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Unraveling the Complexities of Metastasis

Unraveling the Complexities of Metastasis
  • Author : Ammad Ahmad Farooqi,Muhammad Zahid Qureshi,Uteuliyev Yerzhan Sabitaliyevi
  • Publisher :Unknown
  • Release Date :2020-09-15
  • Total pages :200
  • ISBN : 0128217898
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Summary : Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer. The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism. This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis. Explains the mechanism of metastasis from basic to advanced level through easy and comprehensive chapters written by internationally distinguished researchers Provides simplified version of important process of metastasis for the readers to comprehend the latest advancements made in the field Presents colorful diagrams to make different aspects of scientifically difficult topics easier for young researchers and new-comers in the field of cancer metastasis

The Role of Eukaryotic Initiation Factor 4E (eIF4E) in Osteosarcoma Metastasis

The Role of Eukaryotic Initiation Factor 4E (eIF4E) in Osteosarcoma Metastasis
  • Author : Tanasa S. Osborne
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :229
  • ISBN : OCLC:774894274
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Summary : The most significant problem for cancer patients is the dissemination of cancer cells and the formation of metastatic disease. Emblematic of the problem is the clinical progression seen in most patients with osteosarcoma, where metastasis to the lung is the most common cause of death. The primary research need in the field is to understand the biology of metastasis in osteosarcoma so as to improve outcomes for future patients. Unraveling the complexity of metastasis demands a focus on new tools, reagents, and biology in order to investigate hypotheses. Accordingly, this body of work introduces an outcome-linked human ostoesarcoma tissue microarray (new tool) used to detect and validate protein biomarkers across a variety of patients and an ex vivo pulmonary metastasis assay (new reagent) that allows real-time assessment of metastatic progression in a relevant microenvironment. Furthermore, cancer cells are believed to efficiently regulate protein translation at specific times and locations in a cell in response to changes in their environment. Preventing the dynamic regulation of these proteins (many of which have been associated with cancer/metastasis) may be an effective treatment strategy in the management of metastasis. Within the process of protein translation the abundance and activation of the mRNA cap-binding phosphoprotein, eukaryotic initiation factor 4E (eIF4E) is considered to be both rate and process limiting. We describe for the first time, the biological role of eIF4E (new biology) in metastatic osteosarcoma. We employed a comparative approach to study the biology of metastasis in osteosarcoma by using tissues and reagents from murine and human osteosarcomas. Using overexpression and knockdown techniques we modulated eIF4E expression in murine and human osteosarcoma cell lines and then evaluated the consequences at various steps within the metastatic cascade in vitro and in vivo. We found that suppression of eIF4E significantly delayed migration and reduced the number and size of colonies that formed in soft agar. Additionally, suppression of eIF4E inhibited spontaneous pulmonary metastases. eIF4E overexpression did not change the phenotype of previously nonmetastatic cells. These results suggest eIF4E may be a necessary, but not sufficient, requirement for metastasis in osteosarcoma. The goals of this research were to utilize these new tools and reagents to identify proteins and/or processes that define the metastatic phenotype of osteosarcoma and to use our newfound understanding of eIF4E in osteosarcoma metastasis to develop novel therapeutic strategies to prevent growth of metastases and improve treatment outcomes for patients.

Molecular and Cellular Basis of Metastasis: Road to Therapy

Molecular and Cellular Basis of Metastasis: Road to Therapy
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2016-09-03
  • Total pages :390
  • ISBN : 9780128041581
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Summary : Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis. Presents groundbreaking information on the molecular and cellular basis of metastasis Provides information on cancer research Outstanding and original reviews Suitable for both researchers and students

AACR 2018 Proceedings: Abstracts 3028-5930

AACR 2018 Proceedings: Abstracts 3028-5930
  • Author : American Association for Cancer Research
  • Publisher :Unknown
  • Release Date :2018-04-10
  • Total pages :229
  • ISBN : 9781370247707
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Summary :

ICRDB Cancergram

ICRDB Cancergram
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1986
  • Total pages :229
  • ISBN : MINN:30000010709891
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Summary :

Genomic Instability and Cancer Metastasis

Genomic Instability and Cancer Metastasis
  • Author : Chris Maxwell,Cal Roskelley
  • Publisher :Unknown
  • Release Date :2014-12-04
  • Total pages :247
  • ISBN : 9783319121369
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Summary : Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.

