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Vaccines for Biodefense and Emerging and Neglected Diseases

Vaccines for Biodefense and Emerging and Neglected Diseases
  • Author : Alan D.T. Barrett,Lawrence R. Stanberry
  • Publisher :Unknown
  • Release Date :2009-03-05
  • Total pages :1488
  • ISBN : 0080919022
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Summary : The last 20 years has seen a rapid increase in infectious diseases, particularly those that are termed "emerging diseases" such as SARS, "neglected diseases" such as malaria and those that are deemed biothreats such as anthrax. It is well-recognized that the most effective modality for preventing infectious diseases is vaccination. This book provides researchers with a better understanding of what is currently known about these diseases, including whether there is a vaccine available or under development. It also informs readers of the key issues in development of a vaccine for each disease. * Provides a comprehensive treatise of the agents that are responsible for emerging and neglected diseases and those that can be used as biothreats * Includes the processes such as the vaccine development pathway, vaccine manufacturing and regulatory issues that are critical to the generation of these vaccines to the marketplace * Each chapter will include a map of the world showing where that particular disease is naturally found

Vaccinology

Vaccinology
  • Author : W. John W. Morrow,Nadeem A. Sheikh,Clint S. Schmidt,D. Huw Davies
  • Publisher :Unknown
  • Release Date :2012-06-12
  • Total pages :552
  • ISBN : 9781118345344
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Summary : Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

Vaccinology

Vaccinology
  • Author : Alan D. T. Barrett
  • Publisher :Unknown
  • Release Date :2015-02-16
  • Total pages :400
  • ISBN : 9780470656167
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Summary : Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes. Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.

Hurricane of the Human Frame

Hurricane of the Human Frame
  • Author : Urmi Engineer
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :562
  • ISBN : UCAL:X84336
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Summary : "This dissertation examines the history of epidemic yellow fever in New Orleans from 1796 to 1905. In New Orleans, the earliest recorded outbreaks of yellow fever appeared in the 1790s, in the aftermath of the Haitian Revolution, and continued until 1905, when the U.S. Public Health Service intervened and enforced mosquito-eradication policies in the city. Framing the history of the emergence, spread, and decline yellow fever in New Orleans in a world historical context reveals how global events shaped the epidemiological history of the city.

Human Subjects Research after the Holocaust

Human Subjects Research after the Holocaust
  • Author : Sheldon Rubenfeld,Susan Benedict
  • Publisher :Unknown
  • Release Date :2014-06-30
  • Total pages :308
  • ISBN : 9783319057026
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Summary : “An engaging, compelling and disturbing confrontation with evil ...a book that will be transformative in its call for individual and collective moral responsibility." – Michael A. Grodin, M.D., Professor and Director, Project on Medicine and the Holocaust, Elie Wiesel Center for Judaic Studies, Boston University Human Subjects Research after the Holocaust challenges you to confront the misguided medical ethics of the Third Reich personally, and to apply the lessons learned to contemporary human subjects research. While it is comforting to believe that Nazi physicians, nurses, and bioscientists were either incompetent, mad, or few in number, they were, in fact, the best in the world at the time, and the vast majority participated in the government program of “applied biology.” They were not coerced to behave as they did—they enthusiastically exploited widely accepted eugenic theories to design horrendous medical experiments, gas chambers and euthanasia programs, which ultimately led to mass murder in the concentration camps. Americans provided financial support for their research, modeled their medical education and research after the Germans, and continued to perform unethical human subjects research even after the Nuremberg Doctors’ Trial. The German Medical Association apologized in 2012 for the behavior of its physicians during the Third Reich. By examining the medical crimes of human subjects researchers during the Third Reich, you will naturally examine your own behavior and that of your colleagues, and perhaps ask yourself "If the best physicians and bioscientists of the early 20th century could do evil while believing they were doing good, can I be certain that I will never do the same?"

Vaccination Controversies: A Reference Handbook

Vaccination Controversies: A Reference Handbook
  • Author : David E. Newton
  • Publisher :Unknown
  • Release Date :2013-03-21
  • Total pages :352
  • ISBN : 9781610693127
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Summary : Why is there such an active and ongoing resistance to mandatory vaccination? This book examines why vaccination as a public health measure continues to be highly controversial.

