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Understanding Insulin and Insulin Resistance

Understanding Insulin and Insulin Resistance
  • Author : Anil Gupta
  • Publisher :Unknown
  • Release Date :2021-08-01
  • Total pages :300
  • ISBN : 9780128203798
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Summary : Understanding Insulin and Insulin Resistance is written in simple, clear language with diagrams that show the complex interplay of various factors in the initiation of insulin resistance. The design is systematic and meticulous, portraying topics in a flow from simple to complex. This resource is intended for a broad audience spanning across biochemistry, medicine, dentistry, academia, physicians, and research scholars. It extends the approach to biochemistry, physiology, metabolism of insulin along with the coverage of pathophysiology of insulin resistance, its effects on the body tissues, and its analysis on insulin resistance syndrome. Combines both intensive and extensive study material related to the topic Describes insulin resistance syndrome encompassing details regarding its prevalence and components Blends both theoretical and clinical knowledge related to insulin and insulin resistance syndrome Gathers the vast knowledge about insulin and insulin resistance in one volume, eliminating searches through hundreds of journal articles

The Diabetes Code

The Diabetes Code
  • Author : Dr. Jason Fung
  • Publisher :Unknown
  • Release Date :2018-04-03
  • Total pages :288
  • ISBN : 9781771642668
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Summary : From acclaimed author Dr. Jason Fung, a revolutionary guide to reversing diabetes. Dr. Jason Fung forever changed the way we think about obesity with his best-selling book, The Obesity Code. Now he has set out to do the same for type 2 diabetes. Today, most doctors, dietitians, and even diabetes specialists consider type 2 diabetes to be a chronic and progressive disease—a life sentence with no possibility of parole. But the truth, as Dr. Fung reveals in this paradigm-shifting book, is that type 2 diabetes is reversible. Writing with clear, persuasive language, he explains why conventional treatments that rely on insulin or other blood-glucose-lowering drugs can actually exacerbate the problem, leading to significant weight gain and even heart disease. The only way to treat type 2 diabetes effectively, he argues, is proper dieting and intermittent fasting—not medication. Dr. Jason Fung forever changed the way we think about obesity with his best-selling book, The Obesity Code. Now he has set out to do the same for type 2 diabetes. Today, most doctors, dietitians, and even diabetes specialists consider type 2 diabetes to be a chronic and progressive disease—a life sentence with no possibility of parole. But the truth, as Dr. Fung reveals in this paradigm-shifting book, is that type 2 diabetes is reversible. Writing with clear, persuasive language, he explains why conventional treatments that rely on insulin or other blood-glucose-lowering drugs can actually exacerbate the problem, leading to significant weight gain and even heart disease. The only way to treat type 2 diabetes effectively, he argues, is proper dieting and intermittent fasting—not medication.

Mechanisms of Insulin Action

Mechanisms of Insulin Action
  • Author : Alan R. Saltiel,Jeffrey E. Pessin
  • Publisher :Unknown
  • Release Date :2007-10-05
  • Total pages :214
  • ISBN : 9780387722047
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Summary : More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

The Insulin-Resistance Diet--Revised and Updated

The Insulin-Resistance Diet--Revised and Updated
  • Author : Cheryle R. Hart,Mary Kay Grossman
  • Publisher :Unknown
  • Release Date :2007-12-10
  • Total pages :256
  • ISBN : 0071596313
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Summary : Conquer insulin resistance. Reduce cravings. Eat your favorite foods. And lose weight! If you have tried every diet and are still struggling with your weight, the real culprit may be insulin resistance. When you have more glucose than your body needs, your body responds by producing more insulin to stabilize your blood sugar level and store the excess glucose as fat. In The Insulin-Resistance Diet, Cheryle R. Hart and Mary Kay Grossman show you how to control insulin resistance and lose weight without sacrificing all of your favorite foods. Overcome insulin resistance and lose weight with: The exclusive Link-and-Balance Eating Method, which balances carbs with the right amount of protein at the right time for maximum weight loss Self-tests to determine your insulin resistance and check your progress with linking and balancing Real-world strategies for eating at home and out on the town Easy-to-make, tasty recipes and livable meal plans