Metastasis Research Protocols

Metastasis Research Protocols
  • Author : Susan A. Brooks,Udo Schumacher
  • Publisher :Unknown
  • Release Date :2010-11-09
  • Total pages :344
  • ISBN : 1617370967
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Summary : The process of metastasis formation is hugely complex, as described in the introductory chapter of this book, and this complexity has led us to compile two volumes of methods, from a vastly divergent background that attempts to encompass the whole spectrum of cancer biology. This first volume, Metastasis Research Protocols: Analysis of Cells and Tissues, concentrates on analysis and mapping of molecules produced by cells and tissues and analysis of the molecular biology underlying their expression, whereas the second volume, Metastasis Research Protocols: Cell Behavior In Vitro and In Vivo,focuses sharply on the determination of cell behavior in vitro and in vivo. We have deliberately included chapters describing well-established and familiar te- niques (for example, SDS-PAGE and Western blotting [Chapter 11], and immunocytochemistry [Chapter 2]) in addition to the newer and more speci- ized approaches and specific examples of their application, because—although the methodology is readily available in the published literature and established in many laboratories—we wished these volumes to “stand alone” and to make accessible here the standard techniques that underpin much metastasis research for both the newcomer to the field and the seasoned researcher. Undoubtedly, owing to the complexity of the metastatic cascade and the wealth of research techniques involved in scientific approaches to its unraveling, and despite our best efforts to make these volumes as comprehensive as seems feasible, this is a tall order, and there will inevitably be omissions. For these we apologize.

Metastasis Research Protocols

Metastasis Research Protocols
  • Author : Susan A. Brooks,Udo Schumacher
  • Publisher :Unknown
  • Release Date :2001
  • Total pages :344
  • ISBN : 9781592591367
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Summary : Although ninety percent of fatal cancer cases involve the spread of a primary tumor, the formation of metastases is still a poorly understood, complex process and a significant problem in the treatment of cancer patients. In Metastasis Research Protocols, leading international investigators describe the key methods needed to investigate why and how metastasis occurs. Volume I of this two-volume set, Analysis of Cells and Tissues, presents a comprehensive collection of established and leading-edge techniques for analyzing the expression of key molecules and for examining their production at the genetic level. The work focuses on the analysis and mapping of molecules produced by cells and tissues, and on the molecular biology underlying their expression. The traditional methods range from the histopathological and the immunocytochemical to SDS-PAGE, Western blotting, and enzyme zymography. Newer and more specialized techniques for analyzing the genetic aspects of metastasis include in situ hybridization to localize mRNAs, FISH, CGH, methylation analysis of CpG islands, RT-PCR, and differential display. The second volume of this set, Analysis of Cell Behavior In Vitro and In Vivo, moves to the level of living cells and tissues to present methodologies applicable to examining metastatic behavior in vitro and in the whole animal. Comprehensive and authoritative, the two volumes of Metastasis Research Protocols constitute a gold-standard collection of readily reproducible methods for understanding the metastatic cascade-first at the cellular and molecular levels, then at the level of the whole organism-responsible for the spread of cancer and for developing novel strategies to combat its spread.

Proteostasis and Disease

Proteostasis and Disease
  • Author : Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez
  • Publisher :Unknown
  • Release Date :2020-04-09
  • Total pages :348
  • ISBN : 9783030382667
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Summary : This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Cancer Research

Cancer Research
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2009-08
  • Total pages :229
  • ISBN : CORNELL:31924108296363
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Summary :

Cancer Ecosystems

Cancer Ecosystems
  • Author : Ubaldo E. Martinez-Outschoorn,Ramon Bartrons
  • Publisher :Unknown
  • Release Date :2019-11-27
  • Total pages :229
  • ISBN : 9782889631759
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Summary :

