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Volatile Biomarkers

Volatile Biomarkers
  • Author : Anton Amann,David Smith
  • Publisher :Unknown
  • Release Date :2013-03-27
  • Total pages :600
  • ISBN : 9780444626202
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Summary : Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area. Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds Includes case presentations documenting applications in multiple areas of human health and safety

Breathborne Biomarkers and the Human Volatilome

Breathborne Biomarkers and the Human Volatilome
  • Author : Jonathan Beauchamp,Cristina Davis,Joachim Pleil
  • Publisher :Unknown
  • Release Date :2020-06-06
  • Total pages :722
  • ISBN : 9780128223970
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Summary : Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis. Presents recent advances in the field of breath analysis Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments Acts as both a primer for beginners and a reference for seasoned researchers

Identification Methods and Chemometric Analysis of Mammalian Volatile Biomarkers

Identification Methods and Chemometric Analysis of Mammalian Volatile Biomarkers
  • Author : Shamitha Asoka Dissanayake
  • Publisher :Unknown
  • Release Date :2014
  • Total pages :142
  • ISBN : OCLC:892874296
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Summary : The ultimate goal of this research is to provide a low cost, efficient, reproducible, quantitative, non-invasive screening method to diagnose diseases at an early stage through identification of volatile biomarkers of disease. Progress has been made in the areas towards development of an analytical system that can provide a rapid and specific assay for above mentioned Volatile Organic Compounds (VOCs). (i) Methods have been designed for the collection, concentration, identification and quantification of volatile biomarkers. (ii) Advanced signal processing evaluation of data has tentatively identified key VOCs patterns with breath and body odor. (iii) Novel absorbent coatings have been studied for use with miniature chemical sensors that one day may be part of a portable analytical system. Both breath and body odor contain a complex mixture of chemicals, which are influenced by many internal and external factors. Breath and skin odor samples were collected with minimum external contaminations using traditional SPME and active SPME GCMS techniques. Body odor from 65 human subjects was tested with and without selected scent removal products. Breath samples were collected from 21 canine subjects. The VOCs profiles of these samples were determined and then statistically treated with principal component analysis, discriminant analysis, and tree regression techniques to simplify and interpret the complex mixtures. While much of our work has utilized large bench-top equipment, our over-arching goal is to provide a portable device that can diagnose diseases at an early stage. Concurrent work was done to enhance the performance of a miniaturized detector for the detection of potential biomarkers. Two organic polymers mixed with conductive carbon nanoparticles were deposited between the microcapacitor plates of microsensors using ink-jet technology. Microsensors were also fabricated using conducting ionic liquids. The performances of the individual chemicapacitive sensors were characterized through exposure to different concentrations of varied volatile organic compounds with different functional groups in a climate-controlled vapor delivery system.

Volatile Aldehydes in Breath and Tissues as Biomarkers of Carcinogenesis

Volatile Aldehydes in Breath and Tissues as Biomarkers of Carcinogenesis
  • Author : Susan Elizabeth Ebeler
  • Publisher :Unknown
  • Release Date :1993
  • Total pages :202
  • ISBN : UCAL:X53752
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Volatile Biomarkers of Blood Glucose

Volatile Biomarkers of Blood Glucose
  • Author : Bhavin Parekh
  • Publisher :Unknown
  • Release Date :2011
  • Total pages :229
  • ISBN : OCLC:890150453
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The Handbook of Biomarkers

The Handbook of Biomarkers
  • Author : Kewal K. Jain
  • Publisher :Unknown
  • Release Date :2010-02-06
  • Total pages :492
  • ISBN : 1607616858
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Summary : Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today.

Biosensing Technologies for the Detection of Pathogens

Biosensing Technologies for the Detection of Pathogens
  • Author : Toonika Rinken,Kairi Kivirand
  • Publisher :Unknown
  • Release Date :2018-03-21
  • Total pages :216
  • ISBN : 9789535139157
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Summary : Rapid multiplex detection of pathogens in the environment and in our food is a key factor for the prevention and effective treatment of infectious diseases. Biosensing technologies combining the high selectivity of biomolecular recognition and the sensitivity of modern signal detection platforms are a prospective option for automated analyses. They allow rapid detection of single molecules as well as cellular substances. This book, including 12 chapters from 50 authors, introduces the principles of identification of specific pathogen biomarkers along with different biosensor-based technologies applied for pathogen detection.

