Wahls' astonishing personal story of recovery and details the program, with up-to-date research she's now conducting at the University of Iowa. Split into three different levels, this updated edition allows readers to choose the modified Wahls Diet if they're new to the regime, the Wahls Paleo Diet if they're ready to amp up their health, or the more advanced Wahls Paleo Plus Diet if they need more aggressive treatment. They can also incorporate the just-added Wahls Elimination Diet into their plan to pinpoint individual food sensitivities, so their diet is as personal as ever. With new recipes and content on intermittent fasting and how the protocol impacts the microbiome, The Wahls Protocol is a key addition to the "whole food" revolution, and a deeply moving, results-driven testimonial to the healing power of food.

A Synopsis of Parkinson's Disease

A Synopsis of Parkinson's Disease
  • Author : Md, Frcpc, Frcp (hon), Abdul Qayyum Rana
  • Publisher :Unknown
  • Release Date :2014-03-26
  • Total pages :232
  • ISBN : 9789535112297
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Summary : Parkinsons disease is a disabling neurological condition with both motor and non-motor symptoms for which no cure is available at this stage. This book is unique in covering the most important topics related to Parkinsons disease. Current research and updates about some non-motor symptoms, as well as surgical treatment of Parkinsons disease, in addition to the long term complications of pharmacological treatments have been presented. This book can be used by physicians, researchers and neuroscientists who want to learn new information about these topics related to Parkinsons disease. Authors of the individual chapters are well known in their fields and the book has been edited by a world renowned Parkinsons disease expert.