Blood Group Substances

Blood Group Substances
  • Author : Elvin A. Kabat
  • Publisher :Unknown
  • Release Date :2013-10-22
  • Total pages :340
  • ISBN : 9781483274263
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Summary : Blood Group Substances: Their Chemistry and Immunochemistry focuses on the characteristics, reactions, sources, and transformations of blood group substances. The book first offers information on human blood group factors and the methods and reagents used in testing for blood group antibodies and antigens. Topics include autoantibody formation and hemolytic anemia, panagglutinable erythrocytes, effects of temperature on hemagglutination, and effects of periodate on blood group substances. The text also ponders on the sources and purification of blood group substances. The publication examines the chemical and immunochemical characterization of blood group substances and immunochemical similarities and differences among blood group substances from various species. The text then takes a look at antibodies to blood group substances and their biological effects, including purification and concentration of blood group antibodies; studies with antibodies labeled with radioactive isotopes; and passage of antibodies through the placenta. The manuscript is a valuable reference for readers interested in blood group substances.

Cancer Drug Resistance

Cancer Drug Resistance
  • Author : Beverly A. Teicher
  • Publisher :Unknown
  • Release Date :2007-11-09
  • Total pages :617
  • ISBN : 9781597450355
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Summary : Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Unraveling the Safety Profile of Nanoscale Particles and Materials

Unraveling the Safety Profile of Nanoscale Particles and Materials
  • Author : Andreia Ferreira de Castro Gomes,Marisa P. Sárria
  • Publisher :Unknown
  • Release Date :2018-03-21
  • Total pages :172
  • ISBN : 9789535139393
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Summary : As nanomaterials become increasingly present in our daily lives, pertinent questions regarding their safety arise. Nanomaterial risk assessment, as in other areas, directs much of the effort worldwide in defining guidelines that may be translated into national or international directives. Nanomaterials encompass different entities, from nanoparticles to nanostructured materials, with specific effects over cells, tissues, organisms and ecosystems depending on their biophysical characteristics. Such interactions will directly affect the impact of novel nanotechnologies. This book aims to provide the reader with a comprehensive overview of the current state of the art in nanotoxicology, featuring the most important developments and critical issues regarding the use of and exposure to nanoparticles.

Physics of Cancer

Physics of Cancer
  • Author : Claudia Mierke
  • Publisher :Unknown
  • Release Date :2018-10-24
  • Total pages :500
  • ISBN : 0750317515
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Summary : This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.

Pain

Pain
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :1985
  • Total pages :128
  • ISBN : UOM:39015013210870
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The Unwinding of the Miracle

The Unwinding of the Miracle
  • Author : Julie Yip-Williams
  • Publisher :Unknown
  • Release Date :2019-02-05
  • Total pages :336
  • ISBN : 9780525511366
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Summary : NEW YORK TIMES BESTSELLER • Read with Jenna Book Club Pick as Featured on Today • As a young mother facing a terminal diagnosis, Julie Yip-Williams began to write her story, a story like no other. What began as the chronicle of an imminent and early death became something much more—a powerful exhortation to the living. “An exquisitely moving portrait of the daily stuff of life.”—The New York Times Book Review (Editors’ Choice) NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • Time • Real Simple • Good Housekeeping That Julie Yip-Williams survived infancy was a miracle. Born blind in Vietnam, she narrowly escaped euthanasia at the hands of her grandmother, only to flee with her family the political upheaval of her country in the late 1970s. Loaded into a rickety boat with three hundred other refugees, Julie made it to Hong Kong and, ultimately, America, where a surgeon at UCLA gave her partial sight. She would go on to become a Harvard-educated lawyer, with a husband, a family, and a life she had once assumed would be impossible. Then, at age thirty-seven, with two little girls at home, Julie was diagnosed with terminal metastatic colon cancer, and a different journey began. The Unwinding of the Miracle is the story of a vigorous life refracted through the prism of imminent death. When she was first diagnosed, Julie Yip-Williams sought clarity and guidance through the experience and, finding none, began to write her way through it—a chronicle that grew beyond her imagining. Motherhood, marriage, the immigrant experience, ambition, love, wanderlust, tennis, fortune-tellers, grief, reincarnation, jealousy, comfort, pain, the marvel of the body in full rebellion—this book is as sprawling and majestic as the life it records. It is inspiring and instructive, delightful and shattering. It is a book of indelible moments, seared deep—an incomparable guide to living vividly by facing hard truths consciously. With humor, bracing honesty, and the cleansing power of well-deployed anger, Julie Yip-Williams set the stage for her lasting legacy and one final miracle: the story of her life. Praise for The Unwinding of the Miracle “Everything worth understanding and holding on to is in this book. . . . A miracle indeed.”—Kelly Corrigan, New York Times bestselling author “A beautifully written, moving, and compassionate chronicle that deserves to be read and absorbed widely.”—Siddhartha Mukherjee, Pulitzer Prize–winning author of The Emperor of All Maladies