Analysis of Volatile Biomarkers from in Vitro Cell Cultures and Exhaled Breath for Ventilator-associated Pneumonia Diagnosis

Analysis of Volatile Biomarkers from in Vitro Cell Cultures and Exhaled Breath for Ventilator-associated Pneumonia Diagnosis
  • Author : Oluwasola Lawal
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :229
  • ISBN : OCLC:1197754727
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Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers

Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers
  • Author : Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu
  • Publisher :Unknown
  • Release Date :2020-08-03
  • Total pages :231
  • ISBN : 9811544301
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Summary : This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Use of Gas Analysis Technology to Develop Volatile Biomarkers for Lung Cancer and Explore the Association Between Lung Cancer and Air Pollution

Use of Gas Analysis Technology to Develop Volatile Biomarkers for Lung Cancer and Explore the Association Between Lung Cancer and Air Pollution
  • Author : 曾千
  • Publisher :Unknown
  • Release Date :2019
  • Total pages :229
  • ISBN : OCLC:1198970533
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Volatile Organic Compound Analysis in Biomedical Diagnosis Applications

Volatile Organic Compound Analysis in Biomedical Diagnosis Applications
  • Author : Raquel Cumeras,Xavier Correig
  • Publisher :Unknown
  • Release Date :2018-11-22
  • Total pages :272
  • ISBN : 9780429782428
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Summary : This volume presents a thought-provoking state-of-the-art picture of how volatile compounds are used in metabolomics, currently a hot topic in the metabolomics field. It provides a thorough description of what volatile organic compounds (VOCs) are, why they are important in biomedicine, and what the analytical platforms are used. It also looks at multivariate analysis and databases needs. Because VOCs are end-up compounds of metabolic processes, volatiles can be linked to different diseases or pathologies for both diagnosis and prognosis. The authors provide authoritative information and guidance on the analytical and statistical techniques used and how to identify, and they review the main current areas of application, which include breath metabolomics, cancer diagnosis, and microbial volatiles. Key Features: Presents a thorough overview of volatile research in biomedical applications Examines both gold standard techniques (metabolomics based) and artificial olfactory systems Reviews all aspects of volatile metabolites in biomedicine research, from origin to detection platforms Describes relevant diseases diagnosis and prognosis achievements, including cancer

Volatile Biomarkers Emitted by Cell Cultures

Volatile Biomarkers Emitted by Cell Cultures
  • Author : Thomas W. E. Chippendale
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :229
  • ISBN : OCLC:1063475405
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Volatile Biomarkers from Cultured Human Immune Cells, Cultured Human Acute Lymphoblastic Leukemia Cells and the Exhaled Breath of Patients with Acute Myelolgenous Leukemia