Fields Virology: Emerging Viruses

Fields Virology: Emerging Viruses
  • Author : Peter M. Howley,David M. Knipe
  • Publisher :Unknown
  • Release Date :2020-02-11
  • Total pages :840
  • ISBN : 9781975112554
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Summary : Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.

Vaccinology

Vaccinology
  • Author : Gregg N. Milligan,Alan D. T. Barrett
  • Publisher :Unknown
  • Release Date :2014-12-04
  • Total pages :400
  • ISBN : 9781118636527
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Summary : Vaccinology: An Essential Guide outlines in a clear,practical format the entire vaccine development process, fromconceptualization and basic immunological principles through toclinical testing and licensing of vaccines. With anoutstanding introduction to the history and practice ofvaccinology, it also guides the reader through the basic sciencerelating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economicand geographical issues that drive vaccine development and trials,it also presents vaccine delivery strategies, novel vaccineplatforms (including experimental vaccines and pathogens), antigendevelopment and selection, vaccine modelling, and the developmentof vaccines against emerging pathogens and agents of bioterror.There are also sections devoted to veterinary vaccines andassociated regulatory processes. Vaccinology: An Essential Guide is a perfect tool fordesigned for undergraduate and graduate microbiologists andimmunologists, as well as residents, fellows and trainees ofinfectious disease and vaccinology. It is also suitable for allthose involved in designing and conducting clinical vaccine trials,and is the ideal companion to the larger reference bookVaccinology: Principles and Practice.

The End of Plagues

The End of Plagues
  • Author : John Rhodes
  • Publisher :Unknown
  • Release Date :2013-09-24
  • Total pages :256
  • ISBN : 9781137381316
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Summary : At the turn of the twentieth century, smallpox claimed the lives of two million people per year. By 1979, the disease had been eradicated and victory was declared across the globe. Yet the story of smallpox remains the exception, as today a host of deadly contagions, from polio to AIDS, continue to threaten human health around the world. Spanning three centuries, The End of Plagues weaves together the discovery of vaccination, the birth and growth of immunology, and the fight to eradicate the world's most feared diseases. From Edward Jenner's discovery of vaccination in 1796, to the early nineteenth-century foundling voyages in which chains of orphans, vaccinated one by one, were sent to colonies around the globe, to the development of polio vaccines and the stockpiling of smallpox as a biological weapon in the Cold War, world-renown immunologist John Rhodes charts our fight against these plagues, and shows how vaccinations gave humanity the upper hand. Today, aid groups including the Bill and Melinda Gates Foundation and the World Health Organization have made the eradication of polio a priority, and Rhodes takes us behind the scenes to witness how soon we may be celebrating the eradication of polio.

Tropical Infectious Diseases: Principles, Pathogens and Practice E-Book

Tropical Infectious Diseases: Principles, Pathogens and Practice E-Book
  • Author : Richard L. Guerrant,David H. Walker,Peter F. Weller
  • Publisher :Unknown
  • Release Date :2011-04-05
  • Total pages :1156
  • ISBN : 9781437737776
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Summary : Tropical Infectious Diseases: Principles, Pathogens and Practice, by Drs. Richard L. Guerrant, David H. Walker, and Peter F. Weller, delivers the expert, encyclopedic guidance you need to overcome the toughest clinical challenges in diagnosing and treating diseases caused by infectious agents from tropical regions. Sweeping updates to this 3rd edition include vaccines, SARS, hepatitis A-E, Crimean-Congo hemorrhagic fever virus, tick-borne encephalitis and Omsk hemorrhagic fever, human papilloma virus, and mucormycosis. New full-color images throughout allow you to more accurately view the clinical manifestations of each disease and better visualize the life cycles of infectious agents. Definitive, state-of-the-art coverage of pathophysiology as well as clinical management makes this the reference you’ll want to consult whenever you are confronted with tropical infections, whether familiar or unfamiliar! Obtain complete and trustworthy advice from hundreds of the leading experts on tropical diseases worldwide, including cutting-edge summaries of pathophysiology and epidemiology as well as clinical management. Get the latest answers on vaccines, SARS, hepatitis A-E, Crimean-Congo hemorrhagic fever virus, tick-borne encephalitis and Omsk hemorrhagic fever, human papilloma virus, mucormycosis, and much more. Implement best practices from all over the world with guidance from almost twice as many international authors - over 100 representing more than 35 countries. Accurately view the clinical manifestations of each disease and visualize the life cycles of infectious agents with new full-color images throughout.