Neuropsychology of Cancer and Oncology

Neuropsychology of Cancer and Oncology
  • Author : Dr. Dale L. Johnson, PhD
  • Publisher :Unknown
  • Release Date :2012-12-17
  • Total pages :488
  • ISBN : 9780826106940
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Summary : "This book, in both its direct and indirect inferences, points to the need for disease-specific neurocognitive methods in broadly occurring CNS and non-CNS cancers... All in all, this is a beautifully conceptualized book that should be on the bookshelves of many specialists who work in the very challenging field of Oncology."--Carol L. Armstrong, PhD, Children's Hospital of Pennsylvania, Archives of Clinical Neuropsychology Interest in the neurocognitive and sensory impairments resulting from many cancers and their interventions has grown considerably over the past decades as an important aspect of quality of life issues for cancer patients and survivors. The Neuropsychology of Cancer and Oncology features current findings on the neuropsychological effects of these cancers and their treatments along with the most promising neuropsychological and behavioral health interventions available to mitigate these deficits. This edited volume, part of the Contemporary Neuropsychology series, bridges the gap between the knowledge of neuropsychologists, who are grounded in the biological and physiological bases of cognition and behavior but not in pathology, and that of oncologists, who often lack expertise in the neuropsychological aspects of cancer. This text first addresses the biological components and medical care of these cancers, and issues relating to bioimaging. It then discusses the neurological impact of these cancers as they affect different functions, such as memory, learning, and sensory-motor ability, as well as discusses the effects of childhood cancers on neurological development. State-of-the-art neuropsychological and behavioral health interventions are considered, including neuropsychological/cognitive rehabilitation and habituation, pharmacological interventions, and collaborative medical practices. This text is a unique and timely resource for clinical neuropsychologists, clinical psychologists, neurologists, oncologists, oncology nurses, and neurorehabilitation professionals. Key Features: Bridges the gap of knowledge between neuropsychologists and oncologists Explores the most current research on the neuropsychological effects of various cancers and their treatments Provides state-of-the-art information on promising neuropsychological and behavioralñhealth interventions for impairments created by cancers and their treatments Represents a collaboration between some of the foremost scholars and practitioners in neuropsychology and oncology

Introduction to Cancer Metastasis

Introduction to Cancer Metastasis
  • Author : Aamir Ahmad
  • Publisher :Unknown
  • Release Date :2016-11-14
  • Total pages :416
  • ISBN : 9780128040331
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Summary : Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe

Prostate Cancer

Prostate Cancer
  • Author : Leland W. K. Chung,William B. Isaacs,Jonathan W. Simons
  • Publisher :Unknown
  • Release Date :2007-11-10
  • Total pages :508
  • ISBN : 9781597452243
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Summary : Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers. The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth. Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.

From Melanocytes to Melanoma

From Melanocytes to Melanoma
  • Author : Vincent J. Hearing,Stanley P. L. Leong
  • Publisher :Unknown
  • Release Date :2007-11-05
  • Total pages :678
  • ISBN : 9781592599943
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Summary : Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, in the malignant transformation of melanocytes, and in the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The book provides an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.