Volatile Biomarkers from Cultured Human Immune Cells, Cultured Human Acute Lymphoblastic Leukemia Cells and the Exhaled Breath of Patients with Acute Myelolgenous Leukemia
  • Author : Brandon James Umber
  • Publisher :Unknown
  • Release Date :2012
  • Total pages :168
  • ISBN : 1267171073
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Summary : Presented here are the volatile organic compounds (VOCs) that were observed to be produced or consumed by healthy and malignant human immune cells as well as those observed in the exhaled breath of patients with acute myelogenous leukemia (AML). Two lineages of white cells were investigated: the lymphoid and the myeloid line of cellular differentiation. The lymphoid lineage was investigated using cultured human peripheral blood mononuclear cells (PBMCs) from healthy donors and cryogenically preserved leukemic cells collected from patients with acute lymphocytic leukemia (ALL). Likewise, the myeloid lineage was investigated using mature neutrophils from healthy donors, the HL60 cell line (malignant immature neutrophils), and the whole air collection of the exhaled breath of patients with AML. Cell cultures were grown in hermetically sealable glass culture flasks and the headspace above the culture was collected for analysis. The exhaled breath of patients with AML and the exhalant of healthy controls were collected in evacuated stainless steel canisters. Analysis of the samples was performed using gas chromatography. Cultured PBMCs were shown to reduce the concentration of acetaldehyde in the headspace relative to controls. Acetaldehyde in the headspace was 1.9±1 ppbv less than what was present in the media. Likewise hexanaldehyde was lower by 0.10±0.05 ppbv. Acute lymphocytic leukemia cells produced greater amounts of acetaldehyde and dimethyl sulfide relative to controls: 14±5 ppbv and 200±50 ppbv above controls. Healthy nuetrophils in culture produced a concentration of acetaldehyde of 4.5±5.4 ppbv above control and had a level of hexanaldehyde 80±60 pptv below controls. The HL60 cells produced 11±3 ppbv of acetaldehyde and 200±70 pptv of hexanladehyde. The exhaled breath of patients with AML contained levels of five VOCs that were significantly different from those found in the healthy controls: acetaldehyde, butane, carbon disulfide, carbonyl sulfide, and heptane. Carbon disulfide and butane were present in levels above the healthy controls and the ambient room concentrations: 15±17 pptv and 700±1,300 pptv. With the goal of diagnostic efficacy in mind it is hoped that the nascent VOC profile of leukemia discussed in this work may provide a foundation for future studies.

Analysis of Volatile Biomarkers of Airway Inflammation in Breath

Analysis of Volatile Biomarkers of Airway Inflammation in Breath
  • Author : Jack F. Dummer
  • Publisher :Unknown
  • Release Date :2010
  • Total pages :352
  • ISBN : OCLC:774983686
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Olfaction and Electronic Nose

Olfaction and Electronic Nose
  • Author : Matteo Pardo,Giorgio Sberveglieri
  • Publisher :Unknown
  • Release Date :2009-06-09
  • Total pages :614
  • ISBN : UCSD:31822037777786
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Summary : ISOEN addresses research in the fields of gas sensors and artificial olfactory systems. In this edition we broadened the participation spectrum to all kinds of analytical instrumentation for odor measurement and to biological olfaction. We also had a strong involvement in industry. The audience comprises materials scientists, chemists, physicists, engineers, biologists, computer scientists, and application specialists (e.g. food, medical, environmental, security).

Tobacco Smoke Exposure Biomarkers

Tobacco Smoke Exposure Biomarkers
  • Author : Qingyuan Hu,Hongwei Hou
  • Publisher :Unknown
  • Release Date :2015-04-01
  • Total pages :288
  • ISBN : 9781498705615
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Summary : Written by experts in the analytical chemistry of tobacco smoke, Tobacco Smoke Exposure Biomarkers summarizes the toxicology, metabolic pathway, and biomarkers of nicotine, TSNAs, PAHs, VOCs, AAs, Catechol and Hydroquinone, HCN, CO and NOx, and heavy metals, and the use of this biomarker in exposure assessment and/or cigarette smoke exposure environmental epidemiology. A convenient one-stop guide, the book brings together information on some exposure biomarkers and nicotine addiction in humans with regulatory implications and strategies. The authors also include discussions of how smoke exposure biomarkers may be used to shape regulation and health policy. Ethics guidelines, details of method development, and the validated relative bioanalytical method provided in the appendixes rounds out the coverage. The book gives you tools to further research biomarkers for tobacco carcinogens and to face emerging health challenges such as delivery of nicotine via electronic cigarettes.

Exhaled Biomarkers

Exhaled Biomarkers
  • Author : I. Horvath,J.C. de Jongste
  • Publisher :Unknown
  • Release Date :2010-09-01
  • Total pages :260
  • ISBN : 9781849840057
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Summary : Exhaled air contains numerous substances, often in extremely low concentrations. The development of sensitive detection techniques has made it possible to examine the composition of exhaled air in relation to a variety of airway diseases and other disorders. In this book, an overview of current cutting-edge breath analysis techniques and their clinical applications is provided for the clinician. The various contributions give a fascinating perspective of a future where new, highly sensitive methodologies will enable clinicians to diagnose and monitor a wide variety of diseases merely by taking.

Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers

Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers
  • Author : Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu
  • Publisher :Unknown
  • Release Date :2020-07-21
  • Total pages :231
  • ISBN : 9789811544316
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Summary : This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Volatile Organic Biomarkers in Exhaled Breath as a Rapid, Prodromal, Diagnosis of Bioagent Infection

Volatile Organic Biomarkers in Exhaled Breath as a Rapid, Prodromal, Diagnosis of Bioagent Infection
  • Author : Anonim
  • Publisher :Unknown
  • Release Date :2004
  • Total pages :8
  • ISBN : OCLC:227890819
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Summary : We have studied the feasibility of using biomarkers in exhaled breath as a prodromal diagnostic for bioagent infection. A compact sampling system was developed and used to collect more than 75 breath samples from 9 piglets. Three of the sampled piglets were uninfected control animals, three were infected with staphylococcal enterotoxin B (SEB), and three with Actinobacillus pleuropneumoniae (A.p.). We found that: volatile markers appeared several hours before outwardly noticeable physical symptoms of illness; volatile profiles for infected piglets were distinct from the uninfected animals and room background air samples; and the volatile profiles for SEB and A.p. were different.

Volatile Organic Compounds in OCWD Water Samples and Volatile Organic Biomarkers in Exhaled Breath and Plasma of Overweight and Type 2 Diabetes Subjects

Volatile Organic Compounds in OCWD Water Samples and Volatile Organic Biomarkers in Exhaled Breath and Plasma of Overweight and Type 2 Diabetes Subjects
  • Author : Yu-Hsin Hung
  • Publisher :Unknown
  • Release Date :2014
  • Total pages :151
  • ISBN : 1303716453
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Summary : The objective of water sample study is to determine and monitor change of volatile organic compounds in water samples during two steps in the water treatment process at the OCWD, reverse osmosis and ultraviolet(UV)-H2O2 based UV advanced oxidation processes. In order to optimize water reclamation for mitigation of ever-increasing water demand, the production and elimination of pollutants (both known and unidentified) during the water treatment process need to be thoroughly investigated. Volatile organic compounds were collected by purging water samples with ultra high purity helium and collection in 1.9 L stainless canisters. Degassed samples were analyzed with multiple column/detector combinations simultaneously to detect known and unidentified compounds. Chloromethane and four trihalomethanes (Br, Cl) were found, but well below the legal or suggested levels. Increase of methyl nitrate and i-propyl nitrate after the UV-H2O2 based UV advanced oxidation process were observed as well. Estimation of methyl nitrate and i-propyl nitrate annual production based on current results demonstrates no significant air quality effect. The objective of breath and plasma studies among overweight and type 2 diabetes mellitus (T2DM) groups is to determine possible biomarkers for screening of pre-diabetes and diabetes. Financial cost, possible complications of diabetes, and the finger pricking blood sugar monitoring routine are overwhelming for diabetic patients. Biomarkers for pre-diabetes and diabetes may facilitate diabetes screening and/or inspire non-invasive blood sugar monitoring techniques. Exhaled breath, ambient room air, and plasma degas samples were analyzed with multi column/detector combinations. Plasma and/or delta breath isoprene, acetone, and methanol are substantially higher in males than females for overweight and T2DM groups. A larger group covering various age ranges can help further determine the distribution of these three and maybe determine other gases among groups (healthy, overweight, and T2DM) that can serve as diabetes screening biomarkers.

In Vitro Analysis of Volatile Organic Compounds in Search of Potential Biomarkers of Lung Cancer

In Vitro Analysis of Volatile Organic Compounds in Search of Potential Biomarkers of Lung Cancer
  • Author : K. Schmidt
  • Publisher :Unknown
  • Release Date :2016
  • Total pages :229
  • ISBN : OCLC:1079208863
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Summary :