Insulin Resistance

Insulin Resistance
  • Author : Gerald M. Reaven,Ami Laws
  • Publisher :Unknown
  • Release Date :1999-04
  • Total pages :374
  • ISBN : 0896035883
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Summary : In Insulin Resistance: The Metabolic Syndrome X, outstanding investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia (Syndrome X) play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization-as well as polycystic ovary disease. Under the aegis of Gerald Reaven, the discoverer of Syndrome X, the distinguished authorities writing here detail for the first time the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Each author has been encouraged to present a point of view that reflects their unique insights. The first authoritative book on the subject, Insulin Resistance: The Metabolic Syndrome X illuminates the special importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome. Its thoughtful and detailed approach will make it an essential reference for basic and clinical researchers seeking to understand these critical phenomena.

Insulin Resistance Diet for Beginners

Insulin Resistance Diet for Beginners
  • Author : Marlee Coldwell
  • Publisher :Unknown
  • Release Date :2019-12-24
  • Total pages :156
  • ISBN : 1641524596
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Summary : Help your body naturally reverse insulin resistance using delicious food. Whether you're dealing with diabetes, PCOS, or just looking to manage an erratic metabolism, the insulin resistance diet can be key to a very satisfying, healthy lifestyle. Break the monotonous boundaries of managing your insulin response with The Insulin Resistance Diet for Beginners. This complete lifestyle guide will help your body naturally regulate glucose and insulin levels while putting creative, delicious, and diverse meals on the table. Relatable analogies, food humor, and realistic recipes make it fun to understand how the insulin resistance diet and lifestyle can change not only your metabolism, but your entire life outlook. The included shopping guides and meal plans make it easy to start your new lifestyle right away. The path to steady glucose levels and a strong metabolism begins in the kitchen--here's your guide to the insulin resistance diet. Inside The Insulin Resistance Diet for Beginners you'll find: Roadmap for success--A five-step plan makes the insulin resistance diet something you can start today. Shop in a snap--Complete shopping lists to help fill your pantry with all the right food--no more wondering. A meal in 5--Most recipes use just five ingredients so they're fast and easy to prepare, but slow to digest. Insulin resistance and delicious meals don't have to be mutually exclusive. Start reversing insulin resistance and loving the food that you eat with The Insulin Resistance Diet for Beginners.

Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment

Metabolic Syndrome and Psychiatric Illness: Interactions, Pathophysiology, Assessment and Treatment
  • Author : Scott D Mendelson
  • Publisher :Unknown
  • Release Date :2007-12-19
  • Total pages :224
  • ISBN : 0080556523
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Summary : Metabolic syndrome is a set of risk factors that includes: abdominal obesity, a decreased ability to process glucose (insulin resistance), dyslipidemia (unhealthy lipid levels), and hypertension. Patients who have this syndrome have been shown to be at an increased risk of developing cardiovascular disease and/or type 2 diabetes. Metabolic syndrome is a common condition that goes by many names (dysmetabolic syndrome, syndrome X, insulin resistance syndrome, obesity syndrome, and Reaven's syndrome). This is the first book to fully explain the relationships between psychiatric illness, Metabolic Syndrome, diet, sleep, exercise, medications, and lifestyle choices. Metabolic Syndrome is a major risk factor in Major Depression, Alzheimer's Disease, Sleep Disorders, Sexual Dysfunction, Fibromyalgia, and several other illnesses of psychiatric significance. Conversely, some psychiatric illnesses tend to predispose patients to Metabolic Syndrome. Of further interest is the fact that some of the medications used in the treatment of psychiatric illnesses have been found to cause or exacerbate Metabolic Syndrome. The author here provides basic information about what genetic predispositions, medical conditions, and lifestyle choices make Metabolic Syndrome more likely to occur. Among the contributing factors that are discussed are genetics, habitual intake of high glycemic index carbohydrates, fructose, saturated fats, trans fatty acids, vitamins, micronutrients, obesity, smoking, and lack of exercise. The author describes the actual mechanisms by which Metabolic Syndrome progresses and causes damage in the body, including the action of insulin and the pathophysiology of insulin resistance. Details are provided on what occurs in the liver, pancreas, muscle, fat cells, and immune system as Metabolic Syndrome progresses. New findings are presented on fat cells, including the fact that they are beginning to be considered as endocrine cells. There is a substantive discussion of leptin, which is one of the important adipocytokines. Also carbohydrate, 'bad fats', inflammation, oxidative damage, over-stimulation of the 'fight or flight' system, and high levels of the stress hormone cortisol can actually cause the manifestations of Metabolic Syndrome. These explanations set the stage for an explanation of the inter-relationships between Metabolic Syndrome, psychiatric illness, dementia and effects of not only diet and life choices, but also the effects of psychiatric medications. Finally, there is an important and unique section on the relationship between Metabolic Syndrome and various psychiatric illnesses, and how they exacerbate each other. The significance of Metabolic Syndrome in Major Depression, Bipolar Affective Disorder, Schizophrenia, fibromyalgia and Polycystic Ovary Disease is vast and it is important to realise the effects of psychiatric medications on Metabolic Syndrome. The author discusses antidepressants, mood stabilizers and the new atypical antipsychotics. There are dramatic differences among medications in the way they affect Metabolic Syndrome and pharmaceutical companies will want to promote patient awareness with this book.