Priorities for the National Vaccine Plan

Priorities for the National Vaccine Plan
  • Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee on Review of Priorities in the National Vaccine Plan
  • Publisher :Unknown
  • Release Date :2010-05-17
  • Total pages :368
  • ISBN : 0309156203
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Summary : Vaccination is a fundamental component of preventive medicine and public health. The use of vaccines to prevent infectious diseases has resulted in dramatic decreases in disease, disability, and death in the United States and around the world. The current political, economic, and social environment presents both opportunities for and challenges to strengthening the U.S. system for developing, manufacturing, regulating, distributing, funding, and administering safe and effective vaccines for all people. Priorities for the National Vaccine Plan examines the extraordinarily complex vaccine enterprise, from research and development of new vaccines to financing and reimbursement of immunization services. Priorities for the National Vaccine Plan examines the extraordinarily complex vaccine enterprise, from research and development of new vaccines to financing and reimbursement of immunization services. The book makes recommendations about priority actions in the update to the National Vaccine Plan that are intended to achieve the objectives of disease prevention and enhancement of vaccine safety. It is centered on the plan's five goals in the areas of vaccine development, safety, communication, supply and use, and global health.

Veterinary Microbiology

Veterinary Microbiology
  • Author : D. Scott McVey,Melissa Kennedy,M. M. Chengappa
  • Publisher :Unknown
  • Release Date :2013-05-30
  • Total pages :656
  • ISBN : 9781118650622
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Summary : Veterinary Microbiology, Third Edition is a comprehensive reference on the bacterial, fungal, and viral pathogenic agents that cause animal disease. Now in full color with improved images throughout, the new edition has been thoroughly updated to reflect information from current research and diagnostic and clinical publications. Key changes include a review of microbial cell structure and function and increased emphasis on the key points of pathogenesis and host responses to infection. Organized into four sections, the Third Edition begins with an updated and expanded introductory section on infectious disease pathogenesis, diagnosis and clinical management. The second section covers bacterial and fungal pathogens, and the third section describes viral diseases and viruses. The final section presents a systematic approach of describing infection and disease of animals. Equally useful for beginning veterinary students and seasoned practitioners, Veterinary Microbiology offers a thorough introduction and reference text for veterinary infectious disease.

Paleomicrobiology

Paleomicrobiology
  • Author : Didier Raoult,Michel Drancourt
  • Publisher :Unknown
  • Release Date :2008-01-24
  • Total pages :226
  • ISBN : 3540758550
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Summary : This fascinating new volume comes complete with color illustrations and features the methodology and main achievements in the emerging field of paleomicrobiology. It’s an area research at the intersection of microbiology and evolution, history and anthropology. New molecular approaches have already provided exciting results, such as confirmation of a single biotype of Yersinia pestis as the cause of historical plague pandemics. An absorbing read for scientists in related fields.

The British National Bibliography

The British National Bibliography
  • Author : Arthur James Wells
  • Publisher :Unknown
  • Release Date :2009
  • Total pages :229
  • ISBN : STANFORD:36105211722678
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Summary :

Essential Human Virology

Essential Human Virology
  • Author : Jennifer Louten
  • Publisher :Unknown
  • Release Date :2016-03-29
  • Total pages :344
  • ISBN : 9780128011713
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Summary : Essential Human Virology is written for the undergraduate level with case studies integrated into each chapter. The structure and classification of viruses will be covered, as well as virus transmission and virus replication strategies based upon type of viral nucleic acid. Several chapters will focus on notable and recognizable viruses and the diseases caused by them, including influenza, HIV, hepatitis viruses, poliovirus, herpesviruses, and emerging and dangerous viruses. Additionally, how viruses cause disease, or pathogenesis, will be highlighted during the discussion of each virus family, and a chapter on the immune response to viruses will be included. Further, research laboratory assays and viral diagnosis assays will be discussed, as will vaccines, anti-viral drugs, gene therapy, and the beneficial uses of viruses. By focusing on general virology principles, current and future technologies, familiar human viruses, and the effects of these viruses on humans, this textbook will provide a solid foundation in virology while keeping the interest of undergraduate students. Focuses on the human diseases and cellular pathology that viruses cause Highlights current and cutting-edge technology and associated issues Presents real case studies and current news highlights in each chapter Features dynamic illustrations, chapter assessment questions, key terms, and summary of concepts, as well as an instructor website with lecture slides, test bank, and recommended activities