Insulin Resistance

Insulin Resistance
  • Author : Sudhesh Kumar,Stephen O'Rahilly
  • Publisher :Unknown
  • Release Date :2005-07-15
  • Total pages :616
  • ISBN : 9780470011263
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Summary : Diabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects. The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined. * Provides an expert review of the phenomenon of insulin resistance * Brings together a host of recent research for the first time * Written by leading experts in biological and clinical research

The Discovery of Insulin

The Discovery of Insulin
  • Author : Michael Bliss
  • Publisher :Unknown
  • Release Date :2017-06-22
  • Total pages :320
  • ISBN : 9781487516741
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Summary : The discovery of insulin at the University of Toronto in 1921-22 was one of the most dramatic events in the history of the treatment of disease. Insulin was a wonder-drug with ability to bring patients back from the very brink of death, and it was no surprise that in 1923 the Nobel Prize for Medicine was awarded to its discoverers, the Canadian research team of Banting, Best, Collip, and Macleod. In this engaging and award-winning account, historian Michael Bliss recounts the fascinating story behind the discovery of insulin – a story as much filled with fiery confrontation and intense competition as medical dedication and scientific genius. Originally published in 1982 and updated in 1996, The Discovery of Insulin has won the City of Toronto Book Award, the Jason Hannah Medal of the Royal Society of Canada, and the William H. Welch Medal of the American Association for the History of Medicine.

The Obesity Code

The Obesity Code
  • Author : Dr. Jason Fung
  • Publisher :Unknown
  • Release Date :2016-01-26
  • Total pages :296
  • ISBN : 9781771641258
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Summary : In this highly readable and provocative book, Dr. Jason Fung sets out an original, robust theory of obesity that provides startling insights into proper nutrition. Flying in the face of the weight-loss recommendations that have failed in the past, this book reveals that obesity is a hormonal, not a caloric imbalance. As he explores the latest in nutritional science, Dr. Fung provides practical, effective advice on weight loss and the treatment of Type 2 diabetes based on sound scientific principles.

Mastering Diabetes

Mastering Diabetes
  • Author : Cyrus Khambatta, PhD,Robby Barbaro, MPH
  • Publisher :Unknown
  • Release Date :2020-02-18
  • Total pages :400
  • ISBN : 9780525540045
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Summary : The instant New York Times bestseller. A groundbreaking method to master all types of diabetes by reversing insulin resistance. Current medical wisdom advises that anyone suffering from diabetes or prediabetes should eat a low-carbohydrate, high-fat diet. But in this revolutionary book, Cyrus Khambatta, PhD, and Robby Barbaro, MPH, rely on a century of research to show that advice is misguided. While it may improve short-term blood glucose control, such a diet also increases the long-term risk for chronic diseases like cancer, high blood pressure, high cholesterol, chronic kidney disease, and fatty liver disease. The revolutionary solution is to eat a low-fat plant-based whole-food diet, the most powerful way to reverse insulin resistance in all types of diabetes: type 1, type 1.5, type 2, prediabetes, and gestational diabetes. As the creators of the extraordinary and effective Mastering Diabetes Method, Khambatta and Barbaro lay out a step-by-step plan proven to reverse insulin resistance-the root cause of blood glucose variability- while improving overall health and maximizing life expectancy. Armed with more than 800 scientific references and drawing on more than 36 years of personal experience living with type 1 diabetes themselves, the authors show how to eat large quantities of carbohydrate-rich whole foods like bananas, potatoes, and quinoa while decreasing blood glucose, oral medication, and insulin requirements. They also provide life-changing advice on intermittent fasting and daily exercise and offer tips on eating in tricky situations, such as restaurant meals and family dinners. Perhaps best of all: On the Mastering Diabetes Method, you will never go hungry. With more than 30 delicious, filling, and nutrient-dense recipes and backed by cutting-edge nutritional science, Mastering Diabetes will help you maximize your insulin sensitivity, attain your ideal body weight, improve your digestive health, gain energy, live an active life, and feel the best you've felt in years.

The Insulin Resistance Solution

The Insulin Resistance Solution
  • Author : Valerie Berkowitz,Rob Thompson,Dana Carpender
  • Publisher :Unknown
  • Release Date :2016-01-07
  • Total pages :192
  • ISBN : 9781592336463
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Summary : Reduce cravings, improve stamina and energy, and get your metabolism back on track by battling insulin resistance in five easy steps! The Insulin Resistance Solution by noted low-carb nutritional expert Valerie Berkowitz and low-carb proponent Dana Carpender, author of Fat Fast and 500 Low-Carb Recipes, provides a 5-step customizable plan that includes 75 recipes with meal plans that you can use to reverse insulin resistance or impaired glucose metabolism. Inside this guide, you'll discover five ways to kickstart your metabolism and live a healthier and happier life:Slash Carbohydrates, Add Insulin-Regulating Nutritional Supplements, Exercise--the RIGHT way, Address Lifestyle Problems, and Customize the Program. The Insulin Resistance Solution also provides options for portions, meal frequency, and exercise so you can fit the program easily into your lifestyle. Take control and take back your health!

The Everything Guide to the Insulin Resistance Diet

The Everything Guide to the Insulin Resistance Diet
  • Author : Marie Feldman,Jodi Dalyai
  • Publisher :Unknown
  • Release Date :2021-01-12
  • Total pages :272
  • ISBN : 9781507214213
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Summary : Lose weight while enjoying delicious meals with these 125 insulin resistant recipes and meal plans to improve your health and lower your risk for type 2 diabetes. Many people struggle with their weight, trying every new diet and health trend but still are unable to keep the weight off or lose unwanted belly fat. The problem may not be lack of willpower, but insulin resistance. When insulin can’t do its job of removing sugar from the blood, that sugar is turned to fat, causing weight gain and increasing the risk of type 2 diabetes. But this damage can be reversed simply by changing your diet and activity level. In The Everything Guide to the Insulin Resistance Diet, you will learn how to choose healthy foods like fruits, vegetables, whole grains, fish, and lean poultry, while limiting the amount of unhealthy fat, sugar, meats, and processed starches. Now you can make the lifestyle changes you need to lose weight and improve your health with this valuable resource that includes 125 recipes and a 10-week plan for healthy eating and increased activity. With this guidebook you can have the body—and health—of your dreams, all while eating the delicious food you love!

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders

Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders
  • Author : Akhlaq A. Farooqui
  • Publisher :Unknown
  • Release Date :2020-03-20
  • Total pages :498
  • ISBN : 9780128201848
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Summary : Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders provides an overview on the risk factors for insulin resistance in visceral and neurological disorders. The book focuses on molecular mechanisms and signal transduction processes associated with the links. The comprehensive information in this monograph will not only help in the early detection of insulin resistance related visceral and neurological disorders, but also promote the discovery of new drugs which may block or delay onset in elderly patients. Understanding these processes is important not only for patients, caregivers and health professionals, but also for health policymakers who must plan for national resources. Presents the first comprehensive book dedicated to insulin resistance as a risk factor for neurological disorders Focuses on the molecular mechanisms and signal transduction processes associated with insulin resistance Discusses insulin resistance to heart disease, obesity, diabetes, stroke, Alzheimer’s, Parkinson’s, dementia and depression

Glucose Homeostasis and Insulin Resistance

Glucose Homeostasis and Insulin Resistance
  • Author : Leszek Szablewski
  • Publisher :Unknown
  • Release Date :2011-04-14
  • Total pages :211
  • ISBN : 9781608051892
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Summary : "Glucose homeostasis and insulin resistance presents a broad overview of the molecular, biochemical and clinical aspects of glucose metabolism and glucose resistance. The book serves to acquaint the reader with recent information on topics ranging from the"

Insulin Resistance

Insulin Resistance
  • Author : Philip Scott Zeitler,Kristen J. Nadeau
  • Publisher :Unknown
  • Release Date :2008-12-28
  • Total pages :331
  • ISBN : 1597451924
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Summary : In the mid 1990s, Drs. Gerald Reaven identified a constellation of clinical findings, known variously as the metabolic syndrome, syndrome X, insulin resistance s- drome or insulin resistance-related disorders, that are associated with an increased risk of heart disease and diabetes. Interest in this topic grew rapidly, culminating in the publication by this series of the book, Insulin Resistance and the Metabolic Syndrome X, edited by Drs. Reaven and Laws in 1999. Since the original publication of that now classic volume, the world’s population has continued to become more obese and sedentary and the prevalence of disorders related to insulin resistance has continued to increase throughout the developed and developing world. Of great concern in the last decade is the extension of these deleterious lifestyle patterns to the pediatric population, leading to both obesity and the appearance of insulin resistance-related disorders in youth as well as adults. Today, about one in three children and adolescents in the United States is overweight or obese, and this prevalence approaches one in two among adolescents in certain minority groups. In addition, components of this cardiovascular risk constellation are now being recognized in young adults, adolescents, and even children. Youth are increasingly developing type 2 diabetes, fatty liver disease, hypertriglyceridemia, hypertension, polycystic ovarian syndrome, sleep apnea, orthopedic and psychiatric complications, as well as other complications of obesity and insulin resistance.

Obesity-induced inflammation and insulin resistance

Obesity-induced inflammation and insulin resistance
  • Author : Tsuguhito Ota
  • Publisher :Unknown
  • Release Date :2015-03-26
  • Total pages :229
  • ISBN : 9782889194285
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Summary : Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease and cardiovascular disease. Insulin resistance is an underlying basis for the pathogenesis of these metabolic diseases. Overnutrition or obesity activates the innate immune system with subsequent recruitment of immune cells such as macrophages and T cells, which contributes to the development of insulin resistance. In particular, a significant advance in our understanding of obesity-associated inflammation and insulin resistance has been recognition of the critical role of adipose tissue macrophages (ATMs). ATMs are a prominent source of proinflammatory cytokines, such as TNF-a and IL-6, that can block insulin action in adipose tissue, skeletal muscle, and liver autocrine/paracrine signaling and cause systemic insulin resistance via endocrine signaling, providing a potential link between inflammation and insulin resistance. All articles in this topic highlight the interconnection between obesity, inflammation, and insulin resistance in all its diversity to the mechanisms of obesity-induced inflammation and role of immune system in the pathogenesis of insulin resistance and diabetes.

Muscle Cell and Tissue

Muscle Cell and Tissue
  • Author : Kunihiro Sakuma
  • Publisher :Unknown
  • Release Date :2015-09-02
  • Total pages :486
  • ISBN : 9789535121565
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Summary : In order to complete tissue regeneration, various cells such as neuronal, skeletal, smooth, endothelial, and immune (e.g., macrophage) interact smoothly with each other. This book, Muscle Cells and Tissues, offers a wide range of topics such as stem cells, cell culture, biomaterials, epigenetics, therapeutics, and the creation of tissues and organs. Novel applications for cell and tissue engineering including cell therapy, tissue models, and disease pathology modeling are discussed. The book also deals with the functional role of autophagy in modulating muscle homeostasis and molecular mechanism regulating skeletal muscle mass. The chapters can be interesting for graduate students, postdocs, teachers, physicians, and for executives in biotech and pharmaceutical companies, as well as researchers in the fields of molecular biology and regenerative medicine.

The Blood Sugar Solution 10-Day Detox Diet

The Blood Sugar Solution 10-Day Detox Diet
  • Author : Mark Hyman
  • Publisher :Unknown
  • Release Date :2014-02-25
  • Total pages :352
  • ISBN : 9780316229982
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Summary : Dr. Hyman's revolutionary weight-loss program, based on the #1 New York Times bestseller The Blood Sugar Solution, supercharged for immediate results! The key to losing weight and keeping it off is maintaining low insulin levels. Based on Dr. Hyman's groundbreaking Blood Sugar Solution program, THE BLOOD SUGAR SOLUTION 10-DAY DETOX DIET presents strategies for reducing insulin levels and producing fast and sustained weight loss. Dr. Hyman explains how to: activate your natural ability to burn fat--especially belly fat; reduce inflammation; reprogram your metabolism; shut off your fat-storing genes; de-bug your digestive system; create effortless appetite control; and soothe the stress to shed the pounds. With practical tools designed to achieve optimum wellness, including meal plans, recipes, and shopping lists, as well as step-by-step, easy-to-follow advice on green living, supplements, medication, exercise, and more, THE BLOOD SUGAR SOLUTION 10-DAY DETOX DIET is the fastest way to lose weight, prevent disease, and feel your best.

The Insulin-resistance Diet

The Insulin-resistance Diet
  • Author : Cheryle R. Hart,Mary Kay Grossman
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :223
  • ISBN : 0809224275
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Summary : Explains how insulin resistance causes weight gain and how to correct this with the link-and-balance eating method, and includes recipes and tips for eating out.

The Diabetes Reset

The Diabetes Reset
  • Author : George King,Royce Flippin
  • Publisher :Unknown
  • Release Date :2015-01-13
  • Total pages :352
  • ISBN : 9780761183143
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Summary : Imagine controlling—avoiding—reversing!—the “health hazard of the 21st century” (World Health Organization), the disease that afflicts nearly 26 million Americans and is an imminent threat to an additional 80 million adults and children. That’s exactly the promise of The Diabetes Reset by Dr. George King, research director and chief science officer at Harvard’s Joslin Diabetes Center, the world’s largest and most respected diabetes research center, synonymous with revolutionizing the diagnosis, treatment, and prevention of diabetes. Based on the most cutting-edge research—including the groundbreaking discovery of brown fat in adults and its role in burning calories and enhancing the effects of the body’s own insulin—The Diabetes Reset translates the latest findings into a plan that will let readers avoid, control, and even reverse type 2 diabetes. The program begins with losing weight—and shows why losing only 5% of body weight makes a life-changing difference. It explains how a good’s night sleep can significantly lower blood glucose levels (and why sleep deprivation works in reverse). It disentangles the carbohydrate confusion, reveals how to decrease the body’s inflammatory response, and explains the importance of moderate exercise. There are eight strategies in all—if you implement only one, your type 2 diabetes will improve. Pursue all eight of them, and you can stop type 2 diabetes in its tracks. You can even reverse it—effectively resetting your body’s glucose metabolism for a long, healthy life.