The Travel and Tropical Medicine Manual E-Book

The Travel and Tropical Medicine Manual E-Book
  • Author : Christopher A. Sanford,Elaine C. Jong,Paul S. Pottinger
  • Publisher :Unknown
  • Release Date :2016-08-07
  • Total pages :682
  • ISBN : 9780323417426
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Summary : Prevent, evaluate, and manage diseases that can be acquired in tropical environments and foreign countries with The Travel and Tropical Medicine Manual. This pragmatic resource equips medical providers with the knowledge they need to offer effective aid, covering key topics in pre- and post-travel medicine, caring for immigrants and refugees, and working in low-resource settings. It's also the perfect source for travelers seeking quick, easy access to the latest travel medicine information. Dynamic images illustrate key concepts for an enhanced visual understanding. Evidence-based treatment recommendations enable you to manage diseases confidently. This eBook allows you to search all of the text, figures, images, and references from the book on a variety of devices. Highlights new evidence and content surrounding mental health and traveling. Covers emerging hot topics such as Ebola virus disease, viral hemorrhagic fevers, the role of point-of-care testing in travel medicine, and antibiotic-resistant bacteria in returning travelers and students traveling abroad. Includes an enhanced drug appendix in the back of the book.

Global Health and the Future Role of the United States

Global Health and the Future Role of the United States
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Committee on Global Health and the Future of the United States
  • Publisher :Unknown
  • Release Date :2017-09-05
  • Total pages :384
  • ISBN : 9780309457668
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Summary : While much progress has been made on achieving the Millenium Development Goals over the last decade, the number and complexity of global health challenges has persisted. Growing forces for globalization have increased the interconnectedness of the world and our interdependency on other countries, economies, and cultures. Monumental growth in international travel and trade have brought improved access to goods and services for many, but also carry ongoing and ever-present threats of zoonotic spillover and infectious disease outbreaks that threaten all. Global Health and the Future Role of the United States identifies global health priorities in light of current and emerging world threats. This report assesses the current global health landscape and how challenges, actions, and players have evolved over the last decade across a wide range of issues, and provides recommendations on how to increase responsiveness, coordination, and efficiency â€" both within the U.S. government and across the global health field.

Microbial Threats to Health

Microbial Threats to Health
  • Author : Institute of Medicine,Board on Global Health,Committee on Emerging Microbial Threats to Health in the 21st Century
  • Publisher :Unknown
  • Release Date :2003-08-25
  • Total pages :397
  • ISBN : 0309185548
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Summary : Infectious diseases are a global hazard that puts every nation and every person at risk. The recent SARS outbreak is a prime example. Knowing neither geographic nor political borders, often arriving silently and lethally, microbial pathogens constitute a grave threat to the health of humans. Indeed, a majority of countries recently identified the spread of infectious disease as the greatest global problem they confront. Throughout history, humans have struggled to control both the causes and consequences of infectious diseases and we will continue to do so into the foreseeable future. Following up on a high-profile 1992 report from the Institute of Medicine, Microbial Threats to Health examines the current state of knowledge and policy pertaining to emerging and re-emerging infectious diseases from around the globe. It examines the spectrum of microbial threats, factors in disease emergence, and the ultimate capacity of the United States to meet the challenges posed by microbial threats to human health. From the impact of war or technology on disease emergence to the development of enhanced disease surveillance and vaccine strategies, Microbial Threats to Health contains valuable information for researchers, students, health care providers, policymakers, public health officials. and the interested public.

Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases

Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases
  • Author : National Research Council,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Institute of Medicine,Board on Global Health,Committee on Achieving Sustainable Global Capacity for Surveillance and Response to Emerging Diseases of Zoonotic Origin
  • Publisher :Unknown
  • Release Date :2010-01-24
  • Total pages :338
  • ISBN : 9780309137348
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Summary : H1N1 ("swine flu"), SARS, mad cow disease, and HIV/AIDS are a few examples of zoonotic diseases-diseases transmitted between humans and animals. Zoonotic diseases are a growing concern given multiple factors: their often novel and unpredictable nature, their ability to emerge anywhere and spread rapidly around the globe, and their major economic toll on several disparate industries. Infectious disease surveillance systems are used to detect this threat to human and animal health. By systematically collecting data on the occurrence of infectious diseases in humans and animals, investigators can track the spread of disease and provide an early warning to human and animal health officials, nationally and internationally, for follow-up and response. Unfortunately, and for many reasons, current disease surveillance has been ineffective or untimely in alerting officials to emerging zoonotic diseases. Sustaining Global Surveillance and Response to Emerging Zoonotic Diseases assesses some of the disease surveillance systems around the world, and recommends ways to improve early detection and response. The book presents solutions for improved coordination between human and animal health sectors, and among governments and international organizations. Parties seeking to improve the detection and response to zoonotic diseases--including U.S. government and international health policy makers, researchers, epidemiologists, human health clinicians, and veterinarians--can use this book to help curtail the threat zoonotic diseases pose to economies, societies, and health.

Global Health Impacts of Vector-Borne Diseases

Global Health Impacts of Vector-Borne Diseases
  • Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats
  • Publisher :Unknown
  • Release Date :2016-09-21
  • Total pages :396
  • ISBN : 9780309377621
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Summary : Pathogens transmitted among humans, animals, or plants by insects and arthropod vectors have been responsible for significant morbidity and mortality throughout recorded history. Such vector-borne diseases â€" including malaria, dengue, yellow fever, and plague â€" together accounted for more human disease and death in the 17th through early 20th centuries than all other causes combined. Over the past three decades, previously controlled vector-borne diseases have resurged or reemerged in new geographic locations, and several newly identified pathogens and vectors have triggered disease outbreaks in plants and animals, including humans. Domestic and international capabilities to detect, identify, and effectively respond to vector-borne diseases are limited. Few vaccines have been developed against vector-borne pathogens. At the same time, drug resistance has developed in vector-borne pathogens while their vectors are increasingly resistant to insecticide controls. Furthermore, the ranks of scientists trained to conduct research in key fields including medical entomology, vector ecology, and tropical medicine have dwindled, threatening prospects for addressing vector-borne diseases now and in the future. In June 2007, as these circumstances became alarmingly apparent, the Forum on Microbial Threats hosted a workshop to explore the dynamic relationships among host, pathogen(s), vector(s), and ecosystems that characterize vector-borne diseases. Revisiting this topic in September 2014, the Forum organized a workshop to examine trends and patterns in the incidence and prevalence of vector-borne diseases in an increasingly interconnected and ecologically disturbed world, as well as recent developments to meet these dynamic threats. Participants examined the emergence and global movement of vector-borne diseases, research priorities for understanding their biology and ecology, and global preparedness for and progress toward their prevention, control, and mitigation. This report summarizes the presentations and discussions from the workshop.

The Oxford Handbook of Global Health Politics

The Oxford Handbook of Global Health Politics
  • Author : Colin McInnes,Kelley Lee,Jeremy Youde
  • Publisher :Unknown
  • Release Date :2020
  • Total pages :752
  • ISBN : 9780190456818
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Summary : Protecting and promoting health is inherently a political endeavor that requires a sophisticated understanding of the distribution and use of power. Yet while the global nature of health is widely recognized, its political nature is less well understood. In recent decades, the interdisciplinary field of global health politics has emerged to demonstrate the interconnections of health and core political topics, including foreign and security policy, trade, economics, and development. Today a growing body of scholarship examines how the global health landscape has both shaped and been shaped by political actors and structures. The Oxford Handbook of Global Health Politics provides an authoritative overview and assessment of research on this important and complicated subject. The volume is motivated by two arguments. First, health is not simply a technical subject, requiring evidence-based solutions to real-world problems, but an arena of political contestation where norms, values, and interests also compete and collide. Second, globalization has fundamentally changed the nature of health politics in terms of the ideas, interests, and institutions involved. The volume comprises more than 30 chapters by leading experts in global health and politics. Each chaper provides an overview of the state of the art on a given theoretical perspective, major actor, or global health issue. The Handbook offers both an excellent introduction to scholars new to the field and also an invaluable teaching and research resource for experts seeking to understand global health politics and its